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1. 发明申请

WO2008067025A2 ONCOLYTIC ADENOVIRUSES AND USES THEREOF 审中-公开
标题翻译：炎症性腺病毒及其用途
公开(公告)号：WO2008067025A2
公开(公告)日：2008-06-05
申请号：PCT/US2007080098
申请日：2007-10-01
申请人： EVANSTON NORTHWESTERN HEALTHCA , SETH PREM
发明人： SETH PREM
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： A61K35/76 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K35/761 , A61K38/179 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： The disclosed subject matter provides methods and materials relating to viral vectors, such as adenoviral vectors, that effectively target cancer cells and that express a protein that specifically binds to Transforming Growth Factor-ß.
摘要翻译：所公开的主题提供了有效靶向癌细胞并表达与转化生长因子-β特异性结合的蛋白质的病毒载体如腺病毒载体相关的方法和材料。

2. 发明申请

WO2007136880A2 METHOD & APPARATUS FOR RECOGNIZING ABNORMAL TISSUE USING THE DETECTION OF EARLY INCREASE IN MICROVASCULAR BLOOD CONTENT 审中-公开
标题翻译：使用微血管内容物检测早期检测来识别异常组织的方法和装置
公开(公告)号：WO2007136880A2
公开(公告)日：2007-11-29
申请号：PCT/US2007012359
申请日：2007-05-21
申请人： EVANSTON NORTHWESTERN HEALTHCA , UNIV NORTHWESTERN
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B1/00096 , A61B1/00167 , A61B1/31 , A61B5/0084 , A61B5/027
摘要： The present invention, in one aspect, relates to a method of and apparatus for examining a target for tumors or lesions using what is referred to as "Early Increase in microvascular Blood Supply" (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnofmal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.
摘要翻译：本发明在一个方面涉及使用所谓的“微血管供血的早期增加”（EIBS）检测肿瘤或病变的靶标的方法和装置，其存在于接近但是在组织中的组织中不是本身，异常组织和在这种损伤或肿瘤的发展之前的组织。虽然异常组织可以是病变或肿瘤，但是异常组织也可以是在形成病变或肿瘤之前的组织，例如癌前腺瘤，异常隐窝灶，在发育不良病变发展之前的组织，其本身还没有表现出发育不良的表型，以及这些损伤或发育不良前组织附近的组织。

3. 发明申请

WO03034901A2 SCOUTLESS WHOLE-BODY IMAGING WITH FAST POSITIONING 审中-公开
标题翻译：快速定位全身全身成像
公开(公告)号：WO03034901A2
公开(公告)日：2003-05-01
申请号：PCT/US0233720
申请日：2002-10-22
申请人： EVANSTON NORTHWESTERN HEALTHCA
发明人： EDELMAN ROBERT R
IPC分类号： A61B20060101 , A61B5/055 , G01R33/563 , A61B
CPC分类号： G01R33/56375
摘要： A method and apparatus are provided for forming a magnetic resonance angiographic image of a human body. The method includes the steps of applying a plurality of spatially non-selective radio-frequency pulses to the body, varying a magnitude of a phase-encoded gradient through the body in conjunction with application of the plurality of spatially non-selective radio-frequency pulses and detecting magnetic resonance imaging data from the body based upon the spatially non-selective radio-frequency pulses and varied phase-encoded gradient.
摘要翻译：提供了一种用于形成人体的磁共振血管造影图像的方法和装置。该方法包括以下步骤：将多个空间非选择性射频脉冲施加到身体，结合应用多个空间非选择性射频脉冲改变通过身体的相位编码梯度的大小以及基于空间非选择性射频脉冲和改变的相位编码梯度来检测来自身体的磁共振成像数据。

4. 发明申请

WO2008019160A2 METHOD FOR IDENTIFYING REFRACTIVE-INDEX FLUCTUATIONS OF A TARGET 审中-公开
公开(公告)号：WO2008019160A2
公开(公告)日：2008-02-14
申请号：PCT/US2007017894
申请日：2007-08-13
申请人： UNIV NORTHWESTERN , EVANSTON NORTHWESTERN HEALTHCA , BACKMAN VADIM , LIU YANG , KIM YOUNG , ROY HEMANT , GOLDBERG MICHAEL , BRAND RANDALL , PRADHAN PRABHAKAR , SUBRAMANIAN HARIHARAN
发明人： BACKMAN VADIM , LIU YANG , KIM YOUNG , ROY HEMANT , GOLDBERG MICHAEL , BRAND RANDALL , PRADHAN PRABHAKAR , SUBRAMANIAN HARIHARAN
IPC分类号： G01J1/42
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations.

