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1. 发明申请

WO2012085024A3 AUTO-INJECTOR 审中-公开
标题翻译：自动注射器
公开(公告)号：WO2012085024A3
公开(公告)日：2012-08-16
申请号：PCT/EP2011073505
申请日：2011-12-21
申请人： SANOFI AVENTIS DEUTSCHLAND , HOURMAND YANNICK , BRERETON SIMON FRANCIS , EKMAN MATTHEW
发明人： HOURMAND YANNICK , BRERETON SIMON FRANCIS , EKMAN MATTHEW
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32 , A61M5/46
CPC分类号： A61M5/3257 , A61M5/20 , A61M5/2033 , A61M5/24 , A61M5/326 , A61M5/46 , A61M2205/581 , A61M2205/582
摘要： An auto-injector (1) for administering a dose of a liquid medicament (M) comprises - a substantially cylindrical housing (2) arranged to contain a pre-filled syringe (5) with an injection needle (12), a plunger (9) and a stopper (10) for sealing a syringe barrel (11) and - a drive means (8) releasably coupled to the plunger (9) for advancing the syringe (5) in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means (8) is arranged to be decoupled from the plunger (9) for advancing a needle shroud (3) to a safe position (PS) to surround the injection needle (12) after the injection. According to the invention, the drive means (8) bears against a thrust collar (7) arranged to be releasably coupled to the plunger (9) through a ramped engagement of a first tongue (7.1) and a first recess (6.2) so as to rotate the thrust collar (7) on translation in proximal direction (P). At least one longitudinal gap (G1, G2) is provided for guiding at a first and/or second protrusion (7.2, 7.3) of the thrust collar (7) to prevent a rotation of the thrust collar (7). A circumferential gap (G3) is arranged to allow the thrust collar (7) to rotate out of engagement to the plunger (9) on removal of the auto-injector (1) from the injection site.
摘要翻译：一种用于给药液体药物（M）的自动注射器（1）包括 - 基本上为圆柱形的壳体（2），其布置成将注射针（5）与注射针（12），柱塞（9））和用于密封注射器筒（11）的止动件（10）和 - 可释放地联接到所述柱塞（9）的驱动装置（8），用于使所述注射器（5）沿近端方向（P）前进，用于针插入注射部位和用于将剂量的药物（M）置换到注射部位。驱动装置（8）布置成与柱塞（9）分离，用于将针罩（3）推进到安全位置（PS），以在注射之后包围注射针（12）。根据本发明，驱动装置（8）抵靠着通过第一舌片（7.1）和第一凹部（6.2）的倾斜接合布置成可释放地联接到柱塞（9）的止推环（7），以便以使止推环（7）沿近端方向（P）平移。提供至少一个纵向间隙（G1，G2）用于在止推环（7）的第一和/或第二突起（7.2,7.3）处引导，以防止推力环（7）旋转。周向间隙（G3）布置成允许止推环（7）在从注射部位移除自动注射器（1）时旋转离开与柱塞（9）的接合。

2. 发明申请

WO2011061488A1 DELIVERY DEVICE AND DELIVERY METHODS 审中-公开
标题翻译：交付设备和交付方法
公开(公告)号：WO2011061488A1
公开(公告)日：2011-05-26
申请号：PCT/GB2010/002116
申请日：2010-11-17
申请人： PA KNOWLEDGE LIMITED , WHITAKER, David Jonathan Townley , NELSON, Craig Harvey , RUSSELL, David Morrison , KEMP, Thomas Mark , BRERETON, Simon Francis , DENT, Philip Andrew , FARENDEN, Paul
发明人： WHITAKER, David Jonathan Townley , NELSON, Craig Harvey , RUSSELL, David Morrison , KEMP, Thomas Mark , BRERETON, Simon Francis , DENT, Philip Andrew , FARENDEN, Paul
IPC分类号： A61F9/00
CPC分类号： A61F9/0008
摘要： Various delivery devices and methods, including a delivery device (200) for delivering a dose substance (110) in powdered form to an eye, comprising: a pocket (100A, 100B, 100C) for holding dose substance; a propulsion system (202, 204, 908, 1004, 1006) for propelling a dose consisting of a predetermined volume of said dose substance from said pocket towards said eye; wherein one or both of said pocket and said propulsion system are configured to inhibit propulsion of particles having a size greater than a predetermined threshold to said eye.
摘要翻译：各种递送装置和方法，包括用于将粉末形式的剂量物质（110）输送到眼睛的输送装置（200），包括：用于保持剂量物质的口袋（100A，100B，100C）; 推进系统（202,204,908,1004,1006），用于将来自所述口袋的预定体积的所述剂量物质的剂量推向所述眼睛; 其中所述口袋和所述推进系统中的一个或两个构造成禁止具有大于预定阈值的尺寸的颗粒对所述眼睛的推进。

