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1. 发明申请

WO2016119040A1 ANATOMICAL PHANTOM FOR SIMULATED LASER ABLATION PROCEDURES 审中-公开
标题翻译：模拟激光消除程序的解剖学
公开(公告)号：WO2016119040A1
公开(公告)日：2016-08-04
申请号：PCT/CA2015/050066
申请日：2015-01-29
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , WALLO, Amanda Renee , FERNALD, Bradley Allan , WHITTON, Gregory Allan , KERINS, Fergal
发明人： WALLO, Amanda Renee , FERNALD, Bradley Allan , WHITTON, Gregory Allan , KERINS, Fergal
IPC分类号： G09B23/30 , A61B18/20 , A61B19/00
CPC分类号： G09B23/30 , A61B18/20 , A61B90/11 , A61B2018/00577 , A61B2018/00809 , G09B23/285 , G09B23/32 , G09B23/34
摘要： Disclosed herein are physiological phantoms incorporating properties of tissue that respond to laser ablation to replicate a real laser ablation procedure. The materials include waxes, polymers, thermochromic polymer blends or hydrogels, temperature sensitive hydrogels, and photodegradable hydrogels. The materials may mimic tissue as part of the tissue phantom not only in their feel and movement but also in any one or combination of their chemical, physical, mechanical, optical response to a laser ablation application. They may mimic the directionality, density, optical absorption, heat transmittance, heat conductance properties, electrochemical properties, thermochemical properties, and elasticity of the anatomical tissues they may be replicating. The laser ablation responsive materials may change properties such that they provide a measure of the success of a medical procedure.
摘要翻译：本文公开了结合激光烧蚀来复制真实激光消融程序的组织属性的生理体模。材料包括蜡，聚合物，热变色聚合物共混物或水凝胶，温度敏感水凝胶和可光降解水凝胶。材料可以模拟组织，作为组织体模的一部分，不仅在其感觉和运动中，而且还以其对激光烧蚀应用的化学，物理，机械，光学响应的任何一种或组合。它们可以模拟可能复制的解剖组织的方向性，密度，光吸收，热透射率，导热性质，电化学性质，热化学性质和弹性。激光消融响应材料可以改变属性，使得它们提供医疗程序成功的量度。

2. 发明申请

WO2013041844A2 ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE 审中-公开
标题翻译：针对人类使用的抗体，可变域和链
公开(公告)号：WO2013041844A2
公开(公告)日：2013-03-28
申请号：PCT/GB2012052296
申请日：2012-09-18
申请人： KYMAB LTD , BRADLEY ALLAN , FRIEDRICH GLENN , LEE E-CHIANG , STRIVENS MARK , ENGLAND NICHOLAS
发明人： BRADLEY ALLAN , FRIEDRICH GLENN , LEE E-CHIANG , STRIVENS MARK , ENGLAND NICHOLAS
IPC分类号： C12N15/85 , A01K67/027 , C07K16/46
CPC分类号： C07K16/1242 , A01K67/0278 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/085 , C07K16/088 , C07K16/1018 , C07K16/1045 , C07K16/1217 , C07K16/1232 , C07K16/18 , C07K16/46 , C07K16/462 , C07K2317/24 , C07K2317/56 , C12N15/8509 , C12N2800/204
摘要： The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention.
摘要翻译：本发明涉及提供专门针对人类使用而定制的抗体治疗剂和预防剂。本发明提供了文库，脊椎动物和细胞，例如转基因小鼠或大鼠或转基因小鼠或大鼠细胞。此外，本发明涉及使用脊椎动物分离编码抗体的抗体或核苷酸序列的方法。本发明还提供了抗体，重链，多肽，核苷酸序列，药物组合物和用途。

3. 发明申请

WO2018217874A3 ACTIVE CHARGE THROUGH OF A PERIPHERAL DEVICE 审中-公开
公开(公告)号：WO2018217874A3
公开(公告)日：2018-11-29
申请号：PCT/US2018/034108
申请日：2018-05-23
申请人： CIRRUS LOGIC INTERNATIONAL SEMICONDUCTOR, LTD. , LAMBERT, Bradley, Allan
发明人： LAMBERT, Bradley, Allan , KOST, Michael, A. , SARIPALLI, Ganesh , YANCEY, Gregory, C.
IPC分类号： G06F13/42 , G06F1/26
摘要： A method for port policy management for active charge through of a peripheral device that has a first communication port and a second communication port may include detecting whether a valid power connection exists at the peripheral device, in response to detecting the valid power connection, determining a relationship between the first communication port and the second communication port, based on the relationship, determining, by the peripheral device, a power relationship among the peripheral device, the first communication port, and the second communication port, selectively configuring the first communication port, the second communication port, and the peripheral device to match the power relationship, and enabling active charging through of the peripheral device if active charging through is supported by the power relationship.

