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1. 发明申请

WO2016007670A1 ENRICHMENT OF PALMITOLEIC ACID PALMITOLEIC ACID DERIVATIVES BY DRY AND SOLVENT-AIDED WINTERIZATION 审中-公开
标题翻译：通过干燥和溶剂化的冬季来制备棕榈酸棕榈酸衍生物
公开(公告)号：WO2016007670A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039607
申请日：2015-07-08
申请人： OMEGA PROTEIN CORPORATION , BYELASHOV, Oleksandr, A. , YIN, Huaixia , LI, Juan , GRIFFIN, Mark
发明人： BYELASHOV, Oleksandr, A. , YIN, Huaixia , LI, Juan , GRIFFIN, Mark
IPC分类号： A23D9/00 , A23L1/30
CPC分类号： C11B7/0025 , A23D9/04 , A61K31/201 , C11B7/0016 , C11B7/0075
摘要： The present invention provides a fatty acid mixture enriched with palmitoleic acid and palmitoleic acid derivatives relative to the starting lipid mixture; fractionations procedure describe herein are winterization methods. The invention provides methods of dry winterization and solvent-aided winterization alone and in combination. In some embodiments, the palmitoleic acid and palmitoleic acid derivative enriched mixture described herein contains less than 1% of palmitic acid and palmitic acid derivative. The invention also provides palmitoleic derivatives of use as dietary supplements.
摘要翻译：本发明提供了相对于起始脂质混合物富含棕榈油酸和棕榈油酸衍生物的脂肪酸混合物; 本文描述的分馏程序是冬季化方法。本发明提供单独和组合的干燥冬季和溶剂辅助冬季化的方法。在一些实施方案中，本文所述的富含棕榈油酸和棕榈油酸衍生物的混合物含有少于1％的棕榈酸和棕榈酸衍生物。本发明还提供用作膳食补充剂的棕榈油衍生物。

2. 发明申请

WO2008137326A1 SINGLE STAGE HEMOSTASIS CLIPPING DEVICE 审中-公开
标题翻译：单阶段HEMOSTASIS剪辑设备
公开(公告)号：WO2008137326A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/061283
申请日：2008-04-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , COHEN, Adam, L. , OGLE, Bryan, R. , DURGIN, Russell, F. , FURNISH, Gregory, R. , GOLDENBOGEN, Michael , JORDAN, Gary, A. , MORRIS, Benjamin, E. , GRIFFIN, Mark, A. , KELLY, William, C., Mers , ABRAMOV, Vasily, P.
发明人： COHEN, Adam, L. , OGLE, Bryan, R. , DURGIN, Russell, F. , FURNISH, Gregory, R. , GOLDENBOGEN, Michael , JORDAN, Gary, A. , MORRIS, Benjamin, E. , GRIFFIN, Mark, A. , KELLY, William, C., Mers , ABRAMOV, Vasily, P.
IPC分类号： A61B17/122 , A61B17/128 , A61B17/00
CPC分类号： A61B17/1285 , A61B17/122 , A61B17/1227 , A61B2090/037
摘要： Tissue Clipping Apparatus comprises Clip including a proximal end received within a capsule. Clip includes a clip locking member biased to engage a first locking structure of the capsule to lock Clip in the capsule in a closed configuration. Apparatus also comprises a tension member releasably coupling Clip to a proximal end of the device which, during use, remains accessible to a user. The tension member is coupled to Clip by a joint designed to release when subject to a predetermined load to separate Clip from the device, release of the joint releasing the locking member to engage the first locking structure.
摘要翻译：组织剪切装置包括夹子，其包括容纳在胶囊内的近端。夹子包括偏置以接合胶囊的第一锁定结构以将夹子锁定在封闭构造中的夹子的夹子锁定构件。设备还包括可张紧地将夹子连接到设备的近端的张力构件，其在使用期间对于使用者保持可访问。张紧构件通过接头连接到夹子，该接头设计成当受到预定负载时释放，以使夹子与装置分离，释放释放锁定构件以接合第一锁定结构的接头。

3. 发明申请

WO2007100266A3 SYSTEM AND METHOD FOR MODELLING A FLIGHT 审中-公开
公开(公告)号：WO2007100266A3
公开(公告)日：2007-09-07
申请号：PCT/NZ2007/000043
申请日：2007-03-02
申请人： AIRWAYS CORPORATION OF NEW ZEALAND LIMITED , GRIFFIN, Mark Raymond , ROBERTSON, Mervyn Lloyd
发明人： GRIFFIN, Mark Raymond , ROBERTSON, Mervyn Lloyd
IPC分类号： G06Q30/00
摘要： A method of modelling a flight of an aircraft using at least one computer system, said method characterised by the steps of: sourcing flight details (13) from at least one data source using at least one data acquisition system, said flight details (13) representative of the activity of the aircraft within a flight information region (4, 5, 6, 7), and compiling a flight model from said flight details (13) using a processing system (18), said flight model indicating the activity of the aircraft over the duration of the flight in two or more FIRs (4, 5, 6, 7) or for an entire flight undertaken in a single FIR.

