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1. 发明申请

WO2009077356A2 SUNSCREEN COMPOSITIONS COMPRISING COLOUR PIGMENS 审中-公开
标题翻译：包含色素的SUNSCREEN组合物
公开(公告)号：WO2009077356A2
公开(公告)日：2009-06-25
申请号：PCT/EP2008066870
申请日：2008-12-05
申请人： CIBA HOLDING INC , EHLIS THOMAS , SOHN MYRIAM
发明人： EHLIS THOMAS , SOHN MYRIAM
CPC分类号： A61K8/4966 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/418 , A61K8/46 , A61K8/466 , A61K8/494 , A61K8/496 , A61K8/498 , A61K8/4986 , A61K8/987 , A61K2800/43 , A61K2800/621 , A61K2800/651 , A61Q1/02 , A61Q17/04 , A61Q19/08
摘要： Disclosed are cosmetic formulation comprising (a) particulates having an absorption in the range of 400 to 800nm; and (b) UV filters selected from (b1) particulate organic UV-filters; and (b2) soluble organic UV filters.
摘要翻译：公开了化妆品制剂，其包含（a）吸收在400至800nm范围内的颗粒; 和（b）选自（b1）颗粒状有机UV-过滤器的UV过滤器; 和（b2）可溶性有机UV过滤器。

2. 发明申请

WO2011003774A3 UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES 审中-公开
标题翻译：包含苯甲酸二甲酯的UV过滤器组合
公开(公告)号：WO2011003774A3
公开(公告)日：2011-04-21
申请号：PCT/EP2010059181
申请日：2010-06-29
申请人： BASF SE , GRUMELARD JULIE , EHLIS THOMAS , HANSCH MARKUS , SOHN MYRIAM
发明人： GRUMELARD JULIE , EHLIS THOMAS , HANSCH MARKUS , SOHN MYRIAM
IPC分类号： A61K8/29 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/49 , A61K8/58 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/37
摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了UV过滤剂组合的用途，其包含（a）选自式（1）的亚甲基丙二酸酯的第一UV过滤剂，其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，则R是叔。丁基; 公式（II）; 公式（III）; 式（1a）的基团; 或式（1b）的基团; 其中R 2和R 3彼此独立地为氢; 或甲基; R4是甲基; 乙基; 或正丙基; R5和R6彼此独立地为氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，则R是异丙基; 和（b）选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤剂; （b2）丁基甲氧基二苯甲酰基甲烷; （b3）二乙基己基丁酰氨基三嗪酮; （b4）乙基己基三嗪酮; （b5）二乙氨基羟苯甲酰基苯甲酸己酯; （b6）甲氧基肉桂酸乙基己酯; （b7）水杨酸乙基己酯; （b8）胡莫柳油; （b9）奥克立林; （b10）微粉化的亚甲基双 - 苯并三唑基四甲基丁基苯酚; （b11）苯基苯并咪唑磺酸; （b12）二氧化钛; （b13）微粉化的三联苯三嗪; 和（b14）微粉化（2- {4- [2-（4-二乙基氨基-2-羟基 - 苯甲酰基） - 苯甲酰基] - 哌嗪-1-羰基} - 苯基） - （4-二乙基氨基-2-羟基 - 苯基） - 甲酮; （b15）苯甲酸，4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 （b1） - （b14）的至少2个紫外线过滤剂;其中所述紫外线过滤剂组合物包含至少2种组分（b1） - （b14）的紫外线过滤剂; 用于保护人类和动物毛发和皮肤免受紫外线辐射。

3. 发明申请

WO2008090066A3 STABILIZATION OF UV-SENSITIVE ACTIVE INGREDIENTS 审中-公开
标题翻译：稳定紫外敏感活性成分
公开(公告)号：WO2008090066A3
公开(公告)日：2008-09-12
申请号：PCT/EP2008050440
申请日：2008-01-16
申请人： CIBA HOLDING INC , WAGNER BARBARA , HERZOG BERND , MUELLER STEFAN , EHLIS THOMAS
发明人： WAGNER BARBARA , HERZOG BERND , MUELLER STEFAN , EHLIS THOMAS
IPC分类号： A61K8/41 , A61K8/44 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定UV敏感的活性成分如二苯甲酰基甲烷衍生物的用途。

4. 发明申请

WO2007071584A3 USE OF TRANSMISSION DYES FOR PROTECTING HUMAN SKIN FROM BROWNING AND AGEING 审中-公开
标题翻译：用于保护人类皮肤免受衰老和衰老的传染性染料
公开(公告)号：WO2007071584A3
公开(公告)日：2008-07-03
申请号：PCT/EP2006069519
申请日：2006-12-11
申请人： CIBA HOLDING INC , MUELLER STEFAN , HAASE JUERG , EHLIS THOMAS , KREYER GILBERT , GIESINGER JOCHEN , VOGT MARTIN
发明人： MUELLER STEFAN , HAASE JUERG , EHLIS THOMAS , KREYER GILBERT , GIESINGER JOCHEN , VOGT MARTIN
IPC分类号： A61Q17/04 , A61K8/35 , A61K8/37 , A61K8/42
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

