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1. 发明申请

WO1996008228A2 DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM 审中-公开
标题翻译： 2-氨基-1,2,3,4-四氢萘-1-酮对心脏血管系统活性的衍生物
公开(公告)号：WO1996008228A2
公开(公告)日：1996-03-21
申请号：PCT/EP1995003562
申请日：1995-09-11
申请人： ZAMBON GROUP S.P.A. , MONTANARI, Stefania , CAVALLERI, Paolo , FRAIRE, Cristina , GRANCINI, Gian, Carlo , NAPOLETANO, Mauro , SANTANGELO, Francesco
发明人： ZAMBON GROUP S.P.A.
IPC分类号： A61K00/00
CPC分类号： C07D277/68 , C07C59/90 , C07C215/64 , C07C215/80 , C07C217/20 , C07C217/60 , C07C217/74 , C07C229/38 , C07C233/43 , C07C235/20 , C07C235/34 , C07C237/22 , C07C237/30 , C07C271/30 , C07C309/46 , C07C311/08 , C07C311/37 , C07C317/22 , C07C317/44 , C07C323/25 , C07D209/08 , C07D217/14 , C07D277/82 , C07D295/13 , C07D317/58 , C07D319/20
摘要： Derivatives of 2-amino-1,2,3,4-tetrahydro-naphtalene according to formula (I) for the treatment of arterial hypertension, congestive heart failure, renal failure, peripheral arteriopathies or cerebro-vascular insufficiencies.
摘要翻译：用于治疗动脉高血压，充血性心力衰竭，肾衰竭，外周动脉病或脑血管功能不全的根据式（I）的2-氨基-1,2,3,4-四氢 - 萘的衍生物。

2. 发明申请

WO1995007885A1 DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM 审中-公开
标题翻译： 2-氨基-1,2,3,4-四氢萘酮在心脏血管系统中的作用
公开(公告)号：WO1995007885A1
公开(公告)日：1995-03-23
申请号：PCT/EP1994002981
申请日：1994-09-07
申请人： ZAMBON GROUP S.P.A. , MONTANARI, Stefania , CAVALLERI, Paolo , SANTANGELO, Francesco
发明人： ZAMBON GROUP S.P.A.
IPC分类号： C07C323/25
CPC分类号： C07D213/69 , C07C225/16 , C07C323/25 , C07C2602/10 , C07D213/70 , C07D233/64 , C07D233/84 , C07D261/12 , C07D333/20
摘要： Compounds of formula (I), wherein R is a hydrogen atom or an OY group; R1 is a hydrogen atom or an OY' group; R2 is a hydrogen atom or an OY'' group; provided that at least one among R, R1 and R2 is hydrogen but R, R1 and R2 are not contemporaneously hydrogen atoms and R1 and R2 are not contemporaneously OY' or OY'' groups respectively; m &cir& _ is an integer selected between 1 and 2; n &cir& _ is an integer comprised among 3 and 8; p &cir& _ is an integer comprised among 2 and 4; R3 is a hydrogen atom or a C1-C4 alkyl; R4 is a phenyl optionally substituted by halogen atoms, C1-C3 alkyl or alkoxy groups or a 5- or 6-membered heteroaryl containing one or more heteroatoms selected among oxygen, nitrogen and sulphur, optionally substituted by halogen atoms, hydroxy groups, C1-C3 alkyl or alkoxy groups; X is CH2, NH, S, SO, SO2, CO, CF2, O and, when R4 is a 5- or 6-membered heteroaryl, X can be also a single bond; and their pharmaceutically acceptable salts are described. The compounds of formula (I) are useful in the treatment of arterial hypertension and heart failure, of renal insufficiency, of peripheral arteriopathies and of cerebrovascular insufficiencies.
摘要翻译：式（I）的化合物，其中R是氢原子或OY基团; R1是氢原子或OY'基团; R2是氢原子或OY“基团; 条件是R，R 1和R 2中的至少一个是氢，但R，R 1和R 2不是同时存在的氢原子，并且R 1和R 2不是分别同时是OY'或OY“基团; m＆cir＆_是从1到2之间选择的整数; n＆cir＆_是3和8之间的整数; p＆cir＆_是2和4之间的整数; R3是氢原子或C1-C4烷基; R4是任选被卤素原子，C 1 -C 3烷基或烷氧基取代的苯基或含有一个或多个选自氧，氮和硫的杂原子的5-或6-元杂芳基，任选被卤素原子取代，羟基，C1- C3烷基或烷氧基; X是CH 2，NH，S，SO，SO 2，CO，CF 2，O，当R 4是5-或6-元杂芳基时，X也可以是单键; 及其药学上可接受的盐。式（I）化合物可用于治疗动脉高血压和心力衰竭，肾功能不全，外周动脉炎和脑血管功能不全的治疗。

