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1. 发明申请

WO9954728A2 METHOD OF PREDICTING THE ABILITY OF COMPOUNDS TO MODULATE THE BIOLOGICAL ACTIVITY OF RECEPTORS 审中-公开
标题翻译：预测化合物能力以调节受体生物活性的方法
公开(公告)号：WO9954728A2
公开(公告)日：1999-10-28
申请号：PCT/US9906664
申请日：1999-03-26
申请人： NOVALON PHARMACEUTICAL CORP , PAIGE LISA A , HAMILTON PAUL T , FOWLKES DANA M , BUEHRER BENJAMIN , BARNETT TOM , MCDONNELL DONALD P , CHRISTENSEN DALE J
发明人： PAIGE LISA A , HAMILTON PAUL T , FOWLKES DANA M , BUEHRER BENJAMIN , BARNETT TOM , MCDONNELL DONALD P , CHRISTENSEN DALE J
IPC分类号： C07K1/04 , C07K4/12 , C07K7/08 , G01N33/15 , G01N33/50 , G01N33/74 , G01N33/33
CPC分类号： C07K7/08 , C07K1/047 , G01N33/743
摘要： The ability of a query compound to modulate the biological activity of a receptor in a multicellular organism is predicted on the basis of its interaction with that receptor in the presence of various member of a panel of BioKeys. The BioKeys are ligands, especially peptides or nucleic acids, known to modify the conformation of the receptor. This interaction data, known as a "fingerprint", is compared to the fingerprints for reference compounds with known biological activities mediated by that receptor. In the "molecular braille" (MB) embodiment of the present invention, the reference and test fingerprints are based on in vitro (cell-free) assays. In the "cellular-braille" (CB) embodiment of the present invention, the reference and test fingerprints are based on cellular assays (but not on assays of whole multicellular organisms, or their organs or tissues).
摘要翻译：在多细胞生物体组中的各种成员的存在下，基于其与该受体的相互作用来预测查询化合物调节多细胞生物体中受体的生物学活性的能力。 BioKeys是已知修饰受体构象的配体，特别是肽或核酸。称为“指纹”的这种相互作用数据与具有由该受体介导的已知生物活性的参考化合物的指纹进行比较。在本发明的“分子盲文”（MB）实施方案中，参考和测试指纹基于体外（无细胞）测定。在本发明的“细胞盲文”（CB）实施方案中，参考和测试指纹是基于细胞测定（但不是整个多细胞生物或其器官或组织的测定）。

2. 发明申请

WO2011053907A3 HUMAN OMENTAL MESOTHELIAL CELLS, METHODS OF ISOLATION AND USES THEREOF 审中-公开
标题翻译：人类妇科细胞，分离方法及其用途
公开(公告)号：WO2011053907A3
公开(公告)日：2011-09-01
申请号：PCT/US2010054957
申请日：2010-11-01
申请人： ZENBIO INC , BUEHRER BENJAMIN MARCUS , CHEATHAM RICHARD BENTLEY , NICOLL JAMES BRADFORD , PIERACCINI PETER EARL
发明人： BUEHRER BENJAMIN MARCUS , CHEATHAM RICHARD BENTLEY , NICOLL JAMES BRADFORD , PIERACCINI PETER EARL
IPC分类号： C12N5/071 , C12Q1/02 , G01N33/68
CPC分类号： C12N5/0653 , C12N2503/02
摘要： The present invention discloses novel methods and omental, myocardial, liver, lung, renal, peritoneal, intestinal and pancreatic mesothelial cells which are useful for a number of procedures including drug discovery, co-culturing, cell therapy and bioassay. The invention provides a method for isolating these cells that improves upon the methods previously used and provides cells isolated in quantity. The present invention provides a list of secreted proteins from omentum mesothelial cells that can be utilized in the described cell based assays.
摘要翻译：本发明公开了可用于许多方法（包括药物发现，共培养，细胞治疗和生物测定）的新颖方法和网膜，心肌，肝，肺，肾，腹膜，肠和胰间皮细胞。本发明提供了一种用于分离这些细胞的方法，其改进了先前使用的方法并提供了数量分离的细胞。本发明提供了可以在所述基于细胞的测定中使用的来自网膜间皮细胞的分泌蛋白质的列表。

