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1. 发明申请

WO2019027830A1 DEPLOYING A LINER IN A WELLBORE 审中-公开
公开(公告)号：WO2019027830A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/044095
申请日：2018-07-27
申请人： SAUDI ARABIAN OIL COMPANY , ARAMCO SERVICES COMPANY , FRASER, Scott
发明人： FRASER, Scott , AFFLECK, Michael , MOELLENDICK, Timothy, E.
IPC分类号： E21B43/10 , E21B33/138 , E21B21/00
摘要： A downhole liner delivery tool includes a housing configured to couple to a tubular work string. The housing includes an interior volume. The tool also includes a liner store enclosed within the interior volume. The liner store is configured to enclose at least a portion of a wellbore liner that includes a flexible membrane. The flexible membrane includes an imbedded epoxy. The tool also includes a hydraulic circulation system arranged in at least a portion of the interior volume and configured to circulate a fluid to expand the wellbore liner from the liner store to an exterior of the housing to contactingly engage a wellbore wall.

2. 发明申请

WO2012170722A2 ENHANCED OPTICAL ANGIOGRAPHY USING INTENSITY CONTRAST AND PHASE CONTRAST IMAGING METHODS 审中-公开
标题翻译：使用强度对比和相位对比成像方法增强光学摄影
公开(公告)号：WO2012170722A2
公开(公告)日：2012-12-13
申请号：PCT/US2012041403
申请日：2012-06-07
申请人： CALIFORNIA INST OF TECHN , MOTAGHIANNEZAM S M REZA , FRASER SCOTT E
发明人： MOTAGHIANNEZAM S M REZA , FRASER SCOTT E
IPC分类号： G01N21/17 , A61B1/00
CPC分类号： G01B9/02091 , A61B3/0025 , A61B3/102 , A61B5/0066 , A61B5/1128 , A61B5/4836 , A61B5/489 , A61B2576/00 , G01N21/4795
摘要： The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon intensity. The methods of the invention use logarithm operation to convert the multiplicative amplitude or intensity fluctuations (speckle) into the additive variations and recovers the motion contrasts by removing the speckle free signals (static regions) through statistical analysis.
摘要翻译：本文描述的方法是基于强度来确定光学相干断层摄影数据内的运动对比度的方法。本发明的方法使用对数运算来将乘法幅度或强度波动（斑点）转换成加法变化，并通过统计分析去除无斑点信号（静态区域）来恢复运动对比度。

3. 发明申请

WO2011008986A3 A METHOD APPLYING HEMODYNAMIC FORCING AND KLF2 TO INITIATE THE GROWTH AND DEVELOPMENT OF CARDIAC VALVES 审中-公开
标题翻译：应用血流动力学和KLF2技术促进心脏瓣膜生长发育的方法
公开(公告)号：WO2011008986A3
公开(公告)日：2011-06-16
申请号：PCT/US2010042176
申请日：2010-07-15
申请人： CALIFORNIA INST OF TECHN , GHARIB MORTEZA , RINDERKNECHT DEREK , FOROUHAR ARIAN , VERMOT JULIEN , FRASER SCOTT E
发明人： GHARIB MORTEZA , RINDERKNECHT DEREK , FOROUHAR ARIAN , VERMOT JULIEN , FRASER SCOTT E
IPC分类号： C12N5/071 , A61F2/06 , A61F2/24 , C12M3/00 , C12N5/02
CPC分类号： A61L27/3625 , A61F2/2415 , A61L27/3834 , A61L27/507 , A61L2430/20 , C12M21/08 , C12M25/14 , C12M29/12 , C12M35/04 , C12N5/0657 , C12N2501/15 , C12N2501/165 , C12N2521/00
摘要： A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component. The cell population can include stem cells or differentiated cells, or combinations of both. In particular embodiments, a cardiovascular valve is formed. Scaffolds for the support and growth of the cell population, and bioreactors including the scaffolds, are also provided.
摘要翻译：提供了一种在培养物中形成心血管结构的方法。该方法包括对培养中的细胞群体施加机械力以形成心血管结构。在一些实施例中，通过具有逆行部件的脉动液体流在培养基中产生机械力。细胞群可以包括干细胞或分化的细胞，或两者的组合。在特定实施例中，形成心血管瓣膜。还提供了用于支持和生长细胞群的支架以及包括支架的生物反应器。

