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1. 发明申请

WO2010108177A3 A METHOD AND COMPOSITION USING A DUAL SPECIFICITY PROTEIN TYROSINE PHOSPHATASE AS AN ANTIMALARIAL DRUG TARGET 审中-公开
标题翻译：使用双特异性蛋白酪氨酸磷酸化酶作为抗精神病药物目标的方法和组合物
公开(公告)号：WO2010108177A3
公开(公告)日：2011-02-17
申请号：PCT/US2010028152
申请日：2010-03-22
申请人： UNIV SOUTH FLORIDA , ADAMS JOHN H , BALU BHARATH , MAHER STEVEN P , CAMPBELL CHRIS , MANETSCH ROMAN
发明人： ADAMS JOHN H , BALU BHARATH , MAHER STEVEN P , CAMPBELL CHRIS , MANETSCH ROMAN
IPC分类号： A61K38/16 , A61K39/02 , A61K48/00 , A61P33/06
CPC分类号： A61K31/4365 , A61K31/122 , A61K31/403 , A61K31/5355 , A61K31/655 , A61K39/015 , A61K2039/522
摘要： Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development and invasion of erythrocytes by malaria merozoites. Mutation of the PF13_0027 gene or blocking expression of PTP function to create a PTP-null parasite severely attenuates the malaria parasite's ability to survive, making the PTP-null parasite suitable as an attenuated blood-stage parasite vaccine.
摘要翻译：由PF13_0027编码的磷酸酪氨酸磷酸酶（PTP）是人类疟疾寄生虫恶性疟原虫的理想药物靶标。该PTP对于疟原虫发生红细胞和红细胞的侵袭性是至关重要的。 PF13_0027基因的突变或阻断PTP功能的表达以产生PTP无效寄生虫严重地减弱疟原虫的存活能力，使得PTP无效寄生虫适合作为减毒血液寄生虫疫苗。

2. 发明申请

WO2009158470A2 TOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译：毒素基因及其使用方法
公开(公告)号：WO2009158470A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048614
申请日：2009-06-25
申请人： ATHENIX CORPORATION , AGARWAL, Shruti , CAMPBELL, Chris , MCNULTY, Brian , SAMPSON, Kimberly, S. , TOMSO, Daniel, J.
发明人： AGARWAL, Shruti , CAMPBELL, Chris , MCNULTY, Brian , SAMPSON, Kimberly, S. , TOMSO, Daniel, J.
IPC分类号： C07K14/325 , C12N15/82
CPC分类号： C07K14/325 , A01N37/18 , C07K16/1278 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 61-121 and 133-141, or the nucleotide sequence set forth in SEQ ID NO: 1-60, 124-132, and 142-283, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：61-121和133-141所示氨基酸序列的核苷酸序列或SEQ ID NO：1-60,124所示的核苷酸序列 -132和142-283，以及其变体和片段。

3. 发明申请

WO2009088770A1 GAS DELIVERY SYSTEM FOR AN ION SOURCE 审中-公开
标题翻译：用于离子源的气体输送系统
公开(公告)号：WO2009088770A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/088155
申请日：2008-12-23
申请人： VARIAN SEMICONDUCTOR EQUIPMENT ASSOCIATES, INC. , SLOCUM, John , KEEN, Kevin, M. , CAMPBELL, Chris , LINDBERG, Robert , CASEY, Stefan
发明人： SLOCUM, John , KEEN, Kevin, M. , CAMPBELL, Chris , LINDBERG, Robert , CASEY, Stefan
IPC分类号： H01L21/3065 , H01L21/265
CPC分类号： H01J37/3171 , H01J27/08 , H01J37/08 , H01J2237/006 , H01J2237/061 , H01J2237/082
摘要： An ion source has an arc chamber with an electron-emitting element and a repeller. A manifold assembly defines a cavity and a gas outlet configured to allow gas flow to the arc chamber. This gas outlet is closer to the repeller than the electron-emitting element. In one embodiment, the ion source has a first crucible and a second crucible. The first crucible and the second crucible are connected to the manifold assembly. In one instance, the crucibles have tamper-resistant features.
摘要翻译：离子源具有具有电子发射元件和排斥器的电弧室。歧管组件限定了空腔和气体出口，其构造成允许气体流动到电弧室。该气体出口比电子发射元件更靠近排斥器。在一个实施例中，离子源具有第一坩埚和第二坩埚。第一坩埚和第二坩埚连接到歧管组件。在一个实例中，坩埚具有防篡改特征。

