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1. 发明申请

WO2016205745A3 CELL SORTING 审中-公开
公开(公告)号：WO2016205745A3
公开(公告)日：2016-12-22
申请号：PCT/US2016/038234
申请日：2016-06-17
申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KONERMANN, Silvana , FELDMAN, David , ZHANG, Feng , BLAINEY, Paul
发明人： KONERMANN, Silvana , FELDMAN, David , ZHANG, Feng , BLAINEY, Paul
IPC分类号： C12N15/10
摘要： The invention provides for use of CRISPR-Cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous population by targeting a barcode of interest specific for a cell or cell progeny or nucleic acid molecule of interest.

2. 发明申请

WO2010051529A2 ORTHOPEDIC CAST REMOVER 审中-公开
标题翻译：正反切除
公开(公告)号：WO2010051529A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/062954
申请日：2009-11-02
申请人： FELDMAN, David , BERK, David , BAKER, Russell
发明人： BAKER, Russell
IPC分类号： A61F15/02 , B27B19/00
CPC分类号： B26D1/14 , A61F15/02 , B26D7/20 , B26D2001/0066 , Y10T29/49826
摘要： Systems, apparatuses and methods are disclosed for an orthopedic cast remover. The cast remover includes a rotatable cutting assembly having first and second cutting wheel sandwiched between a smaller-sized hub, where the space between the first and second wheel defines a passage in which fractured material may pass. A shear is coupled to the cutting assembly and is positioned in the passage, where edges of the shear are configured to engage with each of the cutting wheels. During operation, rigid material, such as a cast shell, passes along a top surface of the shear and is fractured into a predetermined width at a point where the shear edges engage with the rotating cutting wheels. The fractured material is fed into the passage for easy removal.
摘要翻译：公开了用于整形外科去除剂的系统，装置和方法。脱模器包括可旋转切割组件，其具有夹在较小尺寸轮毂之间的第一和第二切割轮，其中第一和第二轮之间的空间限定了断裂材料可以通过的通道。剪切件联接到切割组件并且定位在通道中，其中剪切的边缘被配置为与每个切割轮接合。在操作过程中，诸如铸造外壳之类的刚性材料沿剪切面的上表面通过并且在剪切边缘与转动的切割轮啮合的点处被破裂成预定的宽度。将断裂的材料送入通道以便于除去。

3. 发明申请

WO1993024516A1 COMPOSITIONS AND METHODS FOR DETECTION OF HORMONE-BINDING PROTEINS 审中-公开
标题翻译：用于检测激素结合蛋白的组合物和方法
公开(公告)号：WO1993024516A1
公开(公告)日：1993-12-09
申请号：PCT/US1993005047
申请日：1993-05-27
申请人： BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ... , FELDMAN, David , MALLOY, Peter, J.
发明人： BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ...
IPC分类号： C07H21/04
CPC分类号： C12Q1/6895 , C07K14/395 , C07K14/40 , C12Q2600/158
摘要： Hormone-binding proteins and methods for detecting organisms by virtue of their hormone-binding proteins. Amplifying and detecting nucleic acid sequences encoding hormone-binding proteins.
摘要翻译：激素结合蛋白和通过其激素结合蛋白检测生物体的方法。扩增和检测编码激素结合蛋白的核酸序列。

4. 发明申请

WO2017035347A1 SCREENING OF NUCLEIC ACID SEQUENCE VARIATIONS VIA RANDOM LOADING OF OPTICALLY-ENCODED PARTICLES 审中-公开
标题翻译：通过光学加工颗粒的随机加载来筛选核酸序列变异
公开(公告)号：WO2017035347A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/048687
申请日：2016-08-25
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FELDMAN, David , SAZER, Daniel , BLAINEY, Paul
发明人： FELDMAN, David , SAZER, Daniel , BLAINEY, Paul
IPC分类号： C12P19/34 , C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6844 , B01L3/502761 , G01N21/253 , G01N21/6452 , G01N21/65 , C12Q2563/155 , C12Q2563/159 , C12Q2565/514
摘要： Embodiments disclosed herein provide reagents and methods for high-throughput screening of nucleic acid sequence variations in nucleic acid containing specimens. Nucleic acid specimens to be screened are loaded into separate discrete volumes. Optically encoded particles are used to deliver primers to amplify one or more sequences comprising the nucleic acid sequence variation. The optically encoded particles may be delivered to the discrete volumes randomly resulting in a random combination of optically encoded particles in each well, or a unique combination of optically encoded particles may be specifically assigned to each discrete volume. The observable combination of optically encoded particles may then be used to identify each discrete volume.
摘要翻译：本文公开的实施方案提供了用于高通量筛选含核酸标本中核酸序列变异的试剂和方法。要筛选的核酸标本被加载到单独的离散体积中。光学编码的颗粒用于递送引物以扩增包含核酸序列变异的一个或多个序列。光学编码的颗粒可以随机地输送到离散的体积，导致每个孔中光学编码的颗粒的随机组合，或者光学编码的颗粒的独特组合可以具体地分配给每个离散的体积。然后可以使用光学编码的颗粒的可观察组合来识别每个离散体积。