4. 发明申请

WO2011008986A2 A METHOD APPLYING HEMODYNAMIC FORCING AND KLF2 TO INITIATE THE GROWTH AND DEVELOPMENT OF CARDIAC VALVES 审中-公开
标题翻译：应用血液动力学和KLF2的方法来启动心脏瓣膜的生长和发育
公开(公告)号：WO2011008986A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/042176
申请日：2010-07-15
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
发明人： GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
IPC分类号： C12N5/071 , C12N5/02 , A61F2/06 , A61F2/24 , C12M3/00
CPC分类号： A61L27/3625 , A61F2/2415 , A61L27/3834 , A61L27/507 , A61L2430/20 , C12M21/08 , C12M25/14 , C12M29/12 , C12M35/04 , C12N5/0657 , C12N2501/15 , C12N2501/165 , C12N2521/00
摘要： A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component. The cell population can include stem cells or differentiated cells, or combinations of both. In particular embodiments, a cardiovascular valve is formed. Scaffolds for the support and growth of the cell population, and bioreactors including the scaffolds, are also provided.
摘要翻译：提供了一种在培养中形成心血管结构的方法。该方法包括对培养物中的细胞群体施加机械力，从而形成心血管结构。在一些实施方案中，通过具有逆行组分的脉动液体流在培养基中产生机械力。细胞群可包括干细胞或分化细胞，或两者的组合。在特定实施例中，形成心血管瓣膜。还提供了用于支持和生长细胞群体的支架，以及包括支架的生物反应器。

5. 发明申请

WO2005110397A1 TREATMENT OF MYOPIA 审中-公开
标题翻译：治疗MYOPIA
公开(公告)号：WO2005110397A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/016072
申请日：2005-05-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE CALIFORNIA INSTITUTE OF TECHNOLOGY , SCHWARTZ, Daniel, M. , YU, Chang, Jun , GRUBBS, Robert, H. , KORNFIELD, Julia, A. , FRASER, Scott, E. , MATTSON, Matthew, S.
发明人： SCHWARTZ, Daniel, M. , YU, Chang, Jun , GRUBBS, Robert, H. , KORNFIELD, Julia, A. , FRASER, Scott, E. , MATTSON, Matthew, S.
IPC分类号： A61K31/295
CPC分类号： A61K31/135 , A61K31/295 , A61K31/325 , A61K31/37 , A61K31/382 , A61K31/47 , A61K31/495 , A61K41/0042 , A61K49/0002
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.
摘要翻译：本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。在具体实施方案中，其涉及治疗和/或预防近视。活化能源用于光聚合或交联巩膜中的分子，从而增加组织的强度。给个体施用交联剂或可光聚合的分子，其与膜相关联，然后将其精确地暴露于能量源，例如光或超声波。

6. 发明申请

WO2003095616A2 DYNAMICS BIONEMS SENSORS AND ARRAYS OF BIONEMS SENSOR IMMERSED IN FLUIDS 审中-公开
标题翻译：动力传感器和液体传感器的传感器阵列
公开(公告)号：WO2003095616A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/014284
申请日：2003-05-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , ROUKES, Michael, L. , FRASER, Scott, E. , SOLOMON, Jerry, E. , CROSS, Michael, C. , ARLETT, Jessica, L.
发明人： ROUKES, Michael, L. , FRASER, Scott, E. , SOLOMON, Jerry, E. , CROSS, Michael, C. , ARLETT, Jessica, L.
IPC分类号： C12N
CPC分类号： G01N33/54373
摘要： A bioNEMS device comprises a piezoresistive cantilever having flexing legs of which attach the cantilever to a support and a biofunctionalized portion at the tip. A bias current applied to the legs is limited by a maximal acceptable temperature increase at the biofunctionalized tip. The length of the cantilever has a magnitude chosen to minimize background Johnson noise. A catalyzed receptor on the device binds to a ligand whose binding rate coefficient is enhanced. The catalyst lowers the receptor-ligand binding activation energy and is designed by forced evolution to preferentially bind with the ligand. A carrier signal is injected by a magnetic film disposed on the cantilever which is electromagnetically coupled to a source of the carrier signal. A plurality of NEMS fluidicly coupled transducers generate a plurality of output signals from which a collective output signal is derived, either by averaging or thresholding. The NEMS devices are disposed in microfluidic flow channels and fabricated in a membrane. A linking molecule is attached to the tip of the transducer and a fluffball attached to the linking molecule to increase damping.
摘要翻译： bioNEMS装置包括压阻悬臂，其具有将悬臂连接到支撑件上的弯曲腿和尖端处的生物功能化部分。施加到腿上的偏置电流受生物功能化尖端的最大可接受的温度升高的限制。悬臂的长度具有选择的最小化背景约翰逊噪声的大小。器件上的催化受体与结合速率系数增强的配体结合。催化剂降低受体 - 配体结合活化能，并通过强制进化来优先与配体结合而设计。载体信号由布置在悬臂上的磁膜注入，该磁膜电磁耦合到载波信号源。多个NEMS流体耦合的换能器产生多个输出信号，通过平均或阈值从该输出信号导出集体输出信号。 NEMS装置设置在微流体流动通道中并制成膜。连接分子连接到换能器的尖端，并且连接到连接分子上的绒毛增加阻尼。

