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1. 发明申请

WO2012156750A1 HIV VACCINE 审中-公开
标题翻译：艾滋病疫苗
公开(公告)号：WO2012156750A1
公开(公告)日：2012-11-22
申请号：PCT/GB2012/051124
申请日：2012-05-18
申请人： ISIS INNOVATION LIMITED , DAVIS, Benjamin G , VIJAYAKRISHNAN, Balakumar , DOORES, Katie , KOEPPE, Julia
发明人： DAVIS, Benjamin G , VIJAYAKRISHNAN, Balakumar , DOORES, Katie , KOEPPE, Julia
IPC分类号： A61K47/48 , A61K39/00 , C07H3/06 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/58 , A61K2039/6037 , A61K2039/6075 , A61K2039/6081 , C07H3/06 , C12N2740/16134
摘要： A glycoconjugate for use in treating or preventing an HIV infection or AIDS, wherein the glycoconjugate comprises an oligosaccharide group which is linked to a carrier protein, wherein the oligosaccharide group is of formula (I): wherein: M3 is a modified mannose unit; each M2 is the same or different and represents a mannose unit or a modified mannose unit; - M1 represents a mannose unit or a modified mannose unit, and the oligosaccharide moiety is linked to the carrier protein via M1; p is 0, or 1; q is 0 or 1; S1 is a saccharide unit or a modified saccharide unit; - r, s and t are zero or an integer from 1 to 5, wherein at least two of r, s and t are zero; wherein the or each modified mannose unit or modified saccharide unit is a mannose unit or saccharide unit having one or more modifications, the or each modification being independently selected from modifications A and B, wherein: modification A is replacement of a hydrogen atom of the mannose unit or saccharide unit with a C1 -3 alkyl group optionally substituted with a hydroxyl group; and modification B is replacement of a hydroxyl group of the mannose unit or saccharide unit with a hydrogen atom.
摘要翻译：一种用于治疗或预防HIV感染或AIDS的糖缀合物，其中糖缀合物包含与载体蛋白连接的寡糖基团，其中寡糖基团为式（I）：其中：M3是修饰的甘露糖单元; 每个M2相同或不同，表示甘露糖单元或修饰的甘露糖单元; M1表示甘露糖单元或修饰的甘露糖单元，寡糖部分通过M1与载体蛋白连接; p为0或1; q为0或1; S1是糖单元或改性糖单元; -r，s和t为零或1至5的整数，其中r，s和t中的至少两个为零; 其中所述或每个修饰的甘露糖单元或修饰的糖单元是具有一个或多个修饰的甘露糖单元或糖单元，所述或每个修饰独立地选自修饰A和B，其中：修饰A是甘露糖的氢原子的取代具有任选被羟基取代的C1-C3烷基的单元或糖单元; 改性B是用氢原子代替甘露糖单元或糖类单元的羟基。

2. 发明申请

WO0064485A8 SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译：特异性靶向催化拮抗剂及其用途
公开(公告)号：WO0064485A8
公开(公告)日：2001-02-08
申请号：PCT/US0010988
申请日：2000-04-21
申请人： GENENCOR INT , DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R , SANFORD KARL JOHN , ESTELL DAVID AARON
发明人： DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R , SANFORD KARL JOHN , ESTELL DAVID AARON
IPC分类号： C12N9/50 , A45C15/06 , A61K38/43 , A61K38/55 , A61K45/00 , A61K47/48 , A61P3/06 , A61P3/10 , A61P5/26 , A61P5/28 , A61P5/30 , A61P7/02 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/02 , A61P11/08 , A61P21/02 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P29/00 , A61P31/12 , A61P43/00 , C12N9/54 , G08B5/00
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898
摘要： The invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
摘要翻译：本发明提供作为靶分子的催化拮抗剂的嵌合分子。本发明的催化拮抗剂优选包含与降解由靶向部分特异性结合的分子的酶连接的靶向部分。因此，本发明的催化拮抗剂与靶向部分识别的靶（例如受体）结合，嵌合体的酶组分然后降解靶的全部或部分。这通常导致靶的活性降低或丧失，并释放嵌合分子。然后嵌合分子可以自由地攻击和降解另一个靶分子。

3. 发明申请

WO2012146914A1 MODIFICATION OF TREHALOSE-6-PHOSPHATE LEVELS IN PLANTS 审中-公开
标题翻译：植物中六氢六磷酸盐水平的改变
公开(公告)号：WO2012146914A1
公开(公告)日：2012-11-01
申请号：PCT/GB2012/050891
申请日：2012-04-23
申请人： ISIS INNOVATION LIMITED , SAGAR, Ram , PRIMAVESI, Lucia F. , PAUL, Matthew J. , DAVIS, Benjamin G.
发明人： SAGAR, Ram , PRIMAVESI, Lucia F. , PAUL, Matthew J. , DAVIS, Benjamin G.
IPC分类号： A01N57/24 , C07F9/09 , C07F9/40 , C07H11/04
CPC分类号： A01N57/16 , A01N57/24 , C07H11/04 , C07H15/04
摘要： Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants.
摘要翻译：提供了式（I）的海藻糖-6-磷酸酯或海藻糖-6-膦酸酯前体或其农业上可接受的盐的化合物：（I）该化合物可用于增加植物中的淀粉生产。

