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1. 发明申请

WO2007002567A2 SELECTIVE ISOLATION AND CONCENTRATION OF NUCLEIC ACIDS FROM COMPLEX SAMPLES 审中-公开
标题翻译：选择性分离和浓缩复杂样品中的核酸
公开(公告)号：WO2007002567A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024761
申请日：2006-06-23
申请人： NANOSPHERE, INC. , MARLA, Sudhakar, S. , PROKHOROVA, Anya , HETZEL, Susan , CORK, William
发明人： MARLA, Sudhakar, S. , PROKHOROVA, Anya , HETZEL, Susan , CORK, William
IPC分类号： C12Q1/68
CPC分类号： B82Y10/00 , B82Y5/00 , C12N1/06 , C12N15/1006 , C12Q1/6806 , C12Q1/6827 , C12Q2537/125 , C12Q2527/125
摘要： The present invention provides methods for detecting a target nucleic acid molecule in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules in a complex environment containing numerous non-nucleic acid components. In particular, the present invention provides methods and probes for isolating DNA with detergents and detecting a single nucleotide polymorphism (SNP) in a complex sample that comprises numerous non-nucleic acid components and nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules.
摘要翻译：本发明提供了检测样品中靶核酸分子的方法，该方法包含比包含许多非核酸组分的复杂环境中的扩增核酸分子具有更高生物学复杂性的核酸分子。特别地，本发明提供了用洗涤剂分离DNA并检测复合物样品中的单核苷酸多态性（SNP）的方法和探针，该复合物样品包含比扩增的核酸更高的生物学复杂性的许多非核酸组分和核酸分子分子。

2. 发明申请

WO2005071417A1 NANOPARTICLE IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：纳米成像系统及方法
公开(公告)号：WO2005071417A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/001011
申请日：2005-01-12
申请人： NANOSPHERE, INC. , CORK, William , PATINO, Tim , WEBER, Mark , MORROW, Dave , BUCKINGHAM, Wesley
发明人： CORK, William , PATINO, Tim , WEBER, Mark , MORROW, Dave , BUCKINGHAM, Wesley
IPC分类号： G01N33/58
CPC分类号： G01N21/552 , G01N21/47 , G01N33/54346 , G01N33/54373 , G01N2015/0038
摘要： An apparatus and method for imaging metallic nanoparticles. The invention teaches an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact system without the need for complex motorized devices to move a camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译：用于金属纳米颗粒成像的装置和方法。本发明教导了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。该装置包括用于保持基板的基板保持器，处理器和存储器件，成像模块，照明模块，输入模块和输出模块。该装置可以具有彼此靠近的固定衬底保持器和成像模块。该设备提供了紧凑的系统，而不需要复杂的电动装置来使相机移动穿过基板。此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。

3. 发明申请

WO2012151243A3 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2012151243A3
公开(公告)日：2014-05-08
申请号：PCT/US2012036062
申请日：2012-05-02
申请人： FENWAL INC , BELT FLETCHER C , KAST MICHAEL J , MIN KYUNGYOON , RADWANSKI KATHERINE , CORK WILLIAM H
发明人： BELT FLETCHER C , KAST MICHAEL J , MIN KYUNGYOON , RADWANSKI KATHERINE , CORK WILLIAM H
IPC分类号： A01N1/02 , C12M1/00
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber containing the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入含有浓缩血液成分的一次性处理室。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

4. 发明申请

WO2012110895A8 STERILE DOCKING DEVICE, MEDICAL FLUID FLOW SYSTEM WITH STERILE DOCKING DEVICE AND METHOD OF USING SAME 审中-公开
标题翻译：无菌装卸装置，具有无菌装卸装置的医用流体流动系统及使用该装置的方法
公开(公告)号：WO2012110895A8
公开(公告)日：2012-11-29
申请号：PCT/IB2012000387
申请日：2012-03-02
申请人： FENWAL INC , MIN KYUNGYOON , CORK WILLIAM H
发明人： MIN KYUNGYOON , CORK WILLIAM H
IPC分类号： A61M39/14
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies (14, 12), each of which has a wall (22, 32) with an exterior surface (24, 34), and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture - forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件（14,12）之间形成密封连通的方法和设备，每个导管子组件具有带外表面（24,34）的壁（22,32），并且至少一个壁包括导电部分。可以使外表面成为面对关系，并且每个导电部分被充分加热以通过在导电部分中产生电流（例如通过施加电压或通过感应）来消毒壁的外表面。然后通过孔形成构件提供孔，穿过相对的壁以提供导管或导管子组件之间的连通。

