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1. 发明申请

WO2006116335A1 LEADING EDGE/TRAILING EDGE TOF DETECTION 审中-公开
标题翻译：领先边缘/追踪边缘TOF检测
公开(公告)号：WO2006116335A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015515
申请日：2006-04-21
申请人： THERMO FINNIGAN LLC , HARDMAN, Mark, E. , EARLEY, Lee , LAND, Adrian
发明人： HARDMAN, Mark, E. , EARLEY, Lee , LAND, Adrian
IPC分类号： B01D59/44
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： Disclosed are a time-of-flight mass spectrometer and signal processing electronics. The signal processing electronics include a plurality of time-to-digital converters configured to receive signal pulses from the same detector anode within the time-of-flight mass spectrometer. The signal processing electronics are further configured to differentiate, and compensate for, those signal pulses caused by the detection of more than one ion. Differentiation and compensation are achieved by using the time-to-digital converters to detect the leading and trailing edges of a signal pulse. The time difference between the detection of the leading edge and detection of the trailing edge is indicative of whether or not the signal pulse was generated by the detection of more than one ion.
摘要翻译：披露了飞行时间质谱仪和信号处理电子学。信号处理电子器件包括多个时间 - 数字转换器，其被配置为在飞行时间质谱仪内接收来自相同检测器阳极的信号脉冲。信号处理电子器件还被配置为区分并补偿由多于一个离子的检测引起的那些信号脉冲。通过使用时间 - 数字转换器来检测信号脉冲的前沿和后沿来实现差分和补偿。前沿检测与后沿检测之间的时间差表示通过检测多于一个离子是否产生了信号脉冲。

2. 发明申请

WO2009148782A1 AUXILIARY DRAG FIELD ELECTRODES 审中-公开
标题翻译：辅助拖拉电场
公开(公告)号：WO2009148782A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/043841
申请日：2009-05-13
申请人： THERMO FINNIGAN LLC , KONICEK, Michael , LAND, Adrian , PERELMAN, Gershon , EARLEY, Lee , HARDMAN, Mark
发明人： KONICEK, Michael , LAND, Adrian , PERELMAN, Gershon , EARLEY, Lee , HARDMAN, Mark
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/4225
摘要： Auxiliary electrodes for creating drag fields may be provided as arrays of finger electrodes on thin substrates such as printed circuit board material for insertion between main RF electrodes of a multipole. A progressive range of voltages can be applied along lengths of the auxiliary electrodes by implementing a voltage divider that utilizes static resisters interconnecting individual finger electrodes of the arrays. Dynamic voltage variations may be applied to individual finger electrodes or to groups of the finger electrodes.
摘要翻译：用于产生拖曳场的辅助电极可以被提供为诸如印刷电路板材料的薄基板上的指状电极阵列，用于插入多极的主RF电极之间。可以通过实施使用互连阵列的各个指状电极的静电阻的分压器来沿辅助电极的长度施加逐渐的电压范围。动态电压变化可以施加到各个指状电极或指状电极的组。

3. 发明申请

WO2006014284A1 METHOD AND APPARATUS FOR CONTROLLING THE ION POPULATION IN A MASS SPECTROMETER 审中-公开
标题翻译：用于控制质谱仪中的离子人口的方法和装置
公开(公告)号：WO2006014284A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/023073
申请日：2005-06-30
申请人： THERMO FINNIGAN LLC , LAND, Adrian , EARLEY, Lee , HARDMAN, Mark , HELLER, Rexford, T. , SENKO, Michael, W.
发明人： LAND, Adrian , EARLEY, Lee , HARDMAN, Mark , HELLER, Rexford, T. , SENKO, Michael, W.
IPC分类号： G01N27/64 , H01J49/04 , H01J49/40
CPC分类号： H01J49/4265 , H01J49/40
摘要： A method of and a corresponding apparatus for controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising an intensity value, and a second sample of ions is introduced into the mass spectrometer. The second sample of ions is introduced in an amount determined at least in part on the measure of abundance of the species of interest in the first sample of ions.
摘要翻译：一种用于控制质谱仪中离子质量的方法和相应装置，其中在质谱仪中提供第一离子样品，测定第一离子样品中感兴趣的物种的丰度，测量包含强度值的丰度和第二离子样品被引入质谱仪。第二离子样品的引入量至少部分取决于第一离子样品中感兴趣物种丰度的量度。

