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1. 发明申请

WO2011119754A3 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A3
公开(公告)日：2012-02-16
申请号：PCT/US2011029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S , TIAN BIN , SCHNEIDER RALPH , COHEN JEFFREY S , JANKOVIC IVAN , MIGLIAZZA JOHN F , WRIGHT GREGORY A , YOUNG JAMES M , CAMPBELL LOUIS A
发明人： DOVE JEFFREY S , TIAN BIN , SCHNEIDER RALPH , COHEN JEFFREY S , JANKOVIC IVAN , MIGLIAZZA JOHN F , WRIGHT GREGORY A , YOUNG JAMES M , CAMPBELL LOUIS A
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并使表面平滑。选择激光器的波长，功率和脉冲率，这将使纤维表面光滑，并将表面烧蚀到合适的厚度。或者，使用皮肤细胞从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用用于稳定膜的交联逐步压缩以避免通过非弹性压缩损坏膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。小叶可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

2. 发明申请

WO2006104820A3 TREATMENT OF BIOPROSTHETIC TISSUES TO MITIGATE POST IMPLANTATION CALCIFICATION 审中-公开
标题翻译：生物多样性组织的治疗以减少后期植入计算
公开(公告)号：WO2006104820A3
公开(公告)日：2007-06-28
申请号：PCT/US2006010540
申请日：2006-03-24
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S
发明人： DOVE JEFFREY S
IPC分类号： A61L27/36
CPC分类号： A61L27/3683 , A61L27/3604 , A61L2400/02
摘要： The present invention provides methods for treating tissue to inhibit post-implant calcification of a biological tissue. In one method of this invention, a tissue is immersed in or otherwise contacted with a pretreated glutaraldehyde solution, i.e., a heat-treated or pH-adjusted glutaraldehyde solution. The tissue may be partially fixed with glutaraldehyde prior to, after, or concurrently with the step of contacting the tissue with the pretreated gluteraldehyde. Contact with the pretreated gluteraldehyde produces free amine groups on the tissue, which are subsequently blocked by contacting the crosslinked tissue with a blocking agent. In another embodiment, a tissue is contacted with either a non- pretreated glutaraldehyde or a pH-adjusted glutaraldehyde solution for a period of time sufficient to crosslink the tissue. The crosslinked tissue is then treated with a reducing agent that reduces aldehyde and carboxylic acid groups on the fixed tissue.
摘要翻译：本发明提供了治疗组织以抑制生物组织的植入后钙化的方法。在本发明的一种方法中，将组织浸入或以其它方式与预处理的戊二醛溶液即热处理或pH调节的戊二醛溶液接触。在使组织与预处理的戊二醛接触的步骤之前，之后或同时，组织可以用戊二醛部分固定。与预处理的戊二醛接触在组织上产生游离胺基，随后通过使交联的组织与封闭剂接触来阻断。在另一个实施方案中，将组织与未预处理的戊二醛或pH调节的戊二醛溶液接触足够交联组织的时间。然后用还原剂处理交联的组织，还原剂可以减少固定组织上的醛和羧酸基团。

3. 发明申请

WO2011160085A2 METHODS FOR STABILIZING A BIOPROSTHETICS TISSUE BY CHEMICAL MODIFICATION OF ANTIGENIC CARBOHYDRATES 审中-公开
标题翻译：通过化学修饰抗生素碳酸酯稳定生物化学组织的方法
公开(公告)号：WO2011160085A2
公开(公告)日：2011-12-22
申请号：PCT/US2011040984
申请日：2011-06-17
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S , TOD TARA
发明人： DOVE JEFFREY S , TOD TARA
IPC分类号： A61L27/50 , A61F2/02 , A61L2/16 , A61L27/54
CPC分类号： A61L27/505 , A61L27/3625 , A61L27/3687 , A61L2300/40 , A61L2400/02 , A61L2430/20
摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive animation of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.
摘要翻译：本文提供了用于通过邻位二醇的氧化形成醛或酸并修饰醛的还原动力来形成稳定的仲胺，或酸的酰胺化或酯化形成稳定的酰胺或酯，从而在变异生物假体组织内修饰抗原性碳水化合物表位的方法。有利地，本文提供的方法减轻生物假体组织的抗原性，同时使整个组织结构基本上不受干扰，从而增强生物假体植入物的耐久性，安全性和性能。

