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1. 发明申请

WO2011150323A3 REAL TIME CSF FLOW MEASUREMENT SYSTEM & METHOD 审中-公开
标题翻译：实时CSF流量测量系统与方法
公开(公告)号：WO2011150323A3
公开(公告)日：2012-05-18
申请号：PCT/US2011038317
申请日：2011-05-27
申请人： NEURODX DEV LLC , SWOBODA MAREK , HOCHMAN MATIAS GABRIEL , MATTIUCCI MARK EVAN , FRITZ FREDERICK J
发明人： SWOBODA MAREK , HOCHMAN MATIAS GABRIEL , MATTIUCCI MARK EVAN , FRITZ FREDERICK J
IPC分类号： A61M5/168 , A61B5/01 , A61F2/02
CPC分类号： A61M27/006 , A61B5/01 , A61B5/031 , A61B5/032 , A61M5/168 , A61M5/16836 , G01F1/684
摘要： A system for measuring quantitative CSF flow in shunt tubing implanted under the skin. The system includes an array of thermo-sensors clustered in three sections, cooling device, placed on the skin surface and an associated data acquisition and analysis device. Two sensor sections are placed over the shunt on the skin and measure real time temperature responses related to CSF movement. One array placed adjacent the cooling device collects data on thermal properties of skin including skin thermal conductivity, specific heat, diffusivity, perfusion, and thermal inertia. The method involves assessing thermal properties of skin and measuring CSF flow in shunt tubing. The method is useful for shunt patency assessment, CSF valve adjustment procedures and CSF flow measurements related to CSF over drainage. Alternatively, only one section of sensors need be used when determining relative CSF flow, without the need to determine thermal skin properties and by applying the cooling device continuously.
摘要翻译：用于测量植入皮下的分流管中定量CSF流量的系统。该系统包括聚集在三个部分的热传感器阵列，放置在皮肤表面上的冷却装置和相关的数据采集和分析装置。将两个传感器部分放置在皮肤上的分流器上，并测量与CSF运动相关的实时温度响应。靠近冷却装置放置的一个阵列收集关于皮肤热性质的数据，包括皮肤热导率，比热，扩散性，灌注和热惯性。该方法包括评估皮肤的热性质并测量分流管中的CSF流量。该方法对于分流通气评估，脑脊液阀调节程序和与流量相关的CSF流量测量有用。或者，当确定相对CSF流量时，仅需要使用一个传感器部分，而不需要确定热皮肤性质并且连续地施加冷却装置。

2. 发明申请

WO2008127867A3 CEREBROSPINAL FLUID EVALUATION SYSTEMS 审中-公开
标题翻译：脑脊液检测系统
公开(公告)号：WO2008127867A3
公开(公告)日：2009-02-26
申请号：PCT/US2008058882
申请日：2008-03-31
申请人： NEURO DIAGNOSTIC DEVICES INC , FRITZ FREDERICK J , SWOBODA MAREK
发明人： FRITZ FREDERICK J , SWOBODA MAREK
IPC分类号： A61B5/00 , A61B5/03
CPC分类号： A61B5/01 , A61B5/031 , A61M27/006 , A61M2205/3379
摘要： Methods and devices for testing for the presence, absence or flow rate in a subcutaneous shunt tubing using a measurement pad having a plurality of temperature sensor configurations which are positioned over, or in the vicinity of, the CSF shunt in substantially an upstream/downstream orientation. A temperature source is then applied at a predetermined location with respect to the measurement pad that is insulated from the temperature sensors. This temperature "pulse" movement is detected by the temperature sensors via the shunt tubing as the CSF carries the temperature pulse while a control sensor detects the pulse via skin convection. Temperature sensor data are provided to a CSF analyzer that subtracts control sensor data from the other sensors for determining a CSF shunt flow status/rate. A reader is used to optically or electrically detect the changes in a temperature sensitive material for determining a CSF shunt flow status or flow rate.
摘要翻译：使用具有多个温度传感器配置的测量垫来测试皮下分流管中存在，不存在或流速的方法和装置，所述测量垫位于基本上游/下游取向的CSF旁路或CSF附近。然后将温度源相对于与温度传感器绝缘的测量焊盘在预定位置施加。温度“脉冲”运动由温度传感器通过分流管检测，因为当携带温度脉冲时，控制传感器通过皮肤对流检测脉冲。将温度传感器数据提供给CSF分析仪，其从其他传感器中减去控制传感器数据，以确定CSF分流流量状态/速率。读取器用于光学或电检测温度敏感材料的变化，以确定CSF分流流状态或流速。

