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1. 发明申请

WO2008080030A3 CARDIOVASCULAR AUTOIMMUNE DISEASE PANEL AND METHODS OF USING SAME 审中-公开
公开(公告)号：WO2008080030A3
公开(公告)日：2008-07-03
申请号：PCT/US2007/088477
申请日：2007-12-21
申请人： ABBOTT LABORATORIES , MATTINGLY, Phillip, G. , ADAMCZYK, Maciej, B. , BRASHEAR, Roy Jeffrey , DOSS, Robert, C.
发明人： MATTINGLY, Phillip, G. , ADAMCZYK, Maciej, B. , BRASHEAR, Roy Jeffrey , DOSS, Robert, C.
IPC分类号： G01N33/53 , G01N33/49
摘要： Provided herein among other things are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed among other things to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease. The method can be employed for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease, but may with time. In one embodiment, the invention also provides a method of determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

2. 发明申请

WO2007059065A2 DIAGNOSTIC METHOD FOR PROTEINACEOUS BINDING PAIRS, CARDIOVASCULAR CONDITIONS AND PREECLAMPSIA 审中-公开
标题翻译：蛋白质结合对，心血管病和前列腺疾病的诊断方法
公开(公告)号：WO2007059065A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/044059
申请日：2006-11-14
申请人： ABBOTT LABORATORIES , SOGIN, David, C. , LAIRD, Donald, M. , YU, Zhiguang , DOSS, Robert, C.
发明人： SOGIN, David, C. , LAIRD, Donald, M. , YU, Zhiguang , DOSS, Robert, C.
IPC分类号： G01N33/566 , G01N33/74 , G01N33/53 , G01N33/50
CPC分类号： G01N33/566 , G01N33/689 , G01N33/74 , G01N2800/368
摘要： Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.
摘要翻译：测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp 是抗体或其片段，其优选是测定样品中sFlt-1，特别是游离sFlt-1的量和PlGF，尤其是游离PlGF的量的方法，其优选用于预测先兆子痫的风险包括将游离PlGF与游离sFlt-1进行比较。

3. 发明申请

WO2008051761A2 ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES 审中-公开
标题翻译： CARDIAC TROPONIN AUTOANTIBODIES的测定
公开(公告)号：WO2008051761A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/081606
申请日：2007-10-17
申请人： ABBOTT LABORATORIES , MATTINGLY, Phillip G , ADAMCZYK, Maciej , BRASHEAR, Roy Jeffrey , DOSS, Robert C
发明人： MATTINGLY, Phillip G , ADAMCZYK, Maciej , BRASHEAR, Roy Jeffrey , DOSS, Robert C
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/54326 , G01N33/564 , G01N2800/324 , G01N2800/325 , Y10T436/10 , Y10T436/101666 , Y10T436/25125
摘要： The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.
摘要翻译：本发明尤其提供基于测定心肌肌钙蛋白自身抗体的方法和试剂盒，或者结合心肌肌钙蛋白的测定和/或作为心脏病理学的独立指示物，例如心肌炎，心肌病和/或缺血性心脏病。本发明的测定方法尤其可用于鉴定患有自身免疫性疾病或与患有自身免疫性疾病的个体相关的个体的心脏病理学或其风险。在具体的实施方案中，本发明还提供了确定患有心脏病理学或处于心脏病理学危险中的受试者是否是免疫抑制疗法或免疫吸收疗法的候选者的方法。本发明还提供对于实施本发明的方法有用的试剂盒和试剂盒组分。

