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1. 发明申请

WO2015127416A1 COMPOSITIONS OF PENTOSAN POLYSULFATE SALTS FOR ORAL ADMINISTRATION AND METHODS OF USE 审中-公开
标题翻译：用于口腔管理的松桃油聚合物组合物及其使用方法
公开(公告)号：WO2015127416A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/017205
申请日：2015-02-24
申请人： URIGEN PHARMACEUTICALS, INC. , PARSONS, C., Lowell , GOLDBERG, Michael , MEENAN, Christopher, P.
发明人： PARSONS, C., Lowell , GOLDBERG, Michael , MEENAN, Christopher, P.
IPC分类号： A61K31/715 , C07H5/10 , A61K47/14 , A61P19/02
CPC分类号： A61K31/737 , A61K31/20 , A61K31/715 , A61K45/06 , A61K47/00 , Y02A50/473 , A61K2300/00
摘要： The present invention is directed to a pharmaceutical composition comprising: (1 ) a therapeutically effective quantity of sodium pentosan polysulfate; (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate; and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. Such compositions and methods allow the administration of sodium pentosan polysulfate at lower dosages to reduce the frequency and severity of side effects.
摘要翻译：本发明涉及药物组合物，其包含：（1）治疗有效量的戊聚糖多聚硫酸钠; （2）一定量的渗透增强剂足以提高戊聚糖多硫酸钠的生物利用度; 和（3）任选的药学上可接受的载体，以及用于口服施用戊聚糖多硫酸钠的方法，其具有改善的生物利用度用于治疗间质性膀胱炎和其它尿道疾病和病症。这种组合物和方法允许以较低剂量施用戊聚糖多硫酸钠以降低副作用的频率和严重性。

2. 发明申请

WO2008019160A3 METHOD FOR IDENTIFYING REFRACTIVE-INDEX FLUCTUATIONS OF A TARGET 审中-公开
公开(公告)号：WO2008019160A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/017894
申请日：2007-08-13
申请人： NORTHWESTERN UNIVERSITY , EVANSTON NORTHWESTERN HEALTHCARE , BACKMAN, Vadim , LIU, Yang , KIM, Young , ROY, Hemant , GOLDBERG, Michael , BRAND, Randall , PRADHAN, Prabhakar , SUBRAMANIAN, Hariharan
发明人： BACKMAN, Vadim , LIU, Yang , KIM, Young , ROY, Hemant , GOLDBERG, Michael , BRAND, Randall , PRADHAN, Prabhakar , SUBRAMANIAN, Hariharan
IPC分类号： G01J3/42
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations.

3. 发明申请

WO2007011958A3 INTRAORAL DOSAGE FORMS OF GLUCAGON 审中-公开
公开(公告)号：WO2007011958A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/027901
申请日：2006-07-17
申请人： EMISPHERE TECHNOLOGIES, INC. , WANG, Nai Fang , LIU, Puchun , DINH, Steven , GOLDBERG, Michael, M. , ARBIT, Ehud
发明人： WANG, Nai Fang , LIU, Puchun , DINH, Steven , GOLDBERG, Michael, M. , ARBIT, Ehud
IPC分类号： A61K31/00
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a therapeutically effective amount of glucagon and the delivery agent compound. The composition of the present invention facilitates the delivery of glucagon and increases its bioavailability compared to administration without the delivery agent compound.

4. 发明申请

WO2006138380A2 AMINE-CONTAINING LIPIDS AND USES THEREOF 审中-公开
标题翻译：含胺的脂肪及其用途
公开(公告)号：WO2006138380A2
公开(公告)日：2006-12-28
申请号：PCT/US2006023171
申请日：2006-06-14
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
发明人： ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
IPC分类号： A61K48/00
CPC分类号： C07D233/61 , A61K9/1617 , A61K47/18 , A61K47/22 , A61K48/00 , A61K48/0033 , C07C227/10 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C231/12 , C07C237/06 , C07D211/26 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28 , C12N15/88
摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。还提供了从市售的起始原料制备这些脂质的方法。这些脂质的这些含胺脂质或盐形式优选是可生物降解的和生物相容的，并且可以用于各种药物递送系统中。鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。本发明的脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