3. 发明申请

WO0078096A2 HEARING AID WITH AN ACOUSTICAL FORMAT 审中-公开
标题翻译：用声音格式听力助听
公开(公告)号：WO0078096A2
公开(公告)日：2000-12-21
申请号：PCT/US0016193
申请日：2000-06-13
申请人： SARNOFF CORP , SJURSEN WALTER P , MCCANDLESS GEARY A , FRITZ FREDERICK J
发明人： SJURSEN WALTER P , MCCANDLESS GEARY A , FRITZ FREDERICK J
IPC分类号： H04R25/00
CPC分类号： H04R25/502 , H04R25/356
摘要： Hearing loss types are segregated into a predetermined number of classes. For each class, an approximate hearing loss is determined and a corresponding fixed acoustical format, e.g. frequency response, is assigned to correct a corresponding type of hearing impairment. Hearing aids are then classified in a matrix based on characteristics of a corresponding frequency response. An appropriate frequency response of a hearing aid is achieved using analog filters, optionally employing switched capacitor forms.
摘要翻译：听力损失类型被隔离成预定数量的班级。对于每个类别，确定近似的听力损失和相应的固定声学格式，例如，频率响应，被分配以纠正相应类型的听力障碍。然后，助听器基于相应的频率响应的特性被分类为矩阵。使用模拟滤波器，可选地采用开关电容器形式来实现助听器的适当的频率响应。

4. 发明申请

WO2009146075A1 CEREBROSPINAL FLUID EVALUATION SYSTEM HAVING THERMAL FLOW AND FLOW RATE MEASUREMENT PAD USING A PLURALITY OF CONTROL SENSORS 审中-公开
标题翻译：具有多个控制传感器的热流量和流速测量垫的脑脊液评估系统
公开(公告)号：WO2009146075A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/039146
申请日：2009-04-01
申请人： NEURO DIAGNOSTIC DEVICES, INC. , FRITZ, Frederick, J. , SWOBODA, Marek
发明人： FRITZ, Frederick, J. , SWOBODA, Marek
IPC分类号： A61B5/03
CPC分类号： A61M27/006 , A61B5/028
摘要： A method and device for testing for the presence, absence and/or rate of flow in a shunt tubing implanted under the skin by using a measurement pad having a plurality of temperature sensors, one of which is aligned with the shunt and the other sensors being symmetrically displaced on either side of the first temperature sensor in a direction transverse to the shunt tubing. These "outer" temperature sensors act as control temperature sensors. A temperature source, e.g., a cooling agent, positioned within an insulated enclosure, is then applied at a predetermined location on the measurement pad that is insulated from the temperature sensors. The movement of this temperature "pulse" is detected by the shunt-aligned temperature sensor via the shunt tubing as the CSF carries the temperature pulse while the control sensors detect the pulse via convection through the skin. The temperature data from these sensors are provided to a CSF analyzer that determines a CSF shunt flow status or flow rate.
摘要翻译：一种用于通过使用具有多个温度传感器的测量垫来测试在皮肤下植入的分流管中的存在，不存在和/或流速的方法和装置，其中一个温度传感器与分流器对准，其它传感器是在横向于分流管的方向上对称地位于第一温度传感器的两侧。这些“外部”温度传感器用作控制温度传感器。然后将位于绝缘外壳内的温度源（例如，冷却剂）施加在与温度传感器绝缘的测量垫上的预定位置处。该温度“脉冲”的运动由分流对准的温度传感器通过分流管检测，因为CSF携带温度脉冲，而控制传感器通过皮肤对流来检测脉冲。来自这些传感器的温度数据被提供给CSF分析器，其确定CSF分流流状态或流速。

