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1. 发明申请

WO2003029224A1 6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译： 6成员不饱和杂环化合物可用于选择性抑制凝聚剂CASCADE
公开(公告)号：WO2003029224A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031784
申请日：2002-10-03
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping , ABBAS, Zaheer , FENTON, Ricky, L. , KUSTURIN, Carrie, L. , HAYAT, Rahman, K. , SAMPLE, Kirby, R. , SCHWEITZER, Barbara, A. , WOOD, Rhonda, S. , SZALONY, Jim , SULEYMANOV, Osman, D. , SALYERS, Anita , NICHOLSON, Nancy, S.
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping , ABBAS, Zaheer , FENTON, Ricky, L. , KUSTURIN, Carrie, L. , HAYAT, Rahman, K. , SAMPLE, Kirby, R. , SCHWEITZER, Barbara, A. , WOOD, Rhonda, S. , SZALONY, Jim , SULEYMANOV, Osman, D. , SALYERS, Anita , NICHOLSON, Nancy, S.
IPC分类号： C07D239/47
CPC分类号： C07D231/38 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

2. 发明申请

WO2003093242A2 SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译：取代的5组分多环化合物可用于选择性抑制凝聚剂CASCADE
公开(公告)号：WO2003093242A2
公开(公告)日：2003-11-13
申请号：PCT/US2002/031770
申请日：2002-10-03
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC分类号： C07D231/00
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

3. 发明申请

WO2003029216A1 6-MEMBERED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译：用于选择性抑制凝聚剂CASCADE的6组分杂环化合物
公开(公告)号：WO2003029216A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031769
申请日：2002-10-03
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffery, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffery, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC分类号： C07D211/98
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

4. 发明申请

WO2012087866A1 DETONATOR IGNITION PROTECTION AND DETECTION CIRCUIT 审中-公开
标题翻译：爆震点火保护和检测电路
公开(公告)号：WO2012087866A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065722
申请日：2011-12-19
申请人： DYNO NOBEL INC. , HAYES, Michael J. , HOOPES, Thomas A. , JURRAS III, Mark I.
发明人： HAYES, Michael J. , HOOPES, Thomas A. , JURRAS III, Mark I.
IPC分类号： F42B3/18 , F42B3/185 , F42B3/188 , F42D1/05
CPC分类号： G01N11/06 , F42B3/18 , F42B3/185 , F42B3/188 , F42C11/001 , F42C15/40 , F42D1/05 , G01R25/00 , G01R31/2832 , G06F19/00 , H01T13/58
摘要： An ignition circuit (200) includes: an igniter (210) having first (211) and second (212) terminals; a first diode (225) electrically connected in series with the igniter at the first terminal; a second diode (230) electrically connected in series with the igniter at the second terminal. The first and second diodes each have an anode terminal (226, 231) and a cathode terminal (227, 232), wherein like terminals of the first and second diodes are electrically connected to the igniter, thereby defining proximal terminals and distal terminals. A capacitor (235) is electrically connected across the distal terminals and connectable in parallel with a series-connected energy source (215) and switch (220). The energy source and a switch are electrically connectable across the distal terminals via test lead wires. Current flow through the igniter sufficient to ignite the igniter is prevented until an ignition voltage is applied to the distal terminals that is equal to or greater than the reverse breakdown voltage of the first diode or the second diode.
摘要翻译：点火电路（200）包括：具有第一（211）和第二（212）端子的点火器（210）与第一端子处的点火器串联电连接的第一二极管（225）; 在第二端子处与点火器串联电连接的第二二极管（230）。第一和第二二极管各自具有阳极端子（226,231）和阴极端子（227,232），其中第一和第二二极管的类似端子电连接到点火器，由此限定近端和远端。电容器（235）跨越远端端子电连接，并且与串联连接的能量源（215）和开关（220）并联连接。能量源和开关通过测试导线在远端之间电连接。防止足以点燃点火器的点火器的电流流过直到点火电压施加到等于或大于第一二极管或第二二极管的反向击穿电压的远端。

