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    • 1. 发明申请
    • AUTO-INJECTOR
    • 自动注射器
    • WO2012085021A1
    • 2012-06-28
    • PCT/EP2011/073502
    • 2011-12-21
    • SANOFI-AVENTIS DEUTSCHLAND GMBHHOURMAND, YannickBARROW-WILLIAMS, Timothy DonaldEKMAN, Matthew
    • HOURMAND, YannickBARROW-WILLIAMS, Timothy DonaldEKMAN, Matthew
    • A61M5/20A61M5/32A61M5/00
    • A61M5/2033A61M5/326A61M5/50A61M2005/206A61M2005/208
    • According to the invention, an auto-injector (1) for administering a dose of a liquid medicament (M) comprises - a substantially cylindrical housing (2) arranged to contain a pre-filled syringe (5) filled with the medicament (M), - a needle shroud (3) slibably arranged with respect to the housing (2) and adapted to rest on the skin of a patient receiving an injection, - a releasable drive means (8) arranged within the housing (2) that is capable of, upon release, translating the needle shroud (3) in a proximal direction (P) towards a safe position (PS) and - a rotating collar (14) rotatably arranged within the housing (2). The needle shroud (3) in the safe position (PS) surrounds the injection needle (12) after the injection has been carried out. The rotating collar (14) engages the needle shroud (3) in a manner that forces the rotating collar (14) to rotate within the housing (2) when the needle shroud (3) is translated in the proximal direction (P).
    • 根据本发明,用于给药剂量的液体药物(M)的自动注射器(1)包括 - 大致圆柱形的壳体(2),其布置成容纳填充有药物(M)的预填充注射器(5) - 相对于所述壳体(2)可自由布置并适于搁置在接受注射的患者的皮肤上的针罩(3), - 布置在所述壳体(2)内的可释放的驱动装置(8),其能够 在释放时,将针罩(3)沿近端方向(P)朝向安全位置(PS)平移;以及可旋转地布置在壳体(2)内的旋转轴环(14)。 在执行注射之后,处于安全位置(PS)的针罩(3)围绕注射针(12)。 当针罩(3)沿近端方向(P)平移时,旋转轴环(14)以使得旋转轴环(14)在壳体(2)内旋转的方式接合针罩(3)。
    • 2. 发明申请
    • AUTO-INJECTOR
    • 自动注射器
    • WO2012000939A1
    • 2012-01-05
    • PCT/EP2011/060726
    • 2011-06-27
    • SANOFI-AVENTIS DEUTSCHLAND GMBHEKMAN, MatthewHOURMAND, YannickBARROW-WILLIAMS, Timothy Donald
    • EKMAN, MatthewHOURMAND, YannickBARROW-WILLIAMS, Timothy Donald
    • A61M5/20A61M5/00
    • A61M5/2033A61M5/3202A61M5/3257A61M2005/206A61M2005/208
    • The invention refers to an auto-injector (1), comprising: - an elongate housing (2) arranged to contain a syringe (3), wherein the syringe (3) is slidably arranged with respect to the housing (2), - spring means (8) capable of, upon activation: - pushing the needle (4) from a covered position inside the housing (2) into an advanced position, - operating the syringe (3) to supply the dose of medicament (M), and - retracting the syringe (3) with the needle (4) into the covered position after delivering the medicament (M), - activating means (20) arranged to lock the spring means (8) in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means (8) for injection, wherein the spring means (8) is a single drive spring (8) in the shape of a compression spring arranged to be grounded at a distal end (8.1) in the housing (2) for advancing the needle (4) and for injecting the dose of medicament (M) via a plunger (9) and wherein the drive spring (8) is for retracting the syringe (3). The activating means (20) is arranged as a trigger button (20) laterally arranged on the housing (2).
