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1. 发明申请

WO2003049670A3 ADJUVANT FORMULATIONS FOR BACTERIAL AND VIRUS VACCINES AND METHOD OF MAKING SAME 审中-公开
公开(公告)号：WO2003049670A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/023765
申请日：2002-07-26
申请人： IMMUNO-RX, INC. , HADDEN, John , NAYLOR, Paul, H. , SIGNORELLI, Kathy, L.
发明人： HADDEN, John , NAYLOR, Paul, H. , SIGNORELLI, Kathy, L.
IPC分类号： A61K31/70
摘要： A pharmaceutical composition including an adjuvant effective amount of a protected inosine monophosphate (IMP) compound. The pharmaceutical composition includes the protected IMP compound alone, or in combination with vaccine agents with or without additional adjuvants. The pharmaceutical composition can be utilized as a vaccine composition or can be included with existing vaccine compositions in order to increase a specific T lymphocyte mediated immune response thereto. Various methods relating to the pharmaceutical composition and the vaccine are described herein. The vaccines can be employed to prevent or treat infections. Additionally, the pharmaceutical compositions not only increase T-cell responses, but also confer, by pretreatment, nonspecific protection against a variety of pathogens. This combination of actions is appropriate for enhancing defense against bioterrorism with organisms like smallpox or anthrax.

2. 发明申请

WO2012037551A2 PRIMARY CELL-DERIVED BIOLOGIC AND WT1 SYNTHETIC LONG PEPTIDE VACCINE 审中-公开
标题翻译：初级细胞衍生生物和WT1合成长肽疫苗
公开(公告)号：WO2012037551A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/052139
申请日：2011-09-19
申请人： IRX THERAPEUTICS, INC. , BERINSTEIN, Neil , NAYLOR, Paul , EGAN, James
发明人： BERINSTEIN, Neil , NAYLOR, Paul , EGAN, James
IPC分类号： A61K38/20
CPC分类号： A61K38/20 , A61K38/162 , A61K38/191 , A61K38/193 , A61K38/217 , A61K39/0011 , A61K45/06 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55566 , A61K2300/00 , A61K38/1764
摘要： A composition for treating cancer or other disease of a primary cell-derived biologic including the cytokines IL-1, IL-2, IL-6, IL-8, TNF-α, and IFN-γ, and a synthetic long peptide of a tumor associated antigen. A composition for treating cancer, including a synthetic long peptide vaccine to a tumor associated antigen. Therapeutic vaccines for cancer or other disease. A method of treating cancer or other disease by activating Tc effector cells, activating Th effector cells, and promoting antigen presenting cells differentiation, maturation and antigen presentation. A method of reversing immune suppression and gaining immunity to cancer. A method of treating cancer, by administering an effective amount of a synthetic long peptide of a tumor associated antigen.
摘要翻译：用于治疗源自原代细胞的生物的癌症或其他疾病的组合物，包括细胞因子IL-1，IL-2，IL-6，IL-8，TNF-α和IFN-γ ，和肿瘤相关抗原的合成长肽。一种治疗癌症的组合物，包括对肿瘤相关抗原的合成长肽疫苗。治疗癌症或其他疾病的疫苗。通过激活Tc效应细胞，活化Th效应细胞，促进抗原呈递细胞分化，成熟和抗原呈递来治疗癌症或其他疾病的方法。一种逆转免疫抑制和获得免疫力的方法。通过给予有效量的肿瘤相关抗原的合成长肽来治疗癌症的方法。

