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1. 发明申请

WO2012074625A1 EXHAUST VALVE COMBINED WITH ACTIVE NOISE CONTROL SYSTEM 审中-公开
标题翻译：排气阀与主动噪声控制系统组合
公开(公告)号：WO2012074625A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/057571
申请日：2011-10-25
申请人： FAURECIA EMISSIONS CONTROL TECHNOLOGIES , ABRAM, Kwin , EGAN, James
发明人： ABRAM, Kwin , EGAN, James
IPC分类号： F01N1/16 , F01N1/18 , F01N13/08
CPC分类号： F01N1/065 , F01N1/16 , F01N1/18
摘要： A vehicle exhaust system includes at least one exhaust component that defines an exhaust passage from an engine to an exhaust outlet. An active noise attenuation component is associated with the exhaust component. A valve is positioned within the exhaust component downstream of the engine and upstream of the active noise attenuation component. The valve and active noise attenuation component cooperate with each other to control noise generated by the exhaust system.
摘要翻译：车辆排气系统包括限定从发动机到排气出口的排气通道的至少一个排气部件。有源噪声衰减分量与排气分量相关联。阀门定位在发动机下游的排气部件内部和有源噪声衰减部件的上游。阀门和主动噪声衰减部件相互配合以控制由排气系统产生的噪声。

2. 发明申请

WO2012037551A2 PRIMARY CELL-DERIVED BIOLOGIC AND WT1 SYNTHETIC LONG PEPTIDE VACCINE 审中-公开
标题翻译：初级细胞衍生生物和WT1合成长肽疫苗
公开(公告)号：WO2012037551A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/052139
申请日：2011-09-19
申请人： IRX THERAPEUTICS, INC. , BERINSTEIN, Neil , NAYLOR, Paul , EGAN, James
发明人： BERINSTEIN, Neil , NAYLOR, Paul , EGAN, James
IPC分类号： A61K38/20
CPC分类号： A61K38/20 , A61K38/162 , A61K38/191 , A61K38/193 , A61K38/217 , A61K39/0011 , A61K45/06 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55566 , A61K2300/00 , A61K38/1764
摘要： A composition for treating cancer or other disease of a primary cell-derived biologic including the cytokines IL-1, IL-2, IL-6, IL-8, TNF-α, and IFN-γ, and a synthetic long peptide of a tumor associated antigen. A composition for treating cancer, including a synthetic long peptide vaccine to a tumor associated antigen. Therapeutic vaccines for cancer or other disease. A method of treating cancer or other disease by activating Tc effector cells, activating Th effector cells, and promoting antigen presenting cells differentiation, maturation and antigen presentation. A method of reversing immune suppression and gaining immunity to cancer. A method of treating cancer, by administering an effective amount of a synthetic long peptide of a tumor associated antigen.
摘要翻译：用于治疗源自原代细胞的生物的癌症或其他疾病的组合物，包括细胞因子IL-1，IL-2，IL-6，IL-8，TNF-α和IFN-γ ，和肿瘤相关抗原的合成长肽。一种治疗癌症的组合物，包括对肿瘤相关抗原的合成长肽疫苗。治疗癌症或其他疾病的疫苗。通过激活Tc效应细胞，活化Th效应细胞，促进抗原呈递细胞分化，成熟和抗原呈递来治疗癌症或其他疾病的方法。一种逆转免疫抑制和获得免疫力的方法。通过给予有效量的肿瘤相关抗原的合成长肽来治疗癌症的方法。

3. 发明申请

WO2010098988A3 TEMPERATURE AND FLOW CONTROL OF EXHAUST GAS FOR THERMOELECTRIC UNITS 审中-公开
公开(公告)号：WO2010098988A3
公开(公告)日：2010-09-02
申请号：PCT/US2010/023993
申请日：2010-02-12
申请人： EMCON TECHNOLOGIES LLC , ARBUCKLE, Ivan , ABRAM, Kwin , CALLAHAN, Joseph, E. , VIRTUE, Michael, D. , EGAN, James , WILLATS, Robin , KEESSER, Thorsten
发明人： ARBUCKLE, Ivan , ABRAM, Kwin , CALLAHAN, Joseph, E. , VIRTUE, Michael, D. , EGAN, James , WILLATS, Robin , KEESSER, Thorsten
IPC分类号： F01N3/26 , F01N3/10
摘要： A vehicle exhaust system includes an exhaust pipe that provides heated exhaust gases to a thermoelectric unit as an input. A temperature control mechanism ensures that exhaust gas is directed into the thermoelectric unit only if the exhaust gas is within a specified temperature range. The thermoelectric unit transforms the exhaust gas heat into electrical power.