    • 本发明涉及一种自动注射器(1),包括:细长壳体(2),其设置成容纳注射器(3),其中所述注射器(3)相对于所述壳体(2)可滑动地布置; - 弹簧 能够在激活时能够将所述针(4)从所述壳体(2)内的覆盖位置推到前进位置的装置(8), - 操作所述注射器(3)以供应所述剂量的药剂(M),以及 - 在输送药物(M)之后,用针(4)将注射器(3)缩回到被覆盖的位置; - 激活装置(20),其布置成在手动操作之前以加压状态锁定弹簧装置(8) 在手动操作时释放用于注射的弹簧装置(8),其中弹簧装置(8)是压缩弹簧形状的单个驱动弹簧(8),其布置成在远端(8.1)处接地 所述壳体(2)用于推进所述针(4)并且用于经由柱塞(9)注射所述剂量的药物(M),并且其中所述驱动器 ng(8)用于缩回注射器(3)。 激活装置(20)被布置为横向布置在壳体(2)上的触发按钮(20)。
    • 3. 发明申请
    • AUTO-INJECTOR
    • 自动注射器
    • WO2012085024A3
    • 2012-08-16
    • PCT/EP2011073505
    • 2011-12-21
    • SANOFI AVENTIS DEUTSCHLANDHOURMAND YANNICKBRERETON SIMON FRANCISEKMAN MATTHEW
    • HOURMAND YANNICKBRERETON SIMON FRANCISEKMAN MATTHEW
    • A61M5/20A61M5/24A61M5/32A61M5/46
    • A61M5/3257A61M5/20A61M5/2033A61M5/24A61M5/326A61M5/46A61M2205/581A61M2205/582
    • An auto-injector (1) for administering a dose of a liquid medicament (M) comprises - a substantially cylindrical housing (2) arranged to contain a pre-filled syringe (5) with an injection needle (12), a plunger (9) and a stopper (10) for sealing a syringe barrel (11) and - a drive means (8) releasably coupled to the plunger (9) for advancing the syringe (5) in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means (8) is arranged to be decoupled from the plunger (9) for advancing a needle shroud (3) to a safe position (PS) to surround the injection needle (12) after the injection. According to the invention, the drive means (8) bears against a thrust collar (7) arranged to be releasably coupled to the plunger (9) through a ramped engagement of a first tongue (7.1) and a first recess (6.2) so as to rotate the thrust collar (7) on translation in proximal direction (P). At least one longitudinal gap (G1, G2) is provided for guiding at a first and/or second protrusion (7.2, 7.3) of the thrust collar (7) to prevent a rotation of the thrust collar (7). A circumferential gap (G3) is arranged to allow the thrust collar (7) to rotate out of engagement to the plunger (9) on removal of the auto-injector (1) from the injection site.
    • 一种用于给药液体药物(M)的自动注射器(1)包括 - 基本上为圆柱形的壳体(2),其布置成将注射针(5)与注射针(12),柱塞(9) )和用于密封注射器筒(11)的止动件(10)和 - 可释放地联接到所述柱塞(9)的驱动装置(8),用于使所述注射器(5)沿近端方向(P)前进,用于针插入 注射部位和用于将剂量的药物(M)置换到注射部位。 驱动装置(8)布置成与柱塞(9)分离,用于将针罩(3)推进到安全位置(PS),以在注射之后包围注射针(12)。 根据本发明,驱动装置(8)抵靠着通过第一舌片(7.1)和第一凹部(6.2)的倾斜接合布置成可释放地联接到柱塞(9)的止推环(7),以便 以使止推环(7)沿近端方向(P)平移。 提供至少一个纵向间隙(G1,G2)用于在止推环(7)的第一和/或第二突起(7.2,7.3)处引导,以防止推力环(7)旋转。 周向间隙(G3)布置成允许止推环(7)在从注射部位移除自动注射器(1)时旋转离开与柱塞(9)的接合。
    • 4. 发明申请
    • AUTO-INJECTOR WITH INJECTION DAMPER
    • 自动注射器带注射阻尼器
    • WO2012000874A1
    • 2012-01-05
    • PCT/EP2011/060506
    • 2011-06-22
    • SANOFI-AVENTIS DEUTSCHLAND GMBHHOURMAND, YannickBARROW-WILLIAMS, Timothy, DonaldEKMAN, Matthew
    • HOURMAND, YannickBARROW-WILLIAMS, Timothy, DonaldEKMAN, Matthew
    • A61M5/20A61M5/315A61M5/32A61M5/48
    • A61M5/484A61M5/20A61M5/2033A61M5/3158A61M5/321A61M5/3234A61M5/3243A61M5/326A61M5/46A61M5/482A61M2005/206A61M2005/208A61M2005/2086A61M2005/31508A61M2005/3151A61M2005/3152
    • The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: an elongate housing (2) arranged to contain a syringe (3) with a hollow needle (4) and a stopper (6) for sealing the syringe (3) and displacing the medicament (M), the housing (2) having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe (3) is slidably arranged with respect to the housing (2), spring means (8) capable of, upon activation: - pushing the needle (4) from a covered position inside the housing (2) into an advanced position through the orifice and past the proximal end (P), operating the syringe (3) to supply the dose of medicament (M), and retracting the syringe (3) with the needle (4) into the covered position after delivering the medicament (M), activating means (20) arranged to lock the spring means (8) in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means (8) for injection. The spring means (8) is a single drive spring (8) arranged to be grounded at a distal end (8.1) in the housing (2) for advancing the needle (4) and for injecting the dose of medicament (M) via a plunger (9) and wherein the drive spring (8) is arranged to have its ground in the housing (2) switched to its proximal end (8.2) for retracting the syringe (3). A damper (28) is arranged around the plunger (9), wherein the damper (28) is arranged with the plunger (9) by a spline (29) so as to cause rotation of either the plunger (9) or the damper (28) at least during part of a translation of the plunger (9) in proximal direction (P) and share the load of the drive spring (8) between the translation and the rotation.