5. 发明申请

WO2009029386A1 NON-INVASIVE INTRACRANIAL PRESSURE SENSOR 审中-公开
标题翻译：非入侵式压力传感器
公开(公告)号：WO2009029386A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/071888
申请日：2008-08-01
申请人： NEURO DIAGNOSTIC DEVICES, INC. , SWOBODA, Marek , HOCHMAN, Matias G. , FRITZ, Frederick J.
发明人： SWOBODA, Marek , HOCHMAN, Matias G. , FRITZ, Frederick J.
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/021 , A61B5/02116 , A61B5/031
摘要： A system and method for non-invasively detecting intracranial pressure (ICP) of a living being by detecting impedance mismatches between carotid arteries and cerebral vessels via a reflection of the carotid pressure waveform using a pressure sensor positioned against the palpable artery, as well as analyzing the reflection and comparing the analysis with known cerebral vasculature data, to calculate ICP non-invasively. A remote blood pressure waveform can also be used to compensate for blood system impedance.
摘要翻译：一种用于通过使用位于可触及动脉位置的压力传感器反映颈动脉压波形来检测颈动脉和脑血管之间的阻抗失配来非活动地检测生物体的颅内压（ICP）的系统和方法，以及分析反映和比较已知脑血管系统数据的分析，非侵入性地计算ICP。远程血压波形也可用于补偿血液系统阻抗。

6. 发明申请

WO2008127867A2 CEREBROSPINAL FLUID EVALUATION SYSTEMS 审中-公开
标题翻译：胚胎液体评估系统（CEREBROSPINAL FLUID EVALUATION SYSTEMS）
公开(公告)号：WO2008127867A2
公开(公告)日：2008-10-23
申请号：PCT/US2008/058882
申请日：2008-03-31
申请人： NEURO DIAGNOSTIC DEVICES, INC. , FRITZ, Frederick, J. , SWOBODA, Marek
发明人： FRITZ, Frederick, J. , SWOBODA, Marek
IPC分类号： A61B5/00 , A61B5/03
CPC分类号： A61B5/01 , A61B5/031 , A61M27/006 , A61M2205/3379
摘要： Methods and devices for testing for the presence, absence or flow rate in a subcutaneous shunt tubing using a measurement pad having a plurality of temperature sensor configurations which are positioned over, or in the vicinity of, the CSF shunt in substantially an upstream/downstream orientation. A temperature source is then applied at a predetermined location with respect to the measurement pad that is insulated from the temperature sensors. This temperature "pulse" movement is detected by the temperature sensors via the shunt tubing as the CSF carries the temperature pulse while a control sensor detects the pulse via skin convection. Temperature sensor data are provided to a CSF analyzer that subtracts control sensor data from the other sensors for determining a CSF shunt flow status/rate. A reader is used to optically or electrically detect the changes in a temperature sensitive material for determining a CSF shunt flow status or flow rate.
摘要翻译：使用具有多个温度传感器配置的测量垫来测试皮下分流管中存在，不存在或流速的方法和装置，所述测量垫位于基本上游/下游取向的CSF旁路或CSF附近。然后将温度源相对于与温度传感器绝缘的测量焊盘在预定位置施加。温度“脉冲”运动由温度传感器通过分流管检测，因为当携带温度脉冲时，控制传感器通过皮肤对流检测脉冲。将温度传感器数据提供给CSF分析仪，其从其他传感器中减去控制传感器数据，以确定CSF分流流量状态/速率。读取器用于光学或电检测温度敏感材料的变化，以确定CSF分流流状态或流速。

