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1. 发明申请

WO2005003295A3 METHODS AND COMPOSITIONS FOR MATURING DENDRITIC CELLS UTILIZING INOSINE-CONTAINING COMPOUNDS 审中-公开
标题翻译：利用含肌苷的化合物使树突细胞成熟的方法和组合物
公开(公告)号：WO2005003295A3
公开(公告)日：2005-09-29
申请号：PCT/US2004013141
申请日：2004-04-27
申请人： IRX THERAPEUTICS INC , SIGNORELLI KATHY L , EGAN JAMES E , SANTIAGO-SCHWARZ FRANCES
发明人： SIGNORELLI KATHY L , EGAN JAMES E , SANTIAGO-SCHWARZ FRANCES
IPC分类号： A61K39/145 , A61K39/39 , A61K45/00 , A61K47/00 , A61K48/00 , C07H19/048 , C12N20060101 , C12N5/0784
CPC分类号： A61K39/39 , A61K31/70 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5252 , A61K2039/55561 , C12N5/0639 , C12N2500/40 , C12N2501/22 , C12N2501/23 , C12N2760/16134
摘要： A method of stimulating in vivo or ex vivo maturation of dendritic cells by applying an effective amount of inosine-containing compounds to the dendritic cells. The maturation of dendritic cells leads to more robust cellular immune responses against antigens including those associated with vaccines, infectious agents, and tumor cells by enhancing the stimulatory activity of dendritic cells toward T cells. An in vivo or ex vivo method of treating diseases in a subject by applying an effective amount of an inosine-containing compound to the dendritic cells to stimulate maturation thereof; and administering matured dendritic cells into the subject. A method of enhancing the immune response of a host mammal by isolating immature dendritic cells from a donor mammal; maturing the immature dendritic cells in the presence of an inosine-containing compound ex vivo; and administering the mature dendritic cells to a host mammal in an amount effective to enhance the immune response of the host mammal. A method of maturing dendritic cells in vivo or ex vivo in the presence of an inosine-containing compound, which results in increasing the stimulation of T cells in response to an antigen. A method of enhancing the immunological response to vaccine antigens by inclusion of an inosine-containing compound. A composition for in vivo or ex vivo maturation of dendritic cells including an inosine-containing compound, wherein one possible form of the inosine-containing compound is an IpR oligonucleotide molecule. Compositions, pharmaceutical composition, adjuvants, immunostimulants, and kits for maturing dendritic cells in vivo or ex vivo including an inosine-containing compound.
摘要翻译：通过将有效量的含肌苷的化合物应用于树突细胞来刺激树突细胞的体内或离体成熟的方法。通过增强树突细胞对T细胞的刺激活性，树突细胞的成熟导致对包括与疫苗，感染因子和肿瘤细胞相关的抗原在内的抗原的更强大的细胞免疫应答。通过将有效量的含肌苷的化合物应用于树突细胞以刺激其成熟来治疗受试者疾病的体内或离体方法; 并将成熟的树突细胞施用于受试者。通过从供体哺乳动物中分离未成熟的树突细胞来增强宿主哺乳动物的免疫应答的方法; 在含有肌苷的化合物存在下体外成熟未成熟的树突细胞; 和以有效增强宿主哺乳动物免疫应答的量将成熟树突细胞施用给宿主哺乳动物。一种在存在含肌苷的化合物的情况下体内或离体成熟树突细胞的方法，其导致T细胞响应于抗原的刺激增加。通过包含含肌苷的化合物增强对疫苗抗原的免疫应答的方法。用于体内或体外成熟树突细胞的组合物，包括含肌苷的化合物，其中所述含肌苷的化合物的一种可能形式是IpR寡核苷酸分子。用于体内或离体成熟树突细胞的组合物，药物组合物，佐剂，免疫刺激剂和试剂盒，包括含肌苷的化合物。

2. 发明申请

WO2005003295A2 METHODS AND COMPOSITIONS FOR MATURING DENDRITIC CELLS UTILIZING INOSINE-CONTAINING COMPOUNDS 审中-公开
标题翻译：使用含有异辛烯的化合物制备感染细胞的方法和组合物
公开(公告)号：WO2005003295A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/013141
申请日：2004-04-27
申请人： IRx THERAPEUTICS, INC. , SIGNORELLI, Kathy, L. , EGAN, James, E. , SANTIAGO-SCHWARZ, Frances
发明人： SIGNORELLI, Kathy, L. , EGAN, James, E. , SANTIAGO-SCHWARZ, Frances
IPC分类号： C12N
CPC分类号： A61K39/39 , A61K31/70 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5252 , A61K2039/55561 , C12N5/0639 , C12N2500/40 , C12N2501/22 , C12N2501/23 , C12N2760/16134
摘要： A method of stimulating in vivo or ex vivo maturation of dendritic cells by applying an effective amount of inosine-containing compounds to the dendritic cells. The maturation of dendritic cells leads to more robust cellular immune responses against antigens including those associated with vaccines, infectious agents, and tumor cells by enhancing the stimulatory activity of dendritic cells toward T cells. An in vivo or ex vivo method of treating diseases in a subject by applying an effective amount of an inosine-containing compound to the dendritic cells to stimulate maturation thereof; and administering matured dendritic cells into the subject. A method of enhancing the immune response of a host mammal by isolating immature dendritic cells from a donor mammal; maturing the immature dendritic cells in the presence of an inosine-containing compound ex vivo; and administering the mature dendritic cells to a host mammal in an amount effective to enhance the immune response of the host mammal. A method of maturing dendritic cells in vivo or ex vivo in the presence of an inosine-containing compound, which results in increasing the stimulation of T cells in response to an antigen. A method of enhancing the immunological response to vaccine antigens by inclusion of an inosine-containing compound. A composition for in vivo or ex vivo maturation of dendritic cells including an inosine-containing compound, wherein one possible form of the inosine-containing compound is an IpR oligonucleotide molecule. Compositions, pharmaceutical composition, adjuvants, immunostimulants, and kits for maturing dendritic cells in vivo or ex vivo including an inosine-containing compound.
摘要翻译：通过将有效量的含有肌苷的化合物施用于树突细胞来刺激树突细胞的体内或体外成熟的方法。树突状细胞的成熟通过增强树突细胞对T细胞的刺激活性而导致针对抗原的更强健的细胞免疫应答，包括与疫苗，感染因子和肿瘤细胞相关的细胞免疫应答。一种通过将有效量的含有肌苷的化合物施用于树突状细胞以刺激其成熟来治疗受试者疾病的体内或离体方法; 并将成熟的树突细胞施用于受试者。一种通过从供体哺乳动物分离未成熟树突状细胞来增强宿主哺乳动物的免疫应答的方法; 在离体含有肌苷的化合物存在下成熟未成熟树突状细胞; 以及以有效增强宿主哺乳动物的免疫应答的量将成熟树突状细胞给予宿主哺乳动物。在含有肌苷的化合物的存在下体内或离体成熟树突状细胞的方法，其导致增加对抗原的T细胞的刺激。通过包含含有肌苷的化合物增强对疫苗抗原的免疫应答的方法。用于体内或体外成熟树突状细胞的组合物，包括含有肌苷的化合物，其中一种可能形式的含有肌苷的化合物是IpR寡核苷酸分子。组合物，药物组合物，佐剂，免疫刺激剂和用于体内或体外成熟树突状细胞的试剂盒，包括含有肌苷的化合物。

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