    • 本发明涉及一种用于施用剂量的液体药物(M)的自动注射器(1),包括:细长壳体(2),其被布置成容纳具有中空针(4)的注射器(3)和塞子 6),用于密封注射器(3)并使药剂(M)移位,具有远端(D)和近端(P)的壳体(2)具有旨在施加到注射部位的孔口,其中 注射器(3)相对于壳体(2)可滑动地布置,弹簧装置(8)能够在启动时: - 将针(4)从壳体(2)内的覆盖位置推入到通过 并且通过近端(P),操作注射器(3)以供给剂量的药物(M),并且在递送药物(M)之后将注射器(3)用针(4)缩回到覆盖位置, ,启动装置(20),其布置成在手动操作之前将弹簧装置(8)锁定在加压状态,并且能够在手动操作 n,释放用于注射的弹簧装置(8)。 弹簧装置(8)是单个驱动弹簧(8),其布置成在壳体(2)中的远端(8.1)处接地,用于推进针(4)并且用于经由 柱塞(9),并且其中驱动弹簧(8)布置成使其在壳体(2)中的接地切换到其近端(8.2)以缩回注射器(3)。 在活塞(9)周围布置有阻尼器(28),其中阻尼器(28)通过花键(29)与柱塞(9)一起设置,以使柱塞(9)或阻尼器 至少在柱塞(9)在近端方向(P)的平移过程的一部分期间,并且在驱动弹簧(8)的平移和旋转之间共享负载。
    • 5. 发明申请
    • AUTO-INJECTOR WITH A TORSION SPRING
    • 自动喷油器带扭力弹簧
    • WO2011101375A1
    • 2011-08-25
    • PCT/EP2011/052297
    • 2011-02-16
    • SANOFI-AVENTIS DEUTSCHLAND GMBHEKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • EKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • A61M5/20A61M5/32A61M5/00
    • A61M5/3257A61M5/2033A61M5/3157A61M5/31583A61M5/326A61M2005/206A61M2005/208A61M2205/581
    • The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: - an elongate housing (2) arranged to contain a syringe (7) with a hollow needle (9) and a bung (10) for sealing the syringe (7) and displacing the medicament (M), the elongate housing (2) having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe (7) is slidably arranged with respect to the housing (2), - spring means (14) capable of, upon activation, pushing the needle (9) from a covered position inside the housing (2) into an advanced position through the orifice and past the proximal end (P) as well as operating the syringe (7) to supply the dose of medicament (M), - activating means (4) arranged to lock the spring means (14) in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means (14) for injection. The spring means (14) is a torsion spring (14) grounded at one end in the housing (2) and at the other end in a first gear member (15) rotatable about a longitudinal axis but axially fixed wherein the first gear member (15), upon rotation, is arranged for translatively moving a second gear member (11), the second gear member (11) prevented from rotating and coupled to the bung (10) in order to push it towards the proximal end (P), wherein the first gear member (15) is engaged with the activating means (4) prior to manual operation in a manner to prevent rotation and disengaged from the activating means (4) upon manual operation.
