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1. 发明申请

WO2007011958A3 INTRAORAL DOSAGE FORMS OF GLUCAGON 审中-公开
公开(公告)号：WO2007011958A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/027901
申请日：2006-07-17
申请人： EMISPHERE TECHNOLOGIES, INC. , WANG, Nai Fang , LIU, Puchun , DINH, Steven , GOLDBERG, Michael, M. , ARBIT, Ehud
发明人： WANG, Nai Fang , LIU, Puchun , DINH, Steven , GOLDBERG, Michael, M. , ARBIT, Ehud
IPC分类号： A61K31/00
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a therapeutically effective amount of glucagon and the delivery agent compound. The composition of the present invention facilitates the delivery of glucagon and increases its bioavailability compared to administration without the delivery agent compound.

2. 发明申请

WO2006124047A3 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
公开(公告)号：WO2006124047A3
公开(公告)日：2006-11-23
申请号：PCT/US2005/028991
申请日：2005-08-15
申请人： EMISPHERE TECHNOLOGIES, INC. , MAJURU, Shingai , LIU, Puchun , DINH, Steven , LIAO, Jun , LEE, Jongbin , ARBIT, Ehud , DHOOT, Nikhil , LEVCHIK, Halina , HARRIS, Jamila , WANG, Nai, Fang , KLEIN, George, F.
发明人： MAJURU, Shingai , LIU, Puchun , DINH, Steven , LIAO, Jun , LEE, Jongbin , ARBIT, Ehud , DHOOT, Nikhil , LEVCHIK, Halina , HARRIS, Jamila , WANG, Nai, Fang , KLEIN, George, F.
IPC分类号： A61K9/14
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and /or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent

3. 发明申请

WO2006017541A2 ANTIDIABETIC ORAL INSULIN-BIGUANIDE COMBINATION 审中-公开
标题翻译：抗生素口服胰岛素 - 双胍组合
公开(公告)号：WO2006017541A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027499
申请日：2005-08-03
申请人： EMISPHERE TECHNOLOGIES, INC. , ARBIT, Ehud , GOLDBERG, Michael, M. , DINH, Steven
发明人： ARBIT, Ehud , GOLDBERG, Michael, M. , DINH, Steven
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61K31/155 , A61K2300/00
摘要： Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or HbA1c levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes.
摘要翻译：公开了包括胰岛素，促进胰岛素以治疗有效量转运至血液的递送剂和双胍，例如二甲双胍的药物剂型，用于口服给患者治疗糖尿病。还公开了用于在糖尿病哺乳动物中实现改善的葡萄糖耐量和血糖控制的方法，而没有任何统计学上显着的重量增加，低血糖或高胰岛素血症的风险，以及监测血糖浓度或HbA1c水平的需要，以及用于降低发生率和/ 或与慢性给药胰岛素相关的一种或多种疾病状态的严重程度; 用于预防性保护（3细胞功能或用于预防（葡萄糖耐量降低或早期糖尿病）的哺乳动物中的3细胞死亡或功能障碍;以及用于长期保护以发展（或延迟发作）明显或胰岛素依赖性具有葡萄糖耐量降低或早期糖尿病的哺乳动物的糖尿病。

4. 发明申请

WO2005112943A1 TOPICAL CROMOLYN FORMULATIONS 审中-公开
标题翻译：主题CROMOLYN制剂
公开(公告)号：WO2005112943A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017816
申请日：2005-05-19
申请人： EMISPHERE TECHNOLOGIES, INC. , LIU, Puchun , DINH, Steve , ARBIT, Ehud , GOLDBERG, Michael
发明人： LIU, Puchun , DINH, Steve , ARBIT, Ehud , GOLDBERG, Michael
IPC分类号： A61K31/609
CPC分类号： A61K31/609 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/183
摘要： The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a cromolyn component. Methods of treatment, and methods of preparing the topical composition are also provided.
摘要翻译：本发明提供一种局部组合物，其包含（a）至少一种递送剂化合物和（b）色素组分。还提供了治疗方法和制备局部组合物的方法。

5. 发明申请

WO2003057170A3 ORAL INSULIN THERAPY 审中-公开
公开(公告)号：WO2003057170A3
公开(公告)日：2003-07-17
申请号：PCT/US2003/000337
申请日：2003-01-07
申请人： EMISPHERE TECHNOLOGIES, INC. , ARBIT, Ehud , ABBAS, Richat , GOLDBERG, Michael , WOOD, T., Cooper , DINH, Steven , WONG, Vivien
发明人： ARBIT, Ehud , ABBAS, Richat , GOLDBERG, Michael , WOOD, T., Cooper , DINH, Steven , WONG, Vivien
IPC分类号： A61K38/28
摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.

