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1. 发明申请

WO2006081443A1 OVERBURDEN MATERIAL FOR IN-CONTAINER VITRIFICATION 审中-公开
标题翻译：用于集装箱维修的OVERBURDEN材料
公开(公告)号：WO2006081443A1
公开(公告)日：2006-08-03
申请号：PCT/US2006/002972
申请日：2006-01-27
申请人： GEOSAFE CORPORATION , LOWERY, Patrick, S. , THOMPSON, Leo, E. , TIMMERMAN, Craig, L. , MCELROY, Jack, L. , CAMPBELL, Brett, E. , HANSEN, James, E.
发明人： LOWERY, Patrick, S. , THOMPSON, Leo, E. , TIMMERMAN, Craig, L. , MCELROY, Jack, L. , CAMPBELL, Brett, E. , HANSEN, James, E.
IPC分类号： C03B5/00 , C03B5/027 , B09B3/00
CPC分类号： C03B5/005 , C03B5/027 , C03B5/42 , C03B5/43 , H05B3/03 , Y02P40/52
摘要： A process for melting waste material to be treated includes placing material (430) to be treated in a container that may include an insulating lining, heating the material to be treated and melting the material to be treated, preferably allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. Heat loss and melt-surface disruptions can be minimized with an engineered or an earthen overburden material (440) , which covers at least a portion of an exposed surface of the material to be treated.
摘要翻译：用于熔化待处理废物的方法包括将要处理的材料（430）放置在可以包括绝缘衬里的容器中，加热待处理的材料并熔化待处理的材料，优选使熔融材料冷却至形成玻璃化和/或结晶物质，并且处理该物质。物料在容器中放置或者在冷却和处理后从容器中取出。用工程或土工覆盖材料（440）可以使热损失和熔体表面破裂最小化，该材料覆盖待处理材料的暴露表面的至少一部分。

2. 发明申请

WO2012135831A1 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR 审中-公开
标题翻译：细胞穿透抗DNA抗体及其抑制DNA修复的用途
公开(公告)号：WO2012135831A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031860
申请日：2012-04-02
申请人： YALE UNIVERSITY , HANSEN, James, E. , GLAZER, Peter, M. , WEISBART, Richard, H. , NISHIMURA, Robert, N. , CHAN, Grace
发明人： HANSEN, James, E. , GLAZER, Peter, M. , WEISBART, Richard, H. , NISHIMURA, Robert, N. , CHAN, Grace
IPC分类号： C07K16/44
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
摘要翻译：提供穿透细胞核并抑制DNA修复或干扰DNA代谢的抗体用于治疗癌症（直接和通过致敏癌细胞对DNA损伤性治疗）或抑制或预防病毒感染，增殖或代谢。该方法包括用包含细胞穿透性抗DNA抗体或其衍生物的组合物单独或与诱导DNA损伤如DNA损伤化学疗法或辐射的治疗组合处理细胞。细胞穿透性抗DNA抗体或其衍生物的影响在DNA修复缺陷的癌细胞中被增强，并且细胞穿透性抗DNA抗体或其衍生物对具有DNA修复缺陷的癌细胞是合成致死的。

3. 发明申请

WO0021823A9 BICYCLE SEAT 审中-公开
标题翻译：自行车座椅
公开(公告)号：WO0021823A9
公开(公告)日：2000-11-16
申请号：PCT/US9922291
申请日：1999-09-27
申请人： HANSEN JAMES E
发明人： HANSEN JAMES E
IPC分类号： B62J1/00 , B62J1/18
CPC分类号： B62J1/002 , B62J1/005 , B62J1/18
摘要： A bicycle seat (10) for improved comfort and performance. The bicycle seat (10) comprises an elongated support member (16) for supporting a rider, wherein the elongated support member (16) includes a central portion (22) and opposed end portions (24, 26) that extend outward and flare backwards and upwards relative to the central portion. The seat further comprises a left and right seat cushion (12, 14) immovably mounted over the elongated support member, and positioned in a V-shape configuration. The configuration of the seat provides improved rider comfort, while maintaining lateral stability for the rider.
摘要翻译：一个自行车座椅（10），提高舒适性和性能。自行车座椅（10）包括用于支撑骑乘者的细长支撑构件（16），其中细长支撑构件（16）包括中央部分（22）和向外延伸并向后张开的相对端部分（24,26），向上相对于中央部分。所述座椅还包括不可移动地安装在所述细长支撑构件上并且定位成V形构造的左右座垫（12,14）。座椅的配置提供了改善的骑乘者舒适性，同时保持骑乘者的横向稳定性。

