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1. 发明申请

WO2003066852A3 PLANT GROWTH MODULATION BY DRL1 AND OTHER PROTEINS OF THE ELONGATOR COMPLEX 审中-公开
公开(公告)号：WO2003066852A3
公开(公告)日：2003-08-14
申请号：PCT/EP2003/001287
申请日：2003-02-07
申请人： VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW , UNIVERSITEIT GENT , NELISSEN, Hilde , DE VEYLDER, Lieven , CLARKE, Jonathan , INZÉ, Dirk , VAN LIJSEBETTENS, Maria
发明人： NELISSEN, Hilde , DE VEYLDER, Lieven , CLARKE, Jonathan , INZÉ, Dirk , VAN LIJSEBETTENS, Maria
IPC分类号： C12N15/82
摘要： The present invention relates to the use of one or more genes, encoding a protein of the elongator complex to modulate plant growth. More specifically, the invention relates to the overexpression of the DRL1 gene, to stimulate growth of leaves and roots.

2. 发明申请

WO2003018818A2 METHOD AND MEANS FOR MODULATING PLANT CELL CYCLE PROTEINS AND THEIR USE IN PLANT CELL GROWTH CONTROL 审中-公开
标题翻译：调节植物细胞周期蛋白的方法和手段及其在植物细胞生长控制中的应用
公开(公告)号：WO2003018818A2
公开(公告)日：2003-03-06
申请号：PCT/EP2002/009504
申请日：2002-08-17
申请人： CROPDESIGN N.V. , DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , SEGERS, Gerda
发明人： DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , SEGERS, Gerda
IPC分类号： C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention relates to modulation of endoreduplication in a plant or part thereof which may be achieved by modifying expression or activity of E2F or E2F in combination with DP.Modulation of endoreduplication has an advantageous influence on plant cell size and storage capacity of plant cells.
摘要翻译：本发明涉及通过改变E2F或E2F与DP组合的表达或活性来实现的植物或其部分中的内切复制的调节。内切复制的调节对植物细胞的大小和储存能力具有有利影响。

3. 发明申请

WO02053589A3 NUCLEIC ACID MOLECULES ENCODING DIM INTERACTORS AND USES THEREFOR 审中-公开
标题翻译：编码DIM相互作用的核酸分子及其用途
公开(公告)号：WO02053589A3
公开(公告)日：2002-11-07
申请号：PCT/EP0200073
申请日：2002-01-07
申请人： CROPDESIGN NV , DE VEYLDER LIEVEN , BOUDOLF VERONIQUE KATELIJNE CE , INZE DIRK , FRANKARD VALERIE MARIE-NOELLE , TERRAS FRANKY
发明人： DE VEYLDER LIEVEN , BOUDOLF VERONIQUE KATELIJNE CE , INZE DIRK , FRANKARD VALERIE MARIE-NOELLE , TERRAS FRANKY
IPC分类号： C07K14/415 , C12N15/82 , C07K16/16 , C12N5/10 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8271 , C12N15/8279 , Y02A40/146
摘要： The invention provides isolated nucleic acids molecules, designated DIM1 interacting molecules (DIMIC) molecules, which encode novel cell cycle associated polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DIMIC nucleic acid molecules, host cells into which the expression vectors have been introduced, and transgenic plants in which a DIMIC gene has been introduced or disrupted. The invention still further provides isolated DIMIC proteins, fusion proteins, antigenic peptides and anti-DIMIC antibodies. Agricultural, and screening methods utilizing molecules and compositions of the invention are also provided. The invention further provides methods for modulating overall growth and yield in a plant, enhancing stress tolerance of a plant, conferring enhanced resistance to pathogens to a plant, modulating pre-mRNA splicing in a plant cell, or modulating vesicle transport/processing in a plant cell, comprising introducing into the plant or plant cell a DIMIC molecule or DIMIC modulator, alone or in combination with a DIM1 molecule.
摘要翻译：本发明提供了编码新的细胞周期相关多肽的分离的核酸分子，称为DIM1相互作用分子（DIMIC）分子。本发明还提供反义核酸分子，含有DIMIC核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏DIMIC基因的转基因植物。本发明还进一步提供了分离的DIMIC蛋白，融合蛋白，抗原肽和抗DIMIC抗体。还提供了利用本发明的分子和组合物的农业和筛选方法。本发明还提供调节植物总体生长和产量的方法，增强植物的胁迫耐受性，赋予对植物病原体的增强的抗性，调节植物细胞中的mRNA前剪接或调节植物中的囊泡转运/加工包括单独或与DIM1分子组合引入到植物或植物细胞中的DIMIC分子或DIMIC调节剂。