5. 发明申请

WO2005032322A3 HEAT PUMP CLOTHES DRYER 审中-公开
标题翻译：热泵干衣机
公开(公告)号：WO2005032322A3
公开(公告)日：2005-10-20
申请号：PCT/US2004031624
申请日：2004-09-23
申请人： SELF PROPELLED RES AND DEV SPE , GOLDBERG MICHAEL , TRUMAN JAMES C , KNIFFIN ALEXANDER B
发明人： GOLDBERG MICHAEL , TRUMAN JAMES C , KNIFFIN ALEXANDER B
IPC分类号： D06F58/20 , F26B21/06
CPC分类号： D06F58/206 , D06F25/00
摘要： A drying apparatus for drying articles such as clothing is provided. The drying apparatus includes a chamber for containing articles to be dried and a system for supplying heated dry air at a first temperature to the chamber. The air supplying system comprises an air flow pathway having an evaporator for removing moisture from air exiting the chamber and for decreasing the temperature of the air to below dew point temperature. The air supply system further has a condenser for increasing the temperature of the air exiting the evaporator to the first temperature. The drying apparatus further has a heat pump system having a refrigerant loop which includes a compressor, the condenser, a TEV valve, and the evaporator.
摘要翻译：提供了用于干燥衣服等物品的干燥装置。干燥装置包括用于容纳待干燥物品的室和用于将加热的干燥空气以第一温度供应到室的系统。空气供应系统包括具有蒸发器的空气流动通道，用于从出口的空气中除去空气，并将空气的温度降低至低于露点温度。空气供应系统还具有用于将离开蒸发器的空气的温度升高到第一温度的冷凝器。干燥装置还具有具有制冷剂回路的热泵系统，该制冷剂回路包括压缩机，冷凝器，TEV阀和蒸发器。

6. 发明申请

WO2004080401A3 ORAL INSULIN THERAPIES AND PROTOCOL 审中-公开
公开(公告)号：WO2004080401A3
公开(公告)日：2004-09-23
申请号：PCT/US2004/006943
申请日：2004-03-05
申请人： EMISPHERE TECHNOLOGIES, INC. , ARBIT, Ehud , GOLDBERG, Michael , MAJURU, Shingai
发明人： ARBIT, Ehud , GOLDBERG, Michael , MAJURU, Shingai
IPC分类号： A61K9/20
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β- cell function, aiding in preventing β- cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

7. 发明申请

WO2004080401A2 ORAL INSULIN THERAPIES AND PROTOCOL 审中-公开
标题翻译：口服胰岛素治疗和协议
公开(公告)号：WO2004080401A2
公开(公告)日：2004-09-23
申请号：PCT/US2004006943
申请日：2004-03-05
申请人： EMISPHERE TECH INC , ARBIT EHUD , GOLDBERG MICHAEL , MAJURU SHINGAI
发明人： ARBIT EHUD , GOLDBERG MICHAEL , MAJURU SHINGAI
IPC分类号： A61K20060101 , A61K6/00 , A61K9/20 , A61K31/00 , A61K38/28 , A61K45/06 , A61K47/16 , A61P3/10 , A61K
CPC分类号： A61K9/2009 , A61K9/2013 , A61K38/28 , A61K45/06
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing beta-cell function, aiding in preventing beta-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.
摘要翻译：用于治疗哺乳动物葡萄糖耐量异常和早期和晚期糖尿病的方法，用于预防性节省β-细胞功能，有助于预防β-细胞死亡，预防2型糖尿病哺乳动物的明显糖尿病发作，治疗目前的水平具有葡萄糖耐量降低或糖尿病的哺乳动物的血糖控制功能障碍，包括在摄食之前或之后约10分钟内口服胰岛素和促进胰岛素从胃肠道吸收的输送剂，长期的。除了施用快速作用的胰岛素以提供第一胰岛素峰之外，所述方法还包括施用缓慢作用的胰岛素以提供在稍后时间但持续时间更长的时间发生的第二胰岛素峰。这些方法可以改善血糖控制，没有低血糖，高胰岛素血症和体重增加的风险，以及通常与胰岛素治疗相关的频繁血糖监测的需要。

