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1. 发明申请

WO2009156840A3 ELECTRONIC FLUID TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：电子流体处理设备和方法
公开(公告)号：WO2009156840A3
公开(公告)日：2010-10-14
申请号：PCT/IB2009006065
申请日：2009-06-26
申请人： CONEQUIPT CC , VROOM IAN DOUGLAS , COOPER MARK BADEN
发明人： VROOM IAN DOUGLAS , COOPER MARK BADEN
IPC分类号： C02F1/461 , B03C3/68 , B03C5/02
CPC分类号： B03C5/02 , A61L9/16 , B03C3/68 , C02F1/46109 , C02F1/4672 , C02F2001/46123 , C02F2001/46138 , C02F2103/008 , C02F2201/46175
摘要： Electronic fluid treatment apparatus is provided comprising an electrode assembly (5) mounted in a housing (9, 15) having an inlet (10, 16) and an outlet (11, 17, 18). The electrode assembly has multiple electrodes (1 ) held in parallel spaced relationship relative to each other. A power supply (8) is connected to the electrodes such that alternate electrodes are interconnected so as to be similarly energised by the power supply. The power supply is adapted to provide a pulsed voltage at an amplitude and frequency dependent on the construction of the individual electrodes, the spacing between them and the dielectric properties of the fluid in which the electrodes are to operate such that the electrodes, in use, provide a capacitive effect. Typically an inductance is connected in parallel with the electrodes so as to create a resonant circuit. The apparatus is able to provide three distinct actions against microorganisms contained in the fluid.
摘要翻译：提供电子流体处理设备，其包括安装在具有入口（10,16）和出口（11,17,18）的壳体（9,15）中的电极组件（5）。电极组件具有多个电极（1），彼此保持平行间隔的关系。电源（8）连接到电极，使得交替电极互连以类似地由电源供电。电源适于以取决于单个电极的结构，它们之间的间隔和其中电极将要操作的流体的介电特性的幅度和频率提供脉冲电压，使得在使用中的电极，提供电容效应。通常，电感与电极并联连接以产生谐振电路。该装置能够提供针对流体中包含的微生物的三种不同的作用。

2. 发明申请

WO2009156840A2 ELECTRONIC FLUID TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：电子流体处理设备和方法
公开(公告)号：WO2009156840A2
公开(公告)日：2009-12-30
申请号：PCT/IB2009/006065
申请日：2009-06-26
申请人： CONEQUIPT CC , VROOM, Ian, Douglas , COOPER, Mark, Baden
发明人： VROOM, Ian, Douglas , COOPER, Mark, Baden
IPC分类号： C02F1/461 , B03C5/02
CPC分类号： B03C5/02 , A61L9/16 , B03C3/68 , C02F1/46109 , C02F1/4672 , C02F2001/46123 , C02F2001/46138 , C02F2103/008 , C02F2201/46175
摘要： Electronic fluid treatment apparatus is provided comprising an electrode assembly (5) mounted in a housing (9, 15) having an inlet (10, 16) and an outlet (11, 17, 18). The electrode assembly has multiple electrodes (1 ) held in parallel spaced relationship relative to each other. A power supply (8) is connected to the electrodes such that alternate electrodes are interconnected so as to be similarly energised by the power supply. The power supply is adapted to provide a pulsed voltage at an amplitude and frequency dependent on the construction of the individual electrodes, the spacing between them and the dielectric properties of the fluid in which the electrodes are to operate such that the electrodes, in use, provide a capacitive effect. Typically an inductance is connected in parallel with the electrodes so as to create a resonant circuit. The apparatus is able to provide three distinct actions against microorganisms contained in the fluid.
摘要翻译：提供电子流体处理设备，其包括安装在具有入口（10,16）和出口（11,17,18）的壳体（9,15）中的电极组件（5）。电极组件具有多个电极（1），彼此保持平行间隔的关系。电源（8）连接到电极，使得交替电极互连以类似地由电源供电。电源适于以取决于单个电极的结构，它们之间的间隔和其中电极将要操作的流体的介电特性的幅度和频率提供脉冲电压，使得在使用中的电极，提供电容效应。通常，电感与电极并联连接以产生谐振电路。该装置能够提供针对流体中包含的微生物的三种不同的作用。