3. 发明申请

WO2012110582A1 DETENT MECHANISM 审中-公开
标题翻译：确定机制
公开(公告)号：WO2012110582A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052652
申请日：2012-02-16
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
发明人： BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M5/3158 , A61M5/2033 , A61M5/31501 , A61M5/31511 , A61M5/3157 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , F04C2270/0421 , Y10T403/32501
摘要： The invention relates to a detent mechanism (18) for controlling translation between two components (2, 7) in a longitudinal direction (P, D), the detent mechanism (18) comprising at least one clip (7.12, 2.6) on one of the components (2, 7) arranged to be in a ramped engagement with a recess in the other one of the components (7, 2) in an initial state in such a manner that translation between the components (2, 7) is constrained and that application of a translative force between the components (2, 7) in one longitudinal direction (P, D) with the clip (7.12, 2.6) engaged with the recess deflects the clip (7.12, 2.6) out of the recess when a predetermined value of the translative force, at least depending on the resilience of the clip (7.12, 2.6), is overcome so as to allow translation between the components (2, 7).
摘要翻译：本发明涉及一种用于控制沿纵向（P，D）的两个部件（2,7）之间的平移的止动机构（18），该止动机构（18）包括至少一个夹子（7.12,2.6）组件（2,7）被布置成处于初始状态下与另一个部件（7,2）中的凹部倾斜接合，使得部件（2,7）之间的平移被约束，并且在一个纵向方向（P，D）上的部件（2,7）之间的平移力的施加与与凹部啮合的夹子（7.12,2.6）的应用将当夹具（7.12,2.6）偏离凹槽时，当预定的至少取决于夹子的弹性（7.12,2.6）的平移力的值被克服以允许部件（2,7）之间的平移。

4. 发明申请

WO2012110578A1 AUTO-INJECTOR 审中-公开
标题翻译：自动注射器
公开(公告)号：WO2012110578A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052647
申请日：2012-02-16
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
发明人： BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/46 , A61M5/20 , A61M5/2033 , A61M5/3157 , A61M5/326 , A61M2005/206 , A61M2205/581 , A61M2205/582
摘要： The invention refers to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: - a tubular chassis (2) telescopable in a tubular case (12), - a carrier subassembly comprising a tubular carrier (7) slidably arranged relative to the chassis (2) inside the case (12), the carrier (7) adapted to contain a syringe (3) with a hollow injection needle (4), a drive spring (8) and a plunger (9) for forwarding load of the drive spring (8) to a stopper (6) of the syringe (3), wherein the syringe (3) is lockable for joint axial translation with the carrier (7), - a control spring (19) arranged around the carrier (7) for translating the carrier (7) in a proximal direction (P) for insertion of the needle (4) through the chassis (2) into an injection site, wherein the control spring (19) is arranged to bias the case (12) against the chassis (2) in a distal direction (D) so as to extend the chassis (2) out of a proximal end (P) of the case (12), wherein an insertion depth of the needle (4) is defined by the carrier (7) abutting the chassis (2) in a predefined position, wherein the case (12) is arranged to release or allow release of the control spring (19) for needle insertion on translation of the case (12) in the proximal direction (P) relative to the chassis (2) against the bias into an advanced position.
摘要翻译：本发明涉及一种用于施用剂量的液体药物（M）的自动注射器（1），其包括： - 可套叠在管状壳体（12）中的管状底盘（2）， - 载体子组件，其包括管状载体 7），其在所述壳体（12）内相对于所述底盘（2）可滑动地布置，所述托架（7）适于容纳具有中空注射针（4）的注射器（3），驱动弹簧（8）和柱塞 9），用于将驱动弹簧（8）的负载传递到注射器（3）的止动件（6），其中注射器（3）可锁定用于与支架（7）的关节轴向平移， - 控制弹簧（19））布置在所述托架（7）周围，用于沿着近端方向（P）平移所述托架（7），以将所述针（4）穿过所述底架（2）插入到注射部位，其中所述控制弹簧（19）布置以使壳体（12）沿远端方向（D）抵靠在底盘（2）上，以将底架（2）从壳体（12）的近端（P）延伸出来，其中插入深度所述针（4）由在所述底架（2）上抵靠预定位置的所述支架（7）限定，其中，所述壳体（12）布置成释放或允许用于针头插入的所述控制弹簧（19）（12）相对于底架（2）在近端方向（P）上的偏压进入到前进位置。

