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1. 发明申请

WO2006060482A2 SYSTEMS, DEVICES AND METHODS OF TREATMENT OF INTERVERTEBRAL DISORDERS 审中-公开
标题翻译：系统，器官和治疗椎间盘疾病的方法
公开(公告)号：WO2006060482A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/043326
申请日：2005-12-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LOTZ, Jeffrey, C. , BRADFORD, David, S.
发明人： LOTZ, Jeffrey, C. , BRADFORD, David, S.
IPC分类号： A61F2/44
CPC分类号： A61F2/30907 , A61B17/0401 , A61B2017/044 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/009 , A61F2002/30014 , A61F2002/30023 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30324 , A61F2002/30565 , A61F2002/30578 , A61F2002/30579 , A61F2002/30586 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2230/0065 , A61F2250/0018 , A61F2250/0034 , A61F2250/0036 , A61F2310/00976
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

2. 发明申请

WO2017222945A1 MAGNETIC RESONANCE SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAIN OR INFECTION ASSOCIATED WITH PROPIONIC ACID 审中-公开
标题翻译：用于诊断与丙酸有关的疼痛或感染的磁共振光谱系统和方法
公开(公告)号：WO2017222945A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038034
申请日：2017-06-16
申请人： NOCIMED, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRADFORD, David, S. , MAGNITSKY, Sergey, G. , DUDLI, Stefan
发明人： BRADFORD, David, S. , MAGNITSKY, Sergey, G. , DUDLI, Stefan , PEACOCK, James, Clayton, III , LOTZ, Jeffrey, C.
IPC分类号： A61B5/055 , A61B5/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA),
摘要翻译： MR光谱（MRS）系统和方法被提供用于测量与丙酸（PA）相对应的光谱信息，或者单独地或者与其他化学品相对应的其他测量结合来诊断和/或监测例如与痤疮丙酸杆菌相关的细菌感染或与其相关的病症如与组织酸度相关的伤害性疼痛中的至少一种。接口DDD-MRS信号处理器接收输出信号以产生经过后处理的光谱，其中光谱区域与包括PA的某些化学品相对应，然后作为生物标志物进行测量。诊断处理器根据涉及退行性疼痛组织病理学中涉及的化学物质的光谱区域的比例（例如乳酸（LA）和丙氨酸（AL）的PA和缺氧标志物），为每个盘衍生诊断值并执行某些标准化，，以及蛋白多糖（PG）和胶原蛋白或碳水化合物（CA）的结构化学物质，

3. 发明申请

WO2007035906A3 SYSTEMS AND METHODS FOR IMAGING-TREATMENT OF PAIN 审中-公开
标题翻译：用于成像治疗疼痛的系统和方法
公开(公告)号：WO2007035906A3
公开(公告)日：2009-04-23
申请号：PCT/US2006036943
申请日：2006-09-21
申请人： UNIV CALIFORNIA , BRADFORD DAVID S , LOTZ JEFFREY C
发明人： BRADFORD DAVID S , LOTZ JEFFREY C
IPC分类号： A61B5/00 , A61K51/00
CPC分类号： A61K51/1096 , A61B5/4041 , A61B5/4824 , A61B6/506 , A61B18/14 , A61B2018/00339 , A61B2018/00577 , A61B2018/00642 , A61K49/0002 , A61M5/007 , A61M5/1723 , A61M2230/005 , A61N7/02
摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.
摘要翻译：疼痛因素用传递到体内的靶向药物或标记进行标记。标记的疼痛因子以适当的成像工具以允许选择性识别和定位疼痛源或传播区域的方式成像。标记的疼痛因子允许成像中的空间分化足以指定疼痛的位置，以便驱动治疗决定和技术以治疗疼痛。以这种方式标记和成像的疼痛因子可包括神经因子，血管因子，细胞因子和炎症因子中的一种或多种。标记的标记可以包括例如放射性材料（例如氚化或碘化分子）或其它材料，例如金属（例如金）纳米颗粒。可以使用中间结合材料，例如双特异性抗体。该系统和方法的治疗组件包括例如局部能量递送或消融治疗，或局部药物或其它化学物质递送。选择性地由靶向药物结合的含有疼痛因子的位置被选择性地用定向能量处理到含有与疼痛因子结合的靶向药剂的区域中。

