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1. 发明申请

WO2015127416A1 COMPOSITIONS OF PENTOSAN POLYSULFATE SALTS FOR ORAL ADMINISTRATION AND METHODS OF USE 审中-公开
标题翻译：用于口腔管理的松桃油聚合物组合物及其使用方法
公开(公告)号：WO2015127416A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/017205
申请日：2015-02-24
申请人： URIGEN PHARMACEUTICALS, INC. , PARSONS, C., Lowell , GOLDBERG, Michael , MEENAN, Christopher, P.
发明人： PARSONS, C., Lowell , GOLDBERG, Michael , MEENAN, Christopher, P.
IPC分类号： A61K31/715 , C07H5/10 , A61K47/14 , A61P19/02
CPC分类号： A61K31/737 , A61K31/20 , A61K31/715 , A61K45/06 , A61K47/00 , Y02A50/473 , A61K2300/00
摘要： The present invention is directed to a pharmaceutical composition comprising: (1 ) a therapeutically effective quantity of sodium pentosan polysulfate; (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate; and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. Such compositions and methods allow the administration of sodium pentosan polysulfate at lower dosages to reduce the frequency and severity of side effects.
摘要翻译：本发明涉及药物组合物，其包含：（1）治疗有效量的戊聚糖多聚硫酸钠; （2）一定量的渗透增强剂足以提高戊聚糖多硫酸钠的生物利用度; 和（3）任选的药学上可接受的载体，以及用于口服施用戊聚糖多硫酸钠的方法，其具有改善的生物利用度用于治疗间质性膀胱炎和其它尿道疾病和病症。这种组合物和方法允许以较低剂量施用戊聚糖多硫酸钠以降低副作用的频率和严重性。

2. 发明申请

WO2007087624A3 TRANSLUMINAL DRUG DELIVERY METHODS AND DEVICES 审中-公开
公开(公告)号：WO2007087624A3
公开(公告)日：2007-08-02
申请号：PCT/US2007/061106
申请日：2007-01-26
申请人： KALIUM, INC. , ZUPKAS, Paul , PARSONS, C., Lowell
发明人： ZUPKAS, Paul , PARSONS, C., Lowell
IPC分类号： A61K9/02
摘要： Transluminal drug delivery method and device embodiments can include a urethral suppository formulated to prevent or treat diseases of the urethra and surrounding organs, such as interstitial cystitis or urethritis, by enhancing the absorption of a therapeutic agent of the suppository into body tissues without adversely affecting the natural defense mechanisms of these tissues. Adverse effects on the glycosaminoglycan (GAG) barrier can be mitigated or eliminated by the presence of a suitable polysaccharide in the suppository.

3. 发明申请

WO2007027614A2 ABNORMAL GLYCOSYLATION IN TAMM-HORSFALL PROTEIN IN INTERSTITIAL CYSTITIS PATIENT 审中-公开
标题翻译：间质性CYSTITIS患者TAMM-HORSFALL蛋白质异常糖化
公开(公告)号：WO2007027614A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033544
申请日：2006-08-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PARSONS, C., Lowell
发明人： PARSONS, C., Lowell
IPC分类号： A61K38/17 , G01N33/50 , A61P13/10
CPC分类号： G01N33/6893 , A61K38/1709 , G01N2400/00 , G01N2500/00 , G01N2800/06 , G01N2800/348
摘要： The invention provides a method for inhibiting Interstitial Cystitis and its symptoms, reducing symptoms of Interstitial Cystitis in a subject and repairing the mucin layer in a subject by administering an effective amount of a Tamm-Horsfall protein to the subject.
摘要翻译：本发明提供一种抑制间质性膀胱炎及其症状的方法，通过向受试者施用有效量的Tamm-Horsfall蛋白来减少受试者间质性膀胱炎的症状并修复受试者的粘蛋白层。