5. 发明申请

WO2012110577A1 AUTO-INJECTOR 审中-公开
标题翻译：自动注射器
公开(公告)号：WO2012110577A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052646
申请日：2012-02-16
申请人： Sanofi-Aventis Deutschland GmbH , BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
发明人： BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/3158 , A61M5/2033 , A61M5/31501 , A61M5/31511 , A61M5/3157 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , F04C2270/0421 , Y10T403/32501
摘要： The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: - an elongate case (12) arranged to be held by a user, - a tubular chassis (2) telescopable in the case (12) and biased against the case (12) so as to protrude from the case (12), - a syringe (3) with a hollow injection needle (4), a drive spring (8) and a plunger (9) for forwarding load of the drive spring (8) to a stopper (6) of the syringe (3), - a trigger button (13) which is initially abutted against the case (12) thus preventing actuation, wherein the chassis (2) is arranged to translate into the case (12) against the bias when pressed against an injection site, wherein the trigger button (13) is at least initially coupled to the chassis (2) in such a manner that the trigger button (13) emerges from the case (12) when the chassis (2) is being pressed against the injection site so as to allow actuation by being translated towards the case (12) for starting an injection cycle.
摘要翻译：本发明涉及一种用于施用一定剂量的液体药物（M）的自动注射器（1），包括： - 布置成由使用者保持的细长壳体（12）， - 可伸缩的管状底盘（2）壳体（12），并且相对于壳体（12）偏压以从壳体（12）突出; - 具有中空注射针（4），驱动弹簧（8）和柱塞（9）的注射器（3）用于将所述驱动弹簧（8）的负载传递到所述注射器（3）的止动件（6）， - 触发按钮（13），其最初抵靠所述壳体（12）从而防止致动，其中所述底盘（2）被布置成当压靠在注射部位时抵抗偏压而转换成壳体（12），其中触发按钮（13）至少首先以触发按钮（13）出现的方式初始地联接到底架（2）当底盘（2）被压靠在注射部位上时，从壳体（12）向壳体（12）转动以便启动注射池 CLE。

6. 发明申请

WO2012110574A1 DETENT MECHANISM 审中-公开
标题翻译：确定机制
公开(公告)号：WO2012110574A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052642
申请日：2012-02-16
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
发明人： BRERETON, Simon Francis , KEMP, Thomas , BURNELL, Rosie , EKMAN, Matthew
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M5/3158 , A61M5/2033 , A61M5/31501 , A61M5/31511 , A61M5/3157 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , F04C2270/0421 , Y10T403/32501
摘要： The invention relates to a detent mechanism (18) for controlling translation between two components (2, 7) in a longitudinal direction (P, D), the detent mechanism (18) comprising a resilient beam (2.1) and a rhomboid ramp member (7.1), the resilient beam (2.1) having a first beam head (2.2) and arranged to interact in a ramped engagement with respectively one of two ramps (7.2, 7.3), each ramp on one longitudinal side of the rhomboid ramp member (7.1) in such a manner that application of a translative force between the components (2, 7) in one longitudinal direction (P, D) with the first beam head (2.2) engaged to one of the ramps (7.2, 7.3) in a first state (A, C) deflects the resilient beam (2.1) in one transversal direction (0, I) when a predetermined value of the translative force, wherein the resilient beam (2.1) is allowed to relax when the first beam head (2.2) has reached the other one of the ramps (7.3, 7.2) in a second state (C, A), wherein application of a translative force between the components (2, 7) in the other longitudinal direction (D, P) with the first beam head (2.2) engaged to the other one of the ramps (7.3, 7.2) deflects the resilient beam (2.1) in the other transversal direction (I, 0) when a predetermined value of the translative force.
摘要翻译：本发明涉及一种用于控制沿纵向（P，D）的两个部件（2,7）之间的平移的制动机构（18），该制动机构（18）包括弹性梁（2.1）和一个菱形斜面构件 7.1）中，弹性梁（2.1）具有第一梁头（2.2）并且布置成与两个斜面（7.2,7.3）中的一个坡道配合地相互作用，每个斜面在菱形斜坡构件的一个纵向侧（7.1 ），以使得在一个纵向方向（P，D）上的部件（2,7）之间的平移力与第一梁头（2.2）在一个第一横梁（2.2）中接合到一个斜面（7.2,7.3）状态（A，C）当弹性梁（2.1）在第一光束头（2.2）处被放宽时，在一个横向方向（0，I）上偏转弹性光束（2.1）已经到达第二个状态（C，A）中的另一个斜坡（7.3,7.2），其中应用平移力在另一个纵向方向（D，P）上的部件（2,7）之间与第一梁头（2.2）接合到另一个斜面（7.3,7.2）中，使弹性梁（2.1）在另一个横向方向（I，0）时的平移力的预定值。

