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1. 发明申请

WO2015195228A1 HETEROARYL COMPOUNDS FOR KINASE INHIBITION 审中-公开
标题翻译：用于激酶抑制的异氟醚化合物
公开(公告)号：WO2015195228A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/030576
申请日：2015-05-13
申请人： ARIAD PHARMACEUTICALS, INC. , HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D403/14 , C07D473/16
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07F9/65583
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.
摘要翻译：本文描述了调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及化合物，药物组合物和治疗与激酶活性相关的疾病和病症（包括突变型EGFR和突变型HER2活性）的方法。

2. 发明申请

WO2015175632A1 HETEROARYL COMPOUNDS FOR KINASE INHIBITION 审中-公开
标题翻译：用于激酶抑制的杂原子化合物
公开(公告)号：WO2015175632A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030522
申请日：2015-05-13
申请人： ARIAD PHARMACEUTICALS, INC. , HUANG, Wei-Sheng , LI, Feng , DALGARNO, David, C. , GONG, Yongjin , ISHCHENKO, Alexey, V. , KOHLMANN, Anna , SHAKESPEARE, William, C. , WEST, Angela, V. , XU, Yongjin , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun , ZHU, Xiaotian
发明人： HUANG, Wei-Sheng , LI, Feng , DALGARNO, David, C. , GONG, Yongjin , ISHCHENKO, Alexey, V. , KOHLMANN, Anna , SHAKESPEARE, William, C. , WEST, Angela, V. , XU, Yongjin , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun , ZHU, Xiaotian
IPC分类号： C07D403/14 , C07D473/16
CPC分类号： C07F9/6561 , C07D471/06 , C07D487/06 , C07D498/06
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.
摘要翻译：调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及化合物，药物组合物和治疗与激酶活性相关的疾病和病症的方法，包括突变型EGFR和突变型HER2 活动，在这里描述。

3. 发明申请

WO2014085372A2 ELECTRICAL NETWORK MODEL SYNCHRONIZATION 审中-公开
标题翻译：电气网络模型同步
公开(公告)号：WO2014085372A2
公开(公告)日：2014-06-05
申请号：PCT/US2013/071820
申请日：2013-11-26
申请人： ABB TECHNOLOGY AG , HUANG, Wei , VODA, Douglass, A. , LAWRENCE, David, C.
发明人： HUANG, Wei , VODA, Douglass, A. , LAWRENCE, David, C.
IPC分类号： G06F17/50
CPC分类号： G06F17/50 , H02J3/006 , H02J3/12 , H02J3/16 , H02J3/1821 , H02J2003/001 , H02J2003/007 , Y02E40/30 , Y02E40/34 , Y02E60/76 , Y04S10/525 , Y04S40/22
摘要： Among other things, one or more techniques and/or systems are provided for maintaining an electrical network model describing an electrical network. A fault detection, fault isolation, and load restoration (FDIR) component, a voltage/var control (VVC) component, and/or other components may be provided with access to the electrical network model so that the components may have access to relatively up- to-date and/or accurate information describing the electrical network when executing functionality for the electrical network. For example, the FDIR component and the VVC component may be synchronized based upon the electrical network model so that the FDIR component may have notice of network changes by the VCC component, and/or the VCC component have may have notice of network changes by the FDIR component.
摘要翻译：除其他之外，提供一个或多个技术和/或系统用于维护描述电网的电网模型。可以向故障检测，故障隔离和负载恢复（FDIR）组件，电压/变量控制（VVC）组件和/或其他组件提供对电网模型的访问，使得组件可以访问相对较高 - 当执行电力网络的功能时，描述电气网络的最新和/或准确的信息。例如，FDIR组件和VVC组件可以基于电网模型进行同步，使得FDIR组件可以注意到VCC组件的网络改变，和/或VCC组件可能具有网络改变的通知 FDIR组件。

