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1. 发明申请

WO2014160930A1 CARDIAC-SAFE ELECTROTHERAPY METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2014160930A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/032163
申请日：2014-03-28
申请人： GALVANI, LTD.
发明人： KROLL, Mark, William
IPC分类号： A61N1/39 , A61N1/362 , A61N1/365
CPC分类号： A61N1/3987 , A61N1/3906
摘要： A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (MVT) adapted to reduce the side effects of MVT. The electrotherapy apparatus is configured to selectively deliver MVT to vectors not involving the ventricles and defibrillation therapy to vectors involving the ventricles. The apparatus can use biphasic waveforms configured to avoid capture of cardiac cells during MVT. The electrotherapy apparatus can minimize the risk of applying MVT at inappropriate times, such as during atrial fibrillation or where conventional ventricular tachycardia or ventricular fibrillation therapy is more appropriate.
摘要翻译：一种多模式电疗装置，包括用于施用除颤治疗和用于施用适于减少MVT的副作用的中压治疗（MVT）的电路。电疗设备被配置为选择性地将MVT递送到不涉及心室的矢量和除颤疗法到涉及心室的矢量。该装置可以使用配置为避免在MVT期间捕获心脏细胞的双相波形。电疗装置可以在不适当的时间（例如在心房颤动期间或在常规的室性心动过速或心室颤动疗法更合适的情况下）最小化应用MVT的风险。

2. 发明申请

WO2006058133A2 MEDIUM VOLTAGE THERAPY APPLICATIONS IN TREATING CARDIAC ARREST 审中-公开
标题翻译：中等电压治疗应用于治疗心脏病
公开(公告)号：WO2006058133A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042569
申请日：2005-11-23
申请人： GALVANI LTD , KROLL KAI , KROLL MARK , BUGLIOSI THOMAS
发明人： KROLL KAI , KROLL MARK , BUGLIOSI THOMAS
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3625 , A61N1/3925 , A61N1/3993
摘要： A method and system for treating an individual experiencing cardiac arrest using an automatic external defibrillator (AED) includes placing a first and a second electrode of the AED in electrical communication with an exterior surface of the individual. A need to apply a high voltage defibrillation signal to the individual is automatically determined. The method also includes automatically causing the AED to apply a medium voltage therapy (MVT) signal through the first and the second electrodes to the individual. The MVT signal is applied to induce a hemodynamic effect in the individual. Alternatively, or additionally, the MVT signal is applied to induce a respiratory effect in the individual. Optionally, the MVT signal is applied before determining the need to apply the defibrillation signal.
摘要翻译：使用自动外部除颤器（AED）治疗体验心跳骤停的个体的方法和系统包括将AED的第一和第二电极放置在与个体的外表面电连通。自动确定对个体施加高电压除颤信号的需要。该方法还包括自动使AED通过第一和第二电极向个体施加中压治疗（MVT）信号。应用MVT信号以诱导个体的血液动力学效应。或者或另外，施加MVT信号以在个体中诱发呼吸作用。可选地，在确定需要施加除颤信号之前施加MVT信号。

3. 发明申请

WO2000013748A1 A METHOD AND APPARATUS FOR PREVENTING CLOTTING DURING ATRIAL FIBRILLATION 审中-公开
标题翻译：一种用于在ATRIAL FIBRILLATION期间防止衣服的方法和装置
公开(公告)号：WO2000013748A1
公开(公告)日：2000-03-16
申请号：PCT/US1999/020589
申请日：1999-09-08
申请人： GALVANI, LTD.
发明人： KROLL, Kai
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395 , A61N1/3956
摘要： The present invention is a device for preventing clotting during atrial fibrillation. The device of the present invention includes optional electrical cardiac output forcing (ECOF) or ICD/AED back-up. The device includes a power supply (40) for operating the device, and for providing the necessary output forcing signals. The power supply is located in a housing which may be implanted into a human patient. In one embodiment of the invention, the housing acts as an electrode. At least one additional electrode is connected to the housing, and may be inserted into the human heart. A ventricular lead (18) is mounted to the electrode along with an atrial lead (14). The housing also contains an electrical cardiac stimulator (34). When a certain cardiac event, such as atrial fibrillation, is detected, anti-clotting pulses are applied to the heart via the atrial lead. If, and when ventricular fibrillation is detected, further pulses of a different voltage level are applied to the heart via the ventricular lead. In one embodiment of the invention, the anti-clotting pulses are synchronized to the R-wave sensed by the ventricular lead.
摘要翻译：本发明是一种用于在心房颤动期间预防凝血的装置。本发明的装置包括可选的电心脏输出强迫（ECOF）或ICD / AED备用。该装置包括用于操作该装置的电源（40），并提供必要的输出强制信号。电源位于可以植入人类患者的外壳中。在本发明的一个实施例中，壳体充当电极。至少一个附加电极连接到壳体，并且可以插入到人的心脏中。心室引线（18）与心房引线（14）一起安装到电极上。壳体还包含电心脏刺激器（34）。当检测到某种心脏事件（例如心房颤动）时，通过心房引线将抗凝血脉冲施加到心脏。如果并且当检测到心室颤动时，通过心室引线将不同电压水平的另外的脉冲施加到心脏。在本发明的一个实施方案中，抗凝血脉冲与由心室导线感测到的R波同步。