    • 本发明涉及一种用于施用一定剂量的液体药物(M)的自动注射器(1),该自动注射器(1)包括: - 细长壳体(2),其布置成容纳具有中空针头(9)的注射器(7) (10),用于密封所述注射器(7)并使所述药物(M)移位,所述细长壳体(2)具有远端(D)和近端(P),其具有用于抵靠注射部位的孔口, 其中所述注射器(7)相对于所述壳体(2)可滑动地布置;弹簧装置(14),其能够在启动时将所述针(9)从所述壳体(2)内的覆盖位置推入到前进位置 穿过所述孔口并经过所述近端(P)并且操作所述注射器(7)以供应所述剂量的药物(M); - 激活装置(4),其布置成在先前的加压状态下将所述弹簧装置(14)锁定 手动操作,并且能够在手动操作时释放用于注射的弹簧装置(14)。 弹簧装置(14)是在壳体(2)的一端处接地并且在另一端处接合在可围绕纵向轴线但可轴向固定的第一齿轮构件(15)中的扭簧(14),其中第一齿轮构件 15),在旋转时被布置成用于平移地移动第二齿轮构件(11),所述第二齿轮构件(11)被阻止旋转并联接到所述栓(10),以将其推向所述近端(P), 其中所述第一齿轮构件(15)在手动操作之前与所述致动装置(4)接合,以防止在手动操作时旋转和从所述致动装置(4)脱离的方式。
    • 7. 发明申请
    • AUTO-INJECTOR
    • 自动注射器
    • WO2012085023A1
    • 2012-06-28
    • PCT/EP2011/073504
    • 2011-12-21
    • SANOFI-AVENTIS DEUTSCHLAND GMBHHOURMAND, YannickEKMAN, Matthew
    • HOURMAND, YannickEKMAN, Matthew
    • A61M5/20A61M5/32
    • A61M5/2033A61M5/3257A61M5/326A61M2005/206A61M2005/208A61M2005/3143
    • Auto - inj ector for administerig a dose of a liquid medicament comprising: - a cylindrical chassis arranged to contain a pre- filled syringe with a syringe barrel filled with the medicament, an injection needle and a stopper for sealing the syringe barrel, - a needle shroud slidably arranged within the chassis and adapted to rest on the skin of a patient receiving an injection, - a plunger adapted to translate the stopper to expel the dose of the medicament through the injection needle, - a coupling shroud slidably arranged within the chassis and releasably coupled to the plunger and - a drive means. Upon release, the drive means is capable of driving the coupling shroud from a first position in a proximal direction. The proximal translatory movement of the coupling shroud with respect to the chassis - translates the pre- filled syringe in the proximal direction to expose the injection needle, - depresses the plunger connected to the stopper into the syringe barrel to expel the dose of the medicament and - advances the needle shroud to a safe position to surround the injection needle after the injection. The coupling shroud is arranged to be decoupled from the plunger at a second position.
    • 用于施用一定剂量的液体药物的自动注射器,包括: - 圆柱形底架,其布置成容纳预填充的注射器,所述注射器具有填充有药物的注射器筒,注射针和用于密封注射器筒的塞子, - 针 护罩,其可滑动地布置在所述底座内并适于搁置在接受注射的患者的皮肤上;柱塞,其适于平移所述止动件以通过所述注射针排出所述药物的剂量, - 可滑动地布置在所述底架内的联接护罩, 可释放地联接到柱塞和 - 驱动装置。 在释放时,驱动装置能够在近端方向上从第一位置驱动联接罩。 联接护罩相对于底架的近端平移运动 - 使预灌注的注射器沿近端方向平移以暴露注射针, - 将连接到塞子的柱塞压入注射器筒中以排出药物的剂量, - 注射后将针罩推进到安全的位置以包围注射针。 联接罩布置成在第二位置处与柱塞脱离。
    • 8. 发明申请
    • AUTO-INJECTOR
    • 自动注射器
    • WO2011101379A1
    • 2011-08-25
    • PCT/EP2011/052301
    • 2011-02-16
    • SANOFI-AVENTIS DEUTSCHLAND GMBHEKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • EKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • A61M5/20A61M5/32A61M5/00
    • A61M5/2033A61M5/3204A61M5/3232A61M5/326A61M2005/206A61M2005/2073
    • The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: - an elongate housing (2) arranged to contain a syringe (3) with a hollow needle (4) and a stopper (6) for sealing the syringe (3) and displacing the medicament(M), the housing (2) having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe (3) is slidably arranged with respect to the housing (2), - spring means (8) capable of, upon activation: - pushing the needle (4) from a covered position inside the housing (2) into an advanced position through the orifice and past the proximal end (P), - operating the syringe (3) to supply the dose of medicament (M), and - retracting the syringe (3)with the needle (4) into the covered position after delivering the medicament (M), - activating means (20) arranged to lock the spring means (8) in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means (8) for injection. The spring means (8) is a single compression spring (8) arranged to be grounded at a distal end (8.1) in the housing (2) for advancing the needle (4) and for injecting the dose of medicament (M) via a plunger (9) and wherein the compression spring (8) is arranged to have its ground in the housing (2) switched to its proximal end (8.2) for retracting the syringe (3).
