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1. 发明申请

WO2011119754A3 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A3
公开(公告)日：2012-02-16
申请号：PCT/US2011029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S , TIAN BIN , SCHNEIDER RALPH , COHEN JEFFREY S , JANKOVIC IVAN , MIGLIAZZA JOHN F , WRIGHT GREGORY A , YOUNG JAMES M , CAMPBELL LOUIS A
发明人： DOVE JEFFREY S , TIAN BIN , SCHNEIDER RALPH , COHEN JEFFREY S , JANKOVIC IVAN , MIGLIAZZA JOHN F , WRIGHT GREGORY A , YOUNG JAMES M , CAMPBELL LOUIS A
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并使表面平滑。选择激光器的波长，功率和脉冲率，这将使纤维表面光滑，并将表面烧蚀到合适的厚度。或者，使用皮肤细胞从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用用于稳定膜的交联逐步压缩以避免通过非弹性压缩损坏膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。小叶可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

2. 发明申请

WO2011075673A3 PROSTHETIC HEART VALVE PACKAGING AND DEPLOYMENT SYSTEM 审中-公开
标题翻译：前置心脏瓣膜包装和部署系统
公开(公告)号：WO2011075673A3
公开(公告)日：2011-11-17
申请号：PCT/US2010061097
申请日：2010-12-17
申请人： EDWARDS LIFESCIENCES CORP , HODSHON FRED , PINTOR RAFAEL , YAMBAO AUGUST , GAUTAM ABHISHEK , CAMPBELL LOUIS A , FARHAT LAWRENCE , HUNTLEY TAMMY , KALAM FAISAL , OBA TRAVIS , ZENG QINGGANG
发明人： HODSHON FRED , PINTOR RAFAEL , YAMBAO AUGUST , GAUTAM ABHISHEK , CAMPBELL LOUIS A , FARHAT LAWRENCE , HUNTLEY TAMMY , KALAM FAISAL , OBA TRAVIS , ZENG QINGGANG
IPC分类号： B65D81/00 , A61F2/24 , B65D81/05 , B65D81/15
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的叶片分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀门和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。该包装系统便于安装用于快速连接阀注入过程的阀输送管。

3. 发明申请

WO2011075673A2 PROSTHETIC HEART VALVE PACKAGING AND DEPLOYMENT SYSTEM 审中-公开
标题翻译：人工心脏瓣膜包装和部署系统
公开(公告)号：WO2011075673A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/061097
申请日：2010-12-17
申请人： EDWARDS LIFESCIENCES CORPORATION , HODSHON, Fred , PINTOR, Rafael , YAMBAO, August , GAUTAM, Abhishek , CAMPBELL, Louis, A. , FARHAT, Lawrence , HUNTLEY, Tammy , KALAM, Faisal , OBA, Travis , ZENG, Qinggang
发明人： HODSHON, Fred , PINTOR, Rafael , YAMBAO, August , GAUTAM, Abhishek , CAMPBELL, Louis, A. , FARHAT, Lawrence , HUNTLEY, Tammy , KALAM, Faisal , OBA, Travis , ZENG, Qinggang
IPC分类号： B65D81/00 , B65D81/05 , B65D81/15 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.
摘要翻译：假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在瓶内并便于从中取出的组件。该组件包括一个紧密配合在罐内的封装套管，并具有用于固定阀门支架的夹子结构。与先前的设计相反，在一个实施例中，阀支架向下引导进入罐中，并且阀以流入端向上保持。瓣膜可具有柔性小叶，并且在轴的端部上的瓣叶分离构件延伸穿过瓣叶并与瓣膜保持器联接。然后可将包装套筒，阀和支架的组件从罐中取出，并将瓣膜输送管与支架或瓣叶分离构件连接。包装套筒可以分成两部分连接在活动铰链处，以便于从阀/支架组件周围移除。包装系统便于连接阀输送管，用于快速连接瓣膜植入程序。

4. 发明申请

WO2011011481A3 INTRODUCER FOR PROSTHETIC HEART VALVE 审中-公开
标题翻译：前置心脏瓣膜介绍
公开(公告)号：WO2011011481A3
公开(公告)日：2011-05-05
申请号：PCT/US2010042697
申请日：2010-07-21
申请人： EDWARDS LIFESCIENCES CORP , OBA TRAVIS Z , CAMPBELL LOUIS A
发明人： OBA TRAVIS Z , CAMPBELL LOUIS A
IPC分类号： A61B17/00 , A61F2/24 , A61M25/01 , A61M31/00
CPC分类号： A61F2/2427 , A61B17/3423 , A61B17/3439 , A61B17/3468 , A61B2017/3425 , A61F2/2433
摘要： The present disclosure concerns embodiments of an introducer that is adapted to facilitate insertion of a prosthetic device, such as a prosthetic heart valve, into a patient's vasculature. In one embodiment, the introducer comprises an elongated body defining a central lumen extending between distal and proximal ends of the body. The introducer body can also have a longitudinally extending gap extending along the length of the body between the distal end proximal ends. The gap in the introducer allows a user to place the introducer around implant sutures by passing the sutures through the gap and into the central lumen. Similarly, the gap allows the introducer to be easily removed from the sutures and/or a delivery device by passing them outwardly through the gap.
摘要翻译：本公开涉及导引器的实施例，其适于促进假体装置（例如假体心脏瓣膜）插入患者的脉管系统中。在一个实施例中，导引器包括限定在身体的远端和近端之间延伸的中心腔的细长主体。导引器主体还可以具有沿主体的长度在远端近端之间延伸的纵向延伸的间隙。引导器中的间隙允许使用者通过使缝合线穿过间隙并进入中心腔而将引入器放置在植入物缝合线周围。类似地，间隙允许导引器通过将其向外通过间隙而从缝合线和/或输送装置中容易地移除。