4. 发明申请

WO2009085883A1 THE ACCURACY OF MYELOPEROXIDASE ASSAYS AND THE DETECTION OF MYELOPEROXIDASE AUTOANTIBODIES 审中-公开
标题翻译：甲氧氯丙酸酶测定的准确性和检测肌醇四氧化酶自身抗体
公开(公告)号：WO2009085883A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087306
申请日：2008-12-18
申请人： ABBOTT LABORATORIES , ADAMCZYK, Maciej B. , DOSS, Robert C. , MATTINGLY, Phillip G.
发明人： ADAMCZYK, Maciej B. , DOSS, Robert C. , MATTINGLY, Phillip G.
IPC分类号： C12Q1/28 , G01N33/564 , G01N33/573
CPC分类号： C12Q1/28 , G01N33/564 , G01N33/573 , G01N2333/908
摘要： The present disclosure relates to methods and kits for determining autoantibodies to myeloperoxidase or a myeloperoxidase fragment and myeloperoxidase or a myeloperoxidase fragment in a test sample. The presence of said autoantibodies in the test sample negatively affects the accuracy of the myeloperoxidase assay. The reliability of the assay is evaluated by comparing myeloperoxidase activity and mass in the sample.
摘要翻译：本公开涉及用于在测试样品中测定髓过氧化物酶或髓过氧化物酶片段和髓过氧化物酶或髓过氧化物酶片段的自身抗体的方法和试剂盒。测试样品中所述自身抗体的存在对髓过氧化物酶测定的准确性产生不利影响。通过比较样品中的髓过氧化物酶活性和质量来评估测定的可靠性。

5. 发明申请

WO2008080030A2 CARDIOVASCULAR AUTOIMMUNE DISEASE PANEL AND METHODS OF USING SAME 审中-公开
标题翻译：心血管自动免疫疾病小组及其使用方法
公开(公告)号：WO2008080030A2
公开(公告)日：2008-07-03
申请号：PCT/US2007088477
申请日：2007-12-21
申请人： ABBOTT LAB , MATTINGLY PHILLIP G , ADAMCZYK MACIEJ B , BRASHEAR ROY JEFFREY , DOSS ROBERT C
发明人： MATTINGLY PHILLIP G , ADAMCZYK MACIEJ B , BRASHEAR ROY JEFFREY , DOSS ROBERT C
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/32
摘要： Provided herein among other things are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed among other things to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease. The method can be employed for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease, but may with time. In one embodiment, the invention also provides a method of determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.
摘要翻译：除此之外，本文提供了诊断测试，使用方法以及用于评估和管理心血管自身免疫疾病和心血管自身免疫疾病风险的试剂盒。本发明的测定方法尤其可用于鉴定患有心血管疾病，自身免疫性疾病或与患有自身免疫性疾病的个体有关的个体的心血管自身免疫疾病或其风险。该方法可用于测试表现出心血管疾病症状的受试者以及明显健康并且尚未表现出心血管疾病症状但可能随时间变化的受试者。在一个实施方案中，本发明还提供了确定患有心血管疾病或处于心血管疾病风险中的受试者是否是用于免疫抑制疗法或免疫吸收疗法的候选者的方法。本发明还提供对于实施本发明的方法有用的试剂盒和试剂盒组分。

6. 发明申请

WO2007059065B1 DIAGNOSTIC METHOD FOR PROTEINACEOUS BINDING PAIRS, CARDIOVASCULAR CONDITIONS AND PREECLAMPSIA 审中-公开
标题翻译：蛋白质结合对照，心血管病和前列腺炎的诊断方法
公开(公告)号：WO2007059065B1
公开(公告)日：2007-09-13
申请号：PCT/US2006044059
申请日：2006-11-14
申请人： ABBOTT LAB , SOGIN DAVID C , LAIRD DONALD M , YU ZHIGUANG , DOSS ROBERT C
发明人： SOGIN DAVID C , LAIRD DONALD M , YU ZHIGUANG , DOSS ROBERT C
IPC分类号： G01N33/566 , G01N33/50 , G01N33/53 , G01N33/68 , G01N33/74
CPC分类号： G01N33/566 , G01N33/689 , G01N33/74 , G01N2800/368
摘要： Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.
摘要翻译：测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp都不是抗体或其片段，其中优选地是测定样品中sFlt-1的量，特别是游离的sFlt-1以及PlGF的量，特别是游离PlGF的量，其优选用于预测先兆子痫风险的方法中，其包括将游离PlGF与免费sFlt-1。