4. 发明申请

WO2013044223A1 INPUT/OUTPUT MEMORY MANAGEMENT UNIT WITH PROTECTION MODE FOR PREVENTING MEMORY ACCESS BY I/O DEVICES 审中-公开
标题翻译：具有用于防止I / O设备存储器访问的保护模式的输入/输出存储器管理单元
公开(公告)号：WO2013044223A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056898
申请日：2012-09-24
申请人： ADVANCED MICRO DEVICES, INC. , KEGEL, Andrew, G. , PEREZ, Ronald , HUANG, Wei
发明人： KEGEL, Andrew, G. , PEREZ, Ronald , HUANG, Wei
IPC分类号： G06F12/10 , G06F12/14 , G06F21/57
CPC分类号： G06F12/1081 , G06F12/145 , G06F12/1491 , G06F21/79 , G06F21/85 , G06F2212/1052 , G06F2221/2129
摘要： A memory management unit is configured to receive requests for memory access from a plurality of I/O devices. The memory management unit implements a protection mode wherein the unit prevents memory accesses by the plurality of I/O devices by mapping memory access requests (from the I/O devices) to the same set of memory address translation data. When the memory management unit is not in the protected mode, the unit maps memory access requests from the plurality of I/O devices to different respective sets of memory address translation data. Thus, the memory management unit may protect memory from access by I/O devices using fewer address translation tables than are typically required (e.g., none).
摘要翻译：存储器管理单元被配置为从多个I / O设备接收对存储器访问的请求。存储器管理单元实现保护模式，其中该单元通过将存储器访问请求（从I / O设备）映射到同一组存储器地址转换数据来防止多个I / O设备的存储器访问。当存储器管理单元不处于保护模式时，该单元将来自多个I / O设备的存储器访问请求映射到不同的各组存储器地址转换数据。因此，存储器管理单元可以使用比通常需要的更少的地址转换表（例如，没有）来保护存储器免受I / O设备的访问。

5. 发明申请

WO2013017963A1 IMPROVING PERFORMANCE OF DIGITAL CIRCUITS USING CURRENT MANAGEMENT 审中-公开
标题翻译：使用当前管理改善数字电路的性能
公开(公告)号：WO2013017963A1
公开(公告)日：2013-02-07
申请号：PCT/IB2012/052396
申请日：2012-05-14
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , IBM (CHINA) INVESTMENT COMPANY LIMITED , ALLEN-WARE, Malcolm, Scott , LEFURGY, Charles, Robert , HANSON, Heather, Lynn , CARTER, John, Bruce , HUANG, Wei , RAJAMANI, Karthick
发明人： ALLEN-WARE, Malcolm, Scott , LEFURGY, Charles, Robert , HANSON, Heather, Lynn , CARTER, John, Bruce , HUANG, Wei , RAJAMANI, Karthick
IPC分类号： H03K7/00
CPC分类号： G06F1/324 , G06F1/3296 , Y02D10/126 , Y02D10/172
摘要： A method, system, and computer program product for improving the performance of a digital circuit are provided in the illustrative embodiments. A real frequency of operation of the digital circuit is adjusted using a control loop in the digital circuit, the adjusting the real frequency being responsive to a change in an operating condition of the digital circuit. A measurement of a current drawn by the digital circuit is received from a voltage regulator supplying electrical power to the digital circuit. An over-current target current value is received. A voltage output from the voltage regulator to the digital circuit is adjusted such that the current drawn by the digital circuit does not exceed the over-current target current value.
摘要翻译：在说明性实施例中提供了用于改善数字电路的性能的方法，系统和计算机程序产品。使用数字电路中的控制环来调整数字电路的实际工作频率，响应于数字电路的工作状态的变化来调整实际频率。从向数字电路提供电力的电压调节器接收由数字电路汲取的电流的测量值。接收过电流目标电流值。调整从电压调节器到数字电路的输出电压，使得由数字电路汲取的电流不超过过电流目标电流值。

6. 发明申请

WO2012116371A1 METHODS AND COMPOSITIONS FOR DETERMINING VIRUS SUSCEPTIBILITY TO INTEGRASE INHIBITORS 审中-公开
标题翻译：用于确定集成抑制剂病毒易感性的方法和组合物
公开(公告)号：WO2012116371A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026794
申请日：2012-02-27
申请人： LABORATORY CORPORATION OF AMERICA HOLDINGS , HUANG, Wei , PETROPOULOS, Christos John
发明人： HUANG, Wei , PETROPOULOS, Christos John
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703 , C12Q2600/106 , C12Q2600/156
摘要： Methods and compositions for the efficient and accurate determination of HIV susceptibility to an integrase inhibitor and/or HIV replication capacity are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV integrase that comprises a primary mutation at codon 143, wherein the mutation at codon 143 does not encode arginine (R) or cysteine (C), and wherein the presence of the integrase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an integrase inhibitor or altered replication capacity relative to a reference HIV. In certain embodiments, the HIV also contains one or more secondary mutations in integrase. Also provided are methods for determining the selective advantage of a mutation or mutation profile based on the difficulty to create the mutation, and its effect on susceptibility to an integrase inhibitor or replication capacity.
摘要翻译：提供了有效和准确地确定对整合酶抑制剂和/或HIV复制能力的HIV敏感性的方法和组合物。在某些方面，所述方法包括在生物样品中检测编码HIV整合酶的核酸，所述核酸编码包含143位密码子的初级突变，其中143位密码子的突变不编码精氨酸（R）或半胱氨酸（C），其中生物样品中整合酶编码核酸的存在表明HIV相对于参考HIV具有降低的对整合酶抑制剂的易感性或改变的复制能力。在某些实施方案中，HIV还含有整合酶中的一个或多个次要突变。还提供了基于产生突变的难度确定突变或突变特征的选择性优势的方法及其对整合酶抑制剂或复制能力的易感性的影响。

