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1. 发明申请

WO2019038155A1 CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS 审中-公开
公开(公告)号：WO2019038155A1
公开(公告)日：2019-02-28
申请号：PCT/EP2018/072127
申请日：2018-08-15
申请人： EPIGEM LIMITED , UNIVERSITY OF ZURICH
发明人： RYAN, Timothy, George , MAKHRO, Asya
IPC分类号： G01N15/02 , G01N15/14 , G01N33/49 , G01N15/00 , G01N15/10
摘要： A method of measuring the morphological profile of a sample of red blood cells including measuring the projected area distribution of the cells and identifying characteristic peak areas from the distribution. The spectrum of peak areas may be compared with those from known blood disorders, and provides a classification, screening and diagnostic methods for a range of blood disorders, especially anaemias. Apparatus for carrying out the methods is also provided, which in some embodiments includes the use of microfluidic devices.

2. 发明申请

WO2018104752A1 A METHOD FOR FORMING MICROSTRUCTURES 审中-公开
公开(公告)号：WO2018104752A1
公开(公告)日：2018-06-14
申请号：PCT/GB2017/053704
申请日：2017-12-11
申请人： EPIGEM LIMITED
发明人： TRAYNOR, Richard , RYAN, Tim, George
IPC分类号： C25D1/00 , C25D1/08 , C25D1/20 , C25D3/12
摘要： A method for producing a microstructure is disclosed. A master is provided having a pattern formed of conductive material embedded in a non-conducting substrate. The master has a master surface having a conducting portion defined by the pattern and a non-conducting portion defined by the non-conducting substrate. A surface treatment is applied to the master surface to alter the adhesion properties of at least one of the conducting portion or the non-conducting portion. The microstructure is formed by deposition or plating of a functionalising material onto the master surface, and the microstructure is then separated from the master. The master can be reused.

3. 发明申请

WO2004022233A1 MODULAR MICROFLUIDIC SYSTEM 审中-公开
标题翻译：模块化微流体系统
公开(公告)号：WO2004022233A1
公开(公告)日：2004-03-18
申请号：PCT/GB2003/003853
申请日：2003-09-05
申请人： EPIGEM LIMITED , SUMMERSGILL, Philip , RYAN, Timothy, George , HARVEY, Thomas, Grierson
发明人： SUMMERSGILL, Philip , RYAN, Timothy, George , HARVEY, Thomas, Grierson
IPC分类号： B01L3/00
CPC分类号： B01J19/0093 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F2215/0431 , B01J2219/00783 , B01J2219/0081 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2300/0861 , B01L2300/0887 , Y10T436/25 , Y10T436/2575
摘要： A modular microfluidic system is described having at least one base board with a plurality of fluidly linked fluid supply apertures, optional intermediate level boards of equivalent construction, a plurality of microfluidic modules adapted to be detachably attached to the base board/ intermediate boards, each having one or more fluid inlets and/or outlets, and a plurality of fluid couplings preferably in the form of projecting ferrules to effect releasable fluid connection between a module and a base board/ intermediate level board via a supply aperture on the board and an inlet/outlet on the module. A method of providing a microfluidic system as a modular assembly is also described.
摘要翻译：描述了一种模块化微流体系统，其具有至少一个具有多个流体连通的流体供应孔的基板，具有等效结构的可选中间水平板，适于可拆卸地附接到基板/中间板的多个微流体模块，每个微流体模块具有一个或多个流体入口和/或出口，以及多个流体联接器，优选地以突出的套圈的形式，以经由板上的供应孔和模块与基板/中间水平板之间的可释放的流体连接，模块上的插座。还描述了提供作为模块化组件的微流体系统的方法。

4. 发明申请

WO2003062872A1 METHOD OF MAKING A PATTERNED OPTICAL ELEMENT 审中-公开
标题翻译：制作图案光学元件的方法
公开(公告)号：WO2003062872A1
公开(公告)日：2003-07-31
申请号：PCT/GB2003/000239
申请日：2003-01-20
申请人： EPIGEM LIMITED , RYAN, Timothy, George , HARVEY, Thomas, Grierson
发明人： RYAN, Timothy, George , HARVEY, Thomas, Grierson
IPC分类号： G02B5/30
CPC分类号： G02B5/3016 , Y10T428/10
摘要： A method for the manufacture of patterned optical elements such as retarders or liquid crystal elements for use in optical retarders is described comprising the steps of forming an alignment layer comprising a spatially patterned monograting-like surface relief microstructure formed into a suitable receptive material; laying down a coating material onto the alignment layer which exhibits an alignable LC phase; solidifying the coating material layer to fix the alignment established during the LC phase. Patterned optical elements such as retarders or liquid crystal elements for use in optical retarders are also described.
摘要翻译：描述了用于制造用于光学延迟器的图案化光学元件如延迟器或液晶元件的方法，其包括以下步骤：形成取向层，该取向层包括形成为合适的接收材料的空间图案化单晶状表面浮雕微结构，将涂层材料涂覆到取向层上，其呈现可对准的LC相，固化涂层材料层以固定在LC相期间建立的对准。还描述了用于光学延迟器的图案化的光学元件，例如缓速器或液晶元件。