4. 发明申请

WO2010098988A2 TEMPERATURE AND FLOW CONTROL OF EXHAUST GAS FOR THERMOELECTRIC UNITS 审中-公开
标题翻译：热电单元废气的温度和流量控制
公开(公告)号：WO2010098988A2
公开(公告)日：2010-09-02
申请号：PCT/US2010023993
申请日：2010-02-12
申请人： EMCON TECHNOLOGIES LLC , ARBUCKLE IVAN , ABRAM KWIN , CALLAHAN JOSEPH E , VIRTUE MICHAEL D , EGAN JAMES , WILLATS ROBIN , KEESSER THORSTEN
发明人： ARBUCKLE IVAN , ABRAM KWIN , CALLAHAN JOSEPH E , VIRTUE MICHAEL D , EGAN JAMES , WILLATS ROBIN , KEESSER THORSTEN
IPC分类号： F01N3/26 , F01N3/10
CPC分类号： H01L35/30 , F01N5/025 , F01N2410/02 , Y02T10/16
摘要： A vehicle exhaust system includes an exhaust pipe that provides heated exhaust gases to a thermoelectric unit as an input. A temperature control mechanism ensures that exhaust gas is directed into the thermoelectric unit only if the exhaust gas is within a specified temperature range. The thermoelectric unit transforms the exhaust gas heat into electrical power.
摘要翻译：车辆排气系统包括排气管，排气管将热排气提供给热电单元作为输入。温度控制机构确保只有当排气处于特定温度范围内时才将废气引入热电单元。热电单元将废气热量转化为电力。

5. 发明申请

WO2008014220A2 VACCINE IMMUNOTHERAPY 审中-公开
标题翻译：疫苗免疫治疗
公开(公告)号：WO2008014220A2
公开(公告)日：2008-01-31
申请号：PCT/US2007074156
申请日：2007-07-24
申请人： IRX THERAPEUTICS INC , HADDEN JOHN W , SIGNORELLI KATHY , EGAN JAMES
发明人： HADDEN JOHN W , SIGNORELLI KATHY , EGAN JAMES
IPC分类号： A61K38/21 , A61K38/19 , A61K38/20
CPC分类号： A61K39/0011 , A61K38/191 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/217 , A61K2300/00
摘要： The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at (east one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-? (gamma) and TNF-a (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.
摘要翻译：本发明提供了用于治疗癌症或其他抗原生成疾病或损伤的免疫疗法的组合物和方法。根据本发明的一个实施方案，提供了一种组合物，用于引发针对患有产生抗原的疾病或损伤的患者中（至少一种抗原）的免疫应答，所述组合物包含有效量的细胞因子混合物，优选包含IL- 1，IL-2，IL-6，IL-8，IFN-γ（γ）和TNF-αα。细胞因子混合物作为与产生抗原的疾病或病变相关的抗原的佐剂来增强因此还提供了用于利用本发明的细胞因子混合物在患有抗原生成疾病或损伤的患者中引发针对至少一种抗原的免疫应答的方法，所述组合物和方法可用于治疗产生抗原的疾病如癌症，感染性疾病或持续性病变。