5. 发明申请

WO2007133684A8 SYSTEMS, METHODS, AND APPARATUSES OF LOW-COHERENCE ENHANCED BACKSCATTERING SPECTROSCOPY 审中-公开
标题翻译：低相关增强背散射光谱的系统，方法和装置
公开(公告)号：WO2007133684A8
公开(公告)日：2009-07-09
申请号：PCT/US2007011404
申请日：2007-05-11
申请人： UNIV NORTHWESTERN , EVANSTON NORTHWESTERN HEALTHCA , BACKMAN VADIM , ROY HERMANT , KIM YOUNG , LIU YANG , TURZHITZKY VLADIMIR , ROGERS JEREMY
发明人： BACKMAN VADIM , ROY HERMANT , KIM YOUNG , LIU YANG , TURZHITZKY VLADIMIR , ROGERS JEREMY
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/31 , G01N21/47 , G01N2021/4709
摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.
摘要翻译：本申请中描述了低相干增强后向散射光谱的系统，方法和装置。一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角是入射光传播方向和反向散射光传播方向之间的角度。分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。

6. 发明申请

WO2007133684A3 SYSTEMS, METHODS, AND APPARATUSES OF LOW-COHERENCE ENHANCED BACKSCATTERING SPECTROSCOPY 审中-公开
标题翻译：低相关增强背散射光谱的系统，方法和装置
公开(公告)号：WO2007133684A3
公开(公告)日：2008-11-06
申请号：PCT/US2007011404
申请日：2007-05-11
申请人： UNIV NORTHWESTERN , EVANSTON NORTHWESTERN HEALTHCA , BACKMAN VADIM , ROY HERMANT , KIM YOUNG , LIU YANG , TURZHITZKY VLADIMIR , ROGERS JEREMY
发明人： BACKMAN VADIM , ROY HERMANT , KIM YOUNG , LIU YANG , TURZHITZKY VLADIMIR , ROGERS JEREMY
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/31 , G01N21/47 , G01N2021/4709
摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.
摘要翻译：本申请中描述了低相干增强后向散射光谱的系统，方法和装置。一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角是入射光传播方向和反向散射光传播方向之间的角度。分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。

7. 发明申请

WO2008019160A9 METHOD FOR IDENTIFYING REFRACTIVE-INDEX FLUCTUATIONS OF A TARGET 审中-公开
标题翻译：识别目标的折射率指数波动的方法
公开(公告)号：WO2008019160A9
公开(公告)日：2008-09-25
申请号：PCT/US2007017894
申请日：2007-08-13
申请人： UNIV NORTHWESTERN , EVANSTON NORTHWESTERN HEALTHCA , BACKMAN VADIM , LIU YANG , KIM YOUNG , ROY HEMANT , GOLDBERG MICHAEL , BRAND RANDALL , PRADHAN PRABHAKAR , SUBRAMANIAN HARIHARAN
发明人： BACKMAN VADIM , LIU YANG , KIM YOUNG , ROY HEMANT , GOLDBERG MICHAEL , BRAND RANDALL , PRADHAN PRABHAKAR , SUBRAMANIAN HARIHARAN
IPC分类号： G01J3/42
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动进一步包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动进一步包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

8. 发明申请

WO2007044761A2 SURGICAL INSTRUMENT AND METHOD FOR TISSUE RESECTION AND DISSECTION 审中-公开
标题翻译：外科手术和组织分离和分离方法
公开(公告)号：WO2007044761A2
公开(公告)日：2007-04-19
申请号：PCT/US2006039634
申请日：2006-10-10
申请人： EVANSTON NORTHWESTERN HEALTHCA , JOHNSTON WILLIAM K
发明人： JOHNSTON WILLIAM K
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B18/22 , A61B2018/1435
摘要： A surgical instrument has an elongate shaft with a longitudinal shaft axis, a proximal grip end, and a distal working end. The shaft is rotatable about its longitudinal axis by user manipulation of the proximal grip end. The instrument has an energy source coupled to the surgical instrument. A tissue retainer is positioned at the distal working end of the shaft and is rotatable with the shaft. The retainer has a curved portion, a tissue holding space within the curved portion, and an entry opening into the holding space. The retainer and holding space define a retainer axis. The retainer is configured to be received over and at least partly circumvent a target structure of a surgical field received in the holding space via the entry opening. A surgical component is positioned on a portion of the retainer laterally offset from both the retainer axis and the holding space and is rotatable with rotation of the shaft and retainer. The surgical component is selectively energizeable by the energy source to dissect selected tissue contacting the surgical component.
摘要翻译：手术器械具有长轴的细长轴，近侧握柄端和远端工作端。轴可以通过用户操纵近端握持端而围绕其纵向轴线旋转。仪器具有耦合到外科器械的能量源。组织保持器定位在轴的远端工作端，并可与轴一起旋转。保持器具有弯曲部分，弯曲部分内的组织保持空间和进入保持空间的入口。保持器和保持空间限定保持器轴。保持器构造成经由入口开口接收并且至少部分地绕过容纳在容纳空间中的手术区域的目标结构。手术部件定位在保持器轴线和保持空间两侧横向偏移的保持器的一部分上，并且可随着轴和保持器的旋转而旋转。外科组件可选择性地通过能量源激励以解剖与外科组件接触的所选择的组织。

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