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1. 发明申请

WO2009131719A1 FLOW SENSOR CONTROLLED INFUSION DEVICE 审中-公开
标题翻译：流量传感器控制输液装置
公开(公告)号：WO2009131719A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/030837
申请日：2009-01-13
申请人： MEDTRONIC, INC. , SEELEY, Dale F. , DENISON, Timothy J.
发明人： SEELEY, Dale F. , DENISON, Timothy J.
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/16804
摘要： An implantable infusion device includes an outlet and a reservoir. A flow path in fluid communication with the reservoir and the outlet includes a pressure regulator and a flow restrictor. The pressure regulator includes a major chamber and a diaphragm that divides the major chamber into first and second minor chambers. The flow restrictor is in fluid communication with the first and second minor chambers of the pressure regulator and is disposed downstream of the first minor chamber and upstream of the second minor chamber. The device also includes a processor coupled to a flow sensor to detect information regarding flow rate of the fluid downstream of the flow restrictor and a pressure adjustment actuator assembly. The processor provides regulates the flow of the fluid by adjusting the pressure in the first minor chamber relative to pressure in the second minor chamber based on the information from the sensor.
摘要翻译：植入式输注装置包括出口和储存器。与储存器和出口流体连通的流路包括压力调节器和限流器。压力调节器包括主室和隔膜，其将主室分成第一和第二小室。限流器与压力调节器的第一和第二小室流体连通并且设置在第一小室的下游和第二小室的上游。该装置还包括耦合到流量传感器的处理器，以检测关于限流器下游的流体的流量的信息和压力调节致动器组件。处理器基于来自传感器的信息，通过相对于第二小室中的压力调节第一小室中的压力来调节流体的流动。

2. 发明申请

WO2013028680A2 METHOD AND APPARATUS FOR DETECTING A BIOMARKER IN THE PRESENCE OF ELECTRICAL STIMULATION 审中-公开
标题翻译：在存在电刺激下检测生物标志物的方法和设备
公开(公告)号：WO2013028680A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/051705
申请日：2012-08-21
申请人： MEDTRONIC, INC. , CARLSON, David L. , AFSHAR, Pedram , DENISON, Timothy J. , GIFTAKIS, Jonathon E. , LINDE, David E. , STANSLASKI, Scott R.
发明人： CARLSON, David L. , AFSHAR, Pedram , DENISON, Timothy J. , GIFTAKIS, Jonathon E. , LINDE, David E. , STANSLASKI, Scott R.
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.
摘要翻译：各种实施方案涉及在存在电刺激的情况下鉴定生物标志物。各种实施例涉及在电刺激正被递送的同时向患者递送电刺激并且感测一个或多个信号，所述一个或多个信号包括指示生理活动的数据。各种实施例还包括确定电刺激的强度并且基于可变阈值确定数据是否指示生物标志物的存在，可变阈值基于电刺激的强度是可变的。各种实施例涉及确定刺激强度与生物标志物参数之间的关系以确定可变阈值的可变性。

3. 发明申请

WO2011152932A1 IMPLANTABLE MEDICAL PUMP WITH PRESSURE SENSOR 审中-公开
标题翻译：带压力传感器的可植入医用泵
公开(公告)号：WO2011152932A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/034068
申请日：2011-04-27
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
IPC分类号： A61M5/142 , A61M39/02
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2205/3317 , A61M2205/3331 , G01L9/0072 , G01L15/00 , G01L19/0023 , G01L19/0069 , G01L19/086 , G01L19/143 , G01L19/148 , G01L19/149
摘要： The disclosure is directed to a pressure sensor (26) of an implantable medical device (16). The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self - aligning housing shape that occludes an opening in the pump bulkhead (14) of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.
摘要翻译：本公开涉及可植入医疗装置（16）的压力传感器（26）。压力传感器可以利用基于两个电容元件之间的变化的电容的检测流体压力。压力传感器可以限定IMD的流体外壳的至少一部分。在一个示例中，压力传感器具有封闭IMD的泵隔板（14）中的开口的自对准壳体形状。压力的操作表面和流体外壳的一部分可以由耐腐蚀和/或生物相容的材料形成。压力传感器的第一电容元件可以是响应于外部流体压力而偏转的金属合金膜片。压力传感器的第二电容元件可以是通过隔膜和传感器的壳体与流体密封的刚性绝缘体上的金属涂层。

4. 发明申请

WO2009042313A1 CHOPPER-STABILIZED ANALOG-TO-DIGITAL CONVERTER 审中-公开
标题翻译： CHOPPER稳定的模拟数字转换器
公开(公告)号：WO2009042313A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/073458
申请日：2008-08-18
申请人： MEDTRONIC, INC. , DENISON, Timothy J. , HEINKS, Michael W. , ANDERSON, Joel A.
发明人： DENISON, Timothy J. , HEINKS, Michael W. , ANDERSON, Joel A.
IPC分类号： H03M3/02
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