7. 发明申请

WO2012000940A3 NEEDLE SAFETY ARRANGEMENT AND METHOD FOR OPERATING IT 审中-公开
标题翻译：针头安全布置及其操作方法
公开(公告)号：WO2012000940A3
公开(公告)日：2012-06-28
申请号：PCT/EP2011060728
申请日：2011-06-27
申请人： SANOFI AVENTIS DEUTSCHLAND , BRERETON SIMON FRANCIS , EKMAN MATTHEW
发明人： BRERETON SIMON FRANCIS , EKMAN MATTHEW
IPC分类号： A61M5/20
CPC分类号： A61M5/3202 , A61M5/2033 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2005/3247
摘要： The invention refers to an auto-injector (1) for administering a dose of a liquid medicament (M), the auto-injector (1) having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising: - an elongate housing (2) arranged to contain a syringe (3) with a hollow needle (4) and a stopper (6) for sealing the syringe (3) and displacing the medicament (M), wherein the syringe (3) is slidably arranged with respect to the housing (2), - a drive means (8) capable of, upon activation: - pushing the needle (4) from a retracted position into an advanced position through the orifice and past the proximal end (P), and - operating the syringe (4) to supply the dose of medicament (M), - a plunger (9) for transmitting power from the drive means (8) to the syringe (3) and/or stopper (6), - activating means arranged to lock the drive means (8) in a compressed state prior to manual operation and capable of, upon manual operation, releasing the drive means (8) for injection, characterized in that translation of the needle (4) and the syringe (3) and/or translation of the plunger (9) in longitudinal direction is controlled by at least one ramp (2.5, 9.6, 2.7, 7.2) or one thread so as to cause the syringe (3) and/or the plunger (9) to rotate when translated at least during part of the translation.
摘要翻译：本发明涉及一种用于给药液体药物（M）的自动注射器（1），所述自动注射器（1）具有远端（P）和近端（D），其具有旨在为施加到注射部位并且包括： - 细长壳体（2），其布置成容纳具有中空针头（4）的注射器（3）和用于密封注射器（3）并使药剂（M）移位的塞子（6），其中所述注射器（3）相对于所述壳体（2）可滑动地布置; - 驱动装置（8），其能够在启动时： - 将所述针（4）从缩回位置推动到通过所述孔并且通过所述近端（P），以及 - 操作所述注射器（4）以供应所述剂量的药物（M）， - 用于将动力从所述驱动装置（8）传递到所述注射器（3）的柱塞（9） /或止动器（6）， - 激活装置，其被布置成在手动操作之前将驱动装置（8）锁定在压缩状态，并且能够在手动操作时释放d 其特征在于，所述针（4）和所述注射器（3）的平移和/或所述柱塞（9）在纵向上的平移由至少一个斜坡（2.5,9.6,2.7 ，7.2）或一个螺纹，以便至少在翻译的一部分期间翻译时使注射器（3）和/或柱塞（9）旋转。