3. 发明申请

WO2009117743A2 NOVEL CHRYSOCHROMULINA SPECIES, METHODS AND MEDIA THEREFOR, AND PRODUCTS DERIVED THEREFROM 审中-公开
标题翻译：新型氯氰菊酯物种，其方法和介质及其衍生物
公开(公告)号：WO2009117743A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037997
申请日：2009-03-23
申请人： UNIVERSITY OF WASHINGTON , CATTOLICO, Rose, Anne , COOPER, Mark, S. , HARDIN, William, Robert , BIGELOW, Nicholas , VO, Cong-Thien
发明人： CATTOLICO, Rose, Anne , COOPER, Mark, S. , HARDIN, William, Robert , BIGELOW, Nicholas , VO, Cong-Thien
IPC分类号： C12N1/12 , C12R1/89
CPC分类号： C12R1/89 , C12N1/12 , C12P7/6409 , C12P7/6463
摘要： An algal cell that is capable of surviving in fresh water and has a high fatty acid content, an algal culture including the algal cell, methods of growing the algal culture, algal growth media, and methods for selectively adapting the algal culture are provided.
摘要翻译：提供了能够在淡水中存活并具有高脂肪酸含量的藻类细胞，包括藻类细胞的藻类培养物，藻类培养物的生长方法，藻类生长培养基和选择性适应藻类培养物的方法。

4. 发明申请

WO2009051804A1 THIAZOLIUM COMPOUNDS FOR TREATING OR PREVENTING DISEASES ASSOCIATED WITH INSULIN RESISTANCE 审中-公开
标题翻译：用于治疗或预防与胰岛素抵抗相关的疾病的噻唑化合物
公开(公告)号：WO2009051804A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011886
申请日：2008-10-17
申请人： SYNVISTA THERAPEUTICS, INC. , FORBES, Josephine , TONG, David , ANDRIKOPOULOS, Sofianos , COOPER, Mark
发明人： FORBES, Josephine , TONG, David , ANDRIKOPOULOS, Sofianos , COOPER, Mark
IPC分类号： A61K31/426 , A61K31/428 , A61P3/08 , A61P3/10
CPC分类号： A61K31/426 , A61K31/428
摘要： Thiazolium derivates for treating a patient having a metabolic disorder related to insulin resistance and/or beta cell dysfunction, including patients with type I diabetes, type II diabetes, metabolic syndrome and/or pre-diabetes.
摘要翻译：噻唑衍生物用于治疗与胰岛素抵抗和/或β细胞功能障碍相关的代谢紊乱患者，包括I型糖尿病，II型糖尿病，代谢综合征和/或前期糖尿病的患者。

5. 发明申请

WO2009036280A1 LONG-TERM IN VIVO TRANSGENE EXPRESSION 审中-公开
标题翻译： VIVO TRANSGENE EXPRESSION的长期使用
公开(公告)号：WO2009036280A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076177
申请日：2008-09-12
申请人： COPERNICUS THERAPEUTICS, INC. , COOPER, Mark J. , PADEGIMAS, Linas
发明人： COOPER, Mark J. , PADEGIMAS, Linas
IPC分类号： C12N15/85
CPC分类号： C07K14/4712 , A61K48/0066 , C12N15/85 , C12N2799/04 , C12N2830/42 , C12N2830/50 , C12N2830/85 , C12N2840/00 , C12N2840/85
摘要： Efficient and prolonged hCFTR expression is one of the major obstacles for cystic fibrosis lung therapy. hCFTR mRNA expression levels depend on eukaryotic expression cassette components, prokaryotic backbone elements, and the gene transfer method may also influence transcriptional silencing mechanisms. A codon-optimized and CpG-reduced human CFTR gene (CO-CFTR) was made. Various vector modifications were tested to facilitate extended duration of CO-CFTR expression. Insertion of an extended 3'BGH transcribed sequence (712 bp) in an inverted orientation produced prolonged expression of CO-CFTR expression at biologically relevant levels. Further studies revealed that prolonged CO-CFTR expression is dependant on the orientation of the extended BGH 3' BGH transcribed sequence and its transcription, is not specific to the UbC promoter, and is less dependent on other vector backbone elements.
摘要翻译：有效和长期的hCFTR表达是囊性纤维化肺部治疗的主要障碍之一。 hCFTR mRNA表达水平取决于真核表达盒组分，原核骨架元素，基因转移方法也可能影响转录沉默机制。制备了密码子优化和CpG还原的人CFTR基因（CO-CFTR）。测试各种载体修饰以促进CO-CFTR表达的延长的持续时间。以倒置方向插入延伸的3'BGH转录序列（712bp）产生CO-CFTR表达在生物相关水平上的延长表达。进一步的研究表明，延长的CO-CFTR表达依赖于扩展的BGH 3'BGH转录序列的方向及其转录，对UbC启动子不是特异性的，并且较少依赖于其它载体骨架元素。