8. 发明申请

WO2017112940A1 IMMUNE CELL-TARGETED PARTICLES 审中-公开
标题翻译：免疫细胞靶向颗粒
公开(公告)号：WO2017112940A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/068541
申请日：2016-12-23
申请人： DANA-FARBER CANCER INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GOLDBERG, Michael, Solomon , SCHMID, Daniela , IRVINE, Darrell, J.
发明人： GOLDBERG, Michael, Solomon , SCHMID, Daniela , IRVINE, Darrell, J.
IPC分类号： A61K9/14 , A61K31/80 , A61K31/785
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/5153 , A61K31/4245 , A61K31/519 , A61K47/6849 , A61K47/6937 , A61K2039/505 , C07K16/2803 , C07K16/2815 , C07K16/2818 , C07K2317/54 , A61K2300/00
摘要： The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent; and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset ( e.g. , an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders ( e.g. , cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.
摘要翻译：本公开提供了具有含药物活性剂的聚合物芯的颗粒; 和缀合至颗粒表面的抗体片段，其中所述抗体片段靶向内源性免疫细胞亚群（例如，内源性T细胞或骨髓衍生的抑制性细胞）。本发明提供了用于形成颗粒的方法和使用该颗粒的方法。本文所述的颗粒可用于治疗和/或预防增殖性疾病，炎性疾病或肿瘤性疾病（例如癌症，自身免疫性疾病）。本发明还提供了包括或使用本文所述颗粒的药物组合物，试剂盒，方法和用途。

9. 发明申请

WO2011115810A2 ISOFORM-SPECIFIC RNAI BASED ON CODON REDUNDANCY/DEGENERACY 审中-公开
标题翻译：基于CODON REDUNDANCY / DEGENERACY的ISOFORM特异性RNAi
公开(公告)号：WO2011115810A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/027886
申请日：2011-03-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GOLDBERG, Michael, Solomon
发明人： GOLDBERG, Michael, Solomon
IPC分类号： C12N15/113 , A61K31/7105 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/7105 , C12N2310/14
摘要： The invention relates to nucleic acid molecules and compositions for specific post-transcriptional inhibition of PKM2 expression. Methods for specific inhibition of PKM2 expression in a target cell, for example a cancer cell, are also provided.
摘要翻译：本发明涉及用于PKM2表达的特异性转录后抑制的核酸分子和组合物。还提供了在靶细胞例如癌细胞中特异性抑制PKM2表达的方法。

10. 发明申请

WO2011097148A2 USE OF ORAL HEPARIN PREPARATIONS TO TREAT URINARY TRACT DISEASES AND CONDITIONS 审中-公开
标题翻译：使用口服肝素制剂治疗尿毒症疾病和病症
公开(公告)号：WO2011097148A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023108
申请日：2011-01-31
申请人： PARSONS, Lowell, C. , GOLDBERG, Michael, M.
发明人： PARSONS, Lowell, C. , GOLDBERG, Michael, M.
IPC分类号： A61K31/727
CPC分类号： A61K31/727
摘要： An improved method of treating lower urinary dysfunctional epithelium (LUDE) or a disease, condition, or syndrome associated with LUDE, including interstitial cystitis, comprises the step of administering orally a pharmaceutically effective quantity of heparin to a patient in need of treatment for LUDE or a disease, condition, or syndrome associated with LUDE in order to treat LUDE or a disease, condition, or syndrome associated with LUDE. The heparin can be administered together with a quantity of a penetration enhancer that is sufficient to result in a tissue concentration of heparin that is sufficient to treat LUDE or a disease, condition, or syndrome associated with LUDE. A suitable penetration enhancer is sodium N-[8-(2- hydroxybenzoyl)amino]caprylate. The method can further comprise the administration of at least one additional pharmaceutical composition to treat LUDE or a disease, condition, or syndrome associated with LUDE The invention further includes a pharmaceutical composition comprising: (1) a quantity of heparin that is pharmaceutically sufficient for the treatment of LUDE or a disease, condition, or syndrome associated with LUDE; and (b) at least one filler, excipient, or carrier; wherein the pharmaceutical composition is formulated for the treatment of LUDE or a disease, condition, or syndrome associated with LUDE.
摘要翻译：治疗下尿路功能障碍性上皮（LUDE）或与LUDE相关的疾病，病症或综合征（包括间质性膀胱炎）的改进方法包括将口服有效量的肝素口服给需要治疗LUDE或与LUDE相关的疾病，病症或综合征，以治疗LUDE或与LUDE相关的疾病，病症或综合征。肝素可与一定量的渗透增强剂一起施用，其足以导致肝素的组织浓度足以治疗LUDE或与LUDE相关的疾病，病症或综合征。合适的渗透增强剂是N- [8-（2-羟基苯甲酰基）氨基]辛酸钠。该方法可进一步包括施用至少一种另外的药物组合物以治疗LUDE或与LUD相关的疾病，病症或综合征。本发明还包括药物组合物，其包含：（1）一定量的肝素，治疗LUDE或与LUDE相关的疾病，病症或综合征; 和（b）至少一种填料，赋形剂或载体; 其中所述药物组合物被配制用于治疗LUDE或与LUDE相关的疾病，病症或综合征。

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