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1. 发明申请

WO2015014794A8 USE OF ALPHA-CRYSTALLIN B (CRYAB) IN THE ASSESSMENT OF HEART FAILURE 审中-公开
标题翻译： ALPHA-CRYSTALLIN B（CRYAB）在心脏衰竭评估中的应用
公开(公告)号：WO2015014794A8
公开(公告)日：2015-08-13
申请号：PCT/EP2014066178
申请日：2014-07-28
申请人： HOFFMANN LA ROCHE , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS , UNIV TORONTO
发明人： WIENHUES-THELEN URSULA-HENRIKE , HESS GEORG , BLOCK DIRK , HUEDIG HENDRIK , EMILI ANDREW , GRAMOLINI ANTHONY , LIU PETER , MACLENNAN DAVID , ARAB SARA
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6887 , G01N2333/4712 , G01N2800/325
摘要： The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker CRYAB, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure selected from the group consisting of a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation, and of assessing heart failure by comparing the concentration determined in for CRYAB and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of CRYAB as a marker protein in the assessment of heart failure, a marker combination comprising CRYAB and a kit for measuring CRYAB.
摘要翻译：本发明涉及一种用于评估体外心脏衰竭的方法，包括以下步骤：在样品中测量标记物CRYAB的浓度，任选地在样品中测量一种或多种其它心力衰竭标志物的浓度，所述其他标志物选自由利尿钠肽标记物，心肌肌钙蛋白标志物和炎症标志物组成的组，并且通过将对于CRYAB测定的浓度与对任选的一种或多种其它标记物测定的浓度与浓度的这种标记物或这些标记物在参考群体中建立。还公开了CRYAB作为评估心力衰竭的标记蛋白的用途，包括CRYAB的标记组合和用于测量CRYAB的试剂盒。

2. 发明申请

WO2013177534A3 NEW SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF 审中-公开
标题翻译：新型脂肪酸衍生物及其药物可接受的盐，其组合物及其使用方法
公开(公告)号：WO2013177534A3
公开(公告)日：2015-05-28
申请号：PCT/US2013042689
申请日：2013-05-24
申请人： UNIV TORONTO , FISHEL MELISSA L
发明人： FISHEL MELISSA L , GUNNING PATRICK THOMAS , HAFTCHENARY SINA , PAGE BRENT DAVID GEORGE , WEISS SAMUEL , LUCHMAN HEMA ARTEE
IPC分类号： A61K31/18
CPC分类号： C07F9/40 , C07C311/19 , C07C311/21 , C07C2601/14 , C07D215/36 , C07D233/84 , C07F9/3882
摘要： The present invention relates to novel compounds (Formula (I)), compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
摘要翻译：本发明涉及新化合物（式（I）），含有它们的组合物以及用于抑制STAT3和/或STAT5活性或使用所述化合物治疗STAT3或STAT5依赖性癌症的方法; 或其药学上可接受的盐，溶剂合物或前药。

3. 发明申请

WO2014153495A3 NOVEL STAT3 INHIBITORS 审中-公开
标题翻译：新的STAT3抑制剂
公开(公告)号：WO2014153495A3
公开(公告)日：2015-02-19
申请号：PCT/US2014031412
申请日：2014-03-21
申请人： UNIV HAWAII , UNIV TORONTO
发明人： TURKSON JAMES , GUNNING PATRICK , HAFTCHENARY SINA
IPC分类号： A01N37/12 , A01N37/44 , A61K31/19 , C07C311/37
CPC分类号： C07C311/18 , C07C311/19 , C07C2601/14
摘要： The present disclosure provides pharmaceutical compositions comprising Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of use.
摘要翻译：本公开提供了包含Stat3抑制剂及其某些药学上可接受的盐的药物组合物，以及使用方法。

4. 发明申请

WO2014140882A2 SCAFFOLDED PEPTIDIC LIBRARIES AND METHODS OF MAKING AND SCREENING THE SAME 审中-公开
标题翻译： SCAFFOLDED PIPTIDIC LIBRARIES AND METHODS OF MAKING AND SCREEN THE THEAME
公开(公告)号：WO2014140882A2
公开(公告)日：2014-09-18
申请号：PCT/IB2014001088
申请日：2014-03-14
申请人： UNIV TORONTO
发明人： UPPALAPATI MARUTI , SIDHU SACHDEV S , KERMAN AARON
IPC分类号： C40B40/10
CPC分类号： C12N15/1044 , C40B40/10
摘要： Scaffolded peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Each library includes distinct peptidic compounds that include a scaffold domain and a distinct variable domain. A variety of libraries are provided where each library is based on an underlying peptidic scaffold having a structural motif. In some embodiments, the peptidic scaffold is a small protein having a protein-protein interaction surface. Libraries of polynucleotides that encode a variety of peptidic compounds are provided. These libraries find use in a variety of applications in which specific binding to target molecules, e.g., target proteins is desired. Also provided are methods of making the libraries and methods of screening the libraries for binding to a target.
摘要翻译：提供了脚手架肽图书馆和筛选相同的特异性结合靶蛋白的方法。每个文库包括不同的肽化合物，其包括支架结构域和不同的可变结构域。提供了各种文库，其中每个文库基于具有结构基序的下面的肽支架。在一些实施方案中，肽支架是具有蛋白质 - 蛋白质相互作用表面的小蛋白质。提供编码多种肽化合物的多核苷酸的文库。这些文库可用于其中期望与靶分子（例如靶蛋白）的特异性结合的多种应用。还提供了制作图书馆和筛选文库以绑定到目标的方法的方法。

