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1. 发明申请

WO2015114373A1 THERAPEUTIC PRODUCT DELIVERY DEVICE 审中-公开
标题翻译：治疗产品交付设备
公开(公告)号：WO2015114373A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050251
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： SHAPLEY, Julian , POWELL, Matthew , CLATWORTHY, Ceri , CEFAI, Joseph
IPC分类号： A61M5/315 , A61M5/142 , A61M5/168 , A61M5/24
CPC分类号： A61M5/14244 , A61B5/14532 , A61M5/31546 , A61M2005/14268 , A61M2005/244 , A61M2205/121 , A61M2205/123 , A61M2205/27 , A61M2205/273 , A61M2205/3584 , A61M2205/3592 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： A therapeutic product delivery device is described which comprises a device body and a cartridge for holding a therapeutic product. An engagement structure is provided for releasably engaging the cartridge with the device body. A fault detector is provided for detecting a fault in the delivery of the therapeutic product from the cartridge. A release trigger is responsive to the detection of a fault to cause the engagement structure to release the cartridge from the device body. In this way, a fault causes the cartridge to be released from the device body, which will prevent any further delivery of the therapeutic product to the patient. This solution is strongly preferable to a solution in which a product delivery mechanism (e.g. a pump) is merely paused or stopped, since when the cartridge separates then no further delivery is possible at all, until the cartridge is reattached (or more probably replaced with a new cartridge in case the fault is with the cartridge).
摘要翻译：描述了治疗产品输送装置，其包括装置主体和用于保持治疗产品的药筒。提供了一种接合结构，用于将盒与装置主体可释放地接合。提供故障检测器，用于检测治疗产品从药筒输送中的故障。释放触发器响应于故障的检测而导致接合结构从装置主体释放盒。以这种方式，故障导致药筒从装置主体释放，这将防止治疗产品进一步递送给患者。该解决方案强烈优于其中产品输送机构（例如泵）仅仅暂停或停止的解决方案，因为当盒分离时，根本不可能进一步传送，直到盒被重新连接（或更可能被替换为一个新的墨盒，以防故障与墨盒）。

2. 发明申请

WO2010038031A2 DISPLACEMENT SENSOR 审中-公开
标题翻译：位移传感器
公开(公告)号：WO2010038031A2
公开(公告)日：2010-04-08
申请号：PCT/GB2009002353
申请日：2009-10-02
申请人： CELLNOVO LTD , CEFAI JOSEPH JOHN , SHAPLEY JULIAN , THOMAS NEIL , POWELL MATTHEW
发明人： CEFAI JOSEPH JOHN , SHAPLEY JULIAN , THOMAS NEIL , POWELL MATTHEW
CPC分类号： G01D5/2405 , A61M5/14224 , A61M5/16809 , A61M5/1684 , A61M5/16886 , A61M2205/3317 , A61M2205/3389 , G01F11/029
摘要： A linear capacitance displacement transducer (1 ) comprising first (2) and second (3) fixed capacitor plate and a dielectric structure (5) moveable longitudinally within a space (4) between the first (2) and second (3) capacitor plates, the dielectric structure (5) being operatively coupled to a moveable element (8). The capacitor plates and the dielectric material may be cylindrical and disposed coaxially and concentrically. The transducer (1) enables a displacement sensor that is capable of monitoring liquid levels in a syringe type drug reservoir (101) with sufficient sensitivity as to allow detection of erroneous drug delivery. The sensor is inexpensive to manufacture and provides reliable performance through robust design.
摘要翻译：一种线性电容位移传感器（1），包括第一（2）和第二（3）固定电容器板以及在第一（2）和第二（3）电容器板之间的空间（4）内纵向移动的介电结构（5）介电结构（5）可操作地耦合到可移动元件（8）。电容器板和电介质材料可以是圆柱形的，并且同轴和同心地设置。换能器（1）能够使位移传感器能够以足够的灵敏度监测注射器型药物储存器（101）中的液位，以允许检测错误的药物输送。该传感器制造成本低廉，并通过坚固的设计提供可靠的性能。

