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1. 发明申请

WO2012156750A1 HIV VACCINE 审中-公开
标题翻译：艾滋病疫苗
公开(公告)号：WO2012156750A1
公开(公告)日：2012-11-22
申请号：PCT/GB2012/051124
申请日：2012-05-18
申请人： ISIS INNOVATION LIMITED , DAVIS, Benjamin G , VIJAYAKRISHNAN, Balakumar , DOORES, Katie , KOEPPE, Julia
发明人： DAVIS, Benjamin G , VIJAYAKRISHNAN, Balakumar , DOORES, Katie , KOEPPE, Julia
IPC分类号： A61K47/48 , A61K39/00 , C07H3/06 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/58 , A61K2039/6037 , A61K2039/6075 , A61K2039/6081 , C07H3/06 , C12N2740/16134
摘要： A glycoconjugate for use in treating or preventing an HIV infection or AIDS, wherein the glycoconjugate comprises an oligosaccharide group which is linked to a carrier protein, wherein the oligosaccharide group is of formula (I): wherein: M3 is a modified mannose unit; each M2 is the same or different and represents a mannose unit or a modified mannose unit; - M1 represents a mannose unit or a modified mannose unit, and the oligosaccharide moiety is linked to the carrier protein via M1; p is 0, or 1; q is 0 or 1; S1 is a saccharide unit or a modified saccharide unit; - r, s and t are zero or an integer from 1 to 5, wherein at least two of r, s and t are zero; wherein the or each modified mannose unit or modified saccharide unit is a mannose unit or saccharide unit having one or more modifications, the or each modification being independently selected from modifications A and B, wherein: modification A is replacement of a hydrogen atom of the mannose unit or saccharide unit with a C1 -3 alkyl group optionally substituted with a hydroxyl group; and modification B is replacement of a hydroxyl group of the mannose unit or saccharide unit with a hydrogen atom.
摘要翻译：一种用于治疗或预防HIV感染或AIDS的糖缀合物，其中糖缀合物包含与载体蛋白连接的寡糖基团，其中寡糖基团为式（I）：其中：M3是修饰的甘露糖单元; 每个M2相同或不同，表示甘露糖单元或修饰的甘露糖单元; M1表示甘露糖单元或修饰的甘露糖单元，寡糖部分通过M1与载体蛋白连接; p为0或1; q为0或1; S1是糖单元或改性糖单元; -r，s和t为零或1至5的整数，其中r，s和t中的至少两个为零; 其中所述或每个修饰的甘露糖单元或修饰的糖单元是具有一个或多个修饰的甘露糖单元或糖单元，所述或每个修饰独立地选自修饰A和B，其中：修饰A是甘露糖的氢原子的取代具有任选被羟基取代的C1-C3烷基的单元或糖单元; 改性B是用氢原子代替甘露糖单元或糖类单元的羟基。

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