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1. 发明申请

WO2014126957A1 MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒
公开(公告)号：WO2014126957A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/015931
申请日：2014-02-12
申请人： 480 BIOMEDICAL, INC. , PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Gregory, T.
发明人： PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Gregory, T.
IPC分类号： A61L31/06 , A61L31/14 , A61L31/10
CPC分类号： A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04 , C08L75/06
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高回收性和所需的机械性能。

2. 发明申请

WO2014120454A1 ELECTROSPINNING PROCESS FOR MANUFACTURE OF MULTI-LAYERED STRUCTURES 审中-公开
标题翻译：用于制造多层结构的电纺工艺
公开(公告)号：WO2014120454A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/011813
申请日：2014-01-16
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , PHAM, Quynh , MARINI, John , YAN, Xuri , CORE, Lee
发明人： ARSENAL MEDICAL, INC. , SHARMA, Upma , PHAM, Quynh , MARINI, John , YAN, Xuri , CORE, Lee
IPC分类号： B05B5/025 , D01D5/00 , D01D5/34
CPC分类号： D01D5/0061 , D01D5/0038 , D01D5/0069 , D01D5/34
摘要： Devices and methods for high-throughput manufacture of concentrically layered nanoscale and microscale fibers by electrospinning are disclosed. The devices include a hollow tube having a lengthwise slit through which a core material can flow, and can be configured to permit introduction of sheath material at multiple sites of Taylor cone formation formation.
摘要翻译：公开了通过静电纺丝高分辨率生产同心层状纳米尺度和微细纤维的装置和方法。这些装置包括具有纵向狭缝的中空管，核心材料可通过该纵向狭缝流动，并且可以被配置为允许在Taylor锥形成形成的多个位置引入护套材料。

3. 发明申请

WO2013066970A1 FOAM AND DELIVERY SYSTEM FOR TREATMENT OF POSTPARTUM HEMORRHAGE 审中-公开
标题翻译：泡沫和输送系统用于治疗血栓形成
公开(公告)号：WO2013066970A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/062732
申请日：2012-10-31
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , GITLIN, Irina , ZAMIRI, Parisa , FREYMAN, Toby , BUSOLD, Rany , CORE, Lee , MORTENSEN, Jennifer , KOMATSU, Janet, Chie
发明人： SHARMA, Upma , GITLIN, Irina , ZAMIRI, Parisa , FREYMAN, Toby , BUSOLD, Rany , CORE, Lee , MORTENSEN, Jennifer , KOMATSU, Janet, Chie
IPC分类号： A61L27/14 , A61L27/56 , A61L31/04 , A61L31/14
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
摘要翻译：公开了用于治疗产后出血的医疗植入物和方法。在一些实施方案中，植入物包含具有有利的机械和其它性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。还公开了制造和部署这种植入物的方法。

4. 发明申请

WO2017004209A1 SCAFFOLD LOADING AND DELIVERY SYSTEMS 审中-公开
标题翻译： SCAFF装载和传送系统
公开(公告)号：WO2017004209A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040102
申请日：2016-06-29
申请人： 480 BIOMEDICAL, INC. , HELMICK, Marc , MERLO, Jonathan , CORE, Lee , PHAM, Quyhn , PROSTROILLO, Anthony , PAULSON, Ross , PETERSON, Danielle , PRAHL, Garrett , BEYREIS, Randall , ROGGEMANN, Michele
发明人： HELMICK, Marc , MERLO, Jonathan , CORE, Lee , PHAM, Quyhn , PROSTROILLO, Anthony , PAULSON, Ross , PETERSON, Danielle , PRAHL, Garrett , BEYREIS, Randall , ROGGEMANN, Michele
IPC分类号： A61F2/966
CPC分类号： A61F2/186 , A61F2/90 , A61F2/958 , A61F2/966 , A61F2002/9522 , A61F2002/9665
摘要： This disclosure describes, inter alia , materials, devices, kits and methods that may be used for loading scaffolds into delivery devices and delivery of scaffolds into the body of a patient, including delivery of scaffolds to the sinuses for the treatment of chronic sinusitis, among other purposes.
摘要翻译：本公开尤其描述了可用于将支架装载到输送装置中并将支架递送到患者体内的材料，装置，试剂盒和方法，包括将支架递送至用于治疗慢性鼻窦炎的鼻窦，其中其他用途