5. 发明申请

WO2010151617A2 UNITARY QUICK-CONNECT PROSTHETIC HEART VALVE AND DEPLOYMENT SYSTEM AND METHODS 审中-公开
标题翻译：单位快速连接心脏瓣膜和部署系统和方法
公开(公告)号：WO2010151617A2
公开(公告)日：2010-12-29
申请号：PCT/US2010/039746
申请日：2010-06-24
申请人： EDWARDS LIFESCIENCES CORPORATION , PINTOR, Rafael , CHAU, Mark , OBA, Travis , YAMBAO, August , CAMPBELL, Louis, A. , HUNTLEY, Tammy , ZENG, Qinggang , CRISTEA, Carey , KALAM, Faisal
发明人： PINTOR, Rafael , CHAU, Mark , OBA, Travis , YAMBAO, August , CAMPBELL, Louis, A. , HUNTLEY, Tammy , ZENG, Qinggang , CRISTEA, Carey , KALAM, Faisal
IPC分类号： A61F2/24 , A61M29/00 , A61F2/82 , A61M25/10 , A61M25/02
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2250/006
摘要： A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
摘要翻译：提供了一种快速连接的心脏瓣膜假体，可以在手术过程中快速方便地植入。心脏瓣膜包括基本上不可膨胀的不可压缩的人造瓣膜和塑性可扩张的联接支架，从而使得能够在不缝合的情况下连接到环形空间。可以提供少量的导向缝线用于主动脉瓣取向。假体瓣膜可以是具有连接有联接支架的缝合环的市售阀。联接支架可以从锥形展开形状扩展到圆锥形膨胀形状，并且可以包括连接在轴向延伸柱之间的腹板状支柱。用于展开的系统和方法包括气球导管通过的中空两件式手柄。与心脏瓣膜一起存储阀保持器，并且手柄容易地附接到其上以改善阀门准备步骤。

6. 发明申请

WO2010117589A2 PROSTHETIC HEART VALVE SYSTEM 审中-公开
标题翻译：人工心脏瓣膜系统
公开(公告)号：WO2010117589A2
公开(公告)日：2010-10-14
申请号：PCT/US2010/027846
申请日：2010-03-18
申请人： UEDWARDS LIFESCIENCES CORPORATION , OBA, Travis , PINTOR, Rafael , CAMPBELL, Louis, A.
发明人： OBA, Travis , PINTOR, Rafael , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61F2/82 , A61M29/00 , A61M39/22
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/008 , A61F2250/0063 , A61F2250/0097 , A61F2250/0098
摘要： An exemplary two-stage prosthetic heart valve system has a radially expandable base stent implanted within a native valve annulus. The two-stage heart valve system also has a valve component that is delivered to and mounted within the base stent in a separate or sequential operation after the base stent has been anchored within the annulus. The valve component in certain embodiments comprises a hybrid valve component that includes a conventional, non-expandable surgical valve that is modified to include an expandable coupling stent that can be expanded to engage the inner surface of the base stent, thereby anchoring the valve component to the base stent. In its expanded configuration, the outflow end portion base stent has tri-lobular shape that closely conforms to the shape of the aortic root and a support ring of the prosthetic valve that is mounted within the base stent.
摘要翻译：示例性的两级假体心脏瓣膜系统具有植入天然瓣膜环内的可径向扩张的基部支架。两级心脏瓣膜系统还具有瓣膜组件，该瓣膜组件在基础支架已被锚定在瓣环内之后以单独的或顺序的操作递送至并安装在基础支架内。在某些实施例中，瓣膜组件包括混合瓣膜组件，该组合瓣膜包括常规的不可膨胀手术瓣膜，该手术瓣膜被修改为包括可扩张的耦合支架，该可扩张的耦合支架可以膨胀以接合基础支架的内表面，由此将瓣膜组件锚定到基础支架。在其扩张构造中，流出端部分基部支架具有与主动脉根部的形状以及安装在基部支架内的假体瓣膜的支撑环紧密相符的三叶形状。