5. 发明申请

WO9635971A2 MICRO RELIEF ELEMENT AND PREPARATION THEREOF 审中-公开
标题翻译： MICRO RELILE元素及其准备
公开(公告)号：WO9635971A2
公开(公告)日：1996-11-14
申请号：PCT/GB9601096
申请日：1996-05-08
申请人： EPIGEM LIMITED , SUMMERSGILL PHILIP , HARVEY THOMAS GRIERSON , RYAN TIMOTHY GEORGE , CARTER NEIL
发明人： SUMMERSGILL PHILIP , HARVEY THOMAS GRIERSON , RYAN TIMOTHY GEORGE , CARTER NEIL
IPC分类号： B29C33/42 , B29C37/00 , B29C41/36 , B29D11/00 , B29L11/00 , G02B3/00 , G02B5/18 , G02B6/12 , G02B6/122 , G03H1/00 , G02B5/13 , G02B6/138
CPC分类号： G02B6/1221 , B29C37/0053 , B29C41/36 , B29D11/00 , B29D11/00278 , B29D11/00365 , B33Y70/00 , G02B3/0012 , G02B3/0031 , G02B3/0056 , G02B5/1876 , G02B5/1885 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G03H1/028 , G03H2001/0284 , Y10T428/24612 , Y10T428/24628
摘要： A micro relief element which comprises: a) a first layer of a first substrate, the first layer having a receptive surface capable of retaining a relief forming polymer; b) an overlay of a desired thickness of the relief forming polymer over the receptive surface; and c) at least one relief feature formed from the relief forming polymer and which protrudes above the overlay; structures and elements comprising such micro relief element; micro-optical, micro-fluidic, micro-electrical and micro-chemical applications thereof; and a method and apparatus for the preparation thereof.
摘要翻译：一种微型浮雕元件，其包括：a）第一基底的第一层，所述第一层具有能够保持凸起形成聚合物的接收表面; b）在接收表面上覆盖形成凸版的聚合物的所需厚度; 和c）由凸版形成聚合物形成并且在覆盖层上方突出的至少一个凸出特征; 包括这种微型浮雕元件的结构和元件; 微光学，微流体学，微电学和微观化学应用; 以及其制备方法和装置。

6. 发明申请

WO2018197837A1 MICROFLUIDIC DEVICE AND APPARATUS 审中-公开
公开(公告)号：WO2018197837A1
公开(公告)日：2018-11-01
申请号：PCT/GB2018/050992
申请日：2018-04-16
申请人： EPIGEM LIMITED
发明人： SUMMERSGILL, Philip , ALLEN, Simon , RYAN, Timothy George , KILKAULEY, Niamh Aine
IPC分类号： B01L3/00 , G01N33/50 , G01N15/14 , B01L3/02 , G01N15/00
摘要： A microfluidic test apparatus is disclosed, comprising a microfluidic device having a first reservoir for receiving a first fluid containing a sample of cells, a microfluidic test region, a first microfluidic pathway provided between the microfluidic test region and the first reservoir; and a port for connection to a pump. The apparatus includes a first pump connected to the port and configured to pump a priming fluid into the port, a second pump connected to the port and configured to apply suction at the port when operated and a controller configured to control operation of the first and second pumps, wherein the controller operates the first pump to prime the microfluidic device and operates the second pump to draw a test volume from the first reservoir into the microfluidic test region.