3. 发明申请

WO2007137767A1 HOSE FITTING FOR HYDRAULIC, INDUSTRIAL AND AIR-CONDITIONING APPLICATIONS, HAVING IMPROVED TIGHTNESS CHARACTERISTICS 审中-公开
标题翻译：用于液压，工业和空调应用的软管接头，具有改进的紧实特性
公开(公告)号：WO2007137767A1
公开(公告)日：2007-12-06
申请号：PCT/EP2007/004640
申请日：2007-05-24
申请人： MANULI RUBBER INDUSTRIES S.P.A. , GIOVANNINI, Mirco , CAVALLERI, Paolo
发明人： GIOVANNINI, Mirco , CAVALLERI, Paolo
IPC分类号： F16L33/22
CPC分类号： F16L33/223
摘要： A hose fitting (1) for hydraulic, industrial and air-conditioning applications, comprising an insert (2) and a collar (3) which can be screwed onto the insert (2), the insert being provided with at least one positive groove (5).
摘要翻译：一种用于液压，工业和空调应用的软管接头（1），包括可插入到所述插入件（2）上的插入件（2）和套环（3），所述插入件设置有至少一个正凹槽 5）。

4. 发明申请

WO9608228A3 DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM 审中-公开
标题翻译： 2-氨基-1,2,3,4-四氢萘-1-酮对心脏血管系统活性的衍生物
公开(公告)号：WO9608228A3
公开(公告)日：1996-07-25
申请号：PCT/EP9503562
申请日：1995-09-11
申请人： ZAMBON SPA , MONTANARI STEFANIA , CAVALLERI PAOLO , FRAIRE CRISTINA , GRANCINI GIAN CARLO , NAPOLETANO MAURO , SANTANGELO FRANCESCO
发明人： MONTANARI STEFANIA , CAVALLERI PAOLO , FRAIRE CRISTINA , GRANCINI GIAN CARLO , NAPOLETANO MAURO , SANTANGELO FRANCESCO
IPC分类号： C07D295/12 , A61K31/10 , A61K31/135 , A61K31/165 , A61K31/18 , A61K31/24 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , C07C59/90 , C07C211/42 , C07C215/64 , C07C215/68 , C07C215/80 , C07C217/20 , C07C217/60 , C07C217/74 , C07C229/08 , C07C229/38 , C07C233/43 , C07C235/20 , C07C235/34 , C07C237/22 , C07C237/30 , C07C271/30 , C07C309/00 , C07C309/45 , C07C309/46 , C07C311/05 , C07C311/08 , C07C311/37 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/00 , C07C323/24 , C07C323/25 , C07D209/08 , C07D217/04 , C07D217/14 , C07D235/26 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D295/04 , C07D295/13 , C07D317/58 , C07D319/16 , C07D319/20
CPC分类号： C07D277/68 , C07C59/90 , C07C215/64 , C07C215/80 , C07C217/20 , C07C217/60 , C07C217/74 , C07C229/38 , C07C233/43 , C07C235/20 , C07C235/34 , C07C237/22 , C07C237/30 , C07C271/30 , C07C309/46 , C07C311/08 , C07C311/37 , C07C317/22 , C07C317/44 , C07C323/25 , C07D209/08 , C07D217/14 , C07D277/82 , C07D295/13 , C07D317/58 , C07D319/20
摘要： Derivatives of 2-amino-1,2,3,4-tetrahydro-naphtalene according to formula (I) for the treatment of arterial hypertension, congestive heart failure, renal failure, peripheral arteriopathies or cerebro-vascular insufficiencies. 00000
摘要翻译：用于治疗动脉高血压，充血性心力衰竭，肾衰竭，外周动脉病或脑血管功能不全的根据式（I）的2-氨基-1,2,3,4-四氢 - 萘的衍生物。 00000