5. 发明申请

WO2011152933A1 CAPACITIVE PRESSURE SENSOR ASSEMBLY 审中-公开
标题翻译：电容式压力传感器总成
公开(公告)号：WO2011152933A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/034071
申请日：2011-04-27
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
IPC分类号： G01L9/00
CPC分类号： G01L9/0072 , G01L19/142 , G01L19/143 , G01L19/147 , H01L2224/48472 , Y10T29/49002 , Y10T29/53265
摘要： The disclosure is directed to a capacitive pressure sensor, and the assembly of a capacitive pressure sensor, that may be used within an implantable medical pump. In one example, a housing ferrule that encloses one capacitive plate and includes at least one protrusion for attaching a support structure of the capacitive plate. The at least one protrusion defines a smaller inner diameter as a reference point for securing the support structure while the ferrule provides a larger inner diameter to allow the support structure to tilt inside the ferrule to orient the capacitive plate into a desired plane. Despite manufacturing irregularities, the capacitive plate can be mounted in the desired plane parallel to another capacitive plate, a diaphragm, mounted to an edge of the ferrule. In another example, an assembly tool provides a stage to orient the capacitive plate and support structure within the ferrule at a desired depth.
摘要翻译：本公开涉及电容式压力传感器以及可在可植入医疗泵内使用的电容式压力传感器的组件。在一个示例中，壳体套圈包围一个电容板并且包括用于附接电容板的支撑结构的至少一个突起。所述至少一个突出部限定较小的内径作为用于固定支撑结构的参考点，同时套圈提供更大的内径以允许支撑结构在套圈内部倾斜以将电容板定向到期望的平面。尽管制造不规则，但是电容板可以安装在平行于另一个电容板的所需平面中，该电容板安装在套圈的边缘上。在另一示例中，组装工具提供了将电容板和支撑结构定位在套圈内的所需深度的阶段。

6. 发明申请

WO2008094271A1 CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER 审中-公开
公开(公告)号：WO2008094271A1
公开(公告)日：2008-08-07
申请号：PCT/US2007/066358
申请日：2007-04-11
申请人： MEDTRONIC, INC. , DENISON, Timothy J.
发明人： DENISON, Timothy J.
IPC分类号： H03F3/38
CPC分类号： H03F3/38 , A61B5/04 , A61B5/053 , A61B5/7203 , A61B5/7217 , A61B5/7225 , A61B5/7228 , A61B5/7242
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

7. 发明申请

WO2010114666A1 HYBRID RECTIFICATION FOR RECHARGING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于补充可植入医疗器械的混合整流器
公开(公告)号：WO2010114666A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/026098
申请日：2010-03-03
申请人： MEDTRONIC, INC. , DINSMOOR, David A. , KALLMYER, Todd A. , ANDERSON, Joel A. , DENISON, Timothy J.
发明人： DINSMOOR, David A. , KALLMYER, Todd A. , ANDERSON, Joel A. , DENISON, Timothy J.
IPC分类号： A61N1/378 , H02M7/04 , H02M7/25 , H02M7/217
CPC分类号： A61N1/3787 , H02J7/025 , H02J50/10
摘要： A charging system is disclosed. In one embodiment, the system includes a charging unit having a primary coil, and an implantable medical device comprising a secondary coil to receive charge from the primary coil. The implantable medical device further includes a half-wave voltage-doubling rectifier coupled to the secondary coil, a full-wave rectifier coupled to the secondary coil, and a rechargeable power source. Control logic is provided to periodically configure the rechargeable power source to receive charge from a selected one of the voltage-doubling circuit and the full-wave rectifier in a manner that increases rate at which charge is transferred from the secondary coil to the rechargeable power source. The control logic may configure the rechargeable power source to receive charge based on one or more monitored conditions which may include an indication of a current, a voltage, a coupling coefficient, back-scatter, and temperature.
摘要翻译：公开了一种充电系统。在一个实施例中，系统包括具有初级线圈的充电单元和包括用于接收来自初级线圈的电荷的次级线圈的可植入医疗装置。可植入医疗装置还包括耦合到次级线圈的半波倍压整流器，耦合到次级线圈的全波整流器和可再充电电源。提供控制逻辑以周期性地配置可再充电电源，以便以增加电荷从次级线圈传递到可再充电电源的速率的方式从所选倍压电路和全波整流器中接收电荷。控制逻辑可以基于一个或多个监视的条件来配置可再充电电源以接收电荷，所述监视条件可以包括电流，电压，耦合系数，反向散射和温度的指示。

