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1. 发明申请

WO2005037855A2 T CELL EPITOPES USEFUL IN A YERSINIA PESTIS VACCINE AND AS DIAGNOSTIC TOOLS AND METHODS FOR IDENTIFYING SAME 审中-公开
标题翻译：一种用于YERSINIA PESTIS VACCINE和诊断工具的T细胞抗原决定因子及其鉴定方法
公开(公告)号：WO2005037855A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/033883
申请日：2004-10-15
申请人： PECOS LABS, INC. , LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
发明人： LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
IPC分类号： C07K
CPC分类号： C07K14/24 , G01N2333/70539 , G01N2500/04 , G06F19/18 , G06F19/24
摘要： In a first aspect the present invention consists of T cell epitopes in the Yersinia pestis genome. More specifically there is provided 1,000 linear peptide epitopes from the Y. pestis genome. In a second aspect, the invention also consists of variants of these sequences. In a third aspect, this invention consists of a method to predict these sequences from genome data and to validate the predictions experimentally. In a fourth aspect, the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool.
摘要翻译：在第一方面，本发明由鼠疫耶尔森氏菌中的T细胞表位组成。更具体地，提供了来自鼠疫耶氏菌基因组的1,000个线性肽表位。在第二方面，本发明还包括这些序列的变体。在第三方面，本发明包括从基因组数据预测这些序列并通过实验来验证预测的方法。在第四方面，本发明提供包含用于疫苗的这些表位并诱导受试者的T细胞应答或作为诊断工具的组合物。

2. 发明申请

WO2003098219A1 AN ELISA MEASURING DE NOVO PEPTIDE-MHC INTERACTION 审中-公开
标题翻译：一种酶联免疫吸附测定法测定抗原肽与MHC的相互作用
公开(公告)号：WO2003098219A1
公开(公告)日：2003-11-27
申请号：PCT/DK2003/000325
申请日：2003-05-15
申请人： UNIVERSITY OF COPENHAGEN , BUUS, Søren , SILVESTER-HVID, Christina
发明人： BUUS, Søren , SILVESTER-HVID, Christina
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2333/70539
摘要： The present invention relates to a quantitative method to measure the interaction between a peptide and a MHC molecule. The basis for measuring this interaction is substantially pure denatured MHC heavy chains. These denatured MHC heavy chains are subsequently renatured in a buffer containing excess of β 2 m and an increasing concentration of the peptide in question, leading to a de novo folding and generation of peptide-MHC complexes. The present invention is exemplified with reference to MHC class I proteins, but it is envisaged that it is possible on a similar manner to generate data from any type of complex where de novo folding is peptide dependent, e.g., MHC class II.
摘要翻译：本发明涉及测量肽与MHC分子之间的相互作用的定量方法。测量这种相互作用的基础是基本上纯的变性MHC重链。这些变性的MHC重链随后在含有过量的β2m的缓冲液和所讨论的肽的浓度增加的情况下复性，导致肽-MHC复合物的从头折叠和产生。参考MHC I类蛋白质来举例说明本发明，但是设想可以以类似的方式从任何类型的复合体产生数据，其中从头折叠是肽依赖性的，例如MHC II类。

3. 发明申请

WO2005038000A2 T CELL EPITOPES USEFUL IN MYCOBACTERIUM TUBERCULOSIS VACCINE AND AS DIAGNOSTIC TOOLS AND METHODS FOR IDENTIFYING SAME 审中-公开
标题翻译：用于MYCOBACTERIUM TUBCCOSOSIS VACCINE和诊断工具的T细胞抗原决定因子及其鉴定方法
公开(公告)号：WO2005038000A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/033939
申请日：2004-10-15
申请人： PECOS LABS, INC. , LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
发明人： LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
IPC分类号： C12N
CPC分类号： C07K14/35 , G01N33/5695
摘要： In a first aspect the present invention consists of T cell epitopes in the Mycobacterium tuberculosis genome. More specifically there is provided 1000 linear peptide epitopes from the M. tuberculosis genome. In a second aspect the invention also consists of variants of these sequences. In a third aspect this invention consists of a method to predict these sequences from genome data and to validate the predictions experimentally. In a fourth aspect the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool. Figure 2 shows a plot of the measured versus the predicted binding affinity score for four different prediction methods (a) Rammensee matrix method, (b) Hidden Markov model trained on sequences in the Rammensee dataset, (c) Neural network trained with sparse sequence encoding, and (d) the Comb-II neural network method.
摘要翻译：在第一方面，本发明由结核分枝杆菌基因组中的T细胞表位组成。更具体地，提供了来自结核分枝杆菌基因组的1000个线性肽表位。在第二方面，本发明也由这些序列的变体组成。在第三方面，本发明包括从基因组数据预测这些序列并通过实验来验证预测的方法。在第四方面，本发明提供包含用于疫苗的这些表位并诱导受试者的T细胞应答或作为诊断工具的组合物。图2显示了四种不同预测方法的测量值与预测的结合亲和度分数的曲线图（a）Rammensee矩阵法，（b）针对Rammensee数据集序列训练的隐马尔可夫模型，（c）用稀疏序列编码训练的神经网络，（d）Comb-II神经网络方法。