5. 发明申请

WO2014172319A1 DRUG ELUTING MEDICAL IMPLANT 审中-公开
标题翻译：药物植入物
公开(公告)号：WO2014172319A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034095
申请日：2014-04-15
申请人： 480 BIOMEDICAL, INC. , PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kirchel , SHARMA, Upma , ZUGATES, Gregory, T.
发明人： PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kirchel , SHARMA, Upma , ZUGATES, Gregory, T.
IPC分类号： A61L31/10 , A61L27/34 , A61L31/16 , A61L27/54
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高回收性和所需的机械性能。

6. 发明申请

WO2014081914A3 STENT WITH ELASTOMERIC ELEMENTS 审中-公开
标题翻译：具有弹性元件的STENT
公开(公告)号：WO2014081914A3
公开(公告)日：2014-07-31
申请号：PCT/US2013071161
申请日：2013-11-21
申请人： 480 BIOMEDICAL INC , CORE LEE , CONCAGH DANNY , RUSK EMILY , WEBBER STEPHANIE , KNOX RAYMOND , HO KICHERL
发明人： CORE LEE , CONCAGH DANNY , RUSK EMILY , WEBBER STEPHANIE , KNOX RAYMOND , HO KICHERL
IPC分类号： A61F2/90 , A61F2/82 , A61F2/91
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/825 , A61F2210/0004 , A61F2210/0071 , A61F2250/0018 , A61F2250/004 , A61F2250/0042 , A61F2250/0048 , Y10T29/49925
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desirable mechanical properties. The implant comprises a plurality of open area (214) having a continuous outer boundary and one or more elements (310) spanning one or more open area of the implant and connecting proximal and distal boundary portions of said open area. The spanning element (310) due to its nature (for instance due to its material) applies a force to the implant that acts in favour of radial expansion and axial contraction, thus enhancing radial strength.
摘要翻译：公开了一种用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。植入物具有高回收性和所需的机械性能。植入物包括具有连续外边界的多个开放区域（214）和跨越植入物的一个或多个开放区域并连接所述开放区域的近端和远端边界部分的一个或多个元件（310）。跨越元件（310）由于其性质（例如由于其材料）而对植入物施加力，其有利于径向膨胀和轴向收缩，从而增强径向强度。

7. 发明申请

WO2007050296A1 CATHETER HAVING OVAL ASPIRATION LUMEN AND METHOD OF MAKING 审中-公开
标题翻译：具有OVAL吸收光的导管及其制备方法
公开(公告)号：WO2007050296A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/039777
申请日：2006-10-10
申请人： MEDTRONIC VASCULAR INC. , PROVOST-TINE, Michelle , CORE, Lee , PAPA, Michael , RIOPEL, Michael
发明人： PROVOST-TINE, Michelle , CORE, Lee , PAPA, Michael , RIOPEL, Michael
IPC分类号： A61M25/00 , B29C65/00
CPC分类号： B29C53/20 , A61M25/0009 , A61M25/003 , A61M25/0032 , A61M25/0053 , A61M2025/0034 , A61M2025/0037 , B29C65/48 , B29C65/4815 , B29C65/4895 , B29C65/68 , B29C66/50 , B29D23/001 , B29K2023/00 , B29K2023/06 , B29K2023/12 , B29K2027/18 , B29K2075/00 , B29K2077/00 , B29K2101/12 , B29K2105/0085 , B29L2009/00 , B29L2031/602 , B29L2031/7542 , B29C65/00
摘要： Catheters (10) for aspiration of thrombotic, atherosclerotic or other particulate embolic debris from a blood vessel. An elongate flexible aspiration tube (31) has an aspiration lumen (12) defined by a reinforced tube wall. A guidewire tube (51) is secured alongside the aspiration tube extending proximally from a distal end thereof to define either over-the-wire or single operator catheter configurations . The portion of the aspiration tube alongside the guidewire tube has an oval transverse cross section with a minor axis extending transversely through the guidewire tube. The oval cross section of the aspiration tube improves the catheter' s efficient use of cross sectional space by making the overall catheter transverse cross section nearly equal in orthogonal dimensions. Methods of making aspiration catheters are also disclosed, including permanently deforming the portion of the aspiration tube into an oval transverse cross section.
摘要翻译：导管（10）用于从血管吸入血栓形成，动脉粥样硬化或其他颗粒状栓塞性碎屑。细长的柔性抽吸管（31）具有由增强的管壁限定的抽吸腔（12）。导丝管（51）被固定在从其远端向近侧延伸的抽吸管旁边以限定线上或单个操作者导管配置。吸引管沿着导丝管的一部分具有椭圆形横截面，其中短轴横向延伸穿过导丝管。抽吸管的椭圆形横截面通过使整个导管的横截面在正交尺寸上几乎相等而改善了导管的横截面空间的有效使用。还公开了制造吸液导管的方法，包括将抽吸管的一部分永久变形为椭圆形横截面。