8. 发明申请

WO2012000871A1 AUTO-INJECTOR 审中-公开
标题翻译：自动注射器
公开(公告)号：WO2012000871A1
公开(公告)日：2012-01-05
申请号：PCT/EP2011/060502
申请日：2011-06-22
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EKMAN, Matthew , BRERETON, Simon Francis , KEMP, Thomas Mark
发明人： EKMAN, Matthew , BRERETON, Simon Francis , KEMP, Thomas Mark
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2086 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , Y10T74/18984
摘要： The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component (7) within an elongate housing (2), the shuttering mechanism comprising at least one set (2.3) of castellations on the housing (2) and at least one resilient arm (7.2) associated with the longitudinally moveable component (7), the resilient arm (7.2) having a dog (7.3) resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm (10.2) is arranged alongside the set (2.3) of castellations, the shutter arm (10.2) having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm (10.2) is moveable in longitudinal direction with respect to the set (2.3) of castellations, wherein the shutter arm (10.2) has at least one locking position with its ramped protrusions essentially in phase with the castellations thus allowing the dog (7.3) of the resilient arm (7.2) to catch between or behind the castellations and wherein the shutter arm (10.2) has at least one unlocking position with its ramped protrusions out of phase with the castellations in such a manner that the ramped protrusions prevent the dog (7.3) from engaging with the castellations or disengage them thus allowing translation of the longitudinally moveable component (7).
摘要翻译：本发明涉及一种用于控制细长壳体（2）内的可纵向移动的部件（7）的平移的快门机构，所述挡板机构包括在所述壳体（2）上的至少一组（2.3）的雉）和至少一个弹性与所述纵向可移动部件（7）相关联的所述臂（7.2），所述弹性臂（7.2）具有朝向所述雉）弹性偏压的掣子（7.3），以便在所述蓖体之间或之后接合并阻挡所述平移，其中相应的襟翼臂（10.2）布置在所述组合（2.3）的旁边，所述快门臂（10.2）具有彼此间隔开的多个连续倾斜的突起，其中所述雉ations和所述倾斜突起具有相同的间距，其中形成成型表面通过所述城堡和所述倾斜的突起，其中所述快门臂（10.2）可相对于所述组合（2.3）在纵向方向上移动，其中所述快门臂（10.2）具有至少一个锁定位置，其斜坡突起基本上与所述城堡相同步，从而允许所述弹性臂（7.2）的所述狗（7.3）捕获在所述蓖体之间或之后，并且其中所述快门臂（10.2）具有至少一个解锁位置，其斜坡突起与雉房异相，使得倾斜的突起防止狗（7.3）与雉鸡接合或脱开，从而允许纵向可移动部件（7）的平移。

9. 发明申请

WO2012085025A1 AUTO-INJECTOR 审中-公开
标题翻译：自动注射器
公开(公告)号：WO2012085025A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073506
申请日：2011-12-21
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BRERETON, Simon Francis , EKMAN, Matthew
发明人： BRERETON, Simon Francis , EKMAN, Matthew
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/3202 , A61M5/2033 , A61M5/31578 , A61M5/326 , A61M5/5086 , A61M2005/2013 , A61M2005/206
摘要： The invention refers to an auto-injector (1) comprising an elongate housing (2), a syringe (5) with a hollow injection needle (6) and a stopper (13), wherein the syringe (5) is arranged in a syringe carrier (4) slidably with respect to the housing (2), -a single compression spring (7) capable of, upon activation: -pushing the needle (6) from a covered position inside the housing (2) into an advanced position through the orifice and past the proximal end (P) for insertion into an injection site, -operating the syringe (5) to inject the dose of medicament (M), and -retracting the syringe (5) with the needle (6) into the covered position after at least partially delivering the medicament (M), -activating means (3) arranged to lock the spring means (7) in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the compression spring (7) for injection. A thrust tube (8) is arranged to transmit load from the compression spring (7) via a plunger (9) to the syringe (5) and/or the stopper (13), wherein the thrust tube (8) is arranged to be rotationally constrained relative to the housing (2), wherein the thrust tube (8) and the plunger (9) exhibit corresponding first and second threads (9.3, 8.2) having a first direction arranged to be engaged at least in an initial state. The plunger (9) is arranged to be rotationally released upon removal of the auto-injector (1) from the injection site resulting in rotation of the plunger (9) and consequently disengagement of the corresponding first and second threads (9.3, 8.2). The thrust tube (8) translates further and engages a corresponding third thread (12.1) of a retract collar (12) which is engaged to the syringe carrier (4) by corresponding fourth and fifth threads (12.2, 4.1) having the opposite direction of the first direction so that continued translation of the thrust tube (8) in proximal direction (P) results in rotation of the retract collar (12) and translation of the syringe carrier (4) in distal direction (D) for needle retraction.
摘要翻译：本发明涉及一种自动注射器（1），其包括细长壳体（2），具有中空注射针头（6）和塞子（13）的注射器（5），其中所述注射器（5）布置在注射器托架（4）相对于所述壳体（2）可滑动; - 单个压缩弹簧（7），其能够在启动时：将所述针（6）从所述壳体（2）内的覆盖位置推入到前进位置所述孔口并经过所述近端（P）以插入注射部位， - 操作所述注射器（5）以注射所述剂量的药物（M），并且用所述针（6）将所述注射器（5）还原成所述注射器至少部分地输送药物（M）的被覆盖位置;激活装置（3），其被布置成在手动操作之前将弹簧装置（7）锁定在加压状态，并且能够在手动操作时释放压缩弹簧（7））注射。推力管（8）布置成将来自压缩弹簧（7）的负载经由柱塞（9）传递到注射器（5）和/或止动件（13），其中推力管（8）被布置为旋转约束相对于壳体（2），其中推力管（8）和柱塞（9）呈现相应的第一和第二螺纹（9.3,8.2），其具有布置成至少在初始状态下接合的第一方向。柱塞（9）被布置成在从注射位置移除自动注射器（1）时被旋转地释放，从而导致柱塞（9）的旋转，并且因此相应的第一和第二螺纹（9.3,8.2）的分离。推力管（8）进一步平移并与相应的第四和第五螺纹（12.2,4.1）接合到注射器托架（4）的相应的第三螺纹（12.1,41）相对应的第三螺纹（12.1）第一方向使得推力管（8）在近端方向（P）上的继续平移导致缩回轴环（12）的旋转和注射器支架（4）在远端方向（D）处的平移以用于针缩回。