7. 发明申请

WO2011053938A8 METHODS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
标题翻译：治疗癌症的方法和组合物
公开(公告)号：WO2011053938A8
公开(公告)日：2011-08-11
申请号：PCT/US2010055016
申请日：2010-11-01
申请人： ARIAD PHARMA INC , HUANG WEI-SHENG , RIVERA VICTOR M , CLACKSON TIMOTHY P , SHAKESPEARE WILLIAM C , SQUILLACE RACHEL M , GOZGIT JOSEPH M
发明人： HUANG WEI-SHENG , RIVERA VICTOR M , CLACKSON TIMOTHY P , SHAKESPEARE WILLIAM C , SQUILLACE RACHEL M , GOZGIT JOSEPH M
IPC分类号： A61K31/00 , A61K31/535 , A61K31/55
CPC分类号： C07D487/04 , A61K31/5025
摘要： The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-y1)-methyl)-3-(trifluoromethyl)phenyl)benzamide.
摘要翻译：（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N-（4 - （（4-甲基哌嗪-1-基）） - 甲基）-3-（三氟甲基）苯基）苯甲酰胺。

8. 发明申请

WO2011076145A1 TISSUE-BASED MICRO-RNA METHODS FOR DIAGNOSIS OF DIFFERENT SUBTYPES OF LUNG CANCER 审中-公开
标题翻译：用于诊断肺癌不同亚型的基于组织的微RNA方法
公开(公告)号：WO2011076145A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080242
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , WU, Ying , LU, Shaohua , HUANG, Wei , ZHU, Hongguang , LI, Jian
发明人： WU, Ying , LU, Shaohua , HUANG, Wei , ZHU, Hongguang , LI, Jian
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/7105 , A61P35/00
CPC分类号： A61K31/7105 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more mammalian target cells exhibiting lung cancer, wherein the nucleic acid molecules are differentially expressed in target cells and in control cells. The invention further provides methods for identifying one or more mammalian target cells exhibiting lung cancer by using said nucleic acid molecules, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码用于鉴定表现出肺癌的一种或多种哺乳动物靶细胞的微小RNA序列的多个核酸分子，其中所述核酸分子在靶细胞和对照细胞中差异表达。本发明还提供了通过使用所述核酸分子鉴定表现出肺癌的一种或多种哺乳动物靶细胞的方法，以及用于预防或治疗肺癌的方法和药物组合物。

9. 发明申请

WO2011076143A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPRESSION PROFILING OF LUNG CANCER 审中-公开
标题翻译：肺癌微阵列分型的组成及方法
公开(公告)号：WO2011076143A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080237
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
发明人： LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
IPC分类号： C12Q1/68 , A61K31/7105 , A61P35/00
CPC分类号： A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more mammalian target cells exhibiting or having a predisposition to develop lung cancer. The nucleic acid molecules encoding microRNA sequences are differentially expressed in target cells and in control cells. The invention further provides methods for identifying mammalian target cells exhibiting or having a predisposition to develop lung cancer using said microRNAs, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码微小RNA序列的多个核酸分子，用于鉴定表现出或具有发生肺癌倾向的一种或多种哺乳动物靶细胞。编码微小RNA序列的核酸分子在靶细胞和对照细胞中差异表达。本发明进一步提供用于鉴定使用所述微小RNA显示或具有发展肺癌倾向的哺乳动物靶细胞的方法，以及用于预防或治疗肺癌的方法和药物组合物。

10. 发明申请

WO2010102042A2 BALANCED METAMATERIAL ANTENNA DEVICE 审中-公开
标题翻译：平衡金属天线装置
公开(公告)号：WO2010102042A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/026099
申请日：2010-03-03
申请人： RAYSPAN CORPORATION , HUANG, Wei , PENEV, Vladimir , PATHAK, Vaneet , POILASNE, Gregory
发明人： HUANG, Wei , PENEV, Vladimir , PATHAK, Vaneet , POILASNE, Gregory
IPC分类号： H01Q1/38 , H01Q9/04
CPC分类号： H01Q9/16 , H01Q15/0086
摘要： This document describes designs and techniques for directly feeding an unbalanced transmission line with a balanced antenna using Composite Right and Left Handed (CRLH) and balun structures.
摘要翻译：本文件描述了使用复合右手和左手（CRLH）和平衡 - 不平衡变换器直接馈送具有平衡天线的不平衡传输线的设计和技术。

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