8. 发明申请

WO2009114050A1 ALIGNMENT AID FOR A MEDICAL INSTRUMENT IN RELATION TO AN IMPLANTED MEDICAL DEVICE 审中-公开
标题翻译：医疗仪器与植入式医疗器械相关的对齐辅助
公开(公告)号：WO2009114050A1
公开(公告)日：2009-09-17
申请号：PCT/US2008/086076
申请日：2008-12-09
申请人： MEDTRONIC, INC. , HOENDERVOOGT, Jason J. , DENISON, Timothy J. , KALLMYER, Todd A. , KALPIN, Scott L. , SARKINEN, Scott A.
发明人： HOENDERVOOGT, Jason J. , DENISON, Timothy J. , KALLMYER, Todd A. , KALPIN, Scott L. , SARKINEN, Scott A.
IPC分类号： A61M5/142 , A61M5/42
CPC分类号： A61M5/14276 , A61M5/427 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3515 , A61M2205/3523 , A61M2209/045
摘要： Systems and methods for orienting a medical instrument relative to at least a portion of a medical device include a first tilt detector (62) associated with the medical instrument and a second tilt detector (58) associated with the medical device (12). The first tilt detector may be within an orientation device (60) that is coupled to or separate from the medical instrument. The tilt detectors generate signals that may be used to determine the relative orientation between at least a portion of the medical device and medical instrument. For example, in some embodiments, the signals may be used to determine whether the orientations of the refill port of an implantable medical device and the medical instrument substantially match.
摘要翻译：用于使医疗器械相对于医疗装置的至少一部分定向的系统和方法包括与医疗器械相关联的第一倾斜检测器（62）和与医疗装置（12）相关联的第二倾斜检测器（58）。第一倾斜检测器可以在与医疗器械联接或分离的取向装置（60）内。倾斜检测器产生可用于确定医疗装置的至少一部分与医疗器械之间的相对取向的信号。例如，在一些实施例中，信号可以用于确定可植入医疗装置的再充填端口和医疗器械的取向是否基本匹配。

9. 发明申请

WO2009055579A1 CLOSED LOOP LONG RANGE RECHARGING 审中-公开
标题翻译：关闭环路长期收紧
公开(公告)号：WO2009055579A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/080975
申请日：2008-10-23
申请人： MEDTRONIC, INC. , WAHLSTRAND, Carl D. , KAST, John E. , DENISON, Timothy J. , GREVIOUS, John J. , KALLMYER, Todd A.
发明人： WAHLSTRAND, Carl D. , KAST, John E. , DENISON, Timothy J. , GREVIOUS, John J. , KALLMYER, Todd A.
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/37229
摘要： A charging system for an implantable medical device having a secondary coil. The charging system includes an external power source having at least one primary coil, a modulation circuit operatively coupled to the primary coil and capable of driving it in a manner characterized by a charging parameter, and a sensor in communication with the modulation circuit and capable of sensing a condition indicating a need to adjust the charging parameter during a charging process. The parameter may be varied so that data sensed by the sensor meets a threshold requirement, which may be based on a patient preference, a government regulation, a recommendation promulgated by a health authority and/or a requirement associated with another device carried by the patient. In one embodiment, the regulation dictates maximum magnetic field exposure, and a field limiting circuit is employed to adjust the charging process.
摘要翻译：一种具有次级线圈的可植入医疗装置的充电系统。充电系统包括具有至少一个初级线圈的外部电源，可操作地耦合到初级线圈并且能够以特征在于充电参数的方式驱动它的调制电路，以及与调制电路通信的传感器，并且能够感测在充电过程中指示需要调整充电参数的条件。该参数可以变化，使得由传感器感测的数据满足阈值要求，其可以基于患者偏好，政府法规，卫生当局颁布的建议和/或与患者携带的另一装置相关联的要求。在一个实施例中，调节规定了最大磁场曝光，并且采用场限制电路来调节充电过程。

10. 发明申请

WO2010123907A1 BLADDER SENSING USING IMPEDANCE AND POSTURE 审中-公开
标题翻译：使用阻力和姿态进行刮板感应
公开(公告)号：WO2010123907A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031760
申请日：2010-04-20
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , DENISON, Timothy J.
IPC分类号： A61N1/36 , A61B5/03
CPC分类号： A61N1/36007 , A61B5/053 , A61B5/1116 , A61B5/204 , A61B5/686 , A61B5/6883 , A61B5/7203 , A61B2560/0462 , A61B2562/0219
摘要： This disclosure provides techniques for bladder sensing. In accordance with the techniques described in this disclosure, a device may measure the impedance of a bladder, determine the posture of a patient, and determine a status of the bladder based on the impedance and posture.
摘要翻译：本公开提供了用于膀胱感测的技术。根据本公开中描述的技术，装置可以测量膀胱的阻抗，确定患者的姿势，并且基于阻抗和姿势来确定膀胱的状态。

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