4. 发明申请

WO2006081471A3 SYSTEMS AND METHODS USING NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO EVALUATE PAIN AND DEGENERATIVE PROPERTIES OF TISSUE 审中-公开
标题翻译：使用核磁共振（NMR）光谱评估组织的疼痛和变性特性的系统和方法
公开(公告)号：WO2006081471A3
公开(公告)日：2007-08-23
申请号：PCT/US2006003036
申请日：2006-01-30
申请人： UNIV CALIFORNIA , MAJUMDAR SHARMILA , KURHANEWICZ JOHN , LOTZ JEFFREY C , BRADFORD DAVID S , KESHARI KAYVAN
发明人： MAJUMDAR SHARMILA , KURHANEWICZ JOHN , LOTZ JEFFREY C , BRADFORD DAVID S , KESHARI KAYVAN
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/4824 , G01N24/08 , G01R33/465 , G01R33/483 , G01R33/485
摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of disc degeneration, or discogenic pain.
摘要翻译：对椎间盘组织进行NMR光谱。基于NMR光谱测定退化程度。制作核磁共振谱区和疼痛之间的相关性。因此，使用NMR光谱来确定椎间盘退变或椎间盘疼痛中的至少一种的位置和/或程度。

5. 发明申请

WO2007038510A1 ARTICULATING INSTRUMENTATION FOR DYNAMIC SPINAL STABILIZATION 审中-公开
标题翻译：用于动态脊柱稳定的仪器仪表
公开(公告)号：WO2007038510A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037479
申请日：2006-09-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LOTZ, Jeffrey, C. , BRADFORD, David, S.
发明人： LOTZ, Jeffrey, C. , BRADFORD, David, S.
IPC分类号： A61B17/56 , A61B17/58
CPC分类号： A61B17/70 , A61B17/7023 , A61B90/03
摘要： Dynamic stabilization apparatus and methods in the context of a spinal implant configured to constraine intervertebral movement, where the constraint is meant to eliminate unwanted, non-physiologic motions. The system provides dynamic stability to motion in a compromised spinal joint by allowing motion along a centrode of the instant axis of rotation (IAR) that substantially approximates the normal centrode for the respective spinal joint.
摘要翻译：在脊柱植入物的上下文中的动态稳定装置和方法被配置为约束椎间盘运动，其中约束意在消除不需要的非生理运动。该系统通过允许沿着基本上接近相应脊柱关节的正常中心的瞬时旋转轴线（IAR）的中心运动来提供在受损脊椎关节中的运动的动态稳定性。

6. 发明申请

WO2006060482A3 SYSTEMS, DEVICES AND METHODS OF TREATMENT OF INTERVERTEBRAL DISORDERS 审中-公开
标题翻译：系统，器官和治疗椎间盘疾病的方法
公开(公告)号：WO2006060482A3
公开(公告)日：2007-02-22
申请号：PCT/US2005043326
申请日：2005-12-01
申请人： UNIV CALIFORNIA , LOTZ JEFFREY C , BRADFORD DAVID S
发明人： LOTZ JEFFREY C , BRADFORD DAVID S
IPC分类号： A61F2/44
CPC分类号： A61F2/30907 , A61B17/0401 , A61B2017/044 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/009 , A61F2002/30014 , A61F2002/30023 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30324 , A61F2002/30565 , A61F2002/30578 , A61F2002/30579 , A61F2002/30586 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2230/0065 , A61F2250/0018 , A61F2250/0034 , A61F2250/0036 , A61F2310/00976
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

