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    • 4. 发明申请
    • NANOWIRE ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRIC ANALYSIS
    • 纳米辅助激光解吸/离子质谱分析
    • WO2005088293A1
    • 2005-09-22
    • PCT/KR2005/000738
    • 2005-03-15
    • KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYCHOI, Heon JinPYUN, Jae Chul
    • CHOI, Heon JinPYUN, Jae Chul
    • G01N27/62
    • H01J49/0418
    • This invention relates to a nanowire-assisted method for mass spectrometric analysis of a specimen. More specifically, by using nanowire which can fix a specimen and perform desorption/ionization of the specimen while effectively transferring laser energy to the specimen to be irradiated, thereby enabling to perform mass spectrometric analysis without using a matrix solution. This invention, by effectively performing desorption/ ionization of a specimen using the above-mentioned nanowire, enables to effectively perform qualitative-, quantitative-, and micro- analyses of specimens as well as low molecular weighted specimens. Further, this invention enables to the typical device of mass spectrometric analysis used in MALDI-T of MS. In particular, this invention can perform mass spectrometric analysis of a specimen with molecular weight of less than 1,000 Da and perform quantitative analysis by fixing a specimen with a predetermined area.
    • 本发明涉及一种用于样品的质谱分析的纳米线辅助方法。 更具体地说,通过使用可固定样品的纳米线,并且能够将激光能量有效地转移到待照射的样品上,从而能够进行质谱分析而不使用基质溶液,从而进行试样的解吸/电离。 本发明通过使用上述纳米线有效地进行样品的解吸/电离,能够有效地进行试样和低分子加权试样的定性,定量和微观分析。 此外,本发明使得能够在MS的MALDI-T中使用的典型的质谱分析装置。 特别地,本发明可以对分子量小于1000Da的样品进行质谱分析,并通过固定具有预定面积的样品进行定量分析。