4. 发明申请

WO2008124407A3 METHOD AND APPARATUS FOR GENERATION OF REAGENT IONS IN A MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008124407A3
公开(公告)日：2008-10-16
申请号：PCT/US2008/059051
申请日：2008-04-01
申请人： THERMO FINNIGAN LLC , LAND, Adrian , EARLEY, Lee , STAFFORD, George, C.
发明人： LAND, Adrian , EARLEY, Lee , STAFFORD, George, C.
IPC分类号： H01J49/14
摘要： A front-end ion source for a mass spectrometer generates both analyte and reagent ions. The reagent source may include a heater for vaporizing a condensed-phase reagent substance and an electron source for ionizing reagent molecules. The interior of the reagent ionization chamber is purged with a purge gas to avoid or minimize reaction of the reagent ions with oxygen or other reactive species, thereby enabling operation of the reagent ionization chamber at or near atmospheric pressure. The reagent and analyte ions are directed into a reduced-pressure chamber through separate passageways. An ion transport optic selectively transmits one of the analyte ions or the reagent ions from the reduced- pressure chamber to downstream regions of the mass spectrometer.

5. 发明申请

WO2006026391A1 TEMPERATURE COMPENSATED TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：温度补偿飞行时间质谱仪
公开(公告)号：WO2006026391A1
公开(公告)日：2006-03-09
申请号：PCT/US2005/030334
申请日：2005-08-25
申请人： THERMO FINNIGAN LLC , DAVIS, Stephen, C. , EARLEY, Lee , HARDMAN, Mark , LAND, Adrian , PERELMAN, Gershon
发明人： DAVIS, Stephen, C. , EARLEY, Lee , HARDMAN, Mark , LAND, Adrian , PERELMAN, Gershon
IPC分类号： H01J49/40
CPC分类号： H01J49/40
摘要： A time-of-flight mass spectrometer that comprises optical elements, including at least a source (120) of ions and an ion detector arrangement (160), and a spacer (330), at least one of the optical elements and the spacer (330) being made of materials which have different thermal expansion coefficients, combined in such a way that the length of the drift region (140) is variant, and self adjusting with temperature. The adjustment is such as to compensate for the length changes resulting from thermal expansion or contraction in other ion optical elements, such that ions of substantially equivalent mass to charge ratios maintain a constant flight time though the system. This allows for use of standard construction methods for the ion optical elements.
摘要翻译：飞行时间质谱仪包括至少包括离子源（120）和离子检测器装置（160）的光学元件和间隔物（330），至少一个光学元件和间隔物（ 330）由具有不同热膨胀系数的材料制成，以漂移区域（140）的长度变化的方式组合，并且随着温度自调节。该调整是为了补偿由其它离子光学元件的热膨胀或收缩导致的长度变化，使得基本相当的质荷比的离子通过系统保持恒定的飞行时间。这允许使用用于离子光学元件的标准施工方法。

6. 发明申请

WO2009155007A1 METHOD AND APPARATUS FOR GENERATION OF REAGENT IONS IN A MASS SPECTROMETER 审中-公开
标题翻译：用于在大量光谱仪中产生试剂离子的方法和装置
公开(公告)号：WO2009155007A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/045350
申请日：2009-05-27
申请人： THERMO FINNIGAN LLC , UNIVERSITY OF VIRGINIA PATENT FOUNDATION , SHABANOWITZ, Jeffrey , COMPTON, Philip, D. , EARLEY, Lee , STAFFORD, George, C. , HUNT, Donald, F. , MULLEN, Christopher
发明人： SHABANOWITZ, Jeffrey , COMPTON, Philip, D. , EARLEY, Lee , STAFFORD, George, C. , HUNT, Donald, F. , MULLEN, Christopher
IPC分类号： H01J49/00 , H01J49/10
CPC分类号： H01J49/12 , H01J49/0072
摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
摘要翻译：公开了用于质谱仪的前端试剂离子源。将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。

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