5. 发明申请

WO2003093242A3 SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
公开(公告)号：WO2003093242A3
公开(公告)日：2003-11-13
申请号：PCT/US2002/031770
申请日：2002-10-03
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC分类号： C07D231/48
摘要： The present invention relates to substituted 5-membered polycyclic compounds and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

6. 发明申请

WO2002042272A3 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
公开(公告)号：WO2002042272A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/043280
申请日：2001-11-20
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , CASE, Brenda , GARLAND, Danny, J. , HAYES, Michael, J. , HUANG, Horng-Chih , HUANG, Wei , JONES, Darin, E. , NEUMANN, William, L. , PARLOW, John, J. , REITZ, David, B. , RUEPPEL, Melvin, L. , WEBBER, Ronald, K.
发明人： SOUTH, Michael, S. , CASE, Brenda , GARLAND, Danny, J. , HAYES, Michael, J. , HUANG, Horng-Chih , HUANG, Wei , JONES, Darin, E. , NEUMANN, William, L. , PARLOW, John, J. , REITZ, David, B. , RUEPPEL, Melvin, L. , WEBBER, Ronald, K.
IPC分类号： A61K31/4418
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

7. 发明申请

WO2009032120A1 APPARATUSES FOR AND METHOD OF PREVENTING DECUBITUS ULCERS 审中-公开
标题翻译：装置和防止肾上腺素的方法
公开(公告)号：WO2009032120A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010140
申请日：2008-08-27
申请人： STRYKER DEVELOPMENT LLC , NEUSTAEDTER, David , HARRIS, Doug , LANCASTER, Ron , STRYKER, Martin, W. , HAYES, Michael, J.
发明人： NEUSTAEDTER, David , HARRIS, Doug , LANCASTER, Ron , STRYKER, Martin, W. , HAYES, Michael, J.
IPC分类号： A61F13/00 , A61B18/04
CPC分类号： A61N1/205 , A61H23/0263 , A61H2201/165 , A61H2201/5058 , A61N1/328 , Y10S5/94
摘要： An apparatus for the prevention of decubitus ulcers includes an overlay and a plurality of stimulation segments disposed throughout the overlay, wherein the stimulation segments provide stimulation. At least one sensor is disposed within at least one of the plurality of stimulation segments. A controller is electrically connected to the at least one sensor, wherein the controller gathers data from the sensor, processes the data, and transmits instructions to the stimulation segments.
摘要翻译：用于预防褥疮溃疡的装置包括覆盖层和遍及覆盖层设置的多个刺激段，其中刺激段提供刺激。至少一个传感器设置在所述多个刺激段中的至少一个中。控制器电连接到所述至少一个传感器，其中所述控制器从所述传感器收集数据，处理所述数据并将指令发送到所述刺激段。

8. 发明申请

WO0242272A2 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译：用于选择性抑制凝聚剂CASCADE的取代的多环芳烃和异丁基吡啶
公开(公告)号：WO0242272A2
公开(公告)日：2002-05-30
申请号：PCT/US0143280
申请日：2001-11-20
申请人： PHARMACIA CORP , SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
发明人： SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , A61P43/00 , C07D213/74 , C07D213/89 , C07D401/10 , C07D409/04 , C07D213/00
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

9. 发明申请

WO0242272A8 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译：用于选择性抑制凝聚剂CASCADE的取代的多环芳烃和异丁基吡啶
公开(公告)号：WO0242272A8
公开(公告)日：2003-10-23
申请号：PCT/US0143280
申请日：2001-11-20
申请人： PHARMACIA CORP , SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
发明人： SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , A61P43/00 , C07D213/74 , C07D213/89 , C07D401/10 , C07D409/04 , C07D213/77 , C07D213/90 , C07D237/20 , C07D239/36 , C07D239/42 , C07D241/20 , C07D253/04 , C07D253/06 , C07D265/02 , C07D417/12
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

10. 发明申请

WO2003028729A3 PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
公开(公告)号：WO2003028729A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031468
申请日：2002-10-03
申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping
IPC分类号： A61K31/4965
摘要： The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.

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