5. 发明申请

WO2016205745A2 CELL SORTING 审中-公开
标题翻译：细胞分选
公开(公告)号：WO2016205745A2
公开(公告)日：2016-12-22
申请号：PCT/US2016/038234
申请日：2016-06-17
申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KONERMANN, Silvana , FELDMAN, David , ZHANG, Feng , BLAINEY, Paul
发明人： KONERMANN, Silvana , FELDMAN, David , ZHANG, Feng , BLAINEY, Paul
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C12N7/00 , C12N9/22 , C12N9/96 , C12N15/1082 , C12N15/11 , C12N15/907 , C12N2310/20 , C12N2310/531 , C12N2740/15043 , C12N2750/14143 , C12Q2563/179
摘要： The invention provides for use of CRISPR-Cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous population by targeting a barcode of interest specific for a cell or cell progeny or nucleic acid molecule of interest.
摘要翻译：本发明提供使用CRISPR-Cas系统对条形码的细胞或分子进行分类。可以通过靶向感兴趣的细胞或细胞后代或核酸分子特异性感兴趣的条形码，从异源群体分选细胞或核酸分子。

6. 发明申请

WO2005115708A1 APPARATUS FOR CAMPACTING DRINK CONTAINERS 审中-公开
标题翻译：饮用饮料容器的装置
公开(公告)号：WO2005115708A1
公开(公告)日：2005-12-08
申请号：PCT/IL2004/001086
申请日：2004-11-25
申请人： FRIENDLY COMPACTOR LTD. , FELDMAN, David
发明人： FELDMAN, David
IPC分类号： B29B17/00
CPC分类号： B29B17/0052 , B29L2031/7158 , Y02W30/62
摘要： A handheld electrical suction device (10) encased by a casing for pumping air from an air outlet to an air inlet, comprising: an electrically powered air pump (14) within the casing: a nozzle (20) attached to the air inlet for engaging the mouth of a collapsible drink container (22) and an ON/OFF switch (24) for controlling supply of power from a power supply to the electrically powered pump, wherein the ON/OFF switch is positioned such that an operator holding the device and a disposable drinks container against the nozzle thereof, can comfortably operate the ON/OFF switch.
摘要翻译：一种手持式电气抽吸装置（10），其由用于将空气从空气出口泵送到空气入口的壳体封装，包括：壳体内的电动空气泵（14）;附接到进气口的喷嘴（20），用于接合可折叠饮料容器（22）和用于控制从电源向电动泵供电的ON / OFF开关（24）的口，其中ON / OFF开关定位成使得操作者保持装置和一次性饮料容器抵靠其喷嘴，可以舒适地操作ON / OFF开关。

7. 发明申请

WO2003097098A1 PHARMACEUTICAL COMPOSITION COMPRISING A RENIN INHIBITOR, A CALCIUM CHANNEL BLOCKER AND A DIURETIC 审中-公开
标题翻译：包含RININ抑制剂，钙通道阻滞剂和DIY的药物组合物
公开(公告)号：WO2003097098A1
公开(公告)日：2003-11-27
申请号：PCT/EP2003/005188
申请日：2003-05-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , FELDMAN, David, Louis , WEBB, Randy, Lee
发明人： FELDMAN, David, Louis , WEBB, Randy, Lee
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： The invention relates to a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic and to a method of treatment of a condition or a disease selected from the group consisting of hypertension, heart failure such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non- diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis (including IgA nephropathy), renal fibrosis, scleroderma, glomerular sclerosis, proteinuria of renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), glaucoma and stroke, pulmonary and hepatic fibrosis, fibrotic diseases resulting from accumulation of excess extracellular matrix induced by TGF, and proliferative diseases of smooth muscle cells, including uterine fibroids comprising administering a therapeutically effective amount of said pharmaceutical composition to a mammal in need of such treatment.
摘要翻译：本发明涉及药物组合物，其包含（i）肾素抑制剂，（ii）钙通道阻断剂（CCB），和（iii）利尿剂和治疗选自以下的疾病或疾病的方法：高血压，心力衰竭（急性和慢性）充血性心力衰竭，左心室功能障碍和肥大性心肌病，糖尿病性心肌病，室上性心室性心律失常，心房颤动，心房扑动，有害血管重塑，心肌梗塞及其后遗症，动脉粥样硬化，心绞痛（不稳定或稳定），肾功能不全（糖尿病和非糖尿病），心力衰竭，心绞痛，糖尿病，继发性醛固酮增多症，原发性和继发性肺动脉高压，肾衰竭病症如糖尿病性肾病，肾小球肾炎（包括IgA肾病）肾纤维化，硬皮病，肾小球硬化，肾脏疾病的蛋白尿，以及肾血管超声紧张，糖尿病性视网膜病变，其他血管疾病如偏头痛，外周血管疾病，雷诺氏病，管腔增生，认知功能障碍（如阿尔茨海默氏症），青光眼和中风，肺和肝纤维化的管理，由过量积累引起的纤维化疾病由TGF诱导的细胞外基质和平滑肌细胞的增殖性疾病，包括子宫肌瘤，包括向需要这种治疗的哺乳动物施用治疗有效量的所述药物组合物。