4. 发明申请

WO2014091301A1 ARRHYTHMIA ELECTROTHERAPY DEVICE AND METHOD WITH PROVISIONS FOR MITIGATING PATIENT DISCOMFORT 审中-公开
标题翻译： ARRHYTHMIA电疗装置及其方法，以减轻患者的不适
公开(公告)号：WO2014091301A1
公开(公告)日：2014-06-19
申请号：PCT/IB2013/002917
申请日：2013-12-12
申请人： GALVANI, LTD.
发明人： GILMAN, Byron, L. , KROLL, Mark, W. , KROLL, Kai, K. , BULLION, John, H.
IPC分类号： A61N1/36 , A61N1/362 , A61N1/08
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/3702
摘要： Apparatus and method for treating an arrhythmia in a patient using an electrotherapy device such as a subcutaneous pacing device. The device applies a series of electrotherapy pulses in response to the presence of the arrhythmia. Various provisions are disclosed for mitigating pain or discomfort as a result of the electrotherapy pulses.
摘要翻译：用于使用诸如皮下起搏装置的电疗装置治疗患者心律失常的装置和方法。该装置响应于心律失常的存在而应用一系列电疗脉冲。公开了用于减轻作为电疗脉冲的结果的疼痛或不适的各种规定。

5. 发明申请

WO2006058133A3 MEDIUM VOLTAGE THERAPY APPLICATIONS IN TREATING CARDIAC ARREST 审中-公开
公开(公告)号：WO2006058133A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042569
申请日：2005-11-23
申请人： GALVANI, LTD. , KROLL, Kai , KROLL, Mark , BUGLIOSI, Thomas
发明人： KROLL, Kai , KROLL, Mark , BUGLIOSI, Thomas
IPC分类号： A61N1/39
摘要： A method and system for treating an individual experiencing cardiac arrest using an automatic external defibrillator (AED) includes placing a first and a second electrode of the AED in electrical communication with an exterior surface of the individual. A need to apply a high voltage defibrillation signal to the individual is automatically determined. The method also includes automatically causing the AED to apply a medium voltage therapy (MVT) signal through the first and the second electrodes to the individual. The MVT signal is applied to induce a hemodynamic effect in the individual. Alternatively, or additionally, the MVT signal is applied to induce a respiratory effect in the individual. Optionally, the MVT signal is applied before determining the need to apply the defibrillation signal.

6. 发明申请

WO2013020135A1 MULTI-MODAL ELECTROTHERAPY METHOD AND APPARATUS 审中-公开
标题翻译：多模式电疗方法和装置
公开(公告)号：WO2013020135A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049765
申请日：2012-08-06
申请人： GALVANI LTD. , KROLL, Mark, William
发明人： KROLL, Mark, William
IPC分类号： A61N1/39 , A61N1/362 , A61N1/378
CPC分类号： A61N1/3975 , A61N1/3621 , A61N1/3627 , A61N1/3782 , A61N1/3962 , A61N1/3981
摘要： A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (MVT). A combined-use capacitor bank of at least one capacitor stores energy to be administered as defibrillation therapy and MVT. Combined-use discharge circuitry electrically is coupled between the combined-use capacitor bank and patient terminals for selectively administering energy from the capacitor bank according to a plurality of controllable waveforms as either defibrillation therapy or MVT. A controller is configured to cause the discharge circuitry to apply the MVT from the capacitor bank while the capacitor bank undergoes charging in preparation for administration of the defibrillation therapy.
摘要翻译：一种多模式电疗装置，包括用于施用除颤疗法和用于中压治疗（MVT）的电路。至少一个电容器的组合使用的电容器组存储作为除颤疗法和MVT施用的能量。组合使用的放电电路电耦合在组合使用的电容器组和患者端子之间，用于根据作为除颤治疗或MVT的多个可控波形从电容器组选择性地施加能量。控制器被配置为使得放电电路从电容器组施加MVT，同时电容器组进行充电以准备施用除颤疗法。