10. 发明申请

WO2012000940A2 NEEDLE SAFETY ARRANGEMENT AND METHOD FOR OPERATING IT 审中-公开
标题翻译：针安全装置和操作IT的方法
公开(公告)号：WO2012000940A2
公开(公告)日：2012-01-05
申请号：PCT/EP2011/060728
申请日：2011-06-27
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BRERETON, Simon Francis , EKMAN, Matthew
发明人： BRERETON, Simon Francis , EKMAN, Matthew
IPC分类号： A61M5/20
CPC分类号： A61M5/3202 , A61M5/2033 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2005/3247
摘要： The invention refers to an auto-injector (1) for administering a dose of a liquid medicament (M), the auto-injector (1) having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising: - an elongate housing (2) arranged to contain a syringe (3) with a hollow needle (4) and a stopper (6) for sealing the syringe (3) and displacing the medicament (M), wherein the syringe (3) is slidably arranged with respect to the housing (2), - a drive means (8) capable of, upon activation: - pushing the needle (4) from a retracted position into an advanced position through the orifice and past the proximal end (P), and - operating the syringe (4) to supply the dose of medicament (M), - a plunger (9) for transmitting power from the drive means (8) to the syringe (3) and/or stopper (6), - activating means arranged to lock the drive means (8) in a compressed state prior to manual operation and capable of, upon manual operation, releasing the drive means (8) for injection, characterized in that translation of the needle (4) and the syringe (3) and/or translation of the plunger (9) in longitudinal direction is controlled by at least one ramp (2.5, 9.6, 2.7, 7.2) or one thread so as to cause the syringe (3) and/or the plunger (9) to rotate when translated at least during part of the translation.
摘要翻译：本发明涉及用于施用一定剂量的液体药物（M）的自动注射器（1），自动注射器（1）具有远端（P）和近端（P） D）具有旨在抵靠注射部位施加的孔口，并且包括： - 细长壳体（2），布置成容纳具有中空针头（4）的注射器（3）和用于密封注射器（3）的塞子（6））并且移动药物（M），其中注射器（3）相对于壳体（2）可滑动地布置， - 驱动装置（8），其能够在启动时： - 将针（4）从缩回通过孔口并经过近端（P）定位到前进位置，以及 - 操作注射器（4）以提供一定剂量的药物（M）， - 柱塞（9），用于从驱动装置（8））连接到注射器（3）和/或止动件（6）， - 在手动操作之前将驱动装置（8）锁定在压缩状态并且能够在手动操作时将r 其特征在于，所述针（4）和所述注射器（3）的平移和/或所述柱塞（9）在纵向上的平移通过至少一个斜坡（2.5,9.6 ，2.7,7.2）或一根线，以便至少在部分平移期间使得注射器（3）和/或柱塞（9）在平移时旋转。

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