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1. 发明申请

WO2010098988A2 TEMPERATURE AND FLOW CONTROL OF EXHAUST GAS FOR THERMOELECTRIC UNITS 审中-公开
标题翻译：热电单元废气的温度和流量控制
公开(公告)号：WO2010098988A2
公开(公告)日：2010-09-02
申请号：PCT/US2010023993
申请日：2010-02-12
申请人： EMCON TECHNOLOGIES LLC , ARBUCKLE IVAN , ABRAM KWIN , CALLAHAN JOSEPH E , VIRTUE MICHAEL D , EGAN JAMES , WILLATS ROBIN , KEESSER THORSTEN
发明人： ARBUCKLE IVAN , ABRAM KWIN , CALLAHAN JOSEPH E , VIRTUE MICHAEL D , EGAN JAMES , WILLATS ROBIN , KEESSER THORSTEN
IPC分类号： F01N3/26 , F01N3/10
CPC分类号： H01L35/30 , F01N5/025 , F01N2410/02 , Y02T10/16
摘要： A vehicle exhaust system includes an exhaust pipe that provides heated exhaust gases to a thermoelectric unit as an input. A temperature control mechanism ensures that exhaust gas is directed into the thermoelectric unit only if the exhaust gas is within a specified temperature range. The thermoelectric unit transforms the exhaust gas heat into electrical power.
摘要翻译：车辆排气系统包括排气管，排气管将热排气提供给热电单元作为输入。温度控制机构确保只有当排气处于特定温度范围内时才将废气引入热电单元。热电单元将废气热量转化为电力。

2. 发明申请

WO2009067430A3 EXHAUST VALVE ASSEMBLY 审中-公开
标题翻译：排气阀总成
公开(公告)号：WO2009067430A3
公开(公告)日：2009-07-23
申请号：PCT/US2008083866
申请日：2008-11-18
申请人： EMCON TECHNOLOGIES LLC , ABRAM KWIN , KALYANASAMY GOVINDARAJ , CALLAHAN JOSEPH , WILLATS ROBIN , ARBUCKLE IVAN , ISKENDEROVA KAMILLA , EGAN JAMES , SHAW DENNIS
发明人： ABRAM KWIN , KALYANASAMY GOVINDARAJ , CALLAHAN JOSEPH , WILLATS ROBIN , ARBUCKLE IVAN , ISKENDEROVA KAMILLA , EGAN JAMES , SHAW DENNIS
IPC分类号： F02D9/04 , F01N7/00 , F01N7/08 , F02D9/10
CPC分类号： F01N13/08 , F01N1/166 , F01N13/02 , F01N2240/36 , F02D9/04 , F02D9/103 , F02D9/104 , F02D9/1065
摘要： A vehicle exhaust system includes various exhaust components. A passive valve assembly is associated with at least one of the exhaust components. The passive valve is spring biased toward a closed position and is movable toward an open position in response to an increase in exhaust pressure that exceeds a biasing force of the spring. One aspect of the invention relates to a location of the passive valve in relation to other exhaust system components. Another aspect of the invention relates to the passive valve in combination with a packed resonator. Another aspect of the invention relates to the passive valve including a stop pad that facilitates noise reduction while also improving valve performance and durability. Another aspect of the invention relates to using the passive valve in a non-bypass configuration with a high percentage of coverage when in a closed position. Another aspect of the invention relates to providing an offset passive valve configuration in the vehicle exhaust system.
摘要翻译：车辆排气系统包括各种排气部件。被动阀组件与至少一个排气部件相关联。被动阀门响应于超过弹簧的偏压力的排气压力的增加而被弹簧偏压向关闭位置并且可朝着打开位置移动。本发明的一个方面涉及被动阀相对于其他排气系统部件的位置。本发明的另一方面涉及与压缩谐振器组合的被动阀。本发明的另一方面涉及被动阀，其包括便于降低噪音同时还改善阀性能和耐用性的停止垫。本发明的另一方面涉及当处于关闭位置时使用具有高百分比覆盖率的非旁路配置的被动阀。本发明的另一方面涉及在车辆排气系统中提供偏置被动阀构造。