    • 本发明涉及一种用于施用一定剂量的液体药物(M)的自动注射器(1),其包括:细长壳体(2),其设置成将注射器(3)容纳有中空针(4)和塞子 (6),用于密封注射器(3)并使药剂(M)移位,具有远端(D)和近端(P)的壳体(2)具有旨在施加到注射部位的孔口,其中 所述注射器(3)相对于所述壳体(2)可滑动地布置; - 弹簧装置(8),其能够在启动时: - 将所述针(4)从所述壳体(2)内部的覆盖位置推入到前进位置 通过孔口并经过近端(P), - 操作注射器(3)以供应剂量的药物(M),以及 - 在将注射器(3)与针头(4)缩回到覆盖位置之后, 药剂(M), - 激活装置(20),其被布置成在手动操作之前将弹簧装置(8)锁定在加压状态,并且能够在手动 操作,释放用于注射的弹簧装置(8)。 弹簧装置(8)是单个压缩弹簧(8),其布置成在壳体(2)中的远端(8.1)处接地,用于推进针(4)并且用于经由 柱塞(9),并且其中压缩弹簧(8)被布置成使其在壳体(2)中的接地切换到其近端(8.2)以缩回注射器(3)。
    • 9. 发明申请
    • CLUTCH MECHANISM
    • 离合器机构
    • WO2011101376A1
    • 2011-08-25
    • PCT/EP2011/052298
    • 2011-02-16
    • SANOFI-AVENTIS DEUTSCHLAND GMBHEKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • EKMAN, MatthewBARROW-WILLIAMS, Timothy DonaldHOURMAND, Yannick
    • A61M5/32A61M5/20A61M5/00
    • A61M5/20A61M5/326A61M5/46A61M2005/206A61M2005/208A61M2005/3247A61M2205/581
    • The invention relates to a clutch mechanism for the transmission of a rotary movement from a gear arrangement comprising a first gear member (15) and a second gear member (11). The first gear member (15) is rotatable about a longitudinal axis but axially fixed wherein the first gear member (15), upon rotation, is arranged for translatively moving a second gear member (11) which is prevented from rotating. The clutch mechanism comprises a circumferential shoulder (28) arranged at the second gear member (11) and at least one or a number of resilient clutch fingers (29) with respective inclined inner surfaces arranged at the first gear member (15), the shoulder (28) arranged for increasingly pressing against the inclined surfaces thereby flexing the clutch fingers (29) outward when the shoulder reaches the clutch fingers in the course of its translation. The clutch mechanism further comprises tube (20) arranged around the clutch fingers (29), the tube (14) having a number of internal longitudinal splines (31 ) for engaging the flexed-out clutch fingers (29).
    • 本发明涉及一种用于从包括第一齿轮构件(15)和第二齿轮构件(11)的齿轮装置传递旋转运动的离合器机构。 第一齿轮构件(15)能够围绕纵向轴线旋转但轴向固定,其中第一齿轮构件(15)在旋转时被布置成平移地移动防止其旋转的第二齿轮构件(11)。 离合器机构包括布置在第二齿轮构件(11)处的圆周肩部(28)和布置在第一齿轮构件(15)处的相应倾斜内表面的至少一个或多个弹性离合器指状物(29),肩部 (28)布置成越来越多地压靠在倾斜表面上,从而当肩部在其平移过程中到达离合器指状件时使离合器指(29)向外弯曲。 离合器机构还包括围绕离合器指状物(29)设置的管(20),管(14)具有用于接合弯曲离合器指(29)的多个内部纵向花键(31)。