5. 发明申请

WO2012151243A2 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2012151243A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/036062
申请日：2012-05-02
申请人： FENWAL, INC. , BELT, Fletcher, C. , KAST, Michael, J. , MIN, Kyungyoon , RADWANSKI, Katherine , CORK, William, H.
发明人： BELT, Fletcher, C. , KAST, Michael, J. , MIN, Kyungyoon , RADWANSKI, Katherine , CORK, William, H.
IPC分类号： A61M1/02
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber containing the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入含有浓缩血液成分的一次性处理室。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

6. 发明申请

WO2012125472A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2012125472A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028532
申请日：2012-03-09
申请人： FENWAL, INC. , BLICKHAN, Bryan , MIN, Kyungyoon , CORK, William, H.
发明人： BLICKHAN, Bryan , MIN, Kyungyoon , CORK, William, H.
IPC分类号： B01D17/12 , A61M37/00 , B01D61/00 , B01D24/28 , B01D33/15
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

7. 发明申请

WO2011101836A3 AUTHORIZATION SCHEME TO MINIMIZE THE USE OF UNAUTHORIZED MEDICAL DEVICE DISPOSABLES ON A MEDICAL DEVICE INSTRUMENT 审中-公开
公开(公告)号：WO2011101836A3
公开(公告)日：2011-08-25
申请号：PCT/IB2011/050827
申请日：2011-02-25
申请人： FENWAL, INC. , NEWLIN, Douglas , KRAUSE, Kevin , CRAMPTON, Robert , FOLEY, John T. , CASE, Brian , CORK, William
发明人： NEWLIN, Douglas , KRAUSE, Kevin , CRAMPTON, Robert , FOLEY, John T. , CASE, Brian , CORK, William
IPC分类号： G06Q50/00 , G06F21/20
摘要： Systems, methods, apparatus, and computer readable media are provided for disposable component authentication with respect to a biological fluid processing device instrument. An example instrument authentication system includes a computer facilitating configuration and operation of the biological fluid processing instrument using a disposable component. A first interface is provided by the computer and is used by a service technician to configure the biological fluid processing instrument for a number of disposable components and to provide a service technician with a validation code. A key generator is to accept the validation code from the service technician and generate an authentication key in response to the entered validation code. A second interface is provided by the computer, the second interface prompting the service technician to enter an authentication key, wherein the authentication key authorizes use of a certain number of disposable components for the biological fluid processing instrument.