6. 发明申请

WO2009006204A1 TRACK TRENCHER PROPULSION SYSTEM WITH LOAD CONTROL 审中-公开
标题翻译：带有负载控制的跟踪加速器推进系统
公开(公告)号：WO2009006204A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068355
申请日：2008-06-26
申请人： VERMEER MANUFACTURING COMPANY , HARTWICK, Ty , COOPER, Mark
发明人： HARTWICK, Ty , COOPER, Mark
IPC分类号： E02F5/14 , E02F9/20 , E02F9/22 , F16H61/46 , B60W30/18 , B60W10/10
CPC分类号： E02F5/145 , B62D11/003 , E02F9/2246 , E02F9/2253 , E02F9/26 , F16H61/465 , F16H2059/6861
摘要： A system and process for controlling propulsion and steering of a track trencher excavation machine (30) powered by an engine (36) includes a multiple mode propulsion and steering control system that performs a plurality of functions depending on a selection of one of a plurality of operational modes. A controller (182) generates a vehicle propulsion hydrostatic drive signal (318,319) using an engine speed (ERPM, 312) to determine a load multiplier (LM). The load multiplier (LM)' being defined as a function of the engine speed (ERPM) and an operator adjustable load control setting (380).
摘要翻译：用于控制由发动机（36）供电的履带挖掘机挖掘机（30）的推进和转向的系统和过程包括多模式推进和转向控制系统，其根据多个操作模式。控制器（182）使用发动机转速（ERPM，312）产生车辆推进静液压驱动信号（318,319）以确定负载倍增器（LM）。负载倍增器（LM）被定义为发动机转速（ERPM）和操作员可调负载控制设置（380）的函数。

7. 发明申请

WO2008045548A2 CODON OPTIMIZED CFTR 审中-公开
公开(公告)号：WO2008045548A2
公开(公告)日：2008-04-17
申请号：PCT/US2007021862
申请日：2007-10-12
申请人： COPERNICUS THERAPEUTICS INC , COOPER MARK J , PADEGIMAS LINAS
发明人： COOPER MARK J , PADEGIMAS LINAS
IPC分类号： A61K48/00
CPC分类号： C07K14/4712 , A61K48/005 , C12N2830/50 , C12N2840/44
摘要： A synthetic hCFTR DNA sequence has been developed that produces remarkably high levels of hCFTR mRNA and protein in dosed murine lungs and human cells in culture compared to the natural hCFTR cDNA. This synthetic DNA addresses.problems inherent in some natural cDNAs, such as premature transcriptional truncation sites introduced during cDNA synthesis. Introns are initially present in mRNA until the mRNA is processed. cDNA made from processed mRNA is devoid of introns. Thus DNA sequences (exon junctions) are present in a cDNA molecule which are not present in cells in nature. These exon junctions may affect transcription. Methods for improving expression of CFTR are based on sequence changes in cDNA molecules. The improvement methods may be applied to other cDNA molecules which are refractory to in vivo expression efforts. Compositions embodying the sequence changes increase the production of both transgenic mRNA and protein from cDNA molecules.
摘要翻译：已经开发了合成的hCFTR DNA序列，其与天然hCFTR cDNA相比在培养的给药鼠肺和人细胞中产生显着高水平的hCFTR mRNA和蛋白质。这种合成的DNA解决了一些天然cDNA中固有的问题，例如在cDNA合成期间引入的早期转录截短位点。内含子最初存在于mRNA中直到mRNA被加工。由加工的mRNA制成的cDNA没有内含子。因此，DNA序列（外显子连接）存在于自然界中不存在于细胞中的cDNA分子中。这些外显子可能会影响转录。改进CFTR表达的方法是基于cDNA分子的序列变化。改进方法可以应用于对体内表达努力难以进行的其它cDNA分子。体现序列变化的组合增加了来自cDNA分子的转基因mRNA和蛋白质的产生。