7. 发明申请

WO0013748A9 A METHOD AND APPARATUS FOR PREVENTING CLOTTING DURING ATRIAL FIBRILLATION 审中-公开
标题翻译：一种用于在ATRIAL FIBRILLATION期间防止衣服的方法和装置
公开(公告)号：WO0013748A9
公开(公告)日：2002-08-22
申请号：PCT/US9920589
申请日：1999-09-08
申请人： GALVANI LTD
发明人： KROLL KAI
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395 , A61N1/3956
摘要： The present invention is a device for preventing clotting during atrial fibrillation. The device of the present invention includes optional electrical cardiac output forcing (ECOF) or ICD/AED back-up. The device includes a power supply (40) for operating the device, and for providing the necessary output forcing signals. The power supply is located in a housing which may be implanted into a human patient. In one embodiment of the invention, the housing acts as an electrode. At least one additional electrode is connected to the housing, and may be inserted into the human heart. A ventricular lead (18) is mounted to the electrode along with an atrial lead (14). The housing also contains an electrical cardiac stimulator (34). When a certain cardiac event, such as atrial fibrillation, is detected, anti-clotting pulses are applied to the heart via the atrial lead. If, and when ventricular fibrillation is detected, further pulses of a different voltage level are applied to the heart via the ventricular lead. In one embodiment of the invention, the anti-clotting pulses are synchronized to the R-wave sensed by the ventricular lead.
摘要翻译：本发明是一种用于在心房颤动期间预防凝血的装置。本发明的装置包括可选的电心脏输出强迫（ECOF）或ICD / AED备用。该装置包括用于操作该装置的电源（40），并提供必要的输出强制信号。电源位于可以植入人类患者的外壳中。在本发明的一个实施例中，壳体充当电极。至少一个附加电极连接到壳体，并且可以插入到人的心脏中。心室引线（18）与心房引线（14）一起安装到电极。壳体还包含电心脏刺激器（34）。当检测到某种心脏事件（例如心房颤动）时，通过心房引线将抗凝血脉冲施加到心脏。如果并且当检测到心室颤动时，通过心室引线将不同电压水平的另外的脉冲施加到心脏。在本发明的一个实施方案中，抗凝血脉冲与由心室导线感测到的R波同步。

8. 发明申请

WO2000013741A2 METHOD AND APPARATUS FOR MONITORING SYNCOPE 审中-公开
标题翻译：用于监测同步的方法和装置
公开(公告)号：WO2000013741A2
公开(公告)日：2000-03-16
申请号：PCT/US1999020565
申请日：1999-09-08
申请人： GALVANI, LTD.
发明人： GALVANI, LTD. , KROLL, Kai
IPC分类号： A61N
CPC分类号： A61N1/08 , A61N1/3702
摘要： The present invention comprises a method and an apparatus for monitoring syncope, and having available for use an electrical cardiac output forcing (ECOF) back up. The present invention is an implantable device for recording the electrical activity within a human heart. The device of the present invention includes ECOF back up. The device includes a power supply for operating the device and for providing the necessary output forcing signals. A monitoring or detection device is provided connected to the power supply. The electrodes are provided to electrically connect the power supply and the detection device to a patient's heart. A memory device is also provided which is connected to the detection device for recording electrical activity and/or blood pressure data of the patient's heart. In a preferred embodiment of the present invention, the memory device is comprised of a short term loop buffer for continuously recording the electrical data from the patient's heart and a long term storage buffer. The short term loop buffer may be of a desired size, for example, capable of storing from 1-30 minutes of data before overriding occurs. Upon the occurrence of a predetermined event, for example, a bout of syncope, the data in the short term loop buffer is transferred to the long term storage buffer. An output control circuit is also provided which is connected to the detection device and to the power supply and to the electrodes. Upon the occurrence of a second predetermined event, such as fibrillation of the heart, the output control circuit causes the delivery of an electrical cardiac output forcing signal to the patient's heart.
摘要翻译：本发明包括用于监测晕厥的方法和装置，并且可用于使用电心电输出强迫（ECOF）备份。本发明是用于记录人心脏内的电活动的可植入装置。本发明的装置包括ECOF备份。该装置包括用于操作该装置并提供必要的输出强制信号的电源。提供连接到电源的监视或检测装置。提供电极以将电源和检测装置电连接到患者的心脏。还提供了一种存储装置，其连接到用于记录患者心脏的电活动和/或血压数据的检测装置。在本发明的一个优选实施例中，存储器件包括用于从患者的心脏和长期存储缓冲器连续记录电气数据的短期环路缓冲器。短期环路缓冲器可以是期望的大小，例如，能够在覆盖发生之前存储1-30分钟的数据。在发生预定事件（例如，晕厥发生）时，将短期环路缓冲器中的数据传送到长期存储缓冲器。还提供了一种输出控制电路，其连接到检测装置以及电源和电极。在发生第二预定事件（例如心脏原纤维）的情况下，输出控制电路导致电心电输出强迫信号送到患者的心脏。