4. 发明申请

WO2013045916A1 CHIMAERIC SURROGATE LIGHT CHAINS (SLC) COMPRISING HUMAN VPREB 审中-公开
标题翻译：包含人类VPREB的CHIMAERIC SURROGATE LIGHT CHAINS（SLC）
公开(公告)号：WO2013045916A1
公开(公告)日：2013-04-04
申请号：PCT/GB2012/052380
申请日：2012-09-26
申请人： KYMAB LIMITED , BRADLEY, Allan , LEE, E-Chiang , LIANG, Qi , SPENSBERGER, Dominik , ENGLAND, Nicholas
发明人： BRADLEY, Allan , LEE, E-Chiang , LIANG, Qi , SPENSBERGER, Dominik , ENGLAND, Nicholas
IPC分类号： C12N15/85 , C12N5/10 , C07K16/46
CPC分类号： C12N15/85 , A01K67/02 , A01K67/0278 , A01K2217/07 , A01K2217/077 , A01K2227/10 , A01K2227/105 , A01K2267/01 , C12N5/10 , C12N15/8509 , C12N2015/8518
摘要： The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
摘要翻译：本发明特别涉及非人转基因脊椎动物（例如携带一个或多个嵌合抗体转基因的小鼠和大鼠）中嵌合抗体的产生的改进。特别地，本发明提供了改良的非人脊椎动物和细胞，其中VpreB已经与嵌合抗体的可变区物种匹配。此外，实施方案还提供整个替代轻链的物种匹配，用于在非人转基因脊椎动物环境中体内B细胞发育期间与嵌合重链进行有效配对。

5. 发明申请

WO2013041844A9 ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE 审中-公开
公开(公告)号：WO2013041844A9
公开(公告)日：2013-03-28
申请号：PCT/GB2012/052296
申请日：2012-09-18
申请人： KYMAB LIMITED , BRADLEY, Allan , FRIEDRICH, Glenn , LEE, E-Chiang , STRIVENS, Mark , ENGLAND, Nicholas
发明人： BRADLEY, Allan , FRIEDRICH, Glenn , LEE, E-Chiang , STRIVENS, Mark , ENGLAND, Nicholas
IPC分类号： C12N15/85 , A01K67/027 , C07K16/46
摘要： The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention.

6. 发明申请

WO2003027311A2 A CLONE-ARRAY POOLED SHOTGUN STRATEGY FOR NUCLEIC ACID SEQUENCING 审中-公开
标题翻译：一种用于核酸测序的克隆式水池SHOTGUN策略
公开(公告)号：WO2003027311A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030464
申请日：2002-09-24
申请人： BAYLOR COLLEGE OF MEDECINE , GIBBS, Richard , BRADLEY, Allan , CAI, Wei-Wen
发明人： GIBBS, Richard , BRADLEY, Allan , CAI, Wei-Wen
IPC分类号： C12Q
CPC分类号： C12N15/1034 , C12Q1/6874
摘要： A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction, Random sequences are accumulated and the data are assembled by sequential comparison of rows and columns, to resolve the sequence of clones at points of intersection, Compared to either a clone-by-clone approach or whole genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebra fish and other important genomes, and can be managed in a cooperative fashion to take advantage of the distributed international DNA sequencing capacity.
摘要翻译：
一个简化的大型基因组测序策略已经开发完成。克隆阵列池化猎枪测序（CAPSS）基于排列基因组克隆的行和列，用于构建霰弹枪文库。随机序列被累积，并通过对行和列进行连续比较来组装数据，以解析克隆序列与无克隆方法或全基因组鸟枪法测序相比，CAPSS需要相对较少的文库构建，并且对于完整的基因组组装而言只需要最小的计算能力。该策略适用于对没有序列准备图的大型基因组进行测序，但对于这些大型基因组，可获得相对高分辨率的STS图谱和高度冗余的BAC文库。它可以立即应用于小鼠，大鼠，斑马鱼和其他重要基因组的测序，并可以合作的方式进行管理，以利用分布式国际DNA测序能力。

7. 发明申请

WO2018217874A2 ACTIVE CHARGE THROUGH OF A PERIPHERAL DEVICE 审中-公开
公开(公告)号：WO2018217874A2
公开(公告)日：2018-11-29
申请号：PCT/US2018/034108
申请日：2018-05-23
申请人： CIRRUS LOGIC INTERNATIONAL SEMICONDUCTOR, LTD. , LAMBERT, Bradley, Allan
发明人： LAMBERT, Bradley, Allan , KOST, Michael, A. , SARIPALLI, Ganesh , YANCEY, Gregory, C.
IPC分类号： G06F13/42 , G06F1/26
摘要： A method for port policy management for active charge through of a peripheral device that has a first communication port and a second communication port may include detecting whether a valid power connection exists at the peripheral device, in response to detecting the valid power connection, determining a relationship between the first communication port and the second communication port, based on the relationship, determining, by the peripheral device, a power relationship among the peripheral device, the first communication port, and the second communication port, selectively configuring the first communication port, the second communication port, and the peripheral device to match the power relationship, and enabling active charging through of the peripheral device if active charging through is supported by the power relationship.