4. 发明申请

WO0015147A8 TRANSMYCARDIAL SHUNT AND ITS ATTACHMENT MECHANISM, FOR LEFT VENTRICULAR REVASCULARIZATION 审中-公开
标题翻译：转移性分支及其附着机制，用于左心室舒张
公开(公告)号：WO0015147A8
公开(公告)日：2000-06-15
申请号：PCT/US9920714
申请日：1999-09-10
申请人： PERCARDIA INC , PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
发明人： PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
IPC分类号： A61B17/00 , A61F2/02 , A61F2/24 , A61F2/82 , A61F2/94 , A61F2/06
CPC分类号： A61F2/915 , A61F2/24 , A61F2/2493 , A61F2/848 , A61F2/91 , A61F2/94 , A61F2/958 , A61F2002/821 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016 , A61F2230/0013 , A61F2230/005 , A61F2230/006
摘要： A conduit is provided to provide a bypass around a blockage in the coronary artery. The conduit is adapted to be positioned in the myocardium or heart wall to provide a passage for blood to flow between a chamber of the heart such as the left ventricle and the coronary artery, distal to the blockage. The stent is self-expanding or uses a balloon to expand the stent in the heart wall. Various attachment means are provided to anchor the stent and prevent its migration. In one embodiment, a conduit is provided having a distal top which is more preferably a ball top, wire top, flare top or flip-down top. These top configurations anchor the shunt at one end in the coronary artery.
摘要翻译：提供导管以提供围绕冠状动脉阻塞的旁路。导管适于定位在心肌或心脏壁中，以提供血液在心脏室之间流动的通路，例如左心室和冠状动脉之间，远离阻塞。支架自扩张或使用球囊来扩张心脏壁内的支架。提供各种附接装置以锚定支架并防止其移动。在一个实施例中，提供了具有远侧顶部的导管，更优选地是球顶，线顶，喇叭口顶部或翻倒顶部。这些顶部配置将冠状动脉一端分流。

5. 发明申请

WO0113984A2 LUMBAR DRAINAGE CATHETER 审中-公开
标题翻译： LUMBAR排水管
公开(公告)号：WO0113984A2
公开(公告)日：2001-03-01
申请号：PCT/US0040736
申请日：2000-08-24
申请人： NEURON THERAPEUTICS INC , GUNASEKARA INDAKA , GRIFFIN MARK , FRAZER GLENN
发明人： GUNASEKARA INDAKA , GRIFFIN MARK , FRAZER GLENN
IPC分类号： A61M1/00 , A61M25/00 , A61M25/02 , A61M27/00
CPC分类号： A61M25/007 , A61M25/0045 , A61M25/02
摘要： This is a catheter assembly designed for accessing the cerebrospinal fluid circulation system and draining fluid therefrom. The polymeric thin-walled catheter has a soft, flexible distal region for minimizing trauma to tissue and angularly accessing the subarachnoid space in the cerebrospinal fluid pathway with an optional guidewire. A stiffer proximal region, which may optionally contain a reinforcing woven braid or coil ensures that the catheter does not kink or compress during use in the tough membranes around the spinal column. One or more apertures in the catheter wall for draining fluid proximally through the catheter central lumen allows for transport of fluid through the catheter at therapeutic flow rates and pressures. A soft polymeric plug that may be disposed in the distal end of the catheter assembly ensure minimal trauma to tissue upon entry. The entire catheter may be coated with hydrophilic coating to facilitate movement through an optional Touhy needle and tissue, and may be radio-opaque for greater visibility under fluoroscopy.
摘要翻译：这是一种设计用于进入脑脊液循环系统并从其排出液体的导管组件。聚合物薄壁导管具有柔软的柔性远端区域，用于使用组织的创伤最小化，并用可选择的导丝角度地访问脑脊液通路中的蛛网膜下腔。可以任选地包含加强编织编织物或线圈的较硬的近端区域确保导管在使用期间在脊柱周围的韧性膜中不会扭结或压缩。在导管壁中用于将流体向近端排出通过导管中心腔的一个或多个孔允许流体以治疗流速和压力输送通过导管。可以设置在导管组件的远端中的软聚合物塞确保进入时对组织的最小创伤。整个导管可以涂覆有亲水性涂层，以促进通过可选的Touhy针和组织的移动，并且可以是不透射线的以在荧光透视下更好的可视性。

