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1. 发明申请

WO1989006545A1 HISTAMINE RELEASE INHIBITORY FACTOR AND PREPARATIONS THEREFORE 审中-公开
标题翻译：组胺释放抑制因子及其制备
公开(公告)号：WO1989006545A1
公开(公告)日：1989-07-27
申请号：PCT/US1989000104
申请日：1989-01-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ALAM, Rafeul , GRANT, J., Andrew , LETT-BROWN, Michael, A.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： A61K45/00
CPC分类号： C12N5/0642 , A61K38/00 , C07K14/52 , C12N2500/32 , C12N2501/23
摘要： The present invention relates to a novel inhibitor of histamine release, designed HRIF which is believed to represent a promising therapeutic agent for treatment of basophil and mast cell dependent disorders, including allergic diseases. This inhibitor is a human cytokine that antagonizes a human histamine releasing cytokine(s) designated HRF. HRIF has a molecular weight of about 8,000 to 10,000 daltons as determined by gel exclusion chromatography and has also been purified by ion exchange chromatography. HRIF is stable when heated at 60 DEG C for one hour, when frozen and thawed four times, and when treated with neuraminidase. Treatment with trypsin or chymotrypsin substantially destroys the activity of HRIF. The present invention includes compositions comprising substantially purified HRIF as well as methods for HRIF production and use. The invention also includes HRIF-producing cell lines and methods for producing such cell lines.
摘要翻译：本发明涉及组胺释放的新型抑制剂，设计的HRIF被认为是治疗嗜碱性粒细胞和肥大细胞依赖性疾病（包括过敏性疾病）的有希望的治疗剂。该抑制剂是人类细胞因子，其拮抗人组胺释放细胞因子（称为HRF）。通过凝胶排阻色谱法测定HRIF的分子量约为8,000至10,000道尔顿，并且还通过离子交换色谱法纯化。 HRIF在60℃下加热1小时，冷冻融化4次，并用神经氨酸酶处理时稳定。用胰蛋白酶或胰凝乳蛋白酶处理显着破坏HRIF的活性。本发明包括包含基本上纯化的HRIF以及用于HRIF生产和使用的方法的组合物。本发明还包括HRIF产生细胞系和用于产生这种细胞系的方法。

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