8. 发明申请

WO2018031456A1 COMMUNICATION PROTOCOL ADAPTER 审中-公开
标题翻译：通信协议适配器
公开(公告)号：WO2018031456A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/045710
申请日：2017-08-07
申请人： CIRRUS LOGIC INTERNATIONAL SEMICONDUCTOR, LTD. , LAMBERT, Bradley Allan
发明人： LAMBERT, Bradley Allan , KOST, Michael
IPC分类号： H04M1/725 , H04M1/60 , G06F13/38 , G06F1/16
CPC分类号： G06F13/102 , G06F13/385 , G06F13/387 , G06F13/4282 , H04M1/6058 , H04M1/72527
摘要： In accordance with embodiments of the present disclosure, an adapter for different types of devices that are defined by a full set of capabilities for a communication protocol may include one or more ports, wherein each of the one or more ports is configured to receive one of the different types of devices, and a device controller communicatively coupled to the one or more ports. The device controller may be configured to, when one of the different types of devices is received by the one or more ports obtain information related to a detection of the one of the different types of devices and, based on the information related to the detection, expose a subset of capabilities from the full set of capabilities to a bus of the communication protocol, wherein the subset of capabilities is defined by the one of the different types of devices for the communication protocol.
摘要翻译：根据本公开的实施例，由用于通信协议的全套能力定义的不同类型的设备的适配器可以包括一个或多个端口，其中所述一个或多个端口中的每一个更多端口被配置为接收不同类型的设备中的一个，以及通信地耦合到一个或多个端口的设备控制器。设备控制器可以被配置为当一个或多个端口接收到不同类型的设备中的一个时，获得与不同类型的设备中的一个设备的检测有关的信息，并且基于与检测有关的信息，将全部能力集合中的能力子集暴露给通信协议的总线，其中能力的子集由用于通信协议的不同类型的设备中的一种来定义。

9. 发明申请

WO2013015695A2 A HOUSING FOR AN ORAL HYGIENE AND MEDICATION DEVICE, AND AN ASSEMBLY THEREOF 审中-公开
标题翻译：口腔卫生和药物装置的住房及其组装
公开(公告)号：WO2013015695A2
公开(公告)日：2013-01-31
申请号：PCT/NZ2012000130
申请日：2012-07-27
申请人： ISSACHAR LTD , HUXFORD CATHERINE MARIA , BROWN BRADLEY ALLAN JAMES , WILCOCK PETER JOHN , FIFIELD JON LEONARD
发明人： HUXFORD CATHERINE MARIA , BROWN BRADLEY ALLAN JAMES , WILCOCK PETER JOHN , FIFIELD JON LEONARD
CPC分类号： A61J1/22 , A46B17/04 , A46B2200/1066 , A47K1/09 , A61M15/0025 , A61M15/009 , A61M2205/58 , A61M2205/6045 , A61M2209/082
摘要： The invention provides a housing adapted to provide for the juxtaposition of an oral hygiene device, such as a toothbrush, with an inhaler medication device, such as a metered dose inhaler (MDI) or dry powder inhaler (DPI). Also provided is an assembly including a housing, an oral hygiene device and an inhaler medication device wherein, in use, the housing and inhaler medication device together secure the oral hygiene device in the housing such that the oral hygiene device cannot be removed for use without first removing the inhaler medication device.
摘要翻译：本发明提供了一种适于提供诸如牙刷的口腔卫生装置与吸入器药物装置如计量吸入器（MDI）或干粉吸入器（DPI）并置的壳体。还提供了一种组件，其包括壳体，口腔卫生装置和吸入器药物装置，其中在使用中，壳体和吸入器药物装置一起将口腔卫生装置固定在壳体中，使得口腔卫生装置不能在没有首先取出吸入器药物装置。

10. 发明申请

WO0194630A3 COMPOSITIONS AND METHODS FOR ARRAY-BASED NUCLEIC ACID HYBRIDIZATION 审中-公开
标题翻译：用于基于阵列核酸混合的组合物和方法
公开(公告)号：WO0194630A3
公开(公告)日：2003-08-21
申请号：PCT/US0112838
申请日：2001-04-19
申请人： BAYLOR COLLEGE MEDICINE , BRADLEY ALLAN , CAI WIN WEN
发明人： BRADLEY ALLAN , CAI WIN WEN
IPC分类号： G01N33/53 , B01L3/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N37/00
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00722 , B01L3/508 , C12Q1/6816 , C12Q1/6832 , C40B40/06 , C12Q2563/107 , C12Q2527/125 , C12Q2565/501 , C12Q2547/101 , C12Q2525/204
摘要： The invention provides compositions and methods for generating a molecular profile of genomic DNA by hybridization of labeled nucleic acid representing the genomic DNA to immobilized nucleic acid probes, e.g., arrays or biochips.
摘要翻译：本发明提供了通过将表示基因组DNA的标记的核酸与固定的核酸探针（例如阵列或生物芯片）杂交来产生基因组DNA的分子谱的组合物和方法。

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