5. 发明申请

WO2009068469A3 GRINDING AIDS FOR MICRONIZED ORGANIC UV ABSORBERS 审中-公开
标题翻译：研磨艾滋病微生物有机紫外线吸收剂
公开(公告)号：WO2009068469A3
公开(公告)日：2009-07-16
申请号：PCT/EP2008065916
申请日：2008-11-20
申请人： CIBA HOLDING INC , MONGIAT SEBASTIEN , GRUMELARD JULIE , EHLIS THOMAS
发明人： MONGIAT SEBASTIEN , GRUMELARD JULIE , EHLIS THOMAS
IPC分类号： A61K8/35 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/411 , A61K8/0241 , A61K8/494 , A61K8/496 , A61K8/4966 , A61K2800/412 , A61Q17/04
摘要： A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b1) carboxylic acids and their salts; (b2) fatty acid esters (b3) alkyl phosphates or phosphoric acid esters; (b4) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b5) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b6) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C4 - C28 fatty acids; (b7) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b8) esters of polyol and mono-, di- or tri-glycerides; (b9) esters of fatty acids and saccharose; (b10) sorbitan mono- and di-esters of saturated and/or unsaturated C6 - C22 fatty acids and ethylene oxide groups; and (b11) surfactants which are mainly acting as detergent or cleansing agents.
摘要翻译：一种制备组合物的方法，该方法包括（a）微粉化的不溶性有机紫外线吸收剂，该方法包括在研磨装置中，在选自以下的研磨助剂存在下以粗颗粒形式研磨不溶性有机紫外线吸收剂： b1）羧酸及其盐; （b2）脂肪酸酯（b3）烷基磷酸酯或磷酸酯; （b4）乙氧基化羧酸或聚乙二醇（PEG）酯; （b5）脂肪醇的脂肪醇聚乙二醇（PEG）醚; （b6）饱和或不饱和C 4 -C 28脂肪酸的聚乙烯/聚丙二醇醚; （b7）乙氧基化烷基酚或乙氧基化烷基苯基醚; （b8）多元醇与甘油单酯，甘油二酯或甘油三酯的酯; （b9）脂肪酸和蔗糖的酯; （b10）饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和（b11）主要用作清洁剂或清洁剂的表面活性剂。

6. 发明申请

WO2008107347A3 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS 审中-公开
标题翻译：用于有机微波紫外线吸收剂稳定化的氨基和氨基酸的使用
公开(公告)号：WO2008107347A3
公开(公告)日：2009-05-07
申请号：PCT/EP2008052336
申请日：2008-02-27
申请人： CIBA HOLDING INC , DESHAYES CYRILLE , EHLIS THOMAS , GRUMELARD JULIE
发明人： DESHAYES CYRILLE , EHLIS THOMAS , GRUMELARD JULIE
IPC分类号： A61K8/04 , A61K8/35 , A61K8/41 , A61K8/42 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/494 , A61K2800/52 , A61Q17/04
摘要： Disclosed is the use of amines and amides for the stabilization of a cosmetic composition comprising: (a) an organic micronized UV absorber selected from a benzophenone derivative and (b) a dibenzoylmethane derivative. The use of the amines and amides results in the stabilization of the end-product formulations.
摘要翻译：公开了胺和酰胺用于稳定化妆品组合物的用途，包括：（a）选自二苯甲酮衍生物和（b）二苯甲酰甲烷衍生物的有机微粉化UV吸收剂。使用胺和酰胺导致最终产品配方的稳定化。

7. 发明申请

WO2008135421A3 CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 审中-公开
标题翻译：传染性染色体的晶体修饰
公开(公告)号：WO2008135421A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008055139
申请日：2008-04-28
申请人： CIBA HOLDING INC , VOGT MARTIN , MUELLER STEFAN , GRUMELARD JULIE , DESHAYES CYRILLE , PAUL HOLGER , HAASE JUERG , EHLIS THOMAS
发明人： VOGT MARTIN , MUELLER STEFAN , GRUMELARD JULIE , DESHAYES CYRILLE , PAUL HOLGER , HAASE JUERG , EHLIS THOMAS
IPC分类号： A61K8/49 , A61Q17/04 , A61Q19/08
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70 Å; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06 Å; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25°C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