3. 发明申请

WO2007136910A2 EIMMUNOTHERAPY FOR IMMUNE SUPPRESSED PATIENTS 审中-公开
标题翻译：免疫抑制患者的电子护理
公开(公告)号：WO2007136910A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/063633
申请日：2007-03-09
申请人： IRX THERAPEUTICS, INC. , HADDEN, John, W. , NAYLOR, Paul
发明人： HADDEN, John, W. , NAYLOR, Paul
IPC分类号： A61K48/00
CPC分类号： A61K38/193 , A61K31/192 , A61K31/405 , A61K31/675 , A61K38/191 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/208 , A61K38/217 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of a natural cytokine mixture (NCM) for treating a cellular immunodeficiency characterized by T lymphocytopenia, one or more dendritic cell functional defects such as those associated with lymph node sinus histiocytosis, and/or one or more monocyte functional defects such as those associated with a negative skin test to NCM. The invention includes methods of treating these cellular immunodeficiencies using the NCM of the invention. The compositions and methods are useful in the treatment of diseases associated with cellular immunodeficiencies such as cancer. Also provided are compositions and methods for reversing tumor-induced immune suppression comprising a chemical inhibitor and a non-steroidal anti-inflammatory drug (NSAID). The invention also provides a diagnostic skin test comprising NCM for predicting treatment outcome in cancer patients.
摘要翻译：本发明提供了一种天然细胞因子混合物（NCM）的组合物，其用于治疗以T淋巴细胞减少为特征的细胞免疫缺陷，一种或多种树突细胞功能缺陷，例如与淋巴结窦组织细胞增多症有关的功能缺陷，和/或一种或多种单核细胞功能缺陷如与NCM的阴性皮肤试验相关的那些。本发明包括使用本发明的NCM治疗这些细胞免疫缺陷的方法。组合物和方法可用于治疗与细胞免疫缺陷如癌症相关的疾病。还提供了用于逆转肿瘤诱导的免疫抑制的组合物和方法，包括化学抑制剂和非甾体抗炎药（NSAID）。本发明还提供了一种诊断性皮肤试验，其包括用于预测癌症患者的治疗结果的NCM。

4. 发明申请

WO2003049670A2 ADJUVANT FORMULATIONS FOR BACTERIAL AND VIRUS VACCINES AND METHOD OF MAKING SAME 审中-公开
标题翻译：用于细菌和病毒疫苗的补充剂制剂及其制备方法
公开(公告)号：WO2003049670A2
公开(公告)日：2003-06-19
申请号：PCT/US2002/023765
申请日：2002-07-26
申请人： IMMUNO-RX, INC. , HADDEN, John , NAYLOR, Paul, H. , SIGNORELLI, Kathy, L.
发明人： HADDEN, John , NAYLOR, Paul, H. , SIGNORELLI, Kathy, L.
IPC分类号： A61K
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57
摘要： A pharmaceutical composition including an adjuvant effective amount of a protected inosine monophosphate (IMP) compound. The pharmaceutical composition includes the protected IMP compound alone, or in combination with vaccine agents with or without additional adjuvants. The pharmaceutical composition can be utilized as a vaccine composition or can be included with existing vaccine compositions in order to increase a specific T lymphocyte mediated immune response thereto. Various methods relating to the pharmaceutical composition and the vaccine are described herein. The vaccines can be employed to prevent or treat infections. Additionally, the pharmaceutical compositions not only increase T-cell responses, but also confer, by pretreatment, nonspecific protection against a variety of pathogens. This combination of actions is appropriate for enhancing defense against bioterrorism with organisms like smallpox or anthrax.
摘要翻译：一种药物组合物，其包含佐剂有效量的受保护的一肌糖苷（IMP）化合物。药物组合物包括单独的受保护的IMP化合物，或与具有或不具有另外的佐剂的疫苗剂组合。药物组合物可以用作疫苗组合物，或者可以与现有疫苗组合物一起使用，以便增加对其的特异性T淋巴细胞介导的免疫应答。本文描述了与药物组合物和疫苗有关的各种方法。疫苗可用于预防或治疗感染。此外，药物组合物不仅增加T细胞应答，而且还通过预处理赋予针对各种病原体的非特异性保护。这种行动的组合适用于加强与天花或炭疽等生物恐怖主义的防御。