4. 发明申请

WO2006055644A3 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
公开(公告)号：WO2006055644A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041549
申请日：2005-11-14
申请人： GENENCOR INTERNATIONAL, INC. , ISIS INNOVATION LTD , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John, Bryan
发明人： BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John, Bryan
IPC分类号： C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

5. 发明申请

WO2004093787A3 USE OF GLYCODENDRIMER REAGENTS FOR INHIBITING ADHESION BY MICROORGANISMS 审中-公开
公开(公告)号：WO2004093787A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/011605
申请日：2004-04-14
申请人： GENENCOR INTERNATIONAL, INC. , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , BOTT, Richard, R. , COWAN, M., M. , DAVIS, Benjamin, G. , JONES, John, Bryan
发明人： BOTT, Richard, R. , COWAN, M., M. , DAVIS, Benjamin, G. , JONES, John, Bryan
IPC分类号： C12N9/48
摘要： The present invention is directed to glyodendrimeric proteases, composition with glycodendrimeric proteases and methods for inhibiting adhesion binding in microorganisms by contacting microorganisms with a glycodendrimeric protease or a composition with a glycodendrimeric protease. The invention may be used to treat patients in need of treatment.

6. 发明申请

WO0064485A9 SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF 审中-公开
公开(公告)号：WO0064485A9
公开(公告)日：2001-07-19
申请号：PCT/US0010988
申请日：2000-04-21
申请人： GENENCOR INT , DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R , SANFORD KARL JOHN , ESTELL DAVID AARON
发明人： DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R , SANFORD KARL JOHN , ESTELL DAVID AARON
IPC分类号： C12N9/50 , A45C15/06 , A61K38/43 , A61K38/55 , A61K45/00 , A61K47/48 , A61P3/06 , A61P3/10 , A61P5/26 , A61P5/28 , A61P5/30 , A61P7/02 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/02 , A61P11/08 , A61P21/02 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P29/00 , A61P31/12 , A61P43/00 , C12N9/54 , G08B5/00
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898
摘要： The invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

7. 发明申请

WO2006055437A2 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO2006055437A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/040989
申请日：2005-11-14
申请人： GENENCOR INTERNATIONAL, INC. , ISIS INNOVATION LTD , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John Bryan
发明人： BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John Bryan
IPC分类号： C07H1/00 , C07H15/14
CPC分类号： C08G83/003 , C07H1/00 , C07H15/14
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

8. 发明申请

WO02079394A3 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO02079394A3
公开(公告)日：2003-07-10
申请号：PCT/US0210903
申请日：2002-04-02
申请人： GENENCOR INT , UNIV TORONTO , DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R
发明人： DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R
IPC分类号： A61K47/48 , C07H5/10 , C07K14/36 , C12N1/21 , C07H1/00 , A61K31/70 , A61K38/16 , C07H17/00
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898 , C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

9. 发明申请

WO2002079394A2 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO2002079394A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/010903
申请日：2002-04-02
申请人： GENENCOR INTERNATIONAL, INC. , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , DAVIS, Benjamin, G. , JONES, John, Bryan , BOTT, Richard, R.
发明人： DAVIS, Benjamin, G. , JONES, John, Bryan , BOTT, Richard, R.
IPC分类号： C12N
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898 , C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

10. 发明申请

WO2013027040A1 CYCLIC OLIGOSACCHARIDES FOR USE IN THE TREATMENT AND PREVENTION OF BACTERIAL INFECTION 审中-公开
标题翻译：用于治疗和预防细菌感染的循环低聚物
公开(公告)号：WO2013027040A1
公开(公告)日：2013-02-28
申请号：PCT/GB2012/052029
申请日：2012-08-20
申请人： ISIS INNOVATION LIMITED , KONG, Lingbing , DAVIS, Benjamin G. , BAYLEY, Hagan
发明人： KONG, Lingbing , DAVIS, Benjamin G. , BAYLEY, Hagan
IPC分类号： A61K31/724 , A61P31/04
CPC分类号： C08B37/0012 , A01N43/16 , A61K31/724 , A61K47/40 , Y02A50/473
摘要： Compounds which inhibit Wza-mediated polysaccharide transport are useful in the prevention or treatment of bacterial infection, in particular of E. coli infection. The compounds are typically cyclic oligosaccharides such as cyclodextrins, which bear positively charged functional groups at the primary carbon position.
摘要翻译：抑制Wza介导的多糖转运的化合物可用于预防或治疗细菌感染，特别是大肠杆菌感染。化合物通常是环状低聚糖，例如环糊精，其在伯碳位置具有带正电荷的官能团。

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