7. 发明申请

WO2011138621A1 COMPOSITE ELECTRODE AND METHOD OF MANUFACTURE THEREOF 审中-公开
标题翻译：复合电极及其制造方法
公开(公告)号：WO2011138621A1
公开(公告)日：2011-11-10
申请号：PCT/GB2011/050888
申请日：2011-05-09
申请人： EPIGEM LIMITED , HARVEY, Thomas , RYAN, Timothy George
发明人： HARVEY, Thomas , RYAN, Timothy George
IPC分类号： H01L51/52 , H01L51/00 , H01K3/10 , H05K3/12
CPC分类号： H05K3/244 , H01L51/0023 , H01L51/003 , H01L51/0097 , H01L51/5212 , H01L2251/5338 , H01L2251/5361 , H05K2201/0108 , Y02E10/549 , Y02P70/521
摘要： The present invention provides a composite electrode and method of manufacturing such a composite electrode, the method comprising the steps of: providing a first substrate layer with an electrically conducting surface; providing a non-conducting curable material; providing a second substrate layer which has a surface relief pattern defining at least one retaining feature corresponding to a desired metal track pattern; forming a line of contact between the conducting carrier layer and at least a part of the surface relief pattern; depositing curable material onto at least part of the surface relief pattern or the electrically conducting surface along the line of contact; advancing the line of contact and curing the curable material through the second substrate layer; releasing the cured material from the surface relief pattern feature so as to leave behind a surface relief pattern on the conducting carrier layer; depositing a first metal layer onto the exposed regions of the electrically conducting surface of the conducting carrier layer and optionally deposition further metal layers on the first metal layer.
摘要翻译：本发明提供一种复合电极及其制造方法，该方法包括以下步骤：提供具有导电表面的第一基底层; 提供不导电的可固化材料; 提供具有限定对应于期望的金属轨道图案的至少一个保持特征的表面浮雕图案的第二基底层; 在所述导电载体层和所述表面浮雕图案的至少一部分之间形成接触线; 将可固化材料沿着所述接触线沉积到所述表面浮雕图案或所述导电表面的至少一部分上; 推进接触线并固化可固化材料通过第二基底层; 从表面浮雕图案特征释放固化材料，以便在导电载体层上留下表面浮雕图案; 将第一金属层沉积到导电载体层的导电表面的暴露区域上，以及任选地在第一金属层上沉积另外的金属层。

8. 发明申请

WO1996035971A3 MICRO RELIEF ELEMENT AND PREPARATION THEREOF 审中-公开
公开(公告)号：WO1996035971A3
公开(公告)日：1996-11-14
申请号：PCT/GB1996001096
申请日：1996-05-08
申请人： EPIGEM LIMITED , SUMMERSGILL, Philip , HARVEY, Thomas, Grierson , RYAN, Timothy, George , CARTER, Neil
发明人： EPIGEM LIMITED
IPC分类号： G02B06/124

9. 发明申请

WO2018162765A1 MICROFLUIDIC DEVICE 审中-公开
公开(公告)号：WO2018162765A1
公开(公告)日：2018-09-13
申请号：PCT/EP2018/056125
申请日：2018-03-12
申请人： EPIGEM LIMITED
发明人： RYAN, Timothy George , SUMMERSGILL, Philip , ALLEN, Simon , BAKER, Andrew
IPC分类号： G01N30/60 , G01N30/88
摘要： A microfluidic device has a cavity in which a functionalised mesh is arranged in a layered configuration to provide a high surface area. The cavity is housed in a body that is easily configured for sample flow to concentrate the analyte, heat release of the analyte from the mesh, and elution of the released analyte. The microfluidic device can be used in a variety of applications by functionalising the mesh with a suitable affinity media.

10. 发明申请

WO2007066110A1 FINE LINE BONDING AND/OR SEALING SYSTEM AND METHOD 审中-公开
标题翻译：精细线接合和/或密封系统和方法
公开(公告)号：WO2007066110A1
公开(公告)日：2007-06-14
申请号：PCT/GB2006/004569
申请日：2006-12-06
申请人： EPIGEM LIMITED , SUMMERSGILL, Philip , RYAN, Timothy, George
发明人： SUMMERSGILL, Philip , RYAN, Timothy, George
IPC分类号： C09J5/00 , B29C65/54 , B29C39/10 , B01L3/00
CPC分类号： B29C39/10 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B29C65/483 , B29C65/4845 , B29C65/542 , B29C66/1122 , B29C66/126 , B29C66/342 , B29C66/53461 , B29C66/54 , B29C66/71 , B29L2031/756 , Y10T428/31504 , B29K2063/00 , B29K2071/00
摘要： A method of providing a fine line adhesive bond and/ or seal or gasket and/ or lined channel, and in particular a fine line bonding seal, between a first (14) and a second ply (16) , especially of dissimilar materials, comprises the steps of : fabricating a microscale recess in at least a first ply; lidding the first ply with a second ply such that the recess or recesses in the ply or plies form a fluidly continuous channel (12) ,- urging curable material into this channel so as to substantially fill the channel with curable material, and in particular urging the material via an inlet (17) into a fluidly continuous channel until it emerges from an outlet (18) remote therefrom; curing the curable material in situ. A system for implementing the method and the bonded and/or sealed and/ or lined product of such method are also described.
摘要翻译：在第一（14）和第二层（16）之间，特别是不同材料之间提供细线粘合剂粘结和/或密封或垫圈和/或衬里通道，特别是细线粘结密封的方法包括以下步骤：在至少第一层中制造微观凹槽; 用第二层盖住第一层，使得层或层中的凹部或凹槽形成流体连续的通道（12）， - 将可固化材料推入该通道，以便基本上用可固化材料填充通道，特别是促使所述材料经由入口（17）进入流体连续的通道，直到其从远离其的出口（18）出来; 原位固化可固化材料。还描述了用于实现该方法的系统以及这种方法的粘合和/或密封和/或衬里产品。

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