5. 发明申请

WO2003037740A1 WATER SOLUBLE CAPSULES 审中-公开
标题翻译：水溶性胶囊
公开(公告)号：WO2003037740A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012015
申请日：2002-10-25
申请人： UNILEVER PLC , UNILEVER NV , HINDUSTAN LEVER LIMITED , BRUGGEMAN, Marcel, Cornelis , HAFKAMP, Rudolfus, Johannes, Hendrikus , NAYLOR, Paul
发明人： BRUGGEMAN, Marcel, Cornelis , HAFKAMP, Rudolfus, Johannes, Hendrikus , NAYLOR, Paul
IPC分类号： B65D65/46
CPC分类号： C11D17/042
摘要： A water soluble capsule (1) containing a detergent composition (2), the capsule having four or more walls and characterised in that the capsule comprises a plurality of protruding portions, the or each protruding portion being formed from co-joined end portions of respective three or more walls. In one embodiment the capsule is in the shape of a pyramid.
摘要翻译：一种含有洗涤剂组合物（2）的水溶性胶囊（1），所述胶囊具有四个或更多个壁，其特征在于，所述胶囊包括多个突出部分，所述突出部分或每个突出部分由各自的共同端部形成三个或更多的墙壁。在一个实施例中，胶囊为金字塔形。

6. 发明申请

WO2012037551A3 PRIMARY CELL-DERIVED BIOLOGIC AND WT1 SYNTHETIC LONG PEPTIDE VACCINE 审中-公开
标题翻译：主要细胞衍生生物学和WT1合成长肽疫苗
公开(公告)号：WO2012037551A3
公开(公告)日：2012-07-12
申请号：PCT/US2011052139
申请日：2011-09-19
申请人： IRX THERAPEUTICS INC , BERINSTEIN NEIL , NAYLOR PAUL , EGAN JAMES
发明人： BERINSTEIN NEIL , NAYLOR PAUL , EGAN JAMES
IPC分类号： A61K45/00 , A61K39/00
CPC分类号： A61K38/20 , A61K38/162 , A61K38/191 , A61K38/193 , A61K38/217 , A61K39/0011 , A61K45/06 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55566 , A61K2300/00 , A61K38/1764
摘要： A composition for treating cancer or other disease of a primary cell-derived biologic including the cytokines IL-1, IL-2, IL-6, IL-8, TNF-a, and IFN-?, and a synthetic long peptide of a tumor associated antigen. A composition for treating cancer, including a synthetic long peptide vaccine to a tumor associated antigen. Therapeutic vaccines for cancer or other disease. A method of treating cancer or other disease by activating Tc effector cells, activating Th effector cells, and promoting antigen presenting cells differentiation, maturation and antigen presentation. A method of reversing immune suppression and gaining immunity to cancer. A method of treating cancer, by administering an effective amount of a synthetic long peptide of a tumor associated antigen.
摘要翻译：用于治疗包括细胞因子IL-1，IL-2，IL-6，IL-8，TNF-α和IFN-γ的原代细胞衍生生物学的癌症或其它疾病的组合物，以及合成的长肽肿瘤相关抗原。用于治疗癌症的组合物，包括对肿瘤相关抗原的合成长肽疫苗。癌症或其他疾病的治疗性疫苗。通过激活Tc效应细胞，激活Th效应细胞和促进抗原呈递细胞分化，成熟和抗原呈递来治疗癌症或其它疾病的方法。逆转免疫抑制和获得癌症免疫力的方法。通过施用有效量的肿瘤相关抗原的合成长肽来治疗癌症的方法。

