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1. 发明申请

WO2006055644A3 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
公开(公告)号：WO2006055644A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041549
申请日：2005-11-14
申请人： GENENCOR INTERNATIONAL, INC. , ISIS INNOVATION LTD , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John, Bryan
发明人： BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John, Bryan
IPC分类号： C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

2. 发明申请

WO2006055437A2 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO2006055437A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/040989
申请日：2005-11-14
申请人： GENENCOR INTERNATIONAL, INC. , ISIS INNOVATION LTD , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John Bryan
发明人： BOTT, Richard, R. , DAVIS, Benjamin G. , JONES, John Bryan
IPC分类号： C07H1/00 , C07H15/14
CPC分类号： C08G83/003 , C07H1/00 , C07H15/14
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

3. 发明申请

WO2004093787A3 USE OF GLYCODENDRIMER REAGENTS FOR INHIBITING ADHESION BY MICROORGANISMS 审中-公开
公开(公告)号：WO2004093787A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/011605
申请日：2004-04-14
申请人： GENENCOR INTERNATIONAL, INC. , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , BOTT, Richard, R. , COWAN, M., M. , DAVIS, Benjamin, G. , JONES, John, Bryan
发明人： BOTT, Richard, R. , COWAN, M., M. , DAVIS, Benjamin, G. , JONES, John, Bryan
IPC分类号： C12N9/48
摘要： The present invention is directed to glyodendrimeric proteases, composition with glycodendrimeric proteases and methods for inhibiting adhesion binding in microorganisms by contacting microorganisms with a glycodendrimeric protease or a composition with a glycodendrimeric protease. The invention may be used to treat patients in need of treatment.

4. 发明申请

WO2002079394A2 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO2002079394A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/010903
申请日：2002-04-02
申请人： GENENCOR INTERNATIONAL, INC. , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , DAVIS, Benjamin, G. , JONES, John, Bryan , BOTT, Richard, R.
发明人： DAVIS, Benjamin, G. , JONES, John, Bryan , BOTT, Richard, R.
IPC分类号： C12N
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898 , C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

5. 发明申请

WO2003076580A2 HIGH THROUGHPUT MUTAGENESIS SCREENING METHOD 审中-公开
标题翻译：高通量MUTAGENESIS筛选方法
公开(公告)号：WO2003076580A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/006908
申请日：2003-03-05
申请人： GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , KELLIS, James, T., Jr. , MORRISON, Thomas, B.
发明人： BOTT, Richard, R. , KELLIS, James, T., Jr. , MORRISON, Thomas, B.
IPC分类号： C12N
CPC分类号： C12Y301/01074 , C12N9/18
摘要： The present invention provides mutagenesis methods for protein engineering. In particular, the present inventionprovides mutagenesis methods that include feedback adjustment from systematic result evaluation. More specifically, the invention provides site-saturation mutagenesis methods that screen for variants with one or more desirable protein properties and evaluates screening results to provide feedback for repeat screening and construction of new libraries. The invention further provides cutinase variants that provide improved stability and activity compared with the wild type cutinase.
摘要翻译：本发明提供蛋白质工程的诱变方法。特别地，本发明提供了包括从系统结果评价的反馈调整的诱变方法。更具体地，本发明提供了筛选具有一种或多种所需蛋白质性质的变体的位点饱和诱变方法，并评估筛选结果以提供重复筛选和构建新文库的反馈。本发明还提供了与野生型角质酶相比提供改善的稳定性和活性的角质酶变体。

6. 发明申请

WO2003062381A3 MULTIPLY-SUBSTITUTED PROTEASE VARIANTS 审中-公开
公开(公告)号：WO2003062381A3
公开(公告)日：2003-07-31
申请号：PCT/US2003/001448
申请日：2003-01-16
申请人： GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J.
发明人： BOTT, Richard, R. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J.
IPC分类号： C12N9/52
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a positionselected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.