7. 发明申请

WO2010043982A3 APPARATUS AND METHOD FOR MEASURING BODY ORIFICE 审中-公开
标题翻译：用于测量身体孔的装置和方法
公开(公告)号：WO2010043982A3
公开(公告)日：2010-08-12
申请号：PCT/IB2009007785
申请日：2009-12-16
申请人： EDWARDS LIFESCIENCES CORP , CAMPBELL LOUIS A , OBA TRAVIS Z , PINTOR RAFAEL
发明人： CAMPBELL LOUIS A , OBA TRAVIS Z , PINTOR RAFAEL
IPC分类号： A61B1/32
CPC分类号： A61B5/1076 , A61B5/6853 , A61B5/6858 , A61B5/6885 , A61B90/08 , A61B2090/061 , A61B2090/064 , A61B2090/0811 , A61F2/2496
摘要： A device for measuring an expanded internal orifice of a patient includes an orifice-expanding device, a pressure measuring device, and a size-measuring device. The size-measuring device measures a dimension of the orifice after it has been expanded by the orifice-expanding device.
摘要翻译：用于测量患者的扩大的内部孔口的装置包括孔口扩张装置，压力测量装置和尺寸测量装置。尺寸测量装置在孔口扩张装置扩张后测量孔口的尺寸。

8. 发明申请

WO2006044679A1 METHODS AND APPARATUS FOR COUPLING AN ALLOGRAFT TISSUE VALVE AND GRAFT 审中-公开
标题翻译：用于联合组织组织瓣和切片的方法和装置
公开(公告)号：WO2006044679A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/037048
申请日：2005-10-14
申请人： MEDTRONIC, INC. , CAMPBELL, Louis, A.
发明人： CAMPBELL, Louis, A.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/06
摘要： Improvements to prosthetic heart valves and grafts for human implantation, particularly to methods and apparatus for coupling a prosthetic heart valve (30) with an artificial graft (12) during a surgical procedure to replace a defective heart valve and blood vessel section, e.g., the aortic valve and a section of the ascending aorta, are disclosed. An annular exterior surface of the prosthetic heart valve (40) is fitted within a vascular graft lumen to dispose the vascular graft proximal end (16) overlying the annular exterior surface, and the proximal end of an elongated vascular graft is compressed against the valve annular exterior surface in a manner that inhibits blood leakage between the vascular graft and the prosthetic heart valve.
摘要翻译：用于人体植入的假体心脏瓣膜和移植物的改进，特别涉及在外科手术过程中将假体心脏瓣膜（30）与人造移植物（12）联接以更换有缺陷的心脏瓣膜和血管部分的方法和装置，例如主动脉瓣和升主动脉的一部分。假体心脏瓣膜（40）的环形外表面装配在血管移植物腔内以将血管移植物近端（16）布置在环形外表面上方，并且细长血管移植物的近端压靠阀环外表面以抑制血管移植物和假体心脏瓣膜之间的血液渗漏的方式。

9. 发明申请

WO2011097355A2 DEVICES AND METHODS FOR TREATING A HEART 审中-公开
标题翻译：用于治疗心脏的装置和方法
公开(公告)号：WO2011097355A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023568
申请日：2011-02-03
申请人： EDWARDS LIFESCIENCES CORPORATION , BOBO, Donald, E. , BASH, Assaf , CAMPBELL, Louis, A. , CURTIS, Alison, S. , CHEUNG, Tak , MIGLIAZZA, John, F.
发明人： BOBO, Donald, E. , BASH, Assaf , CAMPBELL, Louis, A. , CURTIS, Alison, S. , CHEUNG, Tak , MIGLIAZZA, John, F.
IPC分类号： A61B17/12 , A61F2/24 , A61B5/02 , A61B5/107
CPC分类号： A61F2/2445 , A61B5/1076 , A61B6/503 , A61F2/2457 , A61F2/2487 , A61F2220/0008 , A61F2250/0004 , A61F2250/0007 , A61F2250/0012
摘要： Devices and related methods of use are provided for improving heart function. In one embodiment of the present disclosure, a device includes a ring-like structure configured to be secured to a heart valve; at least one elongate member extending from the ring-like structure, wherein an end of the elongate member is configured to be secured to heart geometry other than a heart valve; and an adjustment mechanism for simultaneously altering a dimension of the ring-like structure and a length of the elongate member.
摘要翻译：提供了用于改善心脏功能的装置和相关的使用方法。在本公开的一个实施例中，一种装置包括构造成固定到心脏瓣膜的环状结构; 至少一个细长构件，所述至少一个细长构件从所述环状结构延伸，其中所述细长构件的端部被构造成固定到除心脏瓣膜之外的心脏几何形状; 以及用于同时改变环状结构的尺寸和细长构件的长度的调节机构。

10. 发明申请

WO2011119754A2 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORPORATION , DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。传单可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

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