9. 发明申请

WO2014093674A1 COORDINATED MEDIUM VOLTAGE THERAPY FOR IMPROVING EFFECTIVENESS OF DEFIBRILLATION THERAPY 审中-公开
标题翻译：协调中压治疗改善祛痰治疗的有效性
公开(公告)号：WO2014093674A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074761
申请日：2013-12-12
申请人： GALVANI, LTD.
发明人： GILMAN, Byron, L. , KROLL, Mark, W.
IPC分类号： A61N1/38 , A61N1/39
CPC分类号： A61N1/3987 , A61N1/36003 , A61N1/3621 , A61N1/3918 , A61N1/3925 , A61N1/3962
摘要： Automated treatment of arrhythmia utilizing an electrotherapy device. Time-coordinated applications of medium-voltage therapy (MVT) followed by high-voltage therapy (HVT) include a first MVT waveform to a first target region and a second MVT waveform to a second target region, such that the HVT is synchronized relative to a first compression cycle corresponding to activation of the first target region, and to a second compression cycle corresponding to activation of the second target region resulting from the administration of the MVT.
摘要翻译：使用电疗装置自动治疗心律失常。中压治疗（MVT）随后进行高压治疗（HVT）的时间协调应用包括到第一目标区域的第一MVT波形和到第二目标区域的第二MVT波形，使得HVT相对于对应于第一目标区域的激活的第一压缩循环，以及对应于由管理MVT引起的第二目标区域的激活的第二压缩循环。

10. 发明申请

WO1997015351A1 METHOD AND APPARATUS FOR TEMPORARILY ELECTRICALLY FORCING CARDIAC OUTPUT AS A BACKUP FOR TACHYCARDIA PATIENTS 审中-公开
标题翻译：方法和装置用于临时电力强迫心脏输出作为TACHYCARDIA患者的备用
公开(公告)号：WO1997015351A1
公开(公告)日：1997-05-01
申请号：PCT/US1996017323
申请日：1996-10-25
申请人： GALVANI LTD.
发明人： GALVANI LTD. , KROLL, Kai , KROLL, Mark, W.
IPC分类号： A61N01/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： Upon detection of a cardiac arrhythmia (70), the apparatus delivers a series of pulses (72) followed by a further check for arrythmia or other abnormal conditions. Upon the further detection of such abnormal conditions (74), the apparatus delivers a second series of pulses (78) and again checks for arrhythmia or other abnormal conditions (79). If such an abnormal condition is again sensed, a third series of pulses is applied (80). A further condition sensor senses the selection of continuous operation (82) and continues to apply the third series of pulses to the patient.
摘要翻译：在检测到心律失常（70）时，该装置递送一系列脉冲（72），随后进一步检查是否存在心律不齐或其他异常情况。在进一步检测到这种异常情况（74）时，装置递送第二系列脉冲（78），并再次检查心律失常或其他异常情况（79）。如果再次感测到这样的异常情况，则施加第三系列脉冲（80）。进一步的条件传感器感测连续操作的选择（82），并继续将第三系列脉冲应用于患者。

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