7. 发明申请

WO2011150323A2 REAL TIME CSF FLOW MEASUREMENT SYSTEM & METHOD 审中-公开
标题翻译：实时CSF流量测量系统与方法
公开(公告)号：WO2011150323A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038317
申请日：2011-05-27
申请人： NEURODX DEVELOPMENT, LLC , SWOBODA, Marek , HOCHMAN, Matias Gabriel , MATTIUCCI, Mark Evan , FRITZ, Frederick J.
发明人： SWOBODA, Marek , HOCHMAN, Matias Gabriel , MATTIUCCI, Mark Evan , FRITZ, Frederick J.
IPC分类号： A61M5/168 , A61F2/02 , A61B5/01
CPC分类号： A61M27/006 , A61B5/01 , A61B5/031 , A61B5/032 , A61M5/168 , A61M5/16836 , G01F1/684
摘要： A system for measuring quantitative CSF flow in shunt tubing implanted under the skin. The system includes an array of thermo-sensors clustered in three sections, cooling device, placed on the skin surface and an associated data acquisition and analysis device. Two sensor sections are placed over the shunt on the skin and measure real time temperature responses related to CSF movement. One array placed adjacent the cooling device collects data on thermal properties of skin including skin thermal conductivity, specific heat, diffusivity, perfusion, and thermal inertia. The method involves assessing thermal properties of skin and measuring CSF flow in shunt tubing. The method is useful for shunt patency assessment, CSF valve adjustment procedures and CSF flow measurements related to CSF over drainage. Alternatively, only one section of sensors need be used when determining relative CSF flow, without the need to determine thermal skin properties and by applying the cooling device continuously.
摘要翻译：用于测量植入皮下的分流管中定量CSF流量的系统。该系统包括聚集在三个部分的热传感器阵列，放置在皮肤表面上的冷却装置和相关的数据采集和分析装置。将两个传感器部分放置在皮肤上的分流器上，并测量与CSF运动相关的实时温度响应。靠近冷却装置放置的一个阵列收集关于皮肤热性质的数据，包括皮肤热导率，比热，扩散性，灌注和热惯性。该方法包括评估皮肤的热性质并测量分流管中的CSF流量。该方法对于分流通气评估，脑脊液阀调节程序和与流量相关的CSF流量测量有用。或者，当确定相对CSF流量时，仅需要使用一个传感器部分，而不需要确定热皮肤特性并且连续地施加冷却装置。

8. 发明申请

WO2014088886A1 CSF SHUNT FLOW EVALUATION APPARATUS AND METHOD USING A CONFORMABLE EXPANDED DYNAMIC RANGE THERMOSENSOR 审中-公开
标题翻译： CSF SHUNT FLOW EVALUATION设备和使用一个可扩展的动态范围热传感器的方法
公开(公告)号：WO2014088886A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/071928
申请日：2013-11-26
申请人： FRITZ, Frederick, J. , SWOBODA, Marek , MATTIUCCI, Mark, E. , HOCHMAN, Matias, G. , SHUNTCHECK, INC.
发明人： FRITZ, Frederick, J. , SWOBODA, Marek , MATTIUCCI, Mark, E. , HOCHMAN, Matias, G.
IPC分类号： A61B5/03
CPC分类号： A61B5/01 , A61B5/015 , A61B5/031 , A61B5/032 , A61B5/14507 , A61B5/6833 , A61B5/684 , A61B2562/0271 , A61B2562/043 , A61M27/006
摘要： An apparatus and method that utilizes thermal dilution to detect a wide range of flow rates and/or flow status in cerebrospinal fluid (CSF) shunt systems. The use of a large cold source in combination with thermosensor pad of a particular construction provide a fluid flow analyzer with the ability to detect very low levels of CSF flow. In addition, a method for adjusting thermal dilution readings to compensate for varying shunt catheter depth is shown and for determining a steady state of the thermal dilution readings. The thermosensor pad is conformable to a patient's skin contour thereby making the apparatus and method less sensitive to ambient temperature errors and, as a result, more accurate in assessing CSF flow. Furthermore, a software error check is provided for identifying poor sensor-to-skin contact for alerting an operator to re-apply the thermosensor pad to correct, as well as a post-test check to determine if temperature data is reasonable before determining flow status or flow rate.
摘要翻译：利用热稀释来检测脑脊液（CSF）分流系统中的宽范围的流速和/或流动状态的装置和方法。使用大的冷源与特定结构的热传感器垫组合提供了具有检测非常低水平的CSF流量的能力的流体流量分析仪。此外，显示了用于调节热稀释读数以补偿不同分流导管深度的方法，并且用于确定热稀释读数的稳定状态。热传感器垫符合患者的皮肤轮廓，从而使装置和方法对环境温度误差的敏感性降低，结果在评估CSF流动方面更准确。此外，提供软件错误检查以识别差的传感器到皮肤接触，用于警告操作者重新应用热敏传感器垫以进行校正，以及在确定流量状态之前确定温度数据是否合理的测试后检查或流量。