7. 发明申请

WO2010132867A1 VACCINE IMMUNOTHERAPY 审中-公开
标题翻译：疫苗免疫
公开(公告)号：WO2010132867A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/035060
申请日：2010-05-17
申请人： IRX THERAPEUTICS, INC. , HADDEN, John W. , SIGNORELLI, Kathy , EGAN, James , NAYLOR, Paul
发明人： HADDEN, John W. , SIGNORELLI, Kathy , EGAN, James , NAYLOR, Paul
IPC分类号： A61K45/00 , A61K38/21
CPC分类号： A61K39/39 , A61K38/164 , A61K38/177 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/208 , A61K38/217 , A61K39/0011 , A61K39/39558 , A61K45/06 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/6081 , A61K2300/00
摘要： A composition for treating cancer, including synergistic amounts of a primary cell-derived biologic having the cytokines IL-1, IL-2, IL-6, IL-8, TNF-α, and IFN-γ, and a cancer vaccine having at least one antigen. A composition comprising synergistic amounts of the primary cell-derived biologic in combination with at least one adjuvant. A method of treating cancer by administering the composition. A method of reversing immune suppression and gaining immunity to cancer. A method of producing an immune response to an exogenous antigen. A method of enhancing an immune response in a patient by administering the primary cell-derived biologic in combination with at least one adjuvant, and enhancing the immune response of the patient by a synergistic interaction of the primary cell-derived biologic and the adjuvant. A method of increasing function of an immune system.
摘要翻译：一种用于治疗癌症的组合物，包括具有细胞因子IL-1，IL-2，IL-6，IL-8，TNF-α和IFN-γ的主要细胞衍生生物的协同量，以及具有至少一种抗原。一种组合物，其包含与至少一种佐剂组合的协同量的原代细胞来源的生物制剂。通过施用组合物治疗癌症的方法。逆转免疫抑制和获得癌症免疫力的方法。产生对外源性抗原的免疫应答的方法。一种通过将主要细胞来源的生物与至少一种佐剂组合施用来增强患者的免疫应答的方法，以及通过所述原代细胞衍生的生物学和佐剂的协同相互作用增强患者的免疫应答。增加免疫系统功能的方法。

8. 发明申请

WO2007136910A3 EIMMUNOTHERAPY FOR IMMUNE SUPPRESSED PATIENTS 审中-公开
标题翻译：免疫抑制患者的电子护理
公开(公告)号：WO2007136910A3
公开(公告)日：2008-12-04
申请号：PCT/US2007063633
申请日：2007-03-09
申请人： IRX THERAPEUTICS INC , HADDEN JOHN W , NAYLOR PAUL
发明人： HADDEN JOHN W , NAYLOR PAUL
IPC分类号： A61K48/00
CPC分类号： A61K38/193 , A61K31/192 , A61K31/405 , A61K31/675 , A61K38/191 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/208 , A61K38/217 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of a natural cytokine mixture (NCM) for treating a cellular immunodeficiency characterized by T lymphocytopenia, one or more dendritic cell functional defects such as those associated with lymph node sinus histiocytosis, and/or one or more monocyte functional defects such as those associated with a negative skin test to NCM. The invention includes methods of treating these cellular immunodeficiencies using the NCM of the invention. The compositions and methods are useful in the treatment of diseases associated with cellular immunodeficiencies such as cancer. Also provided are compositions and methods for reversing tumor-induced immune suppression comprising a chemical inhibitor and a non-steroidal anti-inflammatory drug (NSAID). The invention also provides a diagnostic skin test comprising NCM for predicting treatment outcome in cancer patients.
摘要翻译：本发明提供了一种天然细胞因子混合物（NCM）的组合物，其用于治疗以T淋巴细胞减少为特征的细胞免疫缺陷，一种或多种树突细胞功能缺陷，例如与淋巴结窦组织细胞增多症有关的功能缺陷，和/或一种或多种单核细胞功能缺陷如与NCM的阴性皮肤试验相关的那些。本发明包括使用本发明的NCM治疗这些细胞免疫缺陷的方法。组合物和方法可用于治疗与细胞免疫缺陷如癌症相关的疾病。还提供了用于逆转肿瘤诱导的免疫抑制的组合物和方法，包括化学抑制剂和非甾体抗炎药（NSAID）。本发明还提供了一种诊断性皮肤试验，其包括用于预测癌症患者的治疗结果的NCM。