6. 发明申请

WO2005003295A3 METHODS AND COMPOSITIONS FOR MATURING DENDRITIC CELLS UTILIZING INOSINE-CONTAINING COMPOUNDS 审中-公开
标题翻译：利用含肌苷的化合物使树突细胞成熟的方法和组合物
公开(公告)号：WO2005003295A3
公开(公告)日：2005-09-29
申请号：PCT/US2004013141
申请日：2004-04-27
申请人： IRX THERAPEUTICS INC , SIGNORELLI KATHY L , EGAN JAMES E , SANTIAGO-SCHWARZ FRANCES
发明人： SIGNORELLI KATHY L , EGAN JAMES E , SANTIAGO-SCHWARZ FRANCES
IPC分类号： A61K39/145 , A61K39/39 , A61K45/00 , A61K47/00 , A61K48/00 , C07H19/048 , C12N20060101 , C12N5/0784
CPC分类号： A61K39/39 , A61K31/70 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5252 , A61K2039/55561 , C12N5/0639 , C12N2500/40 , C12N2501/22 , C12N2501/23 , C12N2760/16134
摘要： A method of stimulating in vivo or ex vivo maturation of dendritic cells by applying an effective amount of inosine-containing compounds to the dendritic cells. The maturation of dendritic cells leads to more robust cellular immune responses against antigens including those associated with vaccines, infectious agents, and tumor cells by enhancing the stimulatory activity of dendritic cells toward T cells. An in vivo or ex vivo method of treating diseases in a subject by applying an effective amount of an inosine-containing compound to the dendritic cells to stimulate maturation thereof; and administering matured dendritic cells into the subject. A method of enhancing the immune response of a host mammal by isolating immature dendritic cells from a donor mammal; maturing the immature dendritic cells in the presence of an inosine-containing compound ex vivo; and administering the mature dendritic cells to a host mammal in an amount effective to enhance the immune response of the host mammal. A method of maturing dendritic cells in vivo or ex vivo in the presence of an inosine-containing compound, which results in increasing the stimulation of T cells in response to an antigen. A method of enhancing the immunological response to vaccine antigens by inclusion of an inosine-containing compound. A composition for in vivo or ex vivo maturation of dendritic cells including an inosine-containing compound, wherein one possible form of the inosine-containing compound is an IpR oligonucleotide molecule. Compositions, pharmaceutical composition, adjuvants, immunostimulants, and kits for maturing dendritic cells in vivo or ex vivo including an inosine-containing compound.
摘要翻译：通过将有效量的含肌苷的化合物应用于树突细胞来刺激树突细胞的体内或离体成熟的方法。通过增强树突细胞对T细胞的刺激活性，树突细胞的成熟导致对包括与疫苗，感染因子和肿瘤细胞相关的抗原在内的抗原的更强大的细胞免疫应答。通过将有效量的含肌苷的化合物应用于树突细胞以刺激其成熟来治疗受试者疾病的体内或离体方法; 并将成熟的树突细胞施用于受试者。通过从供体哺乳动物中分离未成熟的树突细胞来增强宿主哺乳动物的免疫应答的方法; 在含有肌苷的化合物存在下体外成熟未成熟的树突细胞; 和以有效增强宿主哺乳动物免疫应答的量将成熟树突细胞施用给宿主哺乳动物。一种在存在含肌苷的化合物的情况下体内或离体成熟树突细胞的方法，其导致T细胞响应于抗原的刺激增加。通过包含含肌苷的化合物增强对疫苗抗原的免疫应答的方法。用于体内或体外成熟树突细胞的组合物，包括含肌苷的化合物，其中所述含肌苷的化合物的一种可能形式是IpR寡核苷酸分子。用于体内或离体成熟树突细胞的组合物，药物组合物，佐剂，免疫刺激剂和试剂盒，包括含肌苷的化合物。

7. 发明申请

WO2011072006A1 METHOD OF REVERSING IMMUNE SUPPRESSION OF LANGERHANS CELLS 审中-公开
标题翻译：逆转免疫抑制兰格细胞的方法
公开(公告)号：WO2011072006A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059450
申请日：2010-12-08
申请人： IRX THERAPEUTICS, INC. , EGAN, James , KAST, Martin , DA SILVA, Diane , BRANDWEIN, Harvey
发明人： EGAN, James , KAST, Martin , DA SILVA, Diane , BRANDWEIN, Harvey
IPC分类号： C12P21/04
CPC分类号： A61K38/217 , A61K9/0019 , A61K31/405 , A61K31/664 , A61K31/675 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K38/208 , A61K38/2086 , A61K45/06 , A61K2300/00
摘要： A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.
摘要翻译：一种治疗人乳头状瘤病毒（HPV）的方法，其通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物学，并诱导对HPV的免疫应答。通过对感染HPV的患者施用治疗有效量的原代细胞来源的生物学并激活LC，克服了HPV诱导的朗格汉斯细胞免疫抑制（LC）的方法。通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物体，激活LC并诱导向淋巴结的LC迁移，增加LC向淋巴结迁移的方法。通过向感染HPV的患者施用有效量的原代细胞来源的生物学，产生针对HPV的免疫并且防止新的病变发展，产生针对HPV的免疫力的方法。

8. 发明申请

WO2008014220A3 VACCINE IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2008014220A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/074156
申请日：2007-07-24
申请人： IRx THERAPEUTICS, INC. , HADDEN, John, W. , SIGNORELLI, Kathy , EGAN, James
发明人： HADDEN, John, W. , SIGNORELLI, Kathy , EGAN, James
IPC分类号： A61K38/19 , A61K38/20 , A61K45/00
摘要： The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at (east one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-γ (gamma) and TNF-α (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.

