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1. 发明申请

WO2009105662A9 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) 审中-公开
公开(公告)号：WO2009105662A9
公开(公告)日：2009-08-27
申请号：PCT/US2009/034702
申请日：2009-02-20
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY , VO DINH, Tuan , BOURKE, Frederic, A., Jr.
发明人： VO DINH, Tuan , BOURKE, Frederic, A., Jr.
IPC分类号： A61N5/06 , G01N33/574
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.

2. 发明申请

WO2012019081A3 COLOR ENHANCEMENT UTILIZING UP CONVERTERS AND DOWN CONVERTERS 审中-公开
标题翻译：使用升级转换器和下变频器的颜色增强
公开(公告)号：WO2012019081A3
公开(公告)日：2012-04-05
申请号：PCT/US2011046709
申请日：2011-08-05
申请人： IMMUNOLIGHT LLC , BOURKE FREDERIC A JR , WALDER HAROLD
发明人： BOURKE FREDERIC A JR , WALDER HAROLD
IPC分类号： B32B5/16
CPC分类号： A61Q17/04 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/29 , A61K2800/42 , A61K2800/434 , A61Q1/02 , A61Q1/04 , A61Q1/10 , B82Y30/00 , C09D5/22 , C09D5/29 , C09D7/66 , C09D11/50 , G02B5/008 , G02B5/23
摘要： A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters.
摘要翻译：一种发光组合物，包括第一颜色发射体和第二颜色发射体。第一颜色发射器配置成在暴露于能量源时响应于穿过第一波长带的能量的吸收而发射目标颜色的可见光。第二颜色发射器被配置为响应于穿过第二波长带的能量的吸收而在曝光到能量源时发射目标颜色的可见光。在目标颜色下可观察到的光强度相对于没有来自第一和第二颜色发射器的反射的白光增强。

3. 发明申请

WO2010123996A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 审中-公开
标题翻译：用PSORALEN衍生物治疗细胞增殖障碍的方法和系统
公开(公告)号：WO2010123996A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031902
申请日：2010-04-21
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY , TOONE, Eric , GOODEN, David , BOURKE, Frederic, A., Jr. , VO-DINH, Tuan
发明人： TOONE, Eric , GOODEN, David , BOURKE, Frederic, A., Jr. , VO-DINH, Tuan
IPC分类号： A61K31/41
CPC分类号： C07D493/04 , A61K31/4433 , A61K31/453 , A61K31/4709 , A61K41/0066 , A61K45/06 , A61N5/062 , A61N5/10
摘要： Psoralen compounds of Formula (I): wherein (N + Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: (iv), wherein R is C 1 -C 30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R 1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.
摘要翻译：式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是式（ⅳ）的基团，其中 R是C1-C30烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基 ; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。

4. 发明申请

WO2010107720A3 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES 审中-公开
公开(公告)号：WO2010107720A3
公开(公告)日：2010-09-23
申请号：PCT/US2010/027373
申请日：2010-03-16
申请人： VO-DINH, Tuan , SCAFFIDI, Jonathan, P. , CHADA, Venkata, Gopal Reddy , LAULY, Benoit , ZHANG, Yan , GREGAS, Molly, K. , STANTON, Ian, Nicholas , STECHER, Joshua, T. , THERIEN, Michael, J. , BOURKE, Frederic, A., Jr. , FATHI, Zak , AYRES, Jennifer , ZHANG, Zhenyuan , SIMMONS, Joseph, H. , IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： VO-DINH, Tuan , SCAFFIDI, Jonathan, P. , CHADA, Venkata, Gopal Reddy , LAULY, Benoit , ZHANG, Yan , GREGAS, Molly, K. , STANTON, Ian, Nicholas , STECHER, Joshua, T. , THERIEN, Michael, J. , BOURKE, Frederic, A., Jr. , FATHI, Zak , AYRES, Jennifer , ZHANG, Zhenyuan , SIMMONS, Joseph, H.
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/543
摘要： A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ 1 of radiation, to generate a second wavelength λ 2 of radiation having a higher energy than the first wavelength λ 1 and 2 ) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ 1 or the second wavelength,λ 2 or with both λ 1 and λ 2 . The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ 2 , generates the photostimulated reaction.