6. 发明申请

WO2008088506A1 HIGH FIBER EXTRUSION 审中-公开
标题翻译：高纤维挤出
公开(公告)号：WO2008088506A1
公开(公告)日：2008-07-24
申请号：PCT/US2007/025070
申请日：2007-12-07
申请人： LAND O'LAKES PURINA FEED LLC , GRIFFIN, Mark , LANTER, Kent
发明人： GRIFFIN, Mark , LANTER, Kent
IPC分类号： A23N17/00 , A23K1/14
CPC分类号： A23K50/42 , A23K20/163 , A23K20/20 , A23K40/20 , A23K40/25 , A23L29/231 , A23L29/238 , A23L29/256 , A23L29/272 , A23P30/20 , A23V2002/00 , A23V2200/21 , A23V2250/5024 , A23V2250/50362 , A23V2250/50364 , A23V2250/5054 , A23V2250/5066 , A23V2250/507
摘要： The present invention includes methods for producing an extruded food particle by extruding through an extruder 50 having a screw 56 within a barrel 54, a composition containing nutritional food components, essentially no starch and a gum in an amount sufficient to act as a binder once the composition exits the extruder. The present invention also includes extruded food particles that do not use starch as a binder.
摘要翻译：本发明包括通过挤出机50制造挤出的食品颗粒的方法，所述挤出机50在桶54内具有螺杆56，包含营养食品组分的组合物，基本上不含淀粉和胶，其量足以充当粘合剂一次组合物离开挤出机。本发明还包括不使用淀粉作为粘合剂的挤压食品颗粒。

7. 发明申请

WO2007100266A2 SYSTEM AND METHOD FOR MODELLING A FLIGHT 审中-公开
标题翻译：用于建模飞行的系统和方法
公开(公告)号：WO2007100266A2
公开(公告)日：2007-09-07
申请号：PCT/NZ2007000043
申请日：2007-03-02
申请人： AIRWAYS CORP OF NEW ZEALAND LT , GRIFFIN MARK RAYMOND , ROBERTSON MERVYN LLOYD
发明人： GRIFFIN MARK RAYMOND , ROBERTSON MERVYN LLOYD
IPC分类号： G06Q30/00
CPC分类号： G06Q30/04 , G06Q10/047 , G06Q30/0283 , G06Q40/12
摘要： A method of modelling a flight of an aircraft using at least one computer system, said method characterised by the steps of: sourcing flight details (13) from at least one data source using at least one data acquisition system, said flight details (13) representative of the activity of the aircraft within a flight information region (4, 5, 6, 7), and compiling a flight model from said flight details (13) using a processing system (18), said flight model indicating the activity of the aircraft over the duration of the flight in two or more FIRs (4, 5, 6, 7) or for an entire flight undertaken in a single FIR.
摘要翻译：一种使用至少一个计算机系统对飞行器的飞行进行建模的方法，所述方法的特征在于以下步骤：使用至少一个数据采集系统从至少一个数据源采购飞行细节（13），所述飞行细节（13）代表飞行信息区域内的飞行器的活动（4,5,6,7），以及使用处理系统（18）从所述飞行细节（13）编译飞行模型，所述飞行模型指示飞行信息区域飞机在两架或更多飞行时间（4,5,6,7）内的飞行期间或在单个飞行情报区内进行的整个飞行。

8. 发明申请

WO2006124823A3 INTRAVASCULAR IMPLANT DELIVERY DEVICE WITH ANCHORING FEATURES AND ASSOCIATED METHOD 审中-公开
公开(公告)号：WO2006124823A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/018812
申请日：2006-05-12
申请人： ALVEOLUS INC. , GRIFFIN, Mark, Alan
发明人： GRIFFIN, Mark, Alan
IPC分类号： A61F2/06
摘要： A delivery device for positioning and deploying an implantable device within a lumen is provided. The device includes an inner tube positioned within a outer tube and capable of sliding therein, wherein the inner and outer tubes have proximal and distal ends. A mechanism is coupled to at least one of the inner and outer tubes and is operable to deploy the implantable device within the lumen. At least one anchor is positioned on the inner tube to stabilize the implantable device by engaging at least a portion of the implantable device while the mechanism deploys the device. The anchor is positioned on the inner tube such that the ancho is freely rotatable about the inner tube.