7. 发明申请

WO2003061756A2 IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 审中-公开
标题翻译：可植入热处理方法和装置
公开(公告)号：WO2003061756A2
公开(公告)日：2003-07-31
申请号：PCT/US2003/002211
申请日：2003-01-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DIEDERICH, Chris, J. , LOTZ, Jeffrey, C. , NAU, Will , BRADFORD, David, S. , O'BANION, John, P. , PEACOCK, James, C, III
发明人： DIEDERICH, Chris, J. , LOTZ, Jeffrey, C. , NAU, Will , BRADFORD, David, S. , O'BANION, John, P. , PEACOCK, James, C, III
IPC分类号： A61N
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C, and in particular 75 degrees C, are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度达到其他响应而没有明显的重塑。

8. 发明申请

WO2003059437A2 SYSTEM AND METHOD PROVIDING DIRECTIONAL ULTRASOUND THERAPY TO SKELETAL JOINTS 审中-公开
标题翻译：系统和方法提供方向超声治疗对骨关节
公开(公告)号：WO2003059437A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/001568
申请日：2003-01-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DIEDERICH, Chris, J. , LOTZ, Jeffrey, C. , NAU, Will , BRADFORD, David, S. , WISTROM, Elizabeth , BASS, Elisa
发明人： DIEDERICH, Chris, J. , LOTZ, Jeffrey, C. , NAU, Will , BRADFORD, David, S. , WISTROM, Elizabeth , BASS, Elisa
IPC分类号： A61N
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C, and in particular 75 degrees C, are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度达到其他响应而没有明显的重塑。

9. 发明申请

WO03061756A3 IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 审中-公开
标题翻译：可植入热处理方法和装置
公开(公告)号：WO03061756A3
公开(公告)日：2003-10-16
申请号：PCT/US0302211
申请日：2003-01-23
申请人： UNIV CALIFORNIA , DIEDERICH CHRIS J , LOTZ JEFFREY C , NAU WILL , BRADFORD DAVID S , O'BANION JOHN P , PEACOCK JAMES C III
发明人： DIEDERICH CHRIS J , LOTZ JEFFREY C , NAU WILL , BRADFORD DAVID S , O'BANION JOHN P , PEACOCK JAMES C III
IPC分类号： A61B17/00 , A61B19/00 , A61N7/00 , A61N7/02 , A61B18/04
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system (11) and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer (16) is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs (1), or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C, and in particular 75 degrees C, are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供了长期植入式超声治疗系统（11）和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器（16）输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这样的位置可以包括例如在椎间盘（1）中或周围，或者诸如椎骨体或后椎体元件（例如小关节）的骨结构。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度达到其他响应而没有明显的重塑。

10. 发明申请

WO2007035906A2 SYSTEMS, COMPOSITIONS, AND METHODS FOR LOCAL IMAGING AND TREATMENT OF PAIN 审中-公开
标题翻译：用于局部成像和治疗疼痛的系统，组合物和方法
公开(公告)号：WO2007035906A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036943
申请日：2006-09-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRADFORD, David, S. , LOTZ, Jeffrey, C.
发明人： BRADFORD, David, S. , LOTZ, Jeffrey, C.
IPC分类号： A61B8/14
CPC分类号： A61K51/1096 , A61B5/4041 , A61B5/4824 , A61B6/506 , A61B18/14 , A61B2018/00339 , A61B2018/00577 , A61B2018/00642 , A61K49/0002 , A61M5/007 , A61M5/1723 , A61M2230/005 , A61N7/02
摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.
摘要翻译：疼痛因素用传递到体内的靶向药物或标记进行标记。标记的疼痛因子以适当的成像工具以允许选择性识别和定位疼痛源或传播区域的方式成像。标记的疼痛因子允许成像中的空间分化足以指定疼痛的位置，以便驱动治疗决定和技术以治疗疼痛。以这种方式标记和成像的疼痛因子可包括神经因子，血管因子，细胞因子和炎症因子中的一种或多种。标记的标记可以包括例如放射性材料（例如氚化或碘化分子）或其它材料，例如金属（例如金）纳米颗粒。可以使用中间结合材料，例如双特异性抗体。该系统和方法的治疗组件包括例如局部能量递送或消融治疗，或局部药物或其它化学物质递送。选择性地由靶向药物结合的含有疼痛因子的位置被选择性地用定向能量处理到含有与疼痛因子结合的靶向药剂的区域中。

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