8. 发明申请

WO2009112403A3 DIMERIC BENZYLIDENE MALONATES 审中-公开
标题翻译：二甲苯胆碱
公开(公告)号：WO2009112403A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009052531
申请日：2009-03-04
申请人： BASF SE , HANSCH MARKUS , EHLIS THOMAS , WAGNER BARBARA
发明人： HANSCH MARKUS , EHLIS THOMAS , WAGNER BARBARA
IPC分类号： A61K8/37 , A61Q17/04 , C07C67/347 , C07C69/618
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/585 , C07C67/03 , C07C67/31 , C07C67/343 , C07C69/734 , C07C2601/14 , C07F7/0889 , C07C69/732
摘要： Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is -C1-C20alkylene-, -CH2CH(OH)CH2-, -C5-C20cycloalkylene, --C2-C20alkenylene-, -C5- C10arylene-, or -C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from -O, -S- or -NH-; for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了式（1）的亚苄基丙二酸酯的用途，其中R 1和R 2彼此独立地为氢; 哦; C1-C12烷基; C1-C12烷氧基; C1-C12alkylamino; C1-C12dialkylamino; 选自羧酸盐，磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7，R 4为COOR 8; COR 9; CONR8R9; CN; 或SO2R10; R 5，R 6，R 7，R 8，R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代的-C 1 -C 20亚烷基 - ， - CH 2 CH（OH）CH 2 - ， - C 5 -C 20亚环烷基，-C 2 -C 20亚烯基，-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - （C 1 -C 10亚烷基）任选被一个或多于一个选自-O，-S-或-NH-的杂原子间隔的取代的，直链或支链的; 用于保护人和动物的头发和皮肤免受紫外线辐射。

9. 发明申请

WO2007137958A2 SELF TANNING COMPOSITION 审中-公开
标题翻译：自拍组合
公开(公告)号：WO2007137958A2
公开(公告)日：2007-12-06
申请号：PCT/EP2007054864
申请日：2007-05-21
申请人： CIBA SC HOLDING AG , EHLIS THOMAS , MUELLER STEFAN , MONGIAT SEBASTIEN
发明人： EHLIS THOMAS , MUELLER STEFAN , MONGIAT SEBASTIEN
IPC分类号： A61K8/04 , A61K8/19 , A61K8/49 , A61K8/60 , A61Q19/04
CPC分类号： A61Q19/04 , A61K8/044 , A61K8/4973 , A61K8/498 , A61K8/60 , A61K2800/31 , A61K2800/412 , A61K2800/413 , A61Q5/10 , A61Q17/04 , B82Y5/00
摘要： Disclosed is a method for the colouration of skin or a keratinic fibre, characterized in that the skin or keratinic fibre is contacted with a formulation containing a dispersion of solid particles of a tanning substance selected from a compound of the formula (I) wherein i is 0 or 1 and each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 independently of each other is selected from group consisting of hydrogen, OH, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl and C 2 -C 6 al- kenyl; in an organic liquid of low polarity or non-polar organic liquid.
摘要翻译：公开了一种使皮肤或角质纤维着色的方法，其特征在于使皮肤或角质纤维与含有鞣制物质的固体颗粒分散体的制剂接触，所述鞣制物质的分散体选自式（I）的化合物，其中i是 0或1，R 1，R 2，R 3，R 4，R 3， R 5，R 6，R 7，R 8彼此独立地选自氢，OH，C C 1 -C 6烷基，C 1 -C 6羟烷基和C 2 -C 6烷基，C 1 -C 6 - -C 6亚烯基; 在低极性的有机液体或非极性有机液体中。

10. 发明申请

WO2004085412A3 SYMMETRICAL TRIAZINE DERIVATIVES 审中-公开
标题翻译：对称TRIAZINE衍生物
公开(公告)号：WO2004085412A3
公开(公告)日：2005-02-10
申请号：PCT/EP2004050331
申请日：2004-03-19
申请人： CIBA SC HOLDING AG , EHLIS THOMAS , MUELLER STEFAN , HAYOZ PASCAL
发明人： EHLIS THOMAS , MUELLER STEFAN , HAYOZ PASCAL
IPC分类号： A61K8/49 , A61Q17/04 , C07D251/24 , A61K7/42
CPC分类号： C07D251/24 , A61K8/4966 , A61Q17/04
摘要： Disclosed is the use of the compounds of formula wherein A is a radical of formula (1a) or (1b) R, R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R2, R3 and R4 independently from each other are hydrogen; or a radical of formula wherein at least one of the radicals R2, R3 and R4are a radical of formula (1c); R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; C1-C18alkyl; C1-C18alkoxy;C6-C12aryl; C6-C12aryloxy; C1-C18alkylthio; carboxy; -COOM; C1-C18alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The compounds of formula (1) are high effective UV absorbers for cosmetic formulations aund can - depending on their physical properties - be used in micronized or soluble form.
摘要翻译：公开了下式化合物的用途其中A是式（1a）或（1b）的基团，R，R 1和R 5彼此独立地是氢; C1-C18烷基; 或C6-C12芳基; R2，R3和R4彼此独立地是氢; 或下式的基团，其中基团R 2，R 3和R 4中的至少一个为式（1c）的基团; R 6，R 7，R 8，R 9和R 10彼此独立地为氢; 羟基; C1-C18烷基; C1-C18烷氧基; C 6 -C 12芳基; C6-C12aryloxy; C1-C18alkylthio; 羧基; -COOM; C1-C18alkylcarboxyl; 羰基; 或单或二C1-C18烷基氨基; M是碱金属离子; x为1或2; y为2〜10的数; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。式（1）的化合物是用于化妆品制剂的高效紫外线吸收剂，可根据其物理性质 - 以微粉化或可溶形式使用。

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