4. 发明申请

WO2004035798A2 IDENTIFICATION OF NOVEL E2F TARGET GENES AND USE THEREOF 审中-公开
标题翻译：鉴定E2F目标基因及其用途
公开(公告)号：WO2004035798A2
公开(公告)日：2004-04-29
申请号：PCT/EP0311658
申请日：2003-10-20
申请人： CROPDESIGN NV , INZE DIRK , DE VEYLDER LIEVEN , VLIEGHE KOBE
发明人： INZE DIRK , DE VEYLDER LIEVEN , VLIEGHE KOBE
IPC分类号： A01H1/04 , A01H5/00 , A61K31/713 , A61K38/16 , C07K14/415 , C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention concerns a method for altering characteristics of a plant. The invention describes the identification of genes that are upregulated or downregulated in transgenic plants overexpressing E2Fa/DPa and the use of such sequences to alter plant characteristics. A preferred way for altering characteristics of a plant comprises modifying expression of one or more nucleic acid sequences and or modifying level and/or activity of one or more proteins, which nucleic acids and/or proteins are essentially similar to any one or more of SEQ ID NO 1 to 2755. Some of the genes identified in the present invention have an E2Fa target consensus sequence in their 5' upstream region. The identified genes play a role in a variety of biological processes, such as DNA replication, cell wall biosynthesis, nitrogen and/or carbon metabolism, transcription factors etc.
摘要翻译：本发明涉及改变植物特性的方法。本发明描述了在过表达E2Fa / DPa的转基因植物中上调或下调的基因的鉴定，以及使用这种序列改变植物特征。用于改变植物特征的优选方法包括修饰一个或多个核酸序列的表达和/或修饰一种或多种蛋白质的水平和/或活性，所述核酸和/或蛋白质基本上类似于SEQ ID NO： ID NO 1至2755.本发明中鉴定的一些基因在其5'上游区具有E2Fa靶共有序列。鉴定的基因在多种生物过程中起作用，如DNA复制，细胞壁生物合成，氮和/或碳代谢，转录因子等。

5. 发明申请

WO03018818A3 METHOD AND MEANS FOR MODULATING PLANT CELL CYCLE PROTEINS AND THEIR USE IN PLANT CELL GROWTH CONTROL 审中-公开
标题翻译：调节植物细胞周期蛋白的方法和手段及其在植物细胞生长控制中的用途
公开(公告)号：WO03018818A3
公开(公告)日：2003-09-04
申请号：PCT/EP0209504
申请日：2002-08-26
申请人： CROPDESIGN NV , DE VEYLDER LIEVEN , INZE DIRK , MIRONOV VLADIMIR , SEGERS GERDA
发明人： DE VEYLDER LIEVEN , INZE DIRK , MIRONOV VLADIMIR , SEGERS GERDA
IPC分类号： C07K14/415 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention relates to modulation of endoreduplication in a plant or part thereof which may be achieved by modifying expression or activity of E2F or E2F in combination with DP.Modulation of endoreduplication has an advantageous influence on plant cell size and storage capacity of plant cells.
摘要翻译：本发明涉及通过修饰E2F或E2F与DP组合的表达或活性而实现的植物或其部分中的内部复制的调节。内部复制的调节对植物细胞的大小和储存能力具有有利的影响。

