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1. 发明申请

WO2003097711A1 POLYMER HAVING CHARGED UNITS 审中-公开
标题翻译：具有收费单位的聚合物
公开(公告)号：WO2003097711A1
公开(公告)日：2003-11-27
申请号：PCT/AU2003/000611
申请日：2003-05-21
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , CHAN, Grace, Yim Ngan , HUGHES, Timothy, Charles
发明人： HUGHES, Timothy, Charles
IPC分类号： C08F290/06
CPC分类号： C08F290/062 , A61F2/14 , A61L27/18 , A61L27/34 , A61L2430/16 , C08F290/02 , C08L71/02
摘要： A polymer comprising one or more macromonomer units selected from the group consisting of polysiloxane, perfluoroalkylpolyether (PFPE), fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefin and fluorinated polyolefin, and one or more charged units (such as an anionic, cationic or zwitter-ionic monomer), formed from a polymerization medium containing an aqueous solution of charged units and use of this polymer as an intraocular lens for the implantation into or onto the cornea. Another aspects relates to a process for coating the above polymer with an adhesive comprising covalently coupling co-reactive surface functional groups of a natural or synthetic polymer with functional groups present (or introduced) on the surface of the macromonomer containing polymer, followed by covalently coupling a multifunctionally activated compound having at least one functional group that is co-reactive to the reactive groups of the natural or synthetic polymer.
摘要翻译：包含选自聚硅氧烷，全氟烷基聚醚（PFPE），氟化聚（甲基）丙烯酸酯，聚（甲基）丙烯酸烷基酯，聚烯烃和氟化聚烯烃等）中的一种或多种大分子单体的聚合物和一种或多种带电单元，阳离子或两性离子单体），其由含有带电单元的水溶液的聚合介质形成，并且使用该聚合物作为人工晶状体用于植入角膜或其上。另一方面涉及一种用粘合剂涂覆上述聚合物的方法，包括将天然或合成聚合物的共反应性表面官能团与存在（或引入）的含大分子单体的聚合物的表面共价偶联，然后共价偶联具有至少一个与天然或合成聚合物的反应性基团共反应的官能团的多功能活化化合物。

2. 发明申请

WO2012135831A8 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF TO INHIBIT DNA REPAIR 审中-公开
标题翻译：细胞穿透抗DNA抗体及其用于抑制DNA修复的用途
公开(公告)号：WO2012135831A8
公开(公告)日：2013-11-21
申请号：PCT/US2012031860
申请日：2012-04-02
申请人： UNIV YALE , HANSEN JAMES E , GLAZER PETER M , WEISBART RICHARD H , NISHIMURA ROBERT N , CHAN GRACE , UNIV CALIFORNIA , US GOV REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
发明人： HANSEN JAMES E , GLAZER PETER M , WEISBART RICHARD H , NISHIMURA ROBERT N , CHAN GRACE
IPC分类号： C07K16/44
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
摘要翻译：提供穿透细胞核并抑制DNA修复或干扰DNA代谢的抗体用于治疗癌症（直接和通过致敏癌细胞对DNA损伤性治疗）或抑制或预防病毒感染，增殖或代谢。该方法包括用包含细胞穿透性抗DNA抗体或其衍生物的组合物单独或与诱导DNA损伤如DNA损伤化学疗法或辐射的治疗组合处理细胞。细胞穿透性抗DNA抗体或其衍生物的影响在DNA修复缺陷的癌细胞中被增强，并且细胞穿透性抗DNA抗体或其衍生物对具有DNA修复缺陷的癌细胞是合成致死的。

3. 发明申请

WO2012135831A1 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR 审中-公开
标题翻译：细胞穿透抗DNA抗体及其抑制DNA修复的用途
公开(公告)号：WO2012135831A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031860
申请日：2012-04-02
申请人： YALE UNIVERSITY , HANSEN, James, E. , GLAZER, Peter, M. , WEISBART, Richard, H. , NISHIMURA, Robert, N. , CHAN, Grace
发明人： HANSEN, James, E. , GLAZER, Peter, M. , WEISBART, Richard, H. , NISHIMURA, Robert, N. , CHAN, Grace
IPC分类号： C07K16/44
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
摘要翻译：提供穿透细胞核并抑制DNA修复或干扰DNA代谢的抗体用于治疗癌症（直接和通过致敏癌细胞对DNA损伤性治疗）或抑制或预防病毒感染，增殖或代谢。该方法包括用包含细胞穿透性抗DNA抗体或其衍生物的组合物单独或与诱导DNA损伤如DNA损伤化学疗法或辐射的治疗组合处理细胞。细胞穿透性抗DNA抗体或其衍生物的影响在DNA修复缺陷的癌细胞中被增强，并且细胞穿透性抗DNA抗体或其衍生物对具有DNA修复缺陷的癌细胞是合成致死的。

4. 发明申请

WO1998001419A1 ELECTROPHORESIS GELS AND CROSS-LINKING AGENTS FOR THEIR PREPARATION 审中-公开
标题翻译：电泳胶及其制备的交联剂
公开(公告)号：WO1998001419A1
公开(公告)日：1998-01-15
申请号：PCT/AU1997000437
申请日：1997-07-10
申请人： THE UNIVERSITY OF MELBOURNE , SOLOMON, David, Henry , CHAN, Grace , KAMBOURIS, Peter, Agapitos , LOONEY, Mark, Graham
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C07C233/20
CPC分类号： C07C233/38 , C07C233/20 , C08F222/1006
摘要： This invention relates to the separation of molecules on polymer gels, in particular to novel cross-linked polymer gels comprising the cross-linking moiety of formula (1) and their preparation, the separation of molecules by techniques such as electrophoresis using these gels, novel cross-linking agents useful in the preparation of the gels, and novel intermediates useful in the synthesis of the cross-linking agents. The invention is especially suitable for electrophoretic applications.
摘要翻译：本发明涉及聚合物凝胶上分子的分离，特别是涉及包含式（1）的交联部分的新型交联聚合物凝胶及其制备，通过使用这些凝胶的电泳技术分离分子，新颖的可用于制备凝胶的交联剂，以及可用于合成交联剂的新型中间体。本发明特别适用于电泳应用。

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