4. 发明申请

WO2012135831A8 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF TO INHIBIT DNA REPAIR 审中-公开
标题翻译：细胞穿透抗DNA抗体及其用于抑制DNA修复的用途
公开(公告)号：WO2012135831A8
公开(公告)日：2013-11-21
申请号：PCT/US2012031860
申请日：2012-04-02
申请人： UNIV YALE , HANSEN JAMES E , GLAZER PETER M , WEISBART RICHARD H , NISHIMURA ROBERT N , CHAN GRACE , UNIV CALIFORNIA , US GOV REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
发明人： HANSEN JAMES E , GLAZER PETER M , WEISBART RICHARD H , NISHIMURA ROBERT N , CHAN GRACE
IPC分类号： C07K16/44
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
摘要翻译：提供穿透细胞核并抑制DNA修复或干扰DNA代谢的抗体用于治疗癌症（直接和通过致敏癌细胞对DNA损伤性治疗）或抑制或预防病毒感染，增殖或代谢。该方法包括用包含细胞穿透性抗DNA抗体或其衍生物的组合物单独或与诱导DNA损伤如DNA损伤化学疗法或辐射的治疗组合处理细胞。细胞穿透性抗DNA抗体或其衍生物的影响在DNA修复缺陷的癌细胞中被增强，并且细胞穿透性抗DNA抗体或其衍生物对具有DNA修复缺陷的癌细胞是合成致死的。

5. 发明申请

WO2006081442A1 APPARATUS FOR RAPID STARTUP DURING IN-CONTAINER VITRIFICATION 审中-公开
标题翻译：在集装箱维修期间快速启动的装置
公开(公告)号：WO2006081442A1
公开(公告)日：2006-08-03
申请号：PCT/US2006/002971
申请日：2006-01-27
申请人： GEOSAFE CORPORATION , LOWERY, Patrick, S. , HANSEN, James, E.
发明人： LOWERY, Patrick, S. , HANSEN, James, E.
IPC分类号： H05B3/03 , C03B5/027
CPC分类号： C03B5/005 , C03B5/027 , C03B5/42 , C03B5/43 , H05B3/03 , Y02P40/52
摘要： A process for melting material to be treated includes placing material to be treated in a container (10) that may include an insulating, heating the material to be treated and melting the material to be treated, preferably- allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. The time required for startup of the melting procedure can be reduced by utilizing a plurality of electrodes (100) and multiple starter paths (111) , at least one of which is horizontally-oriented and positioned in a deeper region of the melt container.
摘要翻译：用于熔化待处理材料的方法包括将待处理的材料放置在可包括绝缘的容器（10）中，加热待处理的材料并熔化待处理的材料，优选地允许熔融的材料冷却以形成玻璃化和/或结晶物质，以及物料的处置。物料在容器中放置或者在冷却和处理后从容器中取出。可以通过利用多个电极（100）和多个起动器路径（111）来减少启动熔化过程所需的时间，其中至少一个电极（111）水平取向并位于熔体容器的较深的区域中。

6. 发明申请

WO2005033718A1 INTEGRATED ANTI-DIFFERENTIAL CURRENT SENSING SYSTEM 审中-公开
标题翻译：综合抗差分电流传感系统
公开(公告)号：WO2005033718A1
公开(公告)日：2005-04-14
申请号：PCT/IB2004/051936
申请日：2004-09-30
申请人： EATON CORPORATION , HASTINGS, Jerome K. , GASS, Dale L. , PAHL, Birger , LEE, Davin R. , HANSEN, James E.
发明人： HASTINGS, Jerome K. , GASS, Dale L. , PAHL, Birger , LEE, Davin R. , HANSEN, James E.
IPC分类号： G01R15/20
CPC分类号： G01R15/202 , G01R15/207
摘要： The present invention is directed to system for current sensing including a first Hall effect sensor (H1, 56, 120, 174, 204, 236) and a second Hall effect sensor (H2, 58, 124, 176, 206, 238) constructed to provide feedback (21, 24, 24a, 26, 28, 28a) indicating current flow (14) through a conductor (12, 130, 132, 152, 178, 180, 181, 182, 220, 232) susceptible to external magnetic flux (B2, 17, 166). A housing (184, 186, 188, 212, 214, 216, 244, 246, 248) is configured to position the first Hall effect sensor (H1, 56, 120, 174, 204, 236) and the second Hall effect sensor (H2, 58, 124, 176, 206, 238) about the conductor (12, 130, 132, 152, 178, 180, 181, 182, 220, 232)to provide generally magnitude equal feedback (21, 24) of the current flow (14) through the conductor (12, 130, 132, 152, 178, 180, 181, 182, 220, 232) and generally polarity opposite feedback (26, 28) of the external magnetic flux (B2, 17, 166).
摘要翻译：本发明涉及用于电流感测的系统，包括第一霍尔效应传感器（H1,56,120,174,204,236）和第二霍尔效应传感器（H2,58,124,176,206,238），其构造成提供指示通过易受外部磁通量的导体（12,130,132,152,178,180,181,182,220,232）的电流（14）的反馈（21,24,24,26,28,28a）（B2,17,166）。壳体（184,186,188,212,214,216,244,246,248）被配置成将第一霍尔效应传感器（H1,56,120,174,204,236）和第二霍尔效应传感器（围绕导体（12,130,132,152,178,180,181,182,220,232）的H2，58,124,176,206,238，以提供电流的大致等同的反馈（21,24）流体（14）穿过导体（12,130,132,152,178,180,181,182,220,232），并且通常与外部磁通（B2,17,166）极性相反的反馈（26,28）。

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