3. 发明申请

WO2012037551A3 PRIMARY CELL-DERIVED BIOLOGIC AND WT1 SYNTHETIC LONG PEPTIDE VACCINE 审中-公开
标题翻译：主要细胞衍生生物学和WT1合成长肽疫苗
公开(公告)号：WO2012037551A3
公开(公告)日：2012-07-12
申请号：PCT/US2011052139
申请日：2011-09-19
申请人： IRX THERAPEUTICS INC , BERINSTEIN NEIL , NAYLOR PAUL , EGAN JAMES
发明人： BERINSTEIN NEIL , NAYLOR PAUL , EGAN JAMES
IPC分类号： A61K45/00 , A61K39/00
CPC分类号： A61K38/20 , A61K38/162 , A61K38/191 , A61K38/193 , A61K38/217 , A61K39/0011 , A61K45/06 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55566 , A61K2300/00 , A61K38/1764
摘要： A composition for treating cancer or other disease of a primary cell-derived biologic including the cytokines IL-1, IL-2, IL-6, IL-8, TNF-a, and IFN-?, and a synthetic long peptide of a tumor associated antigen. A composition for treating cancer, including a synthetic long peptide vaccine to a tumor associated antigen. Therapeutic vaccines for cancer or other disease. A method of treating cancer or other disease by activating Tc effector cells, activating Th effector cells, and promoting antigen presenting cells differentiation, maturation and antigen presentation. A method of reversing immune suppression and gaining immunity to cancer. A method of treating cancer, by administering an effective amount of a synthetic long peptide of a tumor associated antigen.
摘要翻译：用于治疗包括细胞因子IL-1，IL-2，IL-6，IL-8，TNF-α和IFN-γ的原代细胞衍生生物学的癌症或其它疾病的组合物，以及合成的长肽肿瘤相关抗原。用于治疗癌症的组合物，包括对肿瘤相关抗原的合成长肽疫苗。癌症或其他疾病的治疗性疫苗。通过激活Tc效应细胞，激活Th效应细胞和促进抗原呈递细胞分化，成熟和抗原呈递来治疗癌症或其它疾病的方法。逆转免疫抑制和获得癌症免疫力的方法。通过施用有效量的肿瘤相关抗原的合成长肽来治疗癌症的方法。

4. 发明申请

WO2008014220A2 VACCINE IMMUNOTHERAPY 审中-公开
标题翻译：疫苗免疫治疗
公开(公告)号：WO2008014220A2
公开(公告)日：2008-01-31
申请号：PCT/US2007074156
申请日：2007-07-24
申请人： IRX THERAPEUTICS INC , HADDEN JOHN W , SIGNORELLI KATHY , EGAN JAMES
发明人： HADDEN JOHN W , SIGNORELLI KATHY , EGAN JAMES
IPC分类号： A61K38/21 , A61K38/19 , A61K38/20
CPC分类号： A61K39/0011 , A61K38/191 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/217 , A61K2300/00
摘要： The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at (east one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-? (gamma) and TNF-a (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.
摘要翻译：本发明提供了用于治疗癌症或其他抗原生成疾病或损伤的免疫疗法的组合物和方法。根据本发明的一个实施方案，提供了一种组合物，用于引发针对患有产生抗原的疾病或损伤的患者中（至少一种抗原）的免疫应答，所述组合物包含有效量的细胞因子混合物，优选包含IL- 1，IL-2，IL-6，IL-8，IFN-γ（γ）和TNF-αα。细胞因子混合物作为与产生抗原的疾病或病变相关的抗原的佐剂来增强因此还提供了用于利用本发明的细胞因子混合物在患有抗原生成疾病或损伤的患者中引发针对至少一种抗原的免疫应答的方法，所述组合物和方法可用于治疗产生抗原的疾病如癌症，感染性疾病或持续性病变。

5. 发明申请

WO2006037028A2 METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES, PESTIVIRUSES AND HEPACIVIRUS 审中-公开
标题翻译：用于治疗感染病毒，杀虫剂和肝炎病毒的方法和组合物
公开(公告)号：WO2006037028A2
公开(公告)日：2006-04-06
申请号：PCT/US2005034786
申请日：2005-09-26
申请人： IDENIX CAYMAN LTD , CENTRE NAT RECH SCIENT , SOMMADOSSI JEAN-PIERRE , GOSSELIN GILLES , STORER RICHARD , EGAN JAMES
发明人： SOMMADOSSI JEAN-PIERRE , GOSSELIN GILLES , STORER RICHARD , EGAN JAMES
IPC分类号： A61K36/18 , A61K31/7076
CPC分类号： A61K45/06 , A61K31/7076 , A61K36/00 , C07H19/00 , C07H19/048 , A61K2300/00
摘要： A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译：提供用于治疗感染黄病毒，瘟病毒或肝炎病毒的宿主的方法和组合物，其包括施用有效的黄病毒，瘟病毒或肝炎病毒处理量的所述碱基修饰的核苷或其药学上可接受的盐或前药。

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