3. 发明申请

WO2015114374A1 ACTUATOR AND ACTUATION METHOD 审中-公开
标题翻译：执行器和执行方法
公开(公告)号：WO2015114374A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050252
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： CEFAI, Joseph , SHAPLEY, Julian , POWELL, Matthew
IPC分类号： F04B43/04 , F04B43/06 , F04B49/06 , A61M5/142 , F03G7/06
CPC分类号： A61M5/142 , A61M5/14224 , A61M5/14244 , A61M5/162 , A61M5/1723 , A61M2205/3337 , A61M2205/3368 , A61M2205/3569 , A61M2205/3584 , A61M2205/3673 , A61M2205/505 , A61M2205/8206 , A61M2205/8237 , A61M2209/086 , A61M2230/005 , A61M2230/201 , A61M2230/63 , F03G7/06 , F04B43/043 , F04B43/06 , F04B49/065
摘要： An actuator comprises: a cavity containing a working medium (B) that reversibly expands as it undergoes a phase change from a solid to a liquid state; a diaphragm disposed adjacent the cavity such that expansion and contraction of the expandable working medium (B) causes the diaphragm to deflect, and a semiconductor element (A) disposed in the cavity. The semiconductor element (A) is operable in a first mode to heat the working medium (B) to cause it to undergo the phase change into the liquid state, and is operable in a second mode to measure the temperature at the semiconductor element (A). The corresponding actuation method is also disclosed.
摘要翻译：致动器包括：包含工作介质（B）的空腔，当工作介质经历从固体到液体状态的相变时可逆地膨胀; 邻近所述空腔设置的隔膜，使得所述可膨胀工作介质（B）的膨胀和收缩导致所述隔膜偏转，以及设置在所述空腔中的半导体元件（A）。半导体元件（A）可以在第一模式下操作以加热工作介质（B）以使其经历相变到液态，并且可在第二模式中操作以测量半导体元件（A ）。还公开了相应的致动方法。

4. 发明申请

WO2015114372A1 MANAGING COMMUNICATIONS TO AND FROM A HANDSET DEVICE CONTROLLING A THERAPEUTIC PRODUCT DELIVERY DEVICE 审中-公开
标题翻译：管理与控制治疗产品交付设备的手段设备的通信
公开(公告)号：WO2015114372A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050250
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： SHAPLEY, Julian , POWELL, Matthew , MARTIN, Anthony , JONES, Mark
IPC分类号： G06F19/00 , H04L29/06 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/002 , A61B5/0022 , A61B5/1118 , A61B5/14532 , A61B5/4839 , A61M5/142 , A61M2205/3389 , A61M2205/3553 , A61M2205/3569 , A61M2230/005 , A61M2230/201 , G06F19/00 , G06F19/3418 , G06F19/3468 , H04L63/0876 , H04L67/06 , H04L67/1095 , H04W4/14 , H04W4/70
摘要： A communication method of managing communications to and from a handset device controlling a therapeutic product delivery device is described. The method comprises transmitting, to a server, at least part of a unique identifier for a handset device for controlling a therapeutic product delivery device, and patient information regarding a user to be associated with the handset device, and at the server, associating the handset device with the patient information, generating a handset specific code, and transmitting the handset specific code to the user. At the handset device, a manual input of the handset specific code is received, and the future transmission of data from the handset device to the server carried out in association with the handset specific code. In this way, the server can be sure that the user is in possession of the handset (because the user received the code via the secure portal, and was required to manually input it to the handset), and can therefore be confident that communications received in association with that code are associated with the correct user and handset.
摘要翻译：描述了管理与来自控制治疗产品传递装置的手持设备装置的通信的通信方法。该方法包括向服务器发送用于手持设备设备的用于控制治疗产品递送设备的唯一标识符的至少一部分，以及关于与手持通话器设备相关联的用户的患者信息，以及在服务器处将手机关联设备，具有患者信息，生成手机特定代码，以及将手机特定代码发送给用户。在手机设备处，接收手机特定代码的手动输入，以及将来自手机设备到服务器的数据的未来传输与手机专用代码相关联。以这种方式，服务器可以确保用户拥有手机（因为用户经由安全门户接收到代码，并且需要手动将其输入到手机），并且因此可以确信接收到的通信与该代码相关联与正确的用户和手机相关联。