8. 发明申请

WO2012066535A1 STABLE AQUEOUS SUSPENSIONS OF DBNPA, THEIR PREPARATION AND USES THEREOF AS BIOCIDES 审中-公开
标题翻译：稳定的DBNPA悬浮液，其制备及其作为生物体的用途
公开(公告)号：WO2012066535A1
公开(公告)日：2012-05-24
申请号：PCT/IL2011/000877
申请日：2011-11-15
申请人： BROMINE COMPOUNDS LTD. , SHAPIRO, Evgeny , FELDMAN, David , KHODAKOVSKAYA, Rimma
发明人： SHAPIRO, Evgeny , FELDMAN, David , KHODAKOVSKAYA, Rimma
IPC分类号： A01N37/44 , A01N25/04 , A01P1/00
CPC分类号： A01N37/34 , A01N25/04 , A01N2300/00
摘要： The present invention discloses novel biocide composition comprising 2,2-dibromo-3-nitrilopropionamide (DBNPA) being in the form of a stable aqueous suspension. Further are disclosed the preparation of these compositions and their biocidal uses.
摘要翻译：本发明公开了包含2,2-二溴-3-次氮基丙酰胺（DBNPA）的稳定水性悬浮液形式的新型杀生物剂组合物。还公开了这些组合物及其杀生物剂用途的制备。

9. 发明申请

WO2010051529A3 ORTHOPEDIC CAST REMOVER 审中-公开
公开(公告)号：WO2010051529A3
公开(公告)日：2010-09-02
申请号：PCT/US2009062954
申请日：2009-11-02
申请人： FELDMAN DAVID , BERK DAVID , BAKER RUSSELL
发明人： BAKER RUSSELL
IPC分类号： A61F15/02 , B27B19/00
CPC分类号： B26D1/14 , A61F15/02 , B26D7/20 , B26D2001/0066 , Y10T29/49826
摘要： Systems, apparatuses and methods are disclosed for an orthopedic cast remover. The cast remover includes a rotatable cutting assembly having first and second cutting wheel sandwiched between a smaller-sized hub, where the space between the first and second wheel defines a passage in which fractured material may pass. A shear is coupled to the cutting assembly and is positioned in the passage, where edges of the shear are configured to engage with each of the cutting wheels. During operation, rigid material, such as a cast shell, passes along a top surface of the shear and is fractured into a predetermined width at a point where the shear edges engage with the rotating cutting wheels. The fractured material is fed into the passage for easy removal.
摘要翻译：系统，设备和方法被公开用于整形外科去除剂。铸造去除器包括可旋转的切割组件，该切割组件具有夹在较小尺寸轮毂之间的第一和第二切割轮，其中第一和第二轮之间的空间限定了通道，在该通道中可以使裂缝材料通过。剪切机连接到切割组件并且定位在通道中，其中剪切机的边缘被构造成与每个切割轮接合。在操作期间，诸如铸造壳体之类的刚性材料沿着剪切机的顶表面通过，并且在剪切边缘与旋转切割轮啮合的点处破碎成预定宽度。破碎的材料被送入通道以便于移除。

10. 发明申请

WO2006041974A1 USE OF RENIN INHIBITORS FOR THE PREVENTION OR TREATMENT OF DIASTOLIC DYSFUNCTION OR DIASTOLIC HEART FAILURE 审中-公开
标题翻译：使用RENIN抑制剂预防或治疗双歧杆菌性功能障碍或DIASTOLIC心脏衰竭
公开(公告)号：WO2006041974A1
公开(公告)日：2006-04-20
申请号：PCT/US2005/035914
申请日：2005-10-06
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , FELDMAN, David, Louis , LUFT, Friedrich, Cameron , MUELLER, Dominik, Nicolas , WEBB, Randy, Lee
发明人： FELDMAN, David, Louis , LUFT, Friedrich, Cameron , MUELLER, Dominik, Nicolas , WEBB, Randy, Lee
IPC分类号： A61K31/00 , A61K31/165 , A61K31/451 , A61K31/55 , A61K31/401 , A61K31/41 , A61P9/00
CPC分类号： A61K31/165 , A61K31/00 , A61K31/409 , A61K31/451
摘要： The present invention provides the use of a therapeutically effective amount of a renin inhibitor, or pharmaceutically acceptable salt thereof, alone or in combination with (i) an ACE inhibitor or a pharmaceutically acceptable salt thereof; or (II) an angiotensin II receptor blocker or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention of, delay progression to overt to, or the treatment of diastolic dysfunction or diastolic heart failure in a warm-blooded animal.
摘要翻译：本发明提供治疗有效量的肾素抑制剂或其药学上可接受的盐单独或与（i）ACE抑制剂或其药学上可接受的盐的组合的用途; 或（II）血管紧张素II受体阻断剂或其药学上可接受的盐，用于制备用于在温血动物中预防，延缓进展到或治疗舒张功能障碍或舒张性心力衰竭的药物。

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