9. 发明申请

WO2002069799A1 METHOD OF PREDICTING STROKE EVOLUTION UTILISING MRI 审中-公开
标题翻译：使用MRI的推进演化方法
公开(公告)号：WO2002069799A1
公开(公告)日：2002-09-12
申请号：PCT/AU2002/000256
申请日：2002-03-06
申请人： THE UNIVERSITY OF QUEENSLAND , ROSE, Stephen, Edward , GRIFFIN, Mark, Philip , JANKE, Andrew, Lindsay , CHALK, Jonathan, Brandon , MCLACHLAN, Geoffrey, John , PEEL, David , WANG, Deming
发明人： ROSE, Stephen, Edward , GRIFFIN, Mark, Philip , JANKE, Andrew, Lindsay , CHALK, Jonathan, Brandon , MCLACHLAN, Geoffrey, John , PEEL, David , WANG, Deming
IPC分类号： A61B5/055
CPC分类号： G06T7/0012 , A61B5/0263 , A61B5/029 , A61B5/055 , A61B5/7264 , A61B5/7267 , G06T2207/30016
摘要： A method predicting stroke evolution uses magnetic resonance diffusion and perfusion images obtained shortly after the onset of stroke symptoms to automatically estimate the eventual volume of dead cerebral tissue resulting from the stroke. The diffusion and perfusion images are processed to extract region(s) of interest presenting tissue at risk of infarction. A midplane algorithm is also used to calculate ratio and diffusion and perfusion measures for modelling infarct evolution. A parametric normal classifier algorithm is used to predict infarct growth using the calculated measures.
摘要翻译：预测卒中发生的方法使用在卒中症状开始后不久获得的磁共振扩散和灌注图像，以自动估计由脑卒中引起的死亡脑组织的最终体积。对扩散和灌注图像进行处理以提取具有梗死风险的组织的感兴趣区域。中平面算法也用于计算梗塞进化建模的比例和扩散和灌注措施。使用参数正态分类器算法使用计算的度量来预测梗死生长。

10. 发明申请

WO1998005376A1 RETROGRADE-ANTEGRADE CATHETERIZATION GUIDE WIRE 审中-公开
标题翻译：重新安装导管导线
公开(公告)号：WO1998005376A1
公开(公告)日：1998-02-12
申请号：PCT/US1997013511
申请日：1997-07-31
申请人： COOK INCORPORATED , COPE, Constantin , GRIFFIN, Mark, A.
发明人： COOK INCORPORATED
IPC分类号： A61M25/09
CPC分类号： A61M25/0152 , A61M25/09 , A61M2025/09083
摘要： An catheterization apparatus (10) for reversing the retrograde or antegrade direction of catheterization includes a guide wire (12) foldable upon itself for partial introduction into a vessel (68) of a patient. The guide wire (12) first includes a resilient, elongated member (14) having a curved end (16) and a remainder (17) having a second, bent end (18). The guide wire (12) also includes a flexible tether (22) connected to the tip (20) of the curved end (16) of the elongated member (14). The elongated member (14) is preferably formed from a wire core or mandrel (24) covered by a continuous coiled wire (30). The catheterization apparatus (10) preferably further includes a catheter through which the guide wire (12) is introduced into the vessel (68). The catheter can be of conventional construction and operability. Preferably, however, the catheter is a highly flexible and relatively short intermediary catheter (56), employed only temporarily during use of the retrograde-antegrade guide wire (12). The catheterization apparatus (10) can also include an inserter sheath (60) engageable with the catheter (56) to facilitate passage of the guide wire (12) through the catheter (56). The apparatus (10) is particularly advantageous in that its use avoids the need to establish a second access site. Moreover, the apparatus (10) is relatively simple and reliable in construction and use, and is relatively low in cost, at least in comparison to the costs and risks of the establishment of a second access site. The apparatus (10) is a traumatic during use, that is, it does not significantly damage the blood vessel or other vessel during reversal of the direction of catheterization. The apparatus (10) is useful in vessels of both large and small diameters, and facilitates the selective engagement of a catheter with a bifurcation branch in a vessel.
摘要翻译：用于反转导尿术的逆行或顺行方向的导管插入装置（10）包括可自行折叠的引导线（12），用于部分引入患者的血管（68）。导丝（12）首先包括具有弯曲端（16）的弹性细长构件（14）和具有第二弯曲端（18）的其余部分（17）。引导线（12）还包括连接到细长构件（14）的弯曲端（16）的尖端（20）的柔性系绳（22）。细长构件（14）优选地由被连续卷绕的线（30）覆盖的线芯或心轴（24）形成。导管装置（10）优选地还包括导管（12）通过该导管引入容器（68）中。导管可以具有常规的结构和可操作性。然而，优选地，导管是高度柔性且相对较短的中间导管（56），其仅在逆行顺行导丝（12）的使用期间临时使用。导管装置（10）还可以包括可与导管（56）接合的插入器护套（60），以便于引导线（12）通过导管（56）的通过。装置（10）的特别有利之处在于，其使用避免了建立第二进入站点的需要。此外，装置（10）的构造和使用相对简单可靠，并且成本相对较低，至少与建立第二进入站点的成本和风险相比较。装置（10）在使用过程中是创伤性的，即在反向导管插入方向期间它不会显着损伤血管或其他容器。该设备（10）可用于大直径和小直径的容器中，并且便于将导管与容器中的分叉支路选择性地接合。

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