7. 发明申请

WO2005056782A2 PERHYDROLASE 审中-公开
标题翻译：水解酶
公开(公告)号：WO2005056782A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040438
申请日：2004-12-03
申请人： GENENCOR INTERNATIONAL, INC. , THE PROCTER & GAMBLE COMPANY , AMIN, Neelam, S. , BOSTON, Matthew, G. , BOTT, Richard, R. , CERVIN, Marguerite, A. , CONCAR, Edward, M. , GUSTWILLER, Marc, E. , JONES, Brian, Edward , LIEBETON, Klaus , MIRACLE, Gregory, S. , OH, Hiroshi , POULOSE, Ayrookaran, J. , RAMER, Sandra, W. , SCHEIBEL, Jeffrey, J. , WEYLER, Walter , WHITED, Gregory M.
发明人： AMIN, Neelam, S. , BOSTON, Matthew, G. , BOTT, Richard, R. , CERVIN, Marguerite, A. , CONCAR, Edward, M. , GUSTWILLER, Marc, E. , JONES, Brian, Edward , LIEBETON, Klaus , MIRACLE, Gregory, S. , OH, Hiroshi , POULOSE, Ayrookaran, J. , RAMER, Sandra, W. , SCHEIBEL, Jeffrey, J. , WEYLER, Walter , WHITED, Gregory M.
IPC分类号： C12N9/00
CPC分类号： A01N63/00 , C11D3/38636 , C12N9/16 , C12N9/50 , C12N9/52
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种用于清洁和其它应用的过水解酶的方法和组合物。在一些特别优选的实施方案中，本发明提供了用于产生过酸的方法和组合物。本发明特别用于涉及清洗，漂白和消毒的应用中。

8. 发明申请

WO2003101404A2 PREPARATIONS FOR TOPICAL SKIN USE AND TREATMENT 审中-公开
标题翻译：用于局部皮肤使用和治疗的准备
公开(公告)号：WO2003101404A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/007411
申请日：2003-03-11
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
发明人： BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
IPC分类号： A61K
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/7007 , A61K9/7069 , A61K38/465 , A61K38/482 , A61L26/0019 , A61L26/0066 , A61L2300/254 , A61L2300/602 , A61L2300/622 , C08L83/04
摘要： The present invention is related to topical preparations for release of an active agent and to methods of making and using the topical preparations. The preparations may have an internal phase dispersed within an external phase. The internal phase may be a hydrophilic carrier and an active agent. The external phase may be a silicone matrix. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：本发明涉及用于释放活性剂的局部制剂以及制备和使用局部制剂的方法。制剂可能具有分散在外部相中的内相。内相可以是亲水载体和活性剂。外部相可以是硅树脂基质。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交的理解是不会用于解释或限制权利要求的范围或含义。

9. 发明申请

WO2005044242A1 PREPARATIONS FOR TOPICAL APPLICATION AND METHODS OF DELIVERING AN ACTIVE AGENT TO A SUBSTRATE 审中-公开
标题翻译：用于局部应用的准备和将活性剂递送给基材的方法
公开(公告)号：WO2005044242A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/035686
申请日：2004-10-27
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , BRANDSTADT, Kurt, Friedrich , KOLLAR, Csilla , LANE, Thomas, Howard , LILES, Donald, Taylor , SALDJENO, Mae , THOMAS, Xavier, Jean-Paul
发明人： BOTT, Richard, R. , BRANDSTADT, Kurt, Friedrich , KOLLAR, Csilla , LANE, Thomas, Howard , LILES, Donald, Taylor , SALDJENO, Mae , THOMAS, Xavier, Jean-Paul
IPC分类号： A61K9/70
CPC分类号： A61K9/107 , A61K8/06 , A61K8/062 , A61K8/89 , A61K9/0014 , A61K47/24 , A61K47/30 , A61Q19/00
摘要： A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate.
摘要翻译：用于局部施用于底物的多层敷料和控释组合物包括乳液和掺入乳液中的活性剂。活性剂包括蛋白质。将活性剂递送到底物的方法提供乳液并将活性剂并入乳液中以将活性剂递送至底物。

10. 发明申请

WO2005025548A1 TOPICAL PREPARATIONS COMPRISING A HYDROPHILIC CARRIER AND A SILICONE MATRIX 审中-公开
标题翻译：包含水文载体和硅胶基质的主题制备
公开(公告)号：WO2005025548A1
公开(公告)日：2005-03-24
申请号：PCT/US2004/026218
申请日：2004-08-13
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
发明人： BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K9/0014 , A61K9/7007 , A61K38/465 , A61K38/482 , A61K47/02 , A61K47/24 , A61K47/34 , A61L26/0019 , A61L26/0066 , A61L2300/254 , A61L2300/602 , A61L2300/622 , C08L83/04
摘要： Topical preparations for release of an active agent to remove necrotic tissue and to methods of making and using the topical preparations are provided. The preparations may have an internal phase dispersed within an external phase. The internal phase may be a hydrophilic carrier and an active agent. The external phase may be a silicone matrix.
摘要翻译：提供用于释放活性剂以除去坏死组织的局部制剂以及制备和使用局部制剂的方法。制剂可能具有分散在外部相中的内相。内相可以是亲水载体和活性剂。外部相可以是硅树脂基质。

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