4. 发明申请

WO2012094515A1 METHOD FOR MANUFACTURING COMPOSITION COMPRISING LOCAL ANESTHETIC, HEPARINOID, AND BUFFER 审中-公开
标题翻译：制备包含局部麻醉，肝素和缓冲液的组合物的方法
公开(公告)号：WO2012094515A1
公开(公告)日：2012-07-12
申请号：PCT/US2012/020357
申请日：2012-01-05
申请人： PARSONS, C., Lowell
发明人： PARSONS, C., Lowell
IPC分类号： A61K31/727
CPC分类号： A61K31/727 , A61K31/167 , A61K45/06 , A61K2300/00
摘要： An improved method for preparing a composition including a heparinoid, a local anesthetic, and a buffer for treatment of a lower urinary tract disease or condition can comprise: (i) providing a heparinoid in solid form or liquid form; (ii) providing a local anesthetic in solid form or liquid form; (iii) adding a liquid buffer to the heparinoid in solid form or liquid form; (Iv) adding the local anesthetic to the mixture of the liquid buffer and the heparinoid; and (v) if necessary, adjusting the pH of the mixture of the liquid buffer, the local anesthetic, and the heparinoid so that a pH is achieved of from about 6.8 to about 8.3 is achieved without precipitation of the local anesthetic.
摘要翻译：用于制备包含类肝素，局部麻醉剂和用于治疗下尿路疾病或病症的缓冲液的组合物的改进方法可以包括：（i）提供固体形式或液体形式的类肝素; （ii）提供固体形式或液体形式的局部麻醉剂; （iii）以固体形式或液体形式向类肝素添加液体缓冲液; （Iv）将局部麻醉剂加入到液体缓冲液和类肝素混合物中; 和（v）如果需要，调节液体缓冲液，局部麻醉剂和类肝素的混合物的pH，使得实现约6.8至约8.3的pH而没有局部麻醉剂的沉淀。

5. 发明申请

WO2005072751A1 NOVEL INTERSTITIAL THERAPY FOR IMMEDIATE SYMPTOM RELIEF AND CHRONIC THERAPY IN INTERSTITIAL CYSTITIS 审中-公开
标题翻译：临床间歇性临床症状缓解和慢性治疗的新型临床治疗
公开(公告)号：WO2005072751A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/003542
申请日：2005-01-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PARSONS, C., Lowell
发明人： PARSONS, C., Lowell
IPC分类号： A61K31/727
CPC分类号： A61K31/737 , A61K9/0034 , A61K9/08 , A61K31/167 , A61K31/24 , A61K31/445 , A61K31/727 , A61K31/728 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment, the present invention relates to treatment formulations and methods for reducing interstitial cystitis in patients.
摘要翻译：本发明涉及下尿路疾病，特别涉及体内间质性膀胱炎的症状（包括治疗）。在优选的实施方案中，本发明涉及用于减少患者间质性膀胱炎的治疗制剂和方法。

6. 发明申请

WO2021011566A1 ALKALIZATION OF URINARY BLADDER WALL PRIOR TO TREATMENT WITH INTRAVESICAL HEPARIN AND ALKALINIZED LIDOCAINE TO ENHANCE RELIEF OF BLADDER PAIN SYMPTOMS 审中-公开
公开(公告)号：WO2021011566A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/041977
申请日：2020-07-14
申请人： PARSONS, C., Lowell
发明人： PARSONS, C., Lowell
IPC分类号： A61B1/307 , A61B18/14 , A61M19/00
摘要： The present invention is directed to an improved method of treating diseases and conditions associated with bladder pain, particularly interstitial cystitis. In general, a method according to the present invention comprises: (1) instilling into the bladder of a subject with a disease or condition associated with bladder pain a quantity and concentration of a physiologically compatible buffer to raise the pH of the bladder epithelium sufficiently to reduce acidosis associated with the disease or condition; (2) allowing the physiologically compatible buffer of (a) to remain in the bladder for a period sufficiently long to enable the buffer to raise the pH; (3) removing the physiologically compatible buffer of (1) from the bladder; and (4) instilling into the bladder a quantity of a composition comprising: (i) a heparinoid; (ii) a local anesthetic; and (ill) a buffer, wherein the composition has a pH of from about 7.0 to about 7.4 to treat the disease or condition associated with bladder pain. The present invention also is directed to kits for practicing the method.

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