6. 发明申请

WO2007054522A1 PLANTS HAVING IMPROVED GROWTH CHARACTERISTICS AND A METHOD FOR MAKING THE SAME 审中-公开
标题翻译：具有改善生长特性的植物及其制备方法
公开(公告)号：WO2007054522A1
公开(公告)日：2007-05-18
申请号：PCT/EP2006/068248
申请日：2006-11-08
申请人： CROPDESIGN N.V. , VIB VZW , UNIVERSITEIT GENT , DE MEUTTER, Jan , MIRONOV, Vladimir , REUZEAU, Christophe , INZE, Dirk , VLIEGHE, Kobe , DE VEYLDER, Lieven
发明人： DE MEUTTER, Jan , MIRONOV, Vladimir , REUZEAU, Christophe , INZE, Dirk , VLIEGHE, Kobe , DE VEYLDER, Lieven
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： The present invention concerns a method for increasing plant yield and/or increased stress resistance by decreasing the level of activity of a DEL1 polypeptide. One such method comprises introducing into a plant a nucleic acid comprising a variant DEL1 nucleic acid. Another method comprises downregulating expression of a DEL1 gene . The invention also relates to transgenic plants having introduced therein a variant DEL1 nucleic acid thereof, which plants have increased yield and/or increased stress resistance relative to control plants. The present invention also concerns a novel DEL1 protein and its encoding sequence, and constructs useful in the methods of the invention.
摘要翻译：本发明涉及通过降低DEL1多肽的活性水平来增加植物产量和/或增加的胁迫抗性的方法。一种这样的方法包括向植物中引入包含变体DEL1核酸的核酸。另一种方法包括下调DEL1基因的表达。本发明还涉及其中引入了其变体DEL1核酸的转基因植物，该植物相对于对照植物具有增加的产量和/或增加的胁迫抗性。本发明还涉及一种新颖的DEL1蛋白及其编码序列，以及可用于本发明方法的构建体。

7. 发明申请

WO2003066852A2 PLANT GROWTH MODULATION 审中-公开
标题翻译：植物生长调节
公开(公告)号：WO2003066852A2
公开(公告)日：2003-08-14
申请号：PCT/EP2003/001287
申请日：2003-02-07
申请人： VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW , NELISSEN, Hilde , DE VEYLDER, Lieven , CLARKE, Jonathan , INZÉ, Dirk , VAN LIJSEBETTENS, Maria
发明人： NELISSEN, Hilde , DE VEYLDER, Lieven , CLARKE, Jonathan , INZÉ, Dirk , VAN LIJSEBETTENS, Maria
IPC分类号： C12N15/00
CPC分类号： C07K14/415 , C12N15/8216 , C12N15/8238 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to the use of one or more genes, encoding a protein of the elongator complex to modulate plant growth. More specifically, the invention relates to the overexpression of the DRL1 gene, to simulate growth of leaves and roots.
摘要翻译：本发明涉及一种或多种编码增长复合物的蛋白质调节植物生长的基因的用途。更具体地，本发明涉及DRL1基因的过表达，以模拟叶和根的生长。

8. 发明申请

WO2003025185A1 A METHOD TO MODIFY CELL NUMBER, ARCHITECTURE AND YIELD OF PLANTS BY OVEREXPRESSING THE E2F TRANSCRIPTION FACTOR 审中-公开
标题翻译：通过过度表达E2F转录因子修饰植物细胞数，构建和产量的方法
公开(公告)号：WO2003025185A1
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010236
申请日：2002-09-12
申请人： CROPDESIGN N.V. , BEECKMAN, Tom , DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , BROEKAERT, Willem , DILLEN, Willy , FRANKARD, Valerie
发明人： BEECKMAN, Tom , DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , BROEKAERT, Willem , DILLEN, Willy , FRANKARD, Valerie
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to a method for modifying plant growth and development processes by affecting cell cycle regulation comprising modulating expression of members of the plant E2F transcription factor family. More specific the invention relates to methods for stimulating cell division in a plant. The invention further relates to transgenic plants produced by the methods of the invention having altered plant growth and development characteristics compared to their isogenic counterparts. Preferably, the plant characteristics modified by the present invention include enlarged cotyledons, enhanced growth rate, stress resistance and seedling survival, more cells, more tillers, more panicles.
摘要翻译：本发明涉及通过影响细胞周期调节来修饰植物生长和发育过程的方法，其包括调节植物E2F转录因子家族成员的表达。更具体地，本发明涉及刺激植物细胞分裂的方法。本发明还涉及通过与其同基因对应物相比具有改变的植物生长和发育特征的本发明方法生产的转基因植物。优选地，通过本发明修饰的植物特征包括扩大的子叶，增强的生长速率，抗胁迫性和幼苗存活，更多的细胞，更多的分蘖，更多的穗。