4. 发明申请

WO2013059252A1 CIGARETTE PACKAGE CODING SYSTEM AND ASSOCIATED METHOD 审中-公开
标题翻译：香烟包装编码系统及相关方法
公开(公告)号：WO2013059252A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060516
申请日：2012-10-17
申请人： R. J. REYNOLDS TOBACCO COMPANY , GATES, Hugh , PHAN, Hung , CAMPBELL, Chris , HALL, David , WOOD, Gary , THOMAS, Reggie , BRANTLEY, Frank
发明人： GATES, Hugh , PHAN, Hung , CAMPBELL, Chris , HALL, David , WOOD, Gary , THOMAS, Reggie , BRANTLEY, Frank
IPC分类号： B65B19/28 , B65B61/26
CPC分类号： B65B19/30 , B65B19/32 , B65B61/26 , B65G47/261 , G05B19/41875 , G05B23/0294
摘要： A package coding system for a cigarette manufacturing process is provided. An imprinting device (400) imprints an alphanumeric code on each of a series of cigarette packages (200). A conveyor device (300) conveys the cigarette packages in a feed direction. An inspection device (600) is operably engaged with the conveyor device and inspects the alphanumeric code (500) imprinted on each cigarette package conveyed by the conveyor device to determine whether any of the cigarette packages includes a defect in the imprinted alphanumeric code, and thus comprises a defective cigarette package. A removal device (700) is operably engaged with the conveyor device and is configured to be in communication with the inspection device. The removal device is configured to remove the defective cigarette package from the series of cigarette packages conveyed by the conveyor device in response to identification thereof by the inspection device. An associated method is also provided.
摘要翻译：提供了一种卷烟制造工艺的包装编码系统。压印装置（400）在一系列香烟包装（200）的每一个上印上字母数字代码。输送装置（300）沿着进给方向输送香烟包装。检查装置（600）可操作地与传送装置接合并且检查印在由传送装置输送的每个卷烟包装上的字母数字代码（500），以确定卷烟包装盒中是否包含印有字母数字代码的缺陷，因此包括有缺陷的香烟包装。移除装置（700）可操作地与输送装置接合并被构造成与检查装置连通。移除装置被配置成响应于检查装置的识别，从由输送装置输送的一系列香烟包装中去除有缺陷的香烟包装。还提供了相关联的方法。

5. 发明申请

WO2010003065A3 AXMI-IL 5, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184 : VIP3A INSECTICIDAL PROTEINS FROM BACILLUS THURINGIENSIS AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-IL 5，AXMI-113，AXMI-005，AXMI-163和AXMI-184：来自BACILLUS THURINGIENSIS的VIP3A杀虫蛋白及其使用方法
公开(公告)号：WO2010003065A3
公开(公告)日：2010-05-20
申请号：PCT/US2009049527
申请日：2009-07-02
申请人： ATHENIX CORP , SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
发明人： SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
IPC分类号： C07K14/325 , A01H5/00 , C12N15/82
CPC分类号： C07K14/325 , A01N37/18 , C07K14/32 , C07K16/1278 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in host cells. Compositions also comprise transformed host cells. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 6, 13, or 14, or the nucleotide sequence set forth in SEQ ID NO: 1, 2, 3, 11, or 12, as well as variants and fragments thereof.
摘要翻译：提供了赋予宿主细胞杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在宿主细胞中转化和表达。组合物还包含转化的宿主细胞。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：4,5,6,13或14所示氨基酸序列的核苷酸序列或SEQ ID NO：1所示的核苷酸序列， 2,3,11或12，以及其变体和片段。