3. 发明申请

WO2011053907A9 HUMAN OMENTAL MESOTHELIAL CELLS, METHODS OF ISOLATION AND USES THEREOF 审中-公开
公开(公告)号：WO2011053907A9
公开(公告)日：2011-05-05
申请号：PCT/US2010/054957
申请日：2010-11-01
申请人： ZENBIO, INC. , BUEHRER, Benjamin, Marcus , CHEATHAM, Richard, Bentley , NICOLL, James, Bradford , PIERACCINI, Peter, Earl
发明人： BUEHRER, Benjamin, Marcus , CHEATHAM, Richard, Bentley , NICOLL, James, Bradford , PIERACCINI, Peter, Earl
IPC分类号： C12N5/071 , C12Q1/02 , G01N33/68
摘要： The present invention discloses novel methods and omental, myocardial, liver, lung, renal, peritoneal, intestinal and pancreatic mesothelial cells which are useful for a number of procedures including drug discovery, co-culturing, cell therapy and bioassay. The invention provides a method for isolating these cells that improves upon the methods previously used and provides cells isolated in quantity. The present invention provides a list of secreted proteins from omentum mesothelial cells that can be utilized in the described cell based assays.

4. 发明申请

WO2004076473A3 ANDROGEN RECEPTOR INTERACTING PEPTIDES 审中-公开
标题翻译：雄激素受体相互作用肽
公开(公告)号：WO2004076473A3
公开(公告)日：2005-03-17
申请号：PCT/US2004003774
申请日：2004-02-10
申请人： KAROBIO AB , BUEHRER BENJAMIN M , BARNETT THOMAS R
发明人： BUEHRER BENJAMIN M , BARNETT THOMAS R
IPC分类号： A61K38/03 , A61K38/10 , C07K20060101 , C07K7/06 , C07K7/08 , G01N33/574 , G01N33/68
CPC分类号： C07K7/08 , A61K38/00 , G01N33/57434 , G01N2333/723
摘要： The present invention is directed to a polypeptide that binds to the androgen receptor, the polypeptide comprising the amino acid sequence Ar-X-X-Z-Ar, or Ser-beta-Ar- X-Delta-Psi-Ar; or Ser-beta-Ar-Delta-X-Psi-Ar; or Ser-X-Ar-X-X-Psi-Ar; wherein Ar is an aromatic amino acid; X is any amino acid; and Z is a hydrophobic amino acid (Psi) or an aromatic amino acid (Ar), beta is a basic amino acid; and A is an acidic amino acid. The present invention is also directed to methods of analyzing the surface conformation of a protein using one or more of the above polypeptide sequences; methods of identifying modulators of protein function using one or more of the above polypeptide sequences; and pharmaceutical compositions comprising a pharmaceutically acceptable carrier and one or more of the above polypeptide sequences.
摘要翻译：本发明涉及结合雄激素受体的多肽，所述多肽包含氨基酸序列Ar-X-X-Z-Ar或Ser-β-Ar-X-Delta-Psi-Ar; 或Ser-β-Ar-Delta-X-Psi-Ar; 或Ser-X-Ar-X-X-Psi-Ar; 其中Ar是芳族氨基酸; X是任何氨基酸; Z是疏水性氨基酸（Psi）或芳香族氨基酸（Ar），β是碱性氨基酸; A是酸性氨基酸。本发明还涉及使用一种或多种上述多肽序列分析蛋白质的表面构象的方法; 使用一种或多种上述多肽序列鉴定蛋白质功能调节剂的方法; 以及包含药学上可接受的载体和一种或多种上述多肽序列的药物组合物。

5. 发明申请

WO2009032943A3 METHODS AND COMPOSITIONS FOR DELIVERY OF GROWTH FACTOR TO FIBROUS CONNECTIVE TISSUE 审中-公开
公开(公告)号：WO2009032943A3
公开(公告)日：2009-03-12
申请号：PCT/US2008/075282
申请日：2008-09-04
申请人： AFFINERGY, INC. , BUEHRER, Benjamin, Marcus , HAMILTON, Paul, Theodore , JUZUMIENE, Dalia, Izolda , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen
发明人： BUEHRER, Benjamin, Marcus , HAMILTON, Paul, Theodore , JUZUMIENE, Dalia, Izolda , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen
IPC分类号： A61F2/02 , A61K38/04
摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