5. 发明申请

WO2015114371A1 HANDSET DEVICE 审中-公开
标题翻译：手提设备
公开(公告)号：WO2015114371A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050249
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： SHAPLEY, Julian , POWELL, Matthew , MARTIN, Anthony
IPC分类号： G06F19/00 , H04W52/02
CPC分类号： H04W52/0209 , G06F19/00 , G06F19/3418 , G06F19/3468 , H04W4/80 , H04W52/0206 , Y02D70/1222 , Y02D70/1224 , Y02D70/142 , Y02D70/144 , Y02D70/21
摘要： A handset device is described, which comprises a first radio transceiver for receiving status information from a medical device worn by a patient, the first radio transceiver being operable only while the handset device is in an active state, and a second radio transceiver for communicating the status information to a remote server, the second radio transceiver being inoperable when the handset device is in the active state. The handset device also comprises a controller, responsive to a first predetermined condition to transition the handset device from the active state to a low power state in which both the first radio transceiver and the second radio transceiver are inoperable. During the transition from the active state to the low power state, the second radio transceiver is used to communicate the status information to the remote server. This process enables status data to be synchronised periodically to the remote server without impairing the function of the medical device. More particularly, this process advantageously triggers synchronisation such that (a) the user does not have to take any action to cause synchronisation, (b) the synchronisation occurs at a time when it is safe for an RF transmission to the server to occur, and (c) the synchronisation is timely –that is, updates are sent soon after they have been logged on the handset device.
摘要翻译：描述了一种手机装置，其包括：第一无线电收发器，用于从患者佩戴的医疗装置接收状态信息，所述第一无线电收发机仅在手机装置处于活动状态时可操作;以及第二无线电收发器，状态信息发送到远程服务器，当手机设备处于活动状态时，第二无线电收发器不可操作。手持通话器设备还包括响应于第一预定条件的控制器，以将手持通话器设备从活动状态转换到低功率状态，其中第一无线电收发器和第二无线电收发器都不可操作。在从活动状态到低功率状态的转换期间，第二无线电收发器用于将状态信息传送到远程服务器。该过程使状态数据能够周期性地与远程服务器同步，而不会损害医疗设备的功能。更具体地，该过程有利地触发同步，使得（a）用户不必采取任何动作来引起同步，（b）在对服务器的RF传输是安全的时候发生同步，以及（c）同步是及时的，即更新在手机设备上登录后不久就会发送。