9. 发明申请

WO2003027299A2 A PLANT CYCLIN DEPENDENT KINASE-LIKE PROTEIN, ITS INTERACTORS AND USES THEREOF 审中-公开
标题翻译：植物细胞依赖性激酶样蛋白，其相互作用及其用途
公开(公告)号：WO2003027299A2
公开(公告)日：2003-04-03
申请号：PCT/EP2002/010364
申请日：2002-09-16
申请人： CROPDESIGN NV , DE VEYLDER, Lieven , DE PINHO BAROCCO, Rosa, Maria , MIRONOV, Vladimir , INZE, Dirk
发明人： DE VEYLDER, Lieven , DE PINHO BAROCCO, Rosa, Maria , MIRONOV, Vladimir , INZE, Dirk
IPC分类号： C12N15/82
CPC分类号： C12N9/1205 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to methods for modifying plant growth and development processes comprising modulating expression of a plant cyclin dependent kinase-like gene and/or one of its interacting proteins or homologues, derivatives or fragments thereof. The invention further relates to the use of vectors for performing the present invention and to transgenic plants produced therewith having altered plant growth and development characteristics compared to their isogenic counterparts. Preferably, the characteristics modified by the present invention include growth rate, yield, senescence, flowering and photosynthesis.
摘要翻译：本发明涉及用于修饰植物生长和发育过程的方法，包括调节植物细胞周期蛋白依赖性激酶样基因和/或其相互作用蛋白质或其同系物，衍生物或片段之一的表达。本发明还涉及用于实施本发明的载体和与其生产的转基因植物相比，其与其同基因对应物相比具有改变的植物生长和发育特征。优选地，本发明修饰的特征包括生长速率，产量，衰老，开花和光合作用。

10. 发明申请

WO0185946A3 NUCLEIC ACID MOLECULES ENCODING PLANT CELL CYCLE PROTEINS AND USES THEREFOR 审中-公开
标题翻译：核酸分子编码植物细胞周期蛋白及其用途
公开(公告)号：WO0185946A3
公开(公告)日：2003-03-13
申请号：PCT/IB0101307
申请日：2001-05-14
申请人： CROPDESIGN NV , INZE DIRK , BOUDOLF VERONIQUE , DE VEYLDER LIEVEN , ACOSTA JUAN ANTONIO TORRES , MAGYAR ZOLTAN
发明人： INZE DIRK , BOUDOLF VERONIQUE , DE VEYLDER LIEVEN , ACOSTA JUAN ANTONIO TORRES , MAGYAR ZOLTAN
IPC分类号： A01H5/00 , C07K14/415 , C07K16/16 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/29 , C12N15/82 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The invention provides isolated nucleic acids molecules, designated CCP nucleic acid molecules, which encode novel cell cycle associated polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CCP nucleic acid molecules, host cells into which the expression vectors have been introduced, and transgenic plants in which a CCP gene has been introduced or disrupted. The invention still further provides isolated CCP proteins, fusion proteins, antigenic peptides and anti-CCP antibodies. Agricultural, diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的细胞周期相关多肽的分离的核酸分子，命名为CCP核酸分子。本发明还提供了反义核酸分子，含有CCP核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及CCP基因被引入或破坏的转基因植物。本发明还进一步提供了分离的CCP蛋白，融合蛋白，抗原肽和抗CCP抗体。还提供了利用本发明组合物的农业，诊断，筛选和治疗方法。

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