5. 发明申请

WO2013080055A2 MOLECULAR DISPLAY METHOD 审中-公开
标题翻译：分子显示方法
公开(公告)号：WO2013080055A2
公开(公告)日：2013-06-06
申请号：PCT/IB2012003016
申请日：2012-09-27
申请人： UNIV TORONTO
发明人： SIDHU SACHDEV , MOFFAT JASON , PERSSON HELENA , PATEL NISH , SUNDARARAJAN SARAVANAN , GAKHAL AMANDEEP , YE WEI
IPC分类号： C40B30/04
CPC分类号： G01N33/6854 , C12N15/1037 , G01N33/6857
摘要： There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.
摘要翻译：本文提供了通过使用分子显示结合来自筛选的阳性和阴性选择库的测序来筛选和/或回收对靶分子特异的至少一种遗传编码的亲和试剂的方法。

6. 发明申请

WO2012020289A3 SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME 审中-公开
标题翻译：酶或底物结合的特定活性位点抑制剂及其生产方法
公开(公告)号：WO2012020289A3
公开(公告)日：2012-05-18
申请号：PCT/IB2011001663
申请日：2011-06-08
申请人： UNIV TORONTO , SIDHU SACHDEV , BEATTY LINDA , ERNST ANDREAS
发明人： SIDHU SACHDEV , BEATTY LINDA , ERNST ANDREAS
IPC分类号： C07K14/47
CPC分类号： C07K14/435 , A61K38/17 , C07K14/47
摘要： The present disclosure provides a method of producing enzyme- specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
摘要翻译：本公开提供了生产酶特异性抑制剂或底物结合配偶体的方法，包括：鉴定酶底物复合物或底物结合配偶体 - 底物复合物中底物的活性位点残基; 使活性位点残基随机化以产生底物变体的组合文库; 并选择抑制酶活性或结合底物作为底物特异性结合配偶体的底物变体。本公开还提供了结合遍在蛋白相互作用基序的遍在蛋白酶特异性抑制剂和泛素变体。

7. 发明申请

WO2009039640A9 A SYSTEM, APPARATUS AND METHOD FOR APPLYING MECHANICAL FORCE TO A MATERIAL 审中-公开
标题翻译：将机械力应用于材料的系统，装置和方法
公开(公告)号：WO2009039640A9
公开(公告)日：2009-05-07
申请号：PCT/CA2008001693
申请日：2008-09-29
申请人： UNIV TORONTO , MORAES CHRISTOPHER , SIMMONS CRAIG , SUN YU
发明人： MORAES CHRISTOPHER , SIMMONS CRAIG , SUN YU
IPC分类号： F15B5/00 , B81B3/00 , B81B7/04 , C12M1/00 , C12Q1/02 , C40B30/06 , C40B30/10 , G01N19/00
CPC分类号： C12M23/16 , C12M25/04 , C12M35/04
摘要： The present invention details the design and operation of a miniaturized device array in which a range of simultaneous mechanical forces are produced by a single external pressure source. The invention is primarily embodied in a microfabricated device arrays designed to rapidly probe biological cell response to various combinations of mechanical, chemical and extra-cellular matrix parameters in a high-throughput fashion.
摘要翻译：本发明详述了小型化装置阵列的设计和操作，其中通过单个外部压力源产生一定范围的同时机械力。本发明主要体现在设计用于以高通量方式快速探测生物细胞对机械，化学和细胞外基质参数的各种组合的响应的微制造装置阵列中。

