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1. 发明申请

WO2009142571A1 PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 审中-公开
标题翻译：苯并噻唑啉衍生物衍生物
公开(公告)号：WO2009142571A1
公开(公告)日：2009-11-26
申请号：PCT/SE2009000267
申请日：2009-05-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AG , BERGER MARKUS , DAHMEN JAN , EDMAN KARL , ERIKSSON ANDERS , HANSSON THOMAS , HEMMERLING MARTIN , HOSSAIN NAFIZAL , KLINGSTEDT TOMAS , LEPISTOE MATTI , NILSSON STINABRITT , REHWINKEL HARTMUT
发明人： BAYER SCHERING PHARMA AG , BERGER MARKUS , DAHMEN JAN , EDMAN KARL , ERIKSSON ANDERS , HANSSON THOMAS , HEMMERLING MARTIN , HOSSAIN NAFIZAL , KLINGSTEDT TOMAS , LEPISTOE MATTI , NILSSON STINABRITT , REHWINKEL HARTMUT
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译：式Ia化合物：（Ia）本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。

2. 发明申请

WO2004099204A1 IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS 审中-公开
标题翻译：作为JAK3激酶抑制剂的咪唑和噻唑吡啶
公开(公告)号：WO2004099204A1
公开(公告)日：2004-11-18
申请号：PCT/SE2004/000694
申请日：2004-05-06
申请人： ASTRAZENECA AB , HEMMERLING, Martin , KLINGSTEDT, Tomas
发明人： HEMMERLING, Martin , KLINGSTEDT, Tomas
IPC分类号： C07D471/04
CPC分类号： C07D513/04 , C07D471/04
摘要： The present invention relates to novel imidazo and thiazolopyridine compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them. Formula (I)
摘要翻译：本发明涉及作为激酶抑制剂的新型咪唑并噻唑并吡啶化合物，其制备方法及其制备方法。式（I）

3. 发明申请

WO2008104752A1 DIHYDROPYRIDONES AS ELASTASE INHIBITORS 审中-公开
标题翻译：作为弹性酶抑制剂的二氢吲哚
公开(公告)号：WO2008104752A1
公开(公告)日：2008-09-04
申请号：PCT/GB2008/000633
申请日：2008-02-26
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , KLINGSTEDT, Tomas , LEPISTÖ, Matti , LUNDKVIST, Michael , LÖNN, Hans
发明人： KLINGSTEDT, Tomas , LEPISTÖ, Matti , LUNDKVIST, Michael , LÖNN, Hans
IPC分类号： C07D211/82 , A61K31/4418 , A61P11/00
CPC分类号： C07D211/82
摘要： The invention provides compounds of formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 , X 2 , X 3 and X 4 are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译：本发明提供下式的化合物其中R 1，R 2，R 3，R 4，R 4， > 5，R 6，R 7，X 1，X 2，X SUP > 3和X 4如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。

4. 发明申请

WO2004016615A1 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY 审中-公开
标题翻译： PYRAZOLO（4,3c）作为ITK激酶活性的抑制剂的氰基化合物
公开(公告)号：WO2004016615A1
公开(公告)日：2004-02-26
申请号：PCT/SE2003/001278
申请日：2003-08-13
申请人： ASTRAZENECA AB , DAHMEN, Jan , HEMMERLING, Martin , KLINGSTEDT, Tomas , SJÖ, Peter
发明人： DAHMEN, Jan , HEMMERLING, Martin , KLINGSTEDT, Tomas , SJÖ, Peter
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： There are provided novel compounds of formula (I) wherein R and X are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.
摘要翻译：提供新的式（I）化合物，其中R和X如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是激酶Itk的抑制剂。

5. 发明申请

WO1996009282A1 IODINATED X-RAY CONTRAST MEDIA 审中-公开
标题翻译： IODINATED X-RAY对比媒体
公开(公告)号：WO1996009282A1
公开(公告)日：1996-03-28
申请号：PCT/GB1995002265
申请日：1995-09-22
申请人： NYCOMED IMAGING A/S , REED, Michael, Antony , ALMÉN, Torsten , ANDERSSON, Sven , WISTRAND, Lars-Göran , GOLMAN, Klaes , ANTONSEN, Oyvind , FOSSHEIM, Rune , WIGGEN, Unni, Nordby , WIKSTRÖM, Håkan , KLINGSTEDT, Tomas , LEUNBACH, Ib , BERG, Arne , DUGSTAD, Harald
发明人： NYCOMED IMAGING A/S , REED, Michael, Antony
IPC分类号： C07C237/46
CPC分类号： C07C33/46 , A61K49/0433 , C07C33/483 , C07C235/16 , C07C237/46
摘要： The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula (I), wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one, and preferably two or three, R groups in each C6R5 moiety being M or M1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M1 independently represents a C1-4alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M1 moiety; with the proviso that where n is zero either at least one M1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M1 group is present at least one nitrogen-attached or hydroxylated-C3-4 alkyl moiety-containing M group is also present and isomers thereof.
摘要翻译：本发明提供了可用作式（I）的X射线造影剂的低粘度碘化芳基化合物，其中n为0或1，并且其中n为1，每个C 6 R 5部分可以相同或不同; 每个基团R是氢原子，碘原子或亲水部分M或M1，每个C 6 R 5部分中两个或三个不相邻的R基团是碘，并且每个C 6 R 5部分中至少一个，优选两个或三个R基团是M或M1部分; X表示键或提供连接两个C 6 R 5部分的1至7个原子链的基团，或其中n为0，X表示基团R; 每个M独立地是非离子亲水部分; 并且每个M1独立地表示被至少一个羟基取代的C 1-4烷基，并且任选地通过羰基，砜或亚砜基与苯环连接，至少一个R基团是M1部分; 条件是在n为0的情况下，至少一个除羟甲基或1,2-二羟乙基之外的M1基团存在或如果一个羟甲基或1,2 - 二羟乙基M1基团存在至少一个含氮连接或羟基化的含C3-4烷基部分的M基团以及其异构体。

6. 发明申请

WO2009142571A8 PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 审中-公开
公开(公告)号：WO2009142571A8
公开(公告)日：2009-11-26
申请号：PCT/SE2009/000267
申请日：2009-05-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
发明人： BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.

7. 发明申请

WO2004043924A1 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE 审中-公开
标题翻译：作为中性弹性蛋白酶抑制剂的2-吡啶酮衍生物
公开(公告)号：WO2004043924A1
公开(公告)日：2004-05-27
申请号：PCT/SE2003/001739
申请日：2003-11-11
申请人： ASTRAZENECA AB , BLADH, Håkan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
发明人： BLADH, Håkan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
IPC分类号： C07D211/86
CPC分类号： C07D213/64 , C07D213/82 , C07D239/557 , C07D241/24 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R¿1?, R¿4?, R¿5?, G¿1?, G¿2?, X, L, Y¿1?, Y¿2? and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译：提供式（I）的新化合物，其中R 1，R 4，R 5，G 1，G 2，X，L，Y 1，Y 2，和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。

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