4. 发明申请

WO2004072112A2 A METHOD FOR FORMULATING MHC-LIKE MOLECULES FOR LONG TIME STORAGE 审中-公开
标题翻译：用于长时间储存的MHC样分子的制备方法
公开(公告)号：WO2004072112A2
公开(公告)日：2004-08-26
申请号：PCT/DK2004/000094
申请日：2004-02-11
申请人： KØBENHAVNS UNIVERSITET , BUUS, Søren , SYLVESTER-HVID, Christina
发明人： BUUS, Søren , SYLVESTER-HVID, Christina
IPC分类号： C07K14/705
CPC分类号： C07K14/70539
摘要： The present invention describes how MHC-like molecules can be formulated in an active form and stored under conditions, which preserve their activity for an extended period of time, while readily allowing the end-user to generate any ligand-MHC-complex of their choice. The present inventors have termed the product of this invention: “formulated MHC molecules”. The utility of such formulated MHC molecules is considerable. One has to keep in mind that an entire arm of the immune system, the T cell immune system, is based upon the recognition of ligands selected and presented by MHC molecules. These ligands constitute the targets of the cellular immune system. They include foreign targets such as vaccine and/or immunotherapy candidates, who can be used to direct immunity against infectious agents and cancers, as well as self-targets involved in the development of autoimmune diseases and transplantation reactions. The availability of formulated MHC molecules affords a non-expert end-user with the enabling technology to identify and validate MHC ligands, and subsequently to generate specific ligand-MHC-complexes for the identification, validation, selection, and induction of specific T cells. The present invention therefore facilitates specific analysis and manipulation of the immune system.
摘要翻译：本发明描述了MHC样分子如何能够以活性形式配制并且在能够长时间保存其活性的条件下储存，同时容易使终端用户产生任何他们选择的配体-MHC-复合物。本发明人称之为本发明的产品：“配制的MHC分子”。这种配制的MHC分子的效用是相当可观的。人们必须记住，免疫系统的整个组成部分--T细胞免疫系统是基于识别由MHC分子选择和呈递的配体。这些配体构成细胞免疫系统的靶标。它们包括外来目标，如疫苗和/或免疫疗法候选物，可用于指导针对传染性病原体和癌症的免疫力，以及涉及自身免疫疾病和移植反应发展的自我靶标。配制的MHC分子的可用性为非专业最终用户提供了启动技术来鉴定和验证MHC配体，并随后产生用于特异性T细胞的鉴定，验证，选择和诱导的特异性配体-MHC-复合物。因此，本发明便于对免疫系统进行特定的分析和操作。

5. 发明申请

WO2003097669A3 METHOD FOR PURIFYING DENATURED PROTEINS HAVING A DESIRED DISULFIDE BOND CONFIGURATION 审中-公开
公开(公告)号：WO2003097669A3
公开(公告)日：2003-11-27
申请号：PCT/DK2003/000324
申请日：2003-05-15
申请人： KØBENHAVNS UNIVERSITET , BUUS, Søren , FERRÉ, Henrik
发明人： BUUS, Søren , FERRÉ, Henrik
IPC分类号： C07K1/113
摘要： The present invention relates to a method for production of a protein having a desired fold. This is especially achieved by subjecting a population of proteins to a separation step under non-reducing conditions. This allows for identification of a sub-population of proteins having the disulfide bond configuration resulting in a desired fold. Most often this will be the protein of proper structure and/or function. Thus, by using the novel method the purity of the protein having a desired fold can be increased as compared to the purity of a similar protein produced by a conventional method. Important aspect of the invention is a functional active MHC heavy chain protein obtainable by the above method and the use of a MHC heavy chain protein in analysis of peptide binding capacity.

