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    • 2. 发明申请
    • IMPROVED LITTER BOX ASSEMBLY AND CLEANING METHOD
    • 改进的LITTER BOX装配和清洁方法
    • WO1997030583A1
    • 1997-08-28
    • PCT/US1997002598
    • 1997-02-21
    • TC INDUSTRIES, L.L.C.BROWN, Michael, A., Jr.ROTHWELL, Timothy, Charles
    • TC INDUSTRIES, L.L.C.
    • A01K29/00
    • A01K1/0114
    • A pet litter box assembly includes an upper box (22) nested within a lower box (24). Upper box (22) has a floor (30) with multiple openings (56) and a plate (58) slidably attached under the floor (30) which also has multiple openings (60). Plate (58) is slidable between a first position, in which openings (56) in floor (30) are blocked by plate (58), and a second position, in which openings (56) in floor (30) and openings (60) in plate (58) correspond. Plate (58) is moved from the first position to the second position to filter unsoiled litter from upper box (22) into bottom box (24), leaving soiled clumped litter in upper box (22) for dumping. Preferably, boxes (22, 24) are identical, and bottom box (24) with filtered clean litter is reversibly nestable in upper box (22) to become the new upper box.
    • 宠物垃圾箱组件包括嵌套在下箱(24)内的上箱(22)。 上箱(22)具有多个开口(56)的底板(30)和可滑动地安装在也具有多个开口(60)的地板(30)下方的板(58)。 板(58)可在第一位置和第二位置之间滑动,在第一位置,地板(30)中的开口(56)被板(58)阻挡,第二位置在地板(30)和开口(60)中的开口 )对应。 板(58)从第一位置移动到第二位置,以将未污染的垃圾从上箱(22)过滤到底箱(24)中,在上箱(22)中留下被弄脏的集尘垃圾以便倾倒。 优选地,盒(22,24)是相同的,并且具有经过过滤的干净垃圾的底盒(24)可逆地嵌套在上盒(22)中以成为新的上盒。
    • 9. 发明申请
    • HISTAMINE RELEASE INHIBITORY FACTOR AND PREPARATIONS THEREFORE
    • 组胺释放抑制因子及其制备
    • WO1989006545A1
    • 1989-07-27
    • PCT/US1989000104
    • 1989-01-11
    • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMALAM, RafeulGRANT, J., AndrewLETT-BROWN, Michael, A.
    • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    • A61K45/00
    • C12N5/0642A61K38/00C07K14/52C12N2500/32C12N2501/23
    • The present invention relates to a novel inhibitor of histamine release, designed HRIF which is believed to represent a promising therapeutic agent for treatment of basophil and mast cell dependent disorders, including allergic diseases. This inhibitor is a human cytokine that antagonizes a human histamine releasing cytokine(s) designated HRF. HRIF has a molecular weight of about 8,000 to 10,000 daltons as determined by gel exclusion chromatography and has also been purified by ion exchange chromatography. HRIF is stable when heated at 60 DEG C for one hour, when frozen and thawed four times, and when treated with neuraminidase. Treatment with trypsin or chymotrypsin substantially destroys the activity of HRIF. The present invention includes compositions comprising substantially purified HRIF as well as methods for HRIF production and use. The invention also includes HRIF-producing cell lines and methods for producing such cell lines.
    • 本发明涉及组胺释放的新型抑制剂,设计的HRIF被认为是治疗嗜碱性粒细胞和肥大细胞依赖性疾病(包括过敏性疾病)的有希望的治疗剂。 该抑制剂是人类细胞因子,其拮抗人组胺释放细胞因子(称为HRF)。 通过凝胶排阻色谱法测定HRIF的分子量约为8,000至10,000道尔顿,并且还通过离子交换色谱法纯化。 HRIF在60℃下加热1小时,冷冻融化4次,并用神经氨酸酶处理时稳定。 用胰蛋白酶或胰凝乳蛋白酶处理显着破坏HRIF的活性。 本发明包括包含基本上纯化的HRIF以及用于HRIF生产和使用的方法的组合物。 本发明还包括HRIF产生细胞系和用于产生这种细胞系的方法。