6. 发明申请

WO2010108177A2 A METHOD AND COMPOSITION USING A DUAL SPECIFICITY PROTEIN TYROSINE PHOSPHATASE AS AN ANTIMALARIAL DRUG TARGET 审中-公开
标题翻译：使用双特异性蛋白酪氨酸磷酸化酶作为抗精神病药物目标的方法和组合物
公开(公告)号：WO2010108177A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/028152
申请日：2010-03-22
申请人： UNIVERSITY OF SOUTH FLORIDA , ADAMS, John H. , BALU, Bharath , MAHER, Steven P. , CAMPBELL, Chris , MANETSCH, Roman
发明人： ADAMS, John H. , BALU, Bharath , MAHER, Steven P. , CAMPBELL, Chris , MANETSCH, Roman
IPC分类号： A61K38/16 , A61K39/02 , A61K48/00 , A61P33/06
CPC分类号： A61K31/4365 , A61K31/122 , A61K31/403 , A61K31/5355 , A61K31/655 , A61K39/015 , A61K2039/522 , Y02A50/412
摘要： Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development and invasion of erythrocytes by malaria merozoites. Mutation of the PF13_0027 gene or blocking expression of PTP function to create a PTP-null parasite severely attenuates the malaria parasite's ability to survive, making the PTP-null parasite suitable as an attenuated blood-stage parasite vaccine.
摘要翻译：由PF13_0027编码的磷酸酪氨酸磷酸酶（PTP）是人类疟疾寄生虫恶性疟原虫的理想药物靶标。该PTP对于疟原虫发生红细胞和红细胞的侵袭性是至关重要的。 PF13_0027基因的突变或阻断PTP功能的表达以产生PTP无效寄生虫严重地减弱疟原虫的存活能力，使得PTP无效寄生虫适合作为减毒血液寄生虫疫苗。

7. 发明申请

WO2009158470A3 TOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译：毒素基因及其使用方法
公开(公告)号：WO2009158470A3
公开(公告)日：2010-04-29
申请号：PCT/US2009048614
申请日：2009-06-25
申请人： ATHENIX CORP , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , SAMPSON KIMBERLY S , TOMSO DANIEL J
发明人： AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , SAMPSON KIMBERLY S , TOMSO DANIEL J
IPC分类号： C07K14/325 , C12N15/82
CPC分类号： C07K14/325 , A01N37/18 , C07K16/1278 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 61-121 and 133-141, or the nucleotide sequence set forth in SEQ ID NO: 1-60, 124-132, and 142-283, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：61-121和133-141所示氨基酸序列的核苷酸序列或SEQ ID NO：1-60,124 -132和142-283，以及其变体和片段。

8. 发明申请

WO2008088971A3 TECHNIQUES FOR PROVIDING ION SOURCE FEED MATERIALS 审中-公开
标题翻译：提供离子源材料的技术
公开(公告)号：WO2008088971A3
公开(公告)日：2009-06-11
申请号：PCT/US2008050478
申请日：2008-01-08
申请人： VARIAN SEMICONDUCTOR EQUIPMENT , HATEM CHRISTOPHER R , CHANEY CRAIG R , COBB ERIC R , OLSON JOSEPH C , CAMPBELL CHRIS
发明人： HATEM CHRISTOPHER R , CHANEY CRAIG R , COBB ERIC R , OLSON JOSEPH C , CAMPBELL CHRIS
IPC分类号： H01J27/02 , F17C9/02 , H01J37/08 , H01J37/317
CPC分类号： H01J27/02 , C23C14/246 , C23C14/48 , H01J37/08 , H01J37/3171 , H01J2237/006
摘要： Techniques for providing ion source feed materials are disclosed. In one particular exemplary embodiment, the techniques may be realized as a container for supplying an ion source feed material. The container may comprise an internal cavity to be pre-filled with an ion source feed material. The container may also comprise an outer body configured to be removably loaded into a corresponding housing that is coupled to an ion source chamber via a nozzle assembly. The container may further comprise an outlet to seal in the pre-filled ion source feed material, the outlet being further configured to engage with the nozzle assembly to establish a flow path between the internal cavity and the ion source chamber. The container may be configured to be a disposable component.
摘要翻译：公开了提供离子源进料的技术。在一个特定的示例性实施例中，这些技术可以被实现为用于提供离子源进料的容器。容器可以包括预先填充有离子源进料的内部空腔。容器还可以包括被配置为可移除地装载到经由喷嘴组件耦合到离子源室的相应壳体中的外主体。容器还可以包括密封在预填充的离子源进料中的出口，该出口进一步构造成与喷嘴组件接合以在内腔和离子源室之间建立流动路径。容器可以被配置为一次性部件。