8. 发明申请

WO2005018728A3 EXPANDABLE SHEATH TUBING 审中-公开
标题翻译：可膨胀的管子
公开(公告)号：WO2005018728A3
公开(公告)日：2005-06-16
申请号：PCT/US2004026998
申请日：2004-08-19
申请人： NMT MEDICAL INC , WRIGHT JOHN A JR , PEAVEY TODD A , KOLBER ANDREA B , CORE LEE A
发明人： WRIGHT JOHN A JR , PEAVEY TODD A , KOLBER ANDREA B , CORE LEE A
IPC分类号： A61B17/12 , A61B17/22 , A61B17/34 , A61B19/00 , A61F2/01 , A61F2/06 , A61F2/84 , A61M25/00 , A61M29/00
CPC分类号： A61M25/0074 , A61B17/22031 , A61B17/3415 , A61B17/3439 , A61B17/3468 , A61B90/40 , A61B2017/1205 , A61B2090/08021 , A61F2/95 , A61F2/97 , A61F2002/011 , A61F2002/9528 , A61F2002/9534 , A61M25/0045 , A61M25/005 , A61M25/008 , A61M29/02 , A61M2025/0024 , A61M2025/0063 , A61M2025/0081 , A61M2025/1068 , A61M2025/1072 , A61M2025/1075 , A61M2025/1081
摘要： An expandable catheter (10) accommodates a medical device that is being removed from a body with a larger diameter than the catheter. The same catheter may be used to reposition a device within the body to an alternative delivery site. A catheter or sheath may be used to deliver a medical device, surgical instrument, or biological sample.
摘要翻译：可扩张导管（10）容纳从具有比导管更大的直径的身体移除的医疗装置。可以使用相同的导管来将身体内的装置重新定位到替代递送部位。可以使用导管或护套来递送医疗装置，手术器械或生物样品。

9. 发明申请

WO2004037333A1 EXPANDABLE SHEATH TUBING 审中-公开
标题翻译：可膨胀护套管
公开(公告)号：WO2004037333A1
公开(公告)日：2004-05-06
申请号：PCT/US2003/034003
申请日：2003-10-24
申请人： NMT MEDICAL, INC. , CORE, Lee, A.
发明人： CORE, Lee, A.
IPC分类号： A61M25/06
CPC分类号： A61B17/3439 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61M25/0023 , A61M25/0662 , A61M2025/0024
摘要： An introducer sheath or catheter can be formed in two or more layers with an inner layer made of a higher durometer material and an outer layer made of a lowerdurometer material. The inner layer can have one or a combination of the following: one or more longitudinal slits, overlapping portions, monolithic hinges, or other formations to allow for radial expansion.
摘要翻译：导入鞘或导管可以形成为两层或更多层，内层由较高硬度材料制成，外层由较低硬度材料制成。内层可具有以下中的一种或其组合：一个或多个纵向狭缝，重叠部分，整体式铰链或允许径向扩张的其他构造。

10. 发明申请

WO2004032993A2 HEMOSTASIS VALVE 审中-公开
标题翻译： HEMOSTASIS阀
公开(公告)号：WO2004032993A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/032133
申请日：2003-10-10
申请人： NMT MEDICAL, INC. , CORE, Lee, A.
发明人： CORE, Lee, A.
IPC分类号： A61M
CPC分类号： A61M39/0606 , A61M2039/062 , A61M2039/0633 , A61M2039/064
摘要： A hemostasis valve includes a single gland with multiple offset longitudinal slits that do no extend through the gland completely. The multiple slits from a complex pathway for the guide dilator/catheter and thus a better seal. The offset slits are joined by a lateral cut in the gland. When a guide wire or dilator/catheter in introduced into the introducer, the gland deforms sufficiently to allow the guide wire or other device to move through the first slits, the lateral cut and the second slits. This complex pathway or slit provides a larger sealing surface thereby creating a better seal. As a result, effective seals may be formed around relatively large, as compared to the inner diameter of an introducer sheath, catheters.
摘要翻译：止血阀包括具有多个偏移纵向狭缝的单个腺体，其不完全延伸穿过腺体。来自导向扩张器/导管的复合路径的多个狭缝，因此更好的密封。偏移狭缝通过腺体中的横向切口连接。当引导线或扩张器/导管引入引导器时，腺体足够变形以允许导丝或其它装置移动穿过第一狭缝，横切和第二狭缝。这个复杂的路径或狭缝提供了更大的密封面，从而形成更好的密封。结果，与引导器套管的内径相比，导管可以相对较大地形成有效的密封。

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