8. 发明申请

WO0068382A9 PrP-LIKE GENE 审中-公开
标题翻译： PrP-like基因
公开(公告)号：WO0068382A9
公开(公告)日：2002-08-29
申请号：PCT/US0013099
申请日：2000-05-11
申请人： UNIV CALIFORNIA , UNIV TORONTO , UNIV WASHINGTON , PRUSINER STANLEY B , TREMBLAY PATRICK , MOORE RICHARD , WESTAWAY DAVID , HOOD LEROY E , LEE INYOUL
发明人： PRUSINER STANLEY B , TREMBLAY PATRICK , MOORE RICHARD , WESTAWAY DAVID , HOOD LEROY E , LEE INYOUL
IPC分类号： A01K67/027 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47
摘要： The present invention provides nucleic acids encoding the Doppel ("Dpl") protein, Dpl peptides, and assays utilizing the Dpl nucleic acids and/or peptides. In related aspects the invention features expression vectors and host cells comprising nucleic acids that encode a human Dpl polypeptide. The present invention also relates to antibodies that bind specifically to a human Dpl polypeptide, methods for producing human Dpl polypeptides, methods for identifying cells expressing Dpl, methods for using the Dpl gene and the Dpl polypeptide to alter cellular function and prion infectivity in culture or in vivo , and identification of individuals at risk for prion disorders by detecting alteration in Dpl coding and regulatory sequences and Dpl expression levels.
摘要翻译：本发明提供编码多巴巴（“Dpl”）蛋白，Dpl肽的核酸和利用Dpl核酸和/或肽的测定。在相关方面，本发明的特征在于包含编码人Dpl多肽的核酸的表达载体和宿主细胞。本发明还涉及与人Dpl多肽特异性结合的抗体，用于产生人Dpl多肽的方法，用于鉴定表达Dpl的细胞的方法，使用Dpl基因和Dpl多肽来改变培养物中的细胞功能和朊病毒感染性的方法，或通过检测Dpl编码和调节序列和Dpl表达水平的变化来鉴定朊病毒病风险的个体。

9. 发明申请

WO0160152A2 TRANSGENIC NON-HUMAN UCP2 KNOCKOUT MAMMAL 审中-公开
标题翻译：转基因非人UCP2 KNOCKOUT MAMMAL
公开(公告)号：WO0160152A2
公开(公告)日：2001-08-23
申请号：PCT/US0104969
申请日：2001-02-15
申请人： BETH ISRAEL HOSPITAL , UNIV PRINCE EDWARD ISLAND , UNIV TORONTO , LOWELL BRADFORD B , ZHANG CHEN YU , CHAN CATHERINE B , WHEELER MICHAEL B
发明人： LOWELL BRADFORD B , ZHANG CHEN-YU , CHAN CATHERINE B , WHEELER MICHAEL B
IPC分类号： A61K38/00 , A61P3/10 , C07K14/47 , C12N15/85 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K38/00 , C07K14/4702 , C12N15/8509
摘要： The present invention provides a transgenic non-human mammal which lacks a functional UCP2 gene. The UCP-2 deficient transgenic knockout mammal described herein provides a source of cells and animals useful to practice methods for the identification and/or evaluation of agents for their ability to affect signaling in cells, such as pancreatic beta -cells, in which ATP serves a regulatory function. Further aspects of the invention provide a method for the identification of agents (e.g., therapeutic agents) which inhibit UCP2 activity; a method for the identification of agents which mimic UCP2 activity and a method of treating diseases or conditions associated with UCP2 function (e.g., negative regulation or uncoupling activity).
摘要翻译：本发明提供缺乏功能性UCP2基因的转基因非人哺乳动物。本文所述的UCP-2缺陷型转基因敲除哺乳动物提供了用于实施用于鉴定和/或评价试剂影响细胞中的信号传导能力的方法的细胞和动物来源，所述细胞例如胰岛β细胞，ATP服用监管功能。本发明的其它方面提供了用于鉴定抑制UCP2活性的药剂（例如治疗剂）的方法; 用于鉴定模拟UCP2活性的药剂的方法和治疗与UCP2功能相关的疾病或病症的方法（例如，负调节或解偶联活性）。

10. 发明申请

WO0047615A3 PROTEINS RELATED TO NEURONAL REGENERATION AND USES THEREOF 审中-公开
标题翻译：与神经元再生有关的蛋白质及其用途
公开(公告)号：WO0047615A3
公开(公告)日：2000-11-30
申请号：PCT/CA0000126
申请日：2000-02-11
申请人： UNIV TORONTO
发明人： ST GEORGE-HYSLOP PETER H , FRASER PAUL E
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P25/00 , A61P25/28 , A61P43/00 , C07K14/48 , C12Q1/02 , C12Q1/68 , C07K14/47 , A61K38/17
CPC分类号： C07K14/48
摘要： The invention provides a method for stimulating nerve growth, which also includes nerve regeneration, by contacting nerve cells with human Neural Plakophilin Related Armadillo Protein (hNPRAP). In a specific embodiment, hNPRAP causes the development of numerous long, cellular extensions, which are similar to axonal sprouting observed during neuronal regeneration and synapse formation. The invention further relates to pharmaceutical compositions comprising an hNPRAP, or alternatively a gene therapy vector that expresses an hNPRAP. Also provided are methods for identifying substances that modulate expression of hNPRAP.
摘要翻译：本发明提供了一种通过使神经细胞与人神经Plakophilin相关犰狳蛋白（hNPRAP）接触来刺激神经生长的方法，其还包括神经再生。在具体的实施方案中，hNPRAP引起许多长的细胞延伸的发展，这类似于在神经元再生和突触形成期间观察到的轴突发芽。本发明还涉及包含hNPRAP或可选地表达hNPRAP的基因治疗载体的药物组合物。还提供了用于鉴定调节hNPRAP表达的物质的方法。

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