9. 发明申请

WO2010017114A3 AN ION SOURCE AND A METHOD FOR IN-SITU CLEANING THEREOF 审中-公开
公开(公告)号：WO2010017114A3
公开(公告)日：2010-02-11
申请号：PCT/US2009/052530
申请日：2009-08-03
申请人： VARIAN SEMICONDUCTOR EQUIPMENT ASSOCIATES , KOO, Bon-woong , CAMPBELL, Chris , CHANEY, Craig, R. , LINDBERG, Robert , PEREL, Alexander, S. , PLATOW, Wilhelm, P.
发明人： KOO, Bon-woong , CAMPBELL, Chris , CHANEY, Craig, R. , LINDBERG, Robert , PEREL, Alexander, S. , PLATOW, Wilhelm, P.
IPC分类号： H01L21/265
摘要： An ion source and method of cleaning are disclosed. One or more heating units are placed in close proximity to the inner volume of the ion source, so as to affect the temperature within the ion source, in one embodiment, one or more walls of the ion source have recesses into which heating units are inserted. In another embodiment, one or more wails of the ion source are constructed of a conducting circuit and an insulating layer. By utilizing heating units near the ion source, it is possible to develop new methods of cleaning the ion source. Cleaning gas is flowed into the ion source, where it is ionized, either by the cathode, as in normal operating mode, or by the heat generated by the heating units. The cleaning gas is able to remove residue from the walls of the ion source more effectively due to the elevated temperature.

10. 发明申请

WO2010017114A2 AN ION SOURCE AND A METHOD FOR IN-SITU CLEANING THEREOF 审中-公开
标题翻译：一种离子源及一种原位清洁的方法
公开(公告)号：WO2010017114A2
公开(公告)日：2010-02-11
申请号：PCT/US2009052530
申请日：2009-08-03
申请人： VARIAN SEMICONDUCTOR EQUIPMENT , KOO BON-WOONG , CAMPBELL CHRIS , CHANEY CRAIG R , LINDBERG ROBERT , PEREL ALEXANDER S , PLATOW WILHELM P
发明人： KOO BON-WOONG , CAMPBELL CHRIS , CHANEY CRAIG R , LINDBERG ROBERT , PEREL ALEXANDER S , PLATOW WILHELM P
IPC分类号： H01L21/265
CPC分类号： H01J27/022 , H01J27/02 , H01J27/14 , H01J37/08 , H01J37/3002 , H01J37/3171 , H01J2237/022 , H01J2237/31705
摘要： An ion source and method of cleaning are disclosed. One or more heating units are placed in close proximity to the inner volume of the ion source, so as to affect the temperature within the ion source, in one embodiment, one or more walls of the ion source have recesses into which heating units are inserted. In another embodiment, one or more wails of the ion source are constructed of a conducting circuit and an insulating layer. By utilizing heating units near the ion source, it is possible to develop new methods of cleaning the ion source. Cleaning gas is flowed into the ion source, where it is ionized, either by the cathode, as in normal operating mode, or by the heat generated by the heating units. The cleaning gas is able to remove residue from the walls of the ion source more effectively due to the elevated temperature.
摘要翻译：公开了一种离子源和清洁方法。一个或多个加热单元紧邻离子源的内部容积放置，以便影响离子源内的温度，在一个实施例中，离子源的一个或多个壁具有凹槽，加热单元插入其中。在另一个实施例中，离子源的一个或多个壁由导电电路和绝缘层构成。通过利用离子源附近的加热单元，可以开发清洁离子源的新方法。清洁气体通过阴极流入离子源，在正常工作模式下，或者由加热单元产生的热量，离子源被离子化。由于温度升高，清洁气体能够更有效地去除离子源壁上的残留物。

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