6. 发明申请

WO2009018484A1 COMPOSITIONS FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS TO SURFACES 审中-公开
标题翻译：用于将生物活性剂递送到表面的组合物
公开(公告)号：WO2009018484A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071825
申请日：2008-07-31
申请人： AFFINERGY, INC. , HAMILTON, Paul, Theodore , BUEHRER, Benjamin, Marcus
发明人： HAMILTON, Paul, Theodore , BUEHRER, Benjamin, Marcus
IPC分类号： A61K38/00 , A61F2/02
CPC分类号： C07K14/001 , A61K9/1635 , A61K9/1647 , A61K47/62 , A61K47/6933 , A61K47/6955 , A61K47/6957 , C07K7/08 , C07K2319/00
摘要： The presently disclosed subject matter relates to compositions for delivering biologically active agent to non-biological substrates, the compositions comprising a surface-binding peptide coupled to a drug delivery vehicle, wherein the surface-binding peptide has binding affinity for the non- biological substrate and the drug delivery vehicle carries the biologically active agent. Also provided are methods of applying the compositions by contacting a non-biological substrate with the composition such that the composition binds non-covalently to the non-biological substrate.
摘要翻译：目前公开的主题涉及用于将生物活性剂递送到非生物底物的组合物，该组合物包含与药物递送载体结合的表面结合肽，其中表面结合肽对非生物底物具有结合亲和力，药物递送载体携带生物活性剂。还提供了通过使非生物底物与组合物接触使得组合物非共价结合至非生物底物来施用组合物的方法。

7. 发明申请

WO0204956A2 METHOD OF IDENTIFYING CONFORMATION-SENSITIVE BINDING PEPTIDES AND USES THEREOF 审中-公开
标题翻译：识别构象敏感性结合肽的方法及其用途
公开(公告)号：WO0204956A2
公开(公告)日：2002-01-17
申请号：PCT/US0121867
申请日：2001-07-11
申请人： KARO BIO USA INC , FOWLKES DANA M , BARNETT THOMAS R , BUEHRER BENJAMIN
发明人： FOWLKES DANA M , BARNETT THOMAS R , BUEHRER BENJAMIN
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/02 , C40B30/04 , G01N33/15 , G01N33/566 , G01N33/68 , H01S5/026 , H01S5/042 , H01S5/0625 , H01S5/12 , H01S5/34 , H01S5/50 , H04B10/17
CPC分类号： C40B30/04 , B82Y20/00 , G01N33/566 , G01N33/6845 , G01N2500/10 , H04B10/2914
摘要： Peptides which bind a cellular (surface or intracellular) receptor, such as a nuclear receptor, may be identified by screening a combinatorial peptide library presented in the form of cells each of which coexpress one member peptide and the receptor, together with a signal producing system for reporting binding. A "two-hybrid" assay is of particular interest. The screen may be carried out in the presence of a ligand, in particular, an exogenous ligand. If this screening is carried out for a plurality of different receptor conformations, then this library screening will also serve to identify conformation-specific peptides for the receptor, which may then be used in a panel for "fingerprinting"query compounds as to their ability to interact with the receptor in the presence of each of the panel peptides. These fingerprints may be compared to those of reference compounds with known biological activities mediated by that receptor.
摘要翻译：结合细胞（表面或细胞内）受体的肽，例如核受体，可以通过筛选以细胞形式存在的组合肽文库来鉴定，所述组合肽文库各自共表达一个成员肽和受体，以及信号产生系统用于报告绑定。 “双杂交”测定特别令人感兴趣。筛选可以在配体，特别是外源配体存在下进行。如果筛选针对多种不同的受体构象进行，那么该文库筛选还将用于鉴定受体的构象特异性肽，然后可将其用于“指纹”查询化合物的小组中，在每个面板肽的存在下与受体相互作用。这些指纹可以与具有由该受体介导的已知生物活性的参考化合物的指纹进行比较。

8. 发明申请

WO2011053907A2 HUMAN OMENTAL MESOTHELIAL CELLS, METHODS OF ISOLATION AND USES THEREOF 审中-公开
标题翻译：人类软骨细胞细胞，分离方法及其用途
公开(公告)号：WO2011053907A2
公开(公告)日：2011-05-05
申请号：PCT/US2010054957
申请日：2010-11-01
申请人： ZENBIO INC , BUEHRER BENJAMIN MARCUS , CHEATHAM RICHARD BENTLEY , NICOLL JAMES BRADFORD , PIERACCINI PETER EARL
发明人： BUEHRER BENJAMIN MARCUS , CHEATHAM RICHARD BENTLEY , NICOLL JAMES BRADFORD , PIERACCINI PETER EARL
IPC分类号： C12N5/071 , C12Q1/02 , G01N33/68
CPC分类号： C12N5/0653 , C12N2503/02
摘要： The present invention discloses novel methods and omental, myocardial, liver, lung, renal, peritoneal, intestinal and pancreatic mesothelial cells which are useful for a number of procedures including drug discovery, co-culturing, cell therapy and bioassay. The invention provides a method for isolating these cells that improves upon the methods previously used and provides cells isolated in quantity. The present invention provides a list of secreted proteins from omentum mesothelial cells that can be utilized in the described cell based assays.
摘要翻译：本发明公开了新颖的方法和大网膜，心肌，肝，肺，肾，腹膜，肠和胰腺间皮细胞，其可用于多种程序，包括药物发现，共培养，细胞治疗和生物测定。本发明提供了一种分离这些细胞的方法，其改善了之前使用的方法并提供了大量分离的细胞。本发明提供了来自网膜间皮细胞的分泌蛋白列表，其可用于所述基于细胞的测定中。