9. 发明申请

WO2006037028A3 METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES, PESTIVIRUSES AND HEPACIVIRUS 审中-公开
公开(公告)号：WO2006037028A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/034786
申请日：2005-09-26
申请人： IDENIX (CAYMAN) LIMITED , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SOMMADOSSI, Jean-Pierre , GOSSELIN, Gilles , STORER, Richard , EGAN, James
发明人： SOMMADOSSI, Jean-Pierre , GOSSELIN, Gilles , STORER, Richard , EGAN, James
IPC分类号： A61K31/70 , C07H19/00 , C07H19/048
摘要： A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

10. 发明申请

WO2005003295A2 METHODS AND COMPOSITIONS FOR MATURING DENDRITIC CELLS UTILIZING INOSINE-CONTAINING COMPOUNDS 审中-公开
标题翻译：使用含有异辛烯的化合物制备感染细胞的方法和组合物
公开(公告)号：WO2005003295A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/013141
申请日：2004-04-27
申请人： IRx THERAPEUTICS, INC. , SIGNORELLI, Kathy, L. , EGAN, James, E. , SANTIAGO-SCHWARZ, Frances
发明人： SIGNORELLI, Kathy, L. , EGAN, James, E. , SANTIAGO-SCHWARZ, Frances
IPC分类号： C12N
CPC分类号： A61K39/39 , A61K31/70 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5252 , A61K2039/55561 , C12N5/0639 , C12N2500/40 , C12N2501/22 , C12N2501/23 , C12N2760/16134
摘要： A method of stimulating in vivo or ex vivo maturation of dendritic cells by applying an effective amount of inosine-containing compounds to the dendritic cells. The maturation of dendritic cells leads to more robust cellular immune responses against antigens including those associated with vaccines, infectious agents, and tumor cells by enhancing the stimulatory activity of dendritic cells toward T cells. An in vivo or ex vivo method of treating diseases in a subject by applying an effective amount of an inosine-containing compound to the dendritic cells to stimulate maturation thereof; and administering matured dendritic cells into the subject. A method of enhancing the immune response of a host mammal by isolating immature dendritic cells from a donor mammal; maturing the immature dendritic cells in the presence of an inosine-containing compound ex vivo; and administering the mature dendritic cells to a host mammal in an amount effective to enhance the immune response of the host mammal. A method of maturing dendritic cells in vivo or ex vivo in the presence of an inosine-containing compound, which results in increasing the stimulation of T cells in response to an antigen. A method of enhancing the immunological response to vaccine antigens by inclusion of an inosine-containing compound. A composition for in vivo or ex vivo maturation of dendritic cells including an inosine-containing compound, wherein one possible form of the inosine-containing compound is an IpR oligonucleotide molecule. Compositions, pharmaceutical composition, adjuvants, immunostimulants, and kits for maturing dendritic cells in vivo or ex vivo including an inosine-containing compound.
摘要翻译：通过将有效量的含有肌苷的化合物施用于树突细胞来刺激树突细胞的体内或体外成熟的方法。树突状细胞的成熟通过增强树突细胞对T细胞的刺激活性而导致针对抗原的更强健的细胞免疫应答，包括与疫苗，感染因子和肿瘤细胞相关的细胞免疫应答。一种通过将有效量的含有肌苷的化合物施用于树突状细胞以刺激其成熟来治疗受试者疾病的体内或离体方法; 并将成熟的树突细胞施用于受试者。一种通过从供体哺乳动物分离未成熟树突状细胞来增强宿主哺乳动物的免疫应答的方法; 在离体含有肌苷的化合物存在下成熟未成熟树突状细胞; 以及以有效增强宿主哺乳动物的免疫应答的量将成熟树突状细胞给予宿主哺乳动物。在含有肌苷的化合物的存在下体内或离体成熟树突状细胞的方法，其导致增加对抗原的T细胞的刺激。通过包含含有肌苷的化合物增强对疫苗抗原的免疫应答的方法。用于体内或体外成熟树突状细胞的组合物，包括含有肌苷的化合物，其中一种可能形式的含有肌苷的化合物是IpR寡核苷酸分子。组合物，药物组合物，佐剂，免疫刺激剂和用于体内或体外成熟树突状细胞的试剂盒，包括含有肌苷的化合物。

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