8. 发明申请

WO0205059A3 MEDICAL SYSTEM, METHOD AND APPARATUS EMPLOYING MEMS 审中-公开
标题翻译：医疗系统，使用MEMS的方法和设备
公开(公告)号：WO0205059A3
公开(公告)日：2008-03-13
申请号：PCT/US0121188
申请日：2001-07-03
申请人： BAXTER INT , CORK WILLIAM H , ULMES JAMES J , WEST RICHARD L , LO YING-CHEN , WEBER MARK C , MIN KYUNGYOON
发明人： CORK WILLIAM H , ULMES JAMES J , WEST RICHARD L , LO YING-CHEN , WEBER MARK C , MIN KYUNGYOON
IPC分类号： A61M37/00 , G01N33/48 , A61B5/00 , A61B5/145 , A61B19/02 , A61M1/02 , A61M1/36 , A61M1/38 , B01D17/00 , B01D37/00 , B01D61/00 , B01D61/22 , B01L99/00 , C02F1/00 , C12M1/34 , G01N33/49 , G01N33/50 , G01N35/00 , G01N35/08 , G06F20060101 , G06F1/00
CPC分类号： A61B5/14546 , A61B5/14557 , A61B5/417 , A61B50/13 , A61B2562/028 , A61M1/0209 , A61M1/3609 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/12 , A61M2205/33 , A61M2205/52 , A61M2230/20 , B01D61/22 , G01N33/491 , G01N33/5005 , G01N33/5094 , G01N35/08 , G01N2035/00237 , Y10T436/117497
摘要： A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
摘要翻译：公开了一种生物悬浮处理系统，其可以包括用于处理生物悬浮液的一种或多种组分的悬浮处理装置，用于将悬浮液引入处理装置的第一流体流动路径和用于取出生物悬浮液的成分的第二流体流动路径从设备暂停。至少在微机电（MEM）传感器上与一个流体流路连通，以便感测流体的选定特性。 MEM传感器可以位于别处，例如在容器或袋上，并与内部连通，以便感测其中所含流体的特性。可以检测各种各样的特征，例如流速，pH，细胞类型，细胞抗原性，DNA，病毒或细菌存在，胆固醇，血细胞比容，细胞浓度，细胞计数，分压，病原体存在或粘度。

9. 发明申请

WO2007002567A3 SELECTIVE ISOLATION AND CONCENTRATION OF NUCLEIC ACIDS FROM COMPLEX SAMPLES 审中-公开
标题翻译：从复杂样品中选择性分离和浓缩核酸
公开(公告)号：WO2007002567A3
公开(公告)日：2007-03-29
申请号：PCT/US2006024761
申请日：2006-06-23
申请人： NANOSPHERE INC , MARLA SUDHAKAR S , PROKHOROVA ANYA , HETZEL SUSAN , CORK WILLIAM
发明人： MARLA SUDHAKAR S , PROKHOROVA ANYA , HETZEL SUSAN , CORK WILLIAM
IPC分类号： C12Q1/68
CPC分类号： B82Y10/00 , B82Y5/00 , C12N1/06 , C12N15/1006 , C12Q1/6806 , C12Q1/6827 , C12Q2537/125 , C12Q2527/125
摘要： The present invention provides methods for detecting a target nucleic acid molecule in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules in a complex environment containing numerous non-nucleic acid components. In particular, the present invention provides methods and probes for isolating DNA with detergents and detecting a single nucleotide polymorphism (SNP) in a complex sample that comprises numerous non-nucleic acid components and nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules.
摘要翻译：本发明提供了用于检测样品中的靶核酸分子的方法，所述样品包含比在包含许多非核酸组分的复杂环境中的扩增核酸分子的生物复杂度更高的生物复杂度的核酸分子。具体而言，本发明提供了用于用洗涤剂分离DNA并检测复合物样品中的单核苷酸多态性（SNP）的方法和探针，所述复合物样品包含许多非核酸组分和比生物复杂度高于扩增核酸的核酸分子分子。

10. 发明申请

WO03053535B1 NANOPARTICLE IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：纳米颗粒成像系统和方法
公开(公告)号：WO03053535B1
公开(公告)日：2003-11-06
申请号：PCT/US0224604
申请日：2002-08-02
申请人： NANOSPHERE INC , CORK WILLIAM , PATNO TIM , WEBER MARK , MORROW DAVE , BUCKINGHAM WESLEY
发明人： CORK WILLIAM , PATNO TIM , WEBER MARK , MORROW DAVE , BUCKINGHAM WESLEY
IPC分类号： G01N33/553 , B01J13/00 , B82B1/00 , C12M1/34 , C12Q1/68 , G01N21/25 , G01N21/27 , G01N21/75
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译：提供了用于成像金属纳米颗粒的设备和方法。优选地，本发明提供了用于检测金胶体颗粒并且准确报告给操作者的设备和方法。该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。该设备可以具有彼此接近的固定衬底支架和成像模块。该设备提供用于小型系统而不需要复杂的机动装置来将照相机移动穿过基板。此外，所述设备和方法提供基板上的斑点/孔的自动检测，基板上的斑点的自动量化以及基于决策统计的斑点的自动解释。

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