7. 发明申请

WO2002018637A3 DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 审中-公开
公开(公告)号：WO2002018637A3
公开(公告)日：2002-03-07
申请号：PCT/GB2001/003940
申请日：2001-09-03
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED , DJAMGOZ, Mustafa, Bilgin, Ali , FRASER, Scott, Paton , DISS, James, Kenneth, Joseph
发明人： DJAMGOZ, Mustafa, Bilgin, Ali , FRASER, Scott, Paton , DISS, James, Kenneth, Joseph
IPC分类号： C12Q1/68
摘要： A method of diagnosing cancer in a human patient comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of hNeNa voltage-gated Na + channel nucleic acid or protein associated with cancer. A method of treating cancer comprising the step of administering to the patient an agent which selectively prevents the function of hNe-Na voltage-gated Na + channel. A genetic construct comprising a nucleic acid encoding a molecule capable of preventing the function of hNeNa voltage-gated Na + channel expressed in a cell. The methods and compositions are particularly suited to prostate cancer.

8. 发明申请

WO1996038184A3 MAGNETIC RESONANCE IMAGING AGENTS FOR THE DETECTION OF PHYSIOLOGICAL AGENTS 审中-公开
公开(公告)号：WO1996038184A3
公开(公告)日：1996-12-05
申请号：PCT/US1996008548
申请日：1996-06-03
申请人： RESEARCH CORPORATION TECHNOLOGIES, INC. , MEADE, Thomas , FRASER, Scott , JACOBS, Russell
发明人： RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC分类号： A61K49/00

9. 发明申请

WO9611712A3 CELL-SPECIFIC GENE DELIVERY VEHICLES CELL-SPECIFIC GENE DELIVERY VEHICLES 审中-公开
标题翻译：细胞特异性基因输送车辆细胞特异性基因交付车辆
公开(公告)号：WO9611712A3
公开(公告)日：1996-11-14
申请号：PCT/US9514621
申请日：1995-10-11
申请人： CALIFORNIA INST OF TECHN , KAYYEM JON F , MEADE THOMAS J , FRASER SCOTT E
发明人： KAYYEM JON F , MEADE THOMAS J , FRASER SCOTT E
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/08 , A61K51/00 , A61P35/00
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

10. 发明申请

WO2012170722A3 ENHANCED OPTICAL ANGIOGRAPHY USING INTENSITY CONTRAST AND PHASE CONTRAST IMAGING METHODS 审中-公开
公开(公告)号：WO2012170722A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/041403
申请日：2012-06-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , MOTAGHIANNEZAM, S.M. Reza , FRASER, Scott E.
发明人： MOTAGHIANNEZAM, S.M. Reza , FRASER, Scott E.
IPC分类号： G01N21/17 , A61B1/00
摘要： The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon intensity. The methods of the invention use logarithm operation to convert the multiplicative amplitude or intensity fluctuations (speckle) into the additive variations and recovers the motion contrasts by removing the speckle free signals (static regions) through statistical analysis.

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