4. 发明申请

WO2011160085A8 METHODS FOR STABILIZING A BIOPROSTHETIC TISSUE BY CHEMICAL MODIFICATION OF ANTIGENIC CARBOHYDRATES 审中-公开
标题翻译：通过化学改性抗坏血酸稳定化生物组织的方法
公开(公告)号：WO2011160085A8
公开(公告)日：2012-05-18
申请号：PCT/US2011040984
申请日：2011-06-17
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S , TOD TARA
发明人： DOVE JEFFREY S , TOD TARA
IPC分类号： A61L27/50 , A61F2/02 , A61L2/16 , A61L27/54
CPC分类号： A61L27/505 , A61L27/3625 , A61L27/3687 , A61L2300/40 , A61L2400/02 , A61L2430/20
摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive animation of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.
摘要翻译：本文提供了用于通过邻位二醇的氧化形成醛或酸并修饰醛的还原动力来形成稳定的仲胺，或酸的酰胺化或酯化形成稳定的酰胺或酯，从而在变异生物假体组织内修饰抗原性碳水化合物表位的方法。有利地，本文提供的方法减轻生物假体组织的抗原性，同时使整个组织结构基本上不受干扰，从而增强生物假体植入物的耐久性，安全性和性能。

5. 发明申请

WO2009085199A3 CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION 审中-公开
标题翻译： CAPPING BIOPROSTHETIC TISSUE减少计算
公开(公告)号：WO2009085199A3
公开(公告)日：2009-12-17
申请号：PCT/US2008013879
申请日：2008-12-19
申请人： EDWARDS LIFESCIENCES CORP , DOVE JEFFREY S , DOBLER DARIN , DAVIDSON JIM A
发明人： DOVE JEFFREY S , DOBLER DARIN , DAVIDSON JIM A
IPC分类号： A61L27/36
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
摘要翻译：用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。此外，该方法可用于抑制脱水组织中的氧化。封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。

6. 发明申请

WO0130876A3 THERMOPLASTIC ELASTOMERIC MATERIAL AS A REPLACEMENT FOR NATURAL RUBBER LATEX 审中-公开
标题翻译：热塑性弹性材料作为天然橡胶的替代品
公开(公告)号：WO0130876A3
公开(公告)日：2001-11-22
申请号：PCT/US0029879
申请日：2000-10-27
申请人： EDWARDS LIFESCIENCES CORP
发明人： DOVE JEFFREY S
IPC分类号： A61M1/00 , A61F6/04 , A61L15/00 , A61L29/00 , A61L29/04 , A61L31/00 , C08F8/00 , C08F297/04 , C08G81/02 , C08J5/00 , C08K5/13 , C08K5/17 , C08K5/41 , C08K9/06 , C08L53/02
CPC分类号： C08L53/025 , A61L29/041 , C08F8/34 , C08F2810/20 , C08G81/022 , C08L53/02 , C08F297/046 , C08F297/044
摘要： The present invention provides functionally modified thermoplastic elastomeric compounds composed of at least one polystyrene hard domain, at least one polyolefin rubber domain and at least one cross-linkable compound interspersed within one or more of the domains. Methods for making and using these thermoplastic elastomeric compounds are also provided as are articles made from these compounds along with methods for making such articles.
摘要翻译：本发明提供由至少一个聚苯乙烯硬结构域，至少一个聚烯烃橡胶结构域和分散在一个或多个结构域内的至少一个可交联化合物组成的功能改性的热塑性弹性体化合物。还提供制备和使用这些热塑性弹性体化合物的方法，就是由这些化合物制成的制品以及制备这些制品的方法。

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