9. 发明申请

WO2011146757A3 CSF SHUNT FLOW ENHANCER, METHOD FOR GENERATING CSF FLOW IN SHUNTS AND ASSESSMENT OF PARTIAL AND COMPLETE OCCLUSION OF CSF SHUNT SYSTEMS 审中-公开
标题翻译： CSF SHUNT FLOW ENHANCER，用于产生脑脊液流动的方法和CSF分流系统部分和完全闭塞的评估
公开(公告)号：WO2011146757A3
公开(公告)日：2012-03-01
申请号：PCT/US2011037218
申请日：2011-05-19
申请人： NEURODX DEV LLC , SWOBODA MAREK , HOCHMAN MATIAS GABRIEL , MATTIUCCI MARK EVAN , FRITZ FREDERICK J
发明人： SWOBODA MAREK , HOCHMAN MATIAS GABRIEL , MATTIUCCI MARK EVAN , FRITZ FREDERICK J
IPC分类号： A61M37/00 , A61B5/00 , A61H39/00 , A61M5/168 , A61M39/22
CPC分类号： A61M27/006 , A61M27/002
摘要： An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.
摘要翻译：能够通过振动分流管，管路或分流阀盖，或者对分流系统的各个部分施加周期性压力，从而在脑脊液（CSF）分流系统中产生流动的装置。还公开了一种产生流动的方法和在分流通气评估中使用该装置的方法，例如水力阻力评估。该装置允许结合热稀释法或放射性核素方法基于CSF分流电阻而不是CSF流量或颅内压（ICP）分别进行快速CSF分流通气评估。与其他方法相比，这提供了更为客观的分流阻塞措施。此外，该装置可以用于增强分路中的流动，在症状发生之前识别部分闭塞，区分专利，部分闭塞和闭塞分流。如果需要降低ICP或移动通过注射室或分流穹顶施用的药物，该装置可用于产生分流中的流动。

10. 发明申请

WO2011146757A2 CSF SHUNT FLOW ENHANCER, METHOD FOR GENERATING CSF FLOW IN SHUNTS AND ASSESSMENT OF PARTIAL AND COMPLETE OCCLUSION OF CSF SHUNT SYSTEMS 审中-公开
标题翻译： CSF SHUNT FLOW ENHANCER，用于产生脑脊液流动的方法和CSF分流系统部分和完全闭塞的评估
公开(公告)号：WO2011146757A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037218
申请日：2011-05-19
申请人： NEURODX DEVELOPMENT, LLC , SWOBODA, Marek , HOCHMAN, Matias Gabriel , MATTIUCCI, Mark Evan , FRITZ, Frederick J.
发明人： SWOBODA, Marek , HOCHMAN, Matias Gabriel , MATTIUCCI, Mark Evan , FRITZ, Frederick J.
CPC分类号： A61M27/006 , A61M27/002
摘要： An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.
摘要翻译：能够通过振动分流管，管路或分流阀盖，或者对分流系统的各个部分施加周期性压力，从而在脑脊液（CSF）分流系统中产生流动的装置。还公开了一种产生流动的方法和在分流通气评估中使用该装置的方法，例如水力阻力评估。该装置允许结合热稀释法或放射性核素方法基于CSF分流电阻而不是CSF流量或颅内压（ICP）分别进行快速CSF分流通气评估。与其他方法相比，这提供了更为客观的分流阻塞措施。此外，该装置可以用于增强分路中的流动，在症状发生之前识别部分闭塞，区分专利，部分闭塞和闭塞分流。如果需要降低ICP或移动通过注射室或分流穹顶施用的药物，该装置可用于产生分流中的流动。

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