6. 发明申请

WO2005042698A2 T CELL EPITOPES USEFUL IN A HEPATITIS C VIRUS VACCINE AND AS DIAGNOSTIC TOOLS AND METHODS FOR IDENTIFYING SAME 审中-公开
标题翻译：乙型肝炎病毒疫苗和诊断工具中使用的T细胞抗原决定因子及其鉴别方法
公开(公告)号：WO2005042698A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/033942
申请日：2004-10-15
申请人： PECOS LABS, INC. , LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
发明人： LUND, Ole , LUNDEGAARD, Claus , NIELSEN, Morten , WORNING, Peder , DEANS, Robert, J. , BUUS, Søren , BRUNAK, Søren
IPC分类号： C12N
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要： In a first aspect the present invention consists of T cell epitopes in the Hepatitis C virus genome. More specifically there is provided 429 linear peptide epitopes from the Hepatitis C Virus genome. In a second aspect the invention also consists of variants of these sequences. In a third aspect this invention consists of a method to predict these sequences from genome data and to validate the predictions experimentally. Ina fourth aspect the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool. Figure 2 shows a plot of the measured versus the predicted binding affinity score for four different prediction methods (1) Rammensee matrix method, (b) Hidden Markov model trained on sequences in the Rammensee dataset, (c) Neural network trained with sparse sequence encoding, and (d) The Comb-II neural network method.
摘要翻译：在第一方面，本发明由丙型肝炎病毒基因组中的T细胞表位组成。更具体地，提供了来自丙型肝炎病毒基因组的429个线性肽表位。在第二方面，本发明也由这些序列的变体组成。在第三方面，本发明包括从基因组数据预测这些序列并通过实验来验证预测的方法。在第四方面，本发明提供了包含用于疫苗的这些表位并诱导受试者的T细胞应答或作为诊断工具的组合物。图2显示了四种不同预测方法的测量与预测的结合亲和度得分的曲线图（1）Rammensee矩阵法，（b）针对Rammensee数据集中序列训练的隐马尔可夫模型，（c）用稀疏序列编码训练的神经网络，（d）Comb-II神经网络方法。

7. 发明申请

WO2005019263A1 A CONTINUOUS PROCESS FOR THE ASSEMBLY OF MACROMOLECULAR SUBSTANCES AND THE SUBSEQUENT CAPTURE AND ISOLATION OF A MACROMOLECULAR ASSEMBLY, AND A SYSTEM SUITABLE FOR THE PROCESS 审中-公开
标题翻译：大分子物质组装的连续方法和大分子组装的后续捕获和分离以及适用于该方法的系统
公开(公告)号：WO2005019263A1
公开(公告)日：2005-03-03
申请号：PCT/DK2004/000534
申请日：2004-08-12
申请人： DANMARKS TEKNISKE UNIVERSITET , KØBENHAVNS UNIVERSITET , FERRÉ, Henrik , HANSEN, Dennis, B. , BUUS, Søren , HOBLEY, Timothy, J. , THOMAS, Owen, R., T.
发明人： FERRÉ, Henrik , HANSEN, Dennis, B. , BUUS, Søren , HOBLEY, Timothy, J. , THOMAS, Owen, R., T.
IPC分类号： C07K14/705
CPC分类号： B03C1/002 , B03C1/288 , C07K1/113 , C07K14/70539
摘要： The present invention relates to a continuous process and a system for macromolecular assembly and capture (refolding or proteins (e.g. refolding of HAT human β2-microglobulin), hybridization of nucleic acid, nucleic acid analogues, and protein-nucleic acid chimera, aggregation of carbohydrates, and assembly of nanostructures/nanomaterials. The process may comprise the steps of providing fluid compositions comprising at least one of said macromolecular substances in a predominantly unassembled form, providing a dispersion comprising coated, essentially non-porous magnetic particles, combining said fluid compositions and the dispersion of magnetic particles thereby providing a continuous stream, passing said continuous stream through a first mixing device thereby forming magnetic complexes each comprising a magnetic particle and a plurality of macromolecular assembly species; passing the continuous stream through a first capture compartment of a magnetic separator thereby capturing said magnetic complexes; and separating said magnetic complexes from said continuous stream, and isolating said macromolecular assembly species.
摘要翻译：本发明涉及用于大分子组装和捕获（重折叠或蛋白质（例如HAT人β2-微球蛋白的重折叠），核酸，核酸类似物和蛋白质的杂交的连续方法和系统 - 核酸嵌合体，碳水化合物聚集体和纳米结构/纳米材料组装体的方法，该方法可以包括以下步骤：提供包含至少一种主要未组装形式的所述大分子物质的流体组合物，提供包含涂布的，基本无孔的结合所述流体组合物和磁性粒子的分散体，从而提供连续流，使所述连续流穿过第一混合装置，由此形成各自包含磁性粒子和多个大分子组装物种的磁性复合物;使所述连续流穿过由此磁性分离器的第一捕获隔室捕获所述磁性复合物; 并从所述连续流中分离所述磁性络合物，并分离所述大分子组装物质。

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