6. 发明申请

WO2004062587A2 NIGHT-TIME ORAL INSULIN THERAPY 审中-公开
标题翻译：夜间口服胰岛素治疗
公开(公告)号：WO2004062587A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000273
申请日：2004-01-06
申请人： EMISPHERE TECHNOLOGIES, INC. , GOLDBERG, Michael , ARBIT, Ehud
发明人： GOLDBERG, Michael , ARBIT, Ehud
IPC分类号： A61K
CPC分类号： A61K38/28
摘要： A method for protection of a mammal that has impaired glucose tolerance or early stage diabetes mellitus from developing overt or insulin dependent diabetes comprises administering an orally effective dose of a pharmaceutical formulation comprising insulin at nighttime, e.g., at or shortly before bedtime.
摘要翻译：保护具有葡萄糖耐量降低或糖尿病早期受损的哺乳动物从发展明显或胰岛素依赖性糖尿病的方法包括在夜间，例如在睡前或在就寝时间之前施用口服有效剂量的包含胰岛素的药物制剂。

7. 发明申请

WO2003045331A2 FORMULATIONS FOR ORAL ADMINISTRATION OF CROMOLYN SODIUM 审中-公开
标题翻译：口服给予CROMOLYN SODIUM的配方
公开(公告)号：WO2003045331A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/038247
申请日：2002-11-29
申请人： EMISPHERE TECHNOLOGIES, INC. , ABBAS, Richat , ARBIT, Ehud , GOLDBERG, Michael , WONG, Vivian , SARUBBI, Donald, J.
发明人： ABBAS, Richat , ARBIT, Ehud , GOLDBERG, Michael , WONG, Vivian , SARUBBI, Donald, J.
IPC分类号： A61K
CPC分类号： A61K31/352 , A61K9/4858 , A61K47/183
摘要： An oral dosage form comprises cromolyn sodium (sodium or disodium cromoglycate), and an acylated amino acid delivery agent.
摘要翻译：口服剂型包含色甘酸钠（色甘酸钠或色甘酸二钠）和酰化氨基酸递送剂。

8. 发明申请

WO2004080401A3 ORAL INSULIN THERAPIES AND PROTOCOL 审中-公开
公开(公告)号：WO2004080401A3
公开(公告)日：2004-09-23
申请号：PCT/US2004/006943
申请日：2004-03-05
申请人： EMISPHERE TECHNOLOGIES, INC. , ARBIT, Ehud , GOLDBERG, Michael , MAJURU, Shingai
发明人： ARBIT, Ehud , GOLDBERG, Michael , MAJURU, Shingai
IPC分类号： A61K9/20
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β- cell function, aiding in preventing β- cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

9. 发明申请

WO2012135537A2 PALM-CONTROLLED INJECTORS 审中-公开
标题翻译：棕榈控制注射器
公开(公告)号：WO2012135537A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031286
申请日：2012-03-29
申请人： HARISH, Ziv , RUBINSTEIN, Isaac , ARBIT, Ehud , WEINZIMMER, Russ
发明人： HARISH, Ziv , RUBINSTEIN, Isaac , ARBIT, Ehud , WEINZIMMER, Russ
IPC分类号： A61M5/24 , A61M5/20 , A61M5/14
CPC分类号： A61M5/2033 , A61M5/19 , A61M5/3234 , A61M5/326 , A61M5/3287 , A61M5/422 , A61M2005/2013 , A61M2005/206 , A61M2005/2073
摘要： A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.
摘要翻译：公开了一种用于将物质注射到生物体中的手掌控制装置。该装置包括用于接纳手掌的手掌接收表面，手掌接收表面被成形为使得手掌在操作装置时基本上平行于生物体的注射部位的表面。手掌接收表面也可以被成形为使得手掌基本垂直于注射部位的表面。该装置还包括具有至少一个预填充注射器的注射器，手掌接收表面与注射器配合，使得当压力施加到手掌接收表面时，注射器被致动以便注射注射器的内容物至少一个预充注射器。喷射器的驱动是通过逐渐的压力来实现的; 不是突然的动作。单次注射器可以包含一次或多次相同或不同的药物。

10. 发明申请

WO2014204457A1 PALM-BASED INJECTOR ACTUATION AND SAFETY SURFACES 审中-公开
标题翻译：基于PALM的注射器启动和安全表面
公开(公告)号：WO2014204457A1
公开(公告)日：2014-12-24
申请号：PCT/US2013/046630
申请日：2013-06-19
申请人： HARISH, Ziv , RUBINSTEIN, Isaac , WEINZIMMER, Russ , ARBIT, Ehud
发明人： RUBINSTEIN, Isaac , WEINZIMMER, Russ , ARBIT, Ehud
IPC分类号： A61M5/178 , A61M3/00
CPC分类号： A61M5/19 , A61M5/2033 , A61M5/3129 , A61M5/31511 , A61M5/326 , A61M5/3287 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2005/3103 , A61M2205/586
摘要： A palm-held device is disclosed for injection of a substance into an organism. The palm-held device has the shape of a computer mouse, and so is very familiar, which helps with ease-of-use and comfort. Like a computer mouse, the device can be moved easily by gently holding and guiding the mouse with the fingers and the palm of the hand. There are many possible button configurations, such as a single button mouse, the button having a large surface at the front top portion of the mouse, and being pressable by any finger. There can also be a two button mouse, such that the left button actuates the injection, and the right button is the "safety" that allows the left button to actuate the injection. The two buttons can be on the top front of the mouse, or can be on the right and left sides of the mouse.
摘要翻译：公开了一种用于将物质注入生物体的手掌装置。手掌设备具有电脑鼠标的形状，因此非常熟悉，这有助于易于使用和舒适。像电脑鼠标一样，通过用手指和手掌轻轻握住并引导鼠标，便可轻松移动设备。存在许多可能的按钮配置，例如单按钮鼠标，该按钮在鼠标的前顶部具有大的表面，并且可被任何手指按压。还可以有一个双按钮鼠标，左按钮可以启动注射，右按钮是允许左按钮启动注射的“安全”。两个按钮可以在鼠标的顶部，也可以在鼠标的左右两侧。

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