9. 发明申请

WO2009032943A2 METHODS AND COMPOSITIONS FOR DELIVERY OF GROWTH FACTOR TO FIBROUS CONNECTIVE TISSUE 审中-公开
标题翻译：向纤维连接组织递送生长因子的方法和组合物
公开(公告)号：WO2009032943A2
公开(公告)日：2009-03-12
申请号：PCT/US2008075282
申请日：2008-09-04
申请人： AFFINERGY INC , BUEHRER BENJAMIN MARCUS , HAMILTON PAUL THEODORE , JUZUMIENE DALIA IZOLDA , NAIR SHRIKUMAR AMBUJAKSHAN , CHEN YUCHEN
发明人： BUEHRER BENJAMIN MARCUS , HAMILTON PAUL THEODORE , JUZUMIENE DALIA IZOLDA , NAIR SHRIKUMAR AMBUJAKSHAN , CHEN YUCHEN
IPC分类号： C07K7/08 , A61K9/00 , A61K38/10 , A61K38/16 , A61P19/04 , C07K14/00
CPC分类号： C07K14/71 , A61K9/0024 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/606 , C07K2319/20
摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
摘要翻译：本发明公开的主题涉及用于将纤维结缔组织诱导生长因子非共价定位于植入物表面的肽组合物，所述组合物包含对与植入物表面材料偶联的肽具有结合亲和力的肽，所述肽具有结合对纤维结缔组织诱导生长因子具有亲和力。提供了以有效促进纤维结缔组织修复和纤维结缔组织形成的量递送纤维结缔组织诱导生长因子GDF-7的方法。还提供了通过使组合物与植入物的表面接触将肽组合物施用于植入物的方法; 和包含组合物的试剂盒。

10. 发明申请

WO2004076473A2 ANDROGEN RECEPTOR INTERACTING PEPTIDES 审中-公开
标题翻译：雄激素受体相互作用肽
公开(公告)号：WO2004076473A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/003774
申请日：2004-02-10
申请人： KARO BIO AB , BUEHRER, Benjamin, M. , BARNETT, Thomas, R.
发明人： BUEHRER, Benjamin, M. , BARNETT, Thomas, R.
IPC分类号： C07K
CPC分类号： C07K7/08 , A61K38/00 , G01N33/57434 , G01N2333/723
摘要： The present invention is directed to a polypeptide that binds to the androgen receptor, the polypeptide comprising the amino acid sequence Ar-X-X-Z-Ar, or Ser-β-Ar- X-Δ-Ψ-Ar; or Ser-β-Ar-Δ-X-Ψ-Ar; or Ser-X-Ar-X-X-Ψ-Ar; wherein Ar is an aromatic amino acid; X is any amino acid; and Z is a hydrophobic amino acid (Ψ) or an aromatic amino acid (Ar), β is a basic amino acid; and A is an acidic amino acid. The present invention is also directed to methods of analyzing the surface conformation of a protein using one or more of the above polypeptide sequences; methods of identifying modulators of protein function using one or more of the above polypeptide sequences; and pharmaceutical compositions comprising a pharmaceutically acceptable carrier and one or more of the above polypeptide sequences.
摘要翻译：本发明涉及结合雄激素受体的多肽，所述多肽包含氨基酸序列Ar-X-X-Z-Ar或Ser-β-Ar-X-Delta-Psi-Ar; 或Ser-β-Ar-Delta-X-Psi-Ar; 或Ser-X-Ar-X-X-Psi-Ar; 其中Ar是芳香族氨基酸; X是任何氨基酸; Z是疏水性氨基酸（Psi）或芳香族氨基酸（Ar），β是碱性氨基酸; A是酸性氨基酸。本发明还涉及使用一种或多种上述多肽序列分析蛋白质的表面构象的方法; 使用一种或多种上述多肽序列鉴定蛋白质功能的调节剂的方法; 以及包含药学上可接受的载体和一种或多种上述多肽序列的药物组合物。

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