9. 发明申请

WO2003037741A1 WATER SOLUBLE CAPSULES 审中-公开
标题翻译：水溶性胶囊
公开(公告)号：WO2003037741A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012016
申请日：2002-10-25
申请人： UNILEVER PLC , UNILEVER NV , HINDUSTAN LEVER LIMITED , BRUGGEMAN, Marcel, Cornelis , HAFKAMP, Rudolfus, Johannes, Hendrikus , NAYLOR, Paul
发明人： BRUGGEMAN, Marcel, Cornelis , HAFKAMP, Rudolfus, Johannes, Hendrikus , NAYLOR, Paul
IPC分类号： B65D65/46
CPC分类号： C11D17/042
摘要： A water soluble capsule (1) containing a detergent composition (2) which may be a laundry or dishwashing cleaning comp , the capsule being in the form of a polyhedron having 4 or more walls and characterised in that each wall (10,12)of the polyhedron is inclined at an angle relative to each other wall (10,12).The invention also provides a water soluble capsule (1) containing a detergent composition (2), the capsule being formed from a flexible film disposed in folded configuration and sealed with a) one or more longitudinal seals (4a,4b,4c); and b) first and second end seals (6,8) located at opposed ends of the capsule (1), characterised in that the first end seal (6) is substantially orthogonal to the or each longitudinal seal(4a,4b,4c) and inclined at an angle to the second end seal (8). In a preferred embodiment the inclination is orthogonal so that the capsule is a tetrahedron.
摘要翻译：一种含有洗涤剂组合物（2）的水溶性胶囊（1），其可以是洗衣或餐具清洗组合物，所述胶囊为具有4个或更多个壁的多面体形式，其特征在于每个壁（10,12）为多面体相对于彼此的壁（10,12）倾斜一定角度。本发明还提供了一种含有洗涤剂组合物（2）的水溶性胶囊（1），该胶囊由设置成折叠构型的柔性膜形成，用a）一个或多个纵向密封件（4a，4b，4c）密封; 和b）位于胶囊（1）的相对端部的第一和第二端部密封件（6,8），其特征在于，所述第一端部密封件（6）基本上垂直于所述或每个纵向密封件（4a，4b，4c）并且与第二端部密封件（8）成一定角度倾斜。在优选实施例中，倾斜是正交的，使得胶囊是四面体。

10. 发明申请

WO2006066683A1 PACKAGING OF MULTIPLE CONSUMER ARTICLES 审中-公开
标题翻译：包装多个消费品
公开(公告)号：WO2006066683A1
公开(公告)日：2006-06-29
申请号：PCT/EP2005/012533
申请日：2005-11-22
申请人： UNILEVER PLC , UNILEVER NV , HINDUSTAN LEVER LIMITED , COLLINS, Paul , NAYLOR, Paul
发明人： COLLINS, Paul , NAYLOR, Paul
IPC分类号： B65D71/00
CPC分类号： B65D71/08 , B65D75/5844 , B65D2571/00561 , B65D2571/00679
摘要： An outer package (1) containing a plurality of consumer articles (13) arranged in an array (17), said outer package (1) comprising a flexible sheet material (19) wrapped and sealed around the array in a configuration which is adapted to the shape of the array so as to retain the arrangement of the array (17), and an easy open tear strip (21) contained within a single face of the outer package (1) and comprising tear zones arranged in sequential pairs (3), the zones within each pair (3) being mutually divergent in the direction of tearing separated by a gap corresponding to the tear strip (21) whereby the arrangement of the array (17) is retained after opening of the package via the tear strip.
摘要翻译：包含排列成阵列（17）的多个消费品（13）的外包装（1），所述外包装（1）包括柔性片材（19），所述柔性片材（19）以阵列的形状包裹和密封，阵列的形状以保持阵列（17）的布置，以及容纳在外包装（1）的单个面内的容易打开的撕条（21），并且包括以顺序对（3）排列的撕裂区域，每对中的区域（3）在撕裂方向上相互发散，分隔开与撕条（21）相对应的间隙，由此在通过撕裂带打开包装件之后保持阵列（17）的布置。

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