6. 发明申请

WO2015114370A1 THERAPEUTIC PRODUCT DELIVERY SYSTEM AND METHOD OF PAIRING 审中-公开
标题翻译：治疗产品交付系统和配对方法
公开(公告)号：WO2015114370A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050248
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： SHAPLEY, Julian , POWELL, Matthew , JONES, Mark
IPC分类号： A61M5/142
CPC分类号： G06F19/3406 , A61M5/14244 , A61M5/1723 , A61M2205/14 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/505 , A61M2205/8206 , A61M2205/8237 , A61M2209/086 , A61M2230/201 , G06F19/00 , G16H40/63 , H04B5/0031 , H04L63/0428 , H04L63/06 , H04W48/16 , H04W76/002 , H04W76/40
摘要： A method of pairing a therapeutic product delivery device to a handset is described. The handset is restricted to controlling only delivery devices which it is paired with. The method comprises the steps of: at the delivery device, setting, in response to the delivery device being connected to a charging device, a pairing indicator indicating that the delivery device is available for pairing, and broadcasting the pairing indicator using a radio transceiver; at the handset, discovering the delivery device based on the broadcast pairing indicator; and pairing the discovered delivery device and the handset together. By limiting the handset to pairing with devices which are broadcasting a pairing indicator, and by limiting the setting and/or broadcast of the pairing indicator to when the delivery device is connected to a charging device, the risk of accidentally pairing the wrong delivery device (for example someone else's) to the handset is greatly reduced.
摘要翻译：描述了将治疗产品递送设备配对到手机的方法。手机仅限于控制与其配对的传送设备。该方法包括以下步骤：在传送设备处，响应于传送设备连接到计费设备，设置指示传送设备可用于配对的配对指示符，以及使用无线电收发器广播配对指示符; 在手机上，基于广播配对指示符发现传送设备; 并将发现的传送设备和手机组合在一起。通过限制手机与正在广播配对指示符的设备配对，并且通过将配对指示器的设置和/或广播限制到何时将传送设备连接到充电设备，导致错误的传送设备（例如别人的）到手机大大减少。

7. 发明申请

WO2015114369A1 THERAPEUTIC PRODUCT DELIVERY DEVICE WITH OCCLUSION DETECTION VIA ELECTRIC CONTACTS 审中-公开
标题翻译：具有通过电气接触检测的治疗产品输送装置
公开(公告)号：WO2015114369A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050247
申请日：2015-01-30
申请人： CELLNOVO LTD
发明人： SHAPLEY, Julian , POWELL, Matthew , GITTENS, Nici , THOMAS, Neil
IPC分类号： A61M5/142
CPC分类号： A61M5/16831 , A61B5/0002 , A61B5/1118 , A61B5/14532 , A61B5/6898 , A61B2562/227 , A61M5/14224 , A61M5/14244 , A61M5/172 , A61M2005/14268 , A61M2005/16863 , A61M2205/18 , A61M2205/3553 , A61M2205/3569 , A61M2205/3576 , A61M2205/3584 , A61M2205/8206 , A61M2230/63
摘要： A therapeutic product delivery device is described, which comprises a circuit layer, an actuator layer carrying an actuator, an occlusion detection layer (118), and a valve layer, through which a therapeutic product is conveyed by the action of the actuator. A plurality of conductive pins (155) extend from the circuit layer through or to each of the actuator layer, the occlusion detection layer and the valve layer, the conductive pins aligning the layers with each other. The occlusion detection layer comprises a plurality of contacts, each electrically connected to a respective one of the conductive pins, the contacts being provided at a detection region at which the therapeutic product is deposited in the event of a blockage. A blockage inhibiting the therapeutic product from being conveyed to the patient is detected when therapeutic product deposited in the detection region provides an electrical connection between the contacts. The conductive pins therefore provide at least two functions; firstly they align the layers of the cartridge (at assembly and during use), and a secondly they provide a conductive route between the circuit layer and the occlusion layer, permitting therapeutic product deposited at the occlusion layer to be able to complete an electric circuit with the circuit layer to enable occlusion detection.
摘要翻译：描述了治疗产品输送装置，其包括电路层，承载致动器的致动器层，闭塞检测层（118）和阀层，通过致动器的作用输送治疗产品。多个导电针（155）从电路层延伸通过致动器层，闭塞检测层和阀层中的每一个，导电引脚彼此对准这些层。闭塞检测层包括多个触点，每个触点电连接到相应的一个导电引脚，触点设置在在阻塞事件中治疗产品被沉积的检测区域处。当在检测区域中沉积的治疗产品提供触点之间的电连接时，检测到抑制治疗产品被输送到患者的阻塞。因此，导电引脚提供至少两个功能; 首先，它们对齐盒的层（在组装和使用期间），其次它们在电路层和遮挡层之间提供导电路径，允许沉积在遮挡层处的治疗产品能够完成具有电路层启用遮挡检测。

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