5. 发明申请

WO1996008489A1 DERIVATIVES OF BENZOPYRAN AND OF BENZOTHIOPYRAN, THEIR PREPARATION AND THEIR USE AS AGONISTS OF DOPAMINERGIC RECEPTORS 审中-公开
标题翻译：苯并噻吩和苯并噻唑的衍生物，其制备及其作为多巴胺受体的激素使用
公开(公告)号：WO1996008489A1
公开(公告)日：1996-03-21
申请号：PCT/EP1995003478
申请日：1995-09-05
申请人： ZAMBON GROUP S.P.A. , NAPOLETANO, Mauro , CAVALLERI, Paolo , FRAIRE, Cristina , GRANCINI, Gian, Carlo , MONTANARI, Stefania , SANTANGELO, Francesco
发明人： ZAMBON GROUP S.P.A.
IPC分类号： C07D417/12
CPC分类号： C07D311/64 , C07D335/06 , C07D417/12
摘要： Compounds of formula (I), wherein R, R', R", Z, m, Y, n, R1, X, p and Ar have the meanings reported in the description; and pharmaceutically acceptable salts thereof are described. The compounds of formula (I) are useful in the treament of arterial hypertension and heart failure, of renal failure, of peripheral arteriopathies, of cerebrovascular insufficiencies and of ischemic cardiopathy.
摘要翻译：式（I）化合物，其中R，R'，R“，Z，m，Y，n，R 1，X，p和Ar具有本说明书中报道的含义;及其药学上可接受的盐，式（I）可用于动脉高血压和心力衰竭，肾衰竭，外周动脉病变，脑血管功能不全和缺血性心脏病的治疗。

6. 发明申请

WO1996008463A1 DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM 审中-公开
标题翻译： 2-氨基-1,2,3,4-四氢萘酮在心脏血管系统中的作用
公开(公告)号：WO1996008463A1
公开(公告)日：1996-03-21
申请号：PCT/EP1995003479
申请日：1995-09-05
申请人： ZAMBON GROUP S.P.A. , MONTANARI, Stefania , BOTTA, Daniela , CAVALLERI, Paolo , SANTANGELO, Francesco
发明人： ZAMBON GROUP S.P.A.
IPC分类号： C07C215/44
CPC分类号： C07D213/38 , C07C215/64
摘要： Compounds of formula (I), wherein m is an integer number selected among 4, 5, 6, 7 and 8; R, R' and R" are hydrogen atoms or OH groups, provided that at least one among R, R' and R" is a hydrogen atom but R, R' and R" are not all contemporaneously hydrogen atoms and R' and R" are not both contemporaneously OH groups; R1 is a hydrogen atom or a C1-C4 alkyl group; R2 is a -(CH2)n-Ar group, wherein n is an integer number selected among 2, 3, 4 and 5; Ar is a pyridyl or a phenyl or R2 is a group of formula (a), wherein one or two among R3, R4, R5 and R6 are OH groups and the remaining are hydrogen atoms; R7 and R8 are hydrogen atoms or together can form a -CH2-CH2-chain; and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of arterial hypertension and heart failure, of renal failure, of peripheral arteriopathies, of cerebrosvascular insufficiencies and of ischemic cardiopathy.
摘要翻译：式（I）化合物，其中m为选自4，5，6，7和8之间的整数; R，R'和R“是氢原子或OH基团，条件是R，R'和R”中的至少一个是氢原子，但R，R'和R“不全部同时为氢原子，R'和R “不是同时是OH组; R1是氢原子或C1-C4烷基; R2是 - （CH2）n-Ar基团，其中n是选自2,3,4和5中的整数; Ar是吡啶基或苯基或R2是式（a）的基团，其中R3，R4，R5和R6中的一个或两个是OH基团，其余是氢原子; R7和R8是氢原子或一起可以形成-CH 2 -CH 2 - 链; 及其药学上可接受的盐。式（I）化合物可用于治疗动脉高血压和心力衰竭，肾衰竭，外周动脉病变，脑血管功能不全和缺血性心脏病的治疗。

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