8. 发明申请

WO2007106077A3 DROP-IN DAMPED HINGE MODULE 审中-公开
标题翻译： DROP-IN阻尼铰链模块
公开(公告)号：WO2007106077A3
公开(公告)日：2008-01-10
申请号：PCT/US2006007936
申请日：2006-03-02
申请人： SOUTHCO , LOWRY DAVID , NOVIN EUGENE , COOPER MARK
发明人： LOWRY DAVID , NOVIN EUGENE , COOPER MARK
IPC分类号： E05F1/08 , E05D11/08 , E05D11/10 , E05F1/14
CPC分类号： E05F1/1215 , E05D11/082 , E05Y2201/21 , E05Y2201/254 , E05Y2201/266 , E05Y2800/205 , Y10T16/53862 , Y10T16/5388 , Y10T16/53888 , Y10T16/5389
摘要： A damped hinge module (10) is disclosed and includes a first member (12), a second member (14) and a torsion spring (16). The second member is rotationally movable relative to the first member between a first position and a second position. The second member being received at least in part within the first member. The torsion spring is located internally with respect to the first member and biases the second member toward the first position relative to the first member. The spring has a preload with the second member in the first position relative to the first member.
摘要翻译：公开了阻尼铰链模块（10），并包括第一构件（12），第二构件（14）和扭转弹簧（16）。第二构件可在第一位置和第二位置之间相对于第一构件旋转移动。第二个成员至少部分被接收在第一个成员内。扭转弹簧相对于第一构件位于内部，并且相对于第一构件朝向第一位置偏压第二构件。弹簧具有相对于第一构件处于第一位置的第二构件的预加载。

9. 发明申请

WO2005014858A3 QTL "MAPPING AS-YOU-GO" 审中-公开
标题翻译： QTL“映射为您”
公开(公告)号：WO2005014858A3
公开(公告)日：2005-12-01
申请号：PCT/US2004020167
申请日：2004-06-22
申请人： PIONEER HI BRED INT , PODLICH DEAN , COOPER MARK , WINKLER CHRISTOPH
发明人： PODLICH DEAN , COOPER MARK , WINKLER CHRISTOPH
IPC分类号： A01H1/04 , C12N15/82 , C12Q1/68 , G06F19/00
CPC分类号： C12Q1/68
摘要： This invention provides methods for monitoring QTL effects and marker assisted selection (MAS) involving providing a recursively determined correlation between one or more markers and a phenotype of interest.
摘要翻译：本发明提供了用于监测QTL效应和标记辅助选择（MAS）的方法，所述标记辅助选择（MAS）涉及提供一种或多种标记与感兴趣的表型之间的递归确定的相关性。

10. 发明申请

WO2005000006A2 PLANT BREEDING METHOD 审中-公开
标题翻译：植物育种方法
公开(公告)号：WO2005000006A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/016850
申请日：2004-05-27
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , SMITH, Oscar, S. , COOPER, Mark , TINGEY, Scott, V. , RAFALSKI, Antoni, J. , LUEDTKE, Roy , NIEBUR, William, S.
发明人： SMITH, Oscar, S. , COOPER, Mark , TINGEY, Scott, V. , RAFALSKI, Antoni, J. , LUEDTKE, Roy , NIEBUR, William, S.
IPC分类号： A01H
CPC分类号： A01H1/04 , A01H1/02 , A01H5/10
摘要： Methods for using genetic marker genotype (e.g., gene sequence diversity information) to improve the process of developing plant varieties (e.g., single cross hybrids) with improved phenotypic performance are provided. Methods for predicting the value of a phenotypic trait in a plant are provided. The methods use genotypic, phenotypic, and optionally family relationship information for a first plant population to identify an association between at least one genetic marker and the phenotypic trait, and then use the association to predict the value of the phenotypic trait in one or more members of a second, target population of known marker genotype. Methods for identifying new allelic variants affecting the trait are also provided. Plants selected, provided, or produced by any of the methods herein, transgenic plants created by any of the methods herein, and digital systems for performing the methods herein are also provided.
摘要翻译：提供了使用遗传标记基因型（例如，基因序列多样性信息）来改进具有改进的表型性能的开发植物品种（例如，单杂交杂交）的过程的方法。提供了预测植物表型性状价值的方法。所述方法使用第一植物群体的基因型，表型和任选的家族关系信息来鉴定至少一个遗传标记和表型性状之间的关联，然后使用该关联来预测一个或多个成员中的表型性状的价值的第二个已知标记基因型的目标群体。还提供了确定影响性状的新的等位基因变异体的方法。本文中通过任何方法选择，提供或产生的植物，通过本文的任何方法产生的转基因植物和用于执行本文方法的数字系统也被提供。

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