7. 发明申请

WO2011116023A1 METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS 审中-公开
标题翻译：在患有CADAVERIC KIDNEY移植物功能的患者中，包括用延迟的功能（DGF）诊断的患者，在A中检测眼睛的方法，用于测定尿中性细胞凝集素LIPOCALIN（uNGAL）的方法
公开(公告)号：WO2011116023A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028562
申请日：2011-03-15
申请人： ABBOTT LABORATORIES , DOSS, Robert C. , HEBBAR, Sudarshan
发明人： DOSS, Robert C. , HEBBAR, Sudarshan
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/245 , G01N2800/50
摘要： A method of prognosticating cadaveric kidney transplant function in a patient; a method of prognosticating cadaveric kidney transplant function in a patient diagnosed with DGF; a method of assessing risk of DGF in a patient, who has been diagnosed with EGF; and a kit comprising at least one component for assaying urine from a patient for NGAL and instructions for assaying the urine for NGAL and assessing cadaveric kidney transplant function or risk of DGF in the patient.
摘要翻译：一种预测患者尸体移植肾功能的方法; 在诊断为DGF的患者中预测尸体肾移植功能的方法; 评估患有EGF的患者DGF风险的方法; 以及包含至少一种用于测定来自患者的尿液的NGAL的试剂盒和用于测定尿液用于NGAL的指导并评估患者的尸体肾移植功能或DGF的风险的试剂盒。

8. 发明申请

WO2008051761A3 ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES 审中-公开
标题翻译： CARDIAC TROPONIN AUTOANTIBODIES的测定
公开(公告)号：WO2008051761A3
公开(公告)日：2008-11-13
申请号：PCT/US2007081606
申请日：2007-10-17
申请人： ABBOTT LAB , MATTINGLY PHILLIP G , ADAMCZYK MACIEJ , BRASHEAR ROY JEFFREY , DOSS ROBERT C
发明人： MATTINGLY PHILLIP G , ADAMCZYK MACIEJ , BRASHEAR ROY JEFFREY , DOSS ROBERT C
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/54326 , G01N33/564 , G01N2800/324 , G01N2800/325 , Y10T436/10 , Y10T436/101666 , Y10T436/25125
摘要： The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.
摘要翻译：本发明还提供了基于心肌肌钙蛋白自身抗体测定的方法和试剂盒，其与心肌肌钙蛋白的测定和/或作为心脏病理学的独立指标，例如心肌炎，心肌病和/或缺血性心脏病。本发明的测定方法可以用于鉴别患有自身免疫疾病或与具有自身免疫疾病的个体相关的受试者的心脏病理学或其风险。在具体实施方案中，本发明还提供了确定具有或具有心脏病理危险的受试者是免疫抑制治疗或免疫吸收治疗的候选者的方法。本发明还提供了可用于实施本发明方法的试剂盒和试剂盒组分。

9. 发明申请

WO2007059065A3 DIAGNOSTIC METHOD FOR PROTEINACEOUS BINDING PAIRS, CARDIOVASCULAR CONDITIONS AND PREECLAMPSIA 审中-公开
标题翻译：蛋白质结合对，心血管病和前列腺疾病的诊断方法
公开(公告)号：WO2007059065A3
公开(公告)日：2007-07-26
申请号：PCT/US2006044059
申请日：2006-11-14
申请人： ABBOTT LAB , SOGIN DAVID C , LAIRD DONALD M , YU ZHIGUANG , DOSS ROBERT C
发明人： SOGIN DAVID C , LAIRD DONALD M , YU ZHIGUANG , DOSS ROBERT C
IPC分类号： G01N33/566 , G01N33/50 , G01N33/53 , G01N33/68 , G01N33/74
CPC分类号： G01N33/566 , G01N33/689 , G01N33/74 , G01N2800/368
摘要： Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.
摘要翻译：测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp都不是抗体或其片段，其优选是确定优选用于预测先兆子痫风险的方法中的样品中sFlt-1，特别是游离sFlt-1的量和PlGF，尤其是游离PlGF的量的方法，其包括将游离PlGF与免费sFlt-1。

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