5. 发明申请

WO2010107720A2 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES 审中-公开
标题翻译：用于生产来自各种能源的发射光的上下转换系统
公开(公告)号：WO2010107720A2
公开(公告)日：2010-09-23
申请号：PCT/US2010027373
申请日：2010-03-16
申请人： VO-DINH TUAN , SCAFFIDI JONATHAN P , CHADA VENKATA GOPAL REDDY , LAULY BENOIT , ZHANG YAN , GREGAS MOLLY K , STANTON IAN NICHOLAS , STECHER JOSHUA T , THERIEN MICHAEL J , BOURKE FREDERIC A JR , FATHI ZAK , AYRES JENNIFER , ZHANG ZHENYUAN , SIMMONS JOSEPH H
发明人： VO-DINH TUAN , SCAFFIDI JONATHAN P , CHADA VENKATA GOPAL REDDY , LAULY BENOIT , ZHANG YAN , GREGAS MOLLY K , STANTON IAN NICHOLAS , STECHER JOSHUA T , THERIEN MICHAEL J , BOURKE FREDERIC A JR , FATHI ZAK , AYRES JENNIFER , ZHANG ZHENYUAN , SIMMONS JOSEPH H
IPC分类号： B32B5/16 , A61L2/08 , A61N5/06 , B01J19/00 , B01J19/08 , B01J19/12 , C08F2/46 , C12M1/34 , F21V9/16 , G01N21/63 , G01N30/96 , G21K1/00
CPC分类号： F21K2/00 , A61L2/08 , A61L2202/22 , A61N5/062 , B82Y20/00 , B82Y30/00 , G01N21/63 , G02B5/003
摘要： A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength ?1 of radiation, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1 and 2 ) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength ?1 or the second wavelength,?2 or with both ?1 and ?2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength ?2, generates the photostimulated reaction.
摘要翻译：用于能量上转换和/或下转换的系统以及用于在介质中产生光激发反应的系统。这些系统包括：1）纳米颗粒，其在暴露于第一波长λ1的辐射时产生具有比第一波长λ1高的能量的第二波长λ2的辐射，以及2）相对于第一波长λ1布置的金属结构纳米粒子。金属结构的物理特性设定为这样的值，其中金属结构中的表面等离子体共振以提供与第一波长λ1或第二波长λ2或者λ1和λ2两者的光谱重叠的频率谐振？2。用于在培养基中产生光刺激反应的系统包括设置在培养基中靠近纳米颗粒的受体，所述受体在通过第二波长λ2活化时产生光刺激反应。

6. 发明申请

WO2009105662A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) 审中-公开
标题翻译：使用PLASMONICS增强光疗法（PEPST）和EXCITON-PLASMON增强型照相疗法（EPEP）治疗细胞增殖性疾病的方法和系统
公开(公告)号：WO2009105662A1
公开(公告)日：2009-08-27
申请号：PCT/US2009034702
申请日：2009-02-20
申请人： IMMUNOLIGHT LLC , UNIV DUKE , VO DINH TUAN , BOURKE FREDERIC A JR
发明人： VO DINH TUAN , BOURKE FREDERIC A JR
IPC分类号： A61N5/06 , G01N33/574
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.
摘要翻译：使用等离子体激元增强光谱疗法（PEPST）和离子等离子体增强光疗法（EPEP）治疗各种细胞增殖障碍，以及其中使用的PEPST和EPEP试剂和探针。

7. 发明申请

WO2010009106A1 ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS 审中-公开
标题翻译：用于治疗细胞增殖障碍的先进方法和系统
公开(公告)号：WO2010009106A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/050514
申请日：2009-07-14
申请人： BOURKE, Frederic A., Jr. , VO DINH, Tuan
发明人： BOURKE, Frederic A., Jr. , VO DINH, Tuan
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： A61N5/062 , A61K31/4427 , A61K31/7052 , A61K31/7056 , A61K41/008 , A61K47/55 , A61K47/551
摘要： The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) admimsteπng at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of vaπous cell proliferation disorders, and the PEPST and EPEP agents and probes
摘要翻译：本发明涉及治疗细胞增殖紊乱的方法，其包括（1）向受试者施用至少一种能够同时进行两个光子吸收事件激活并在被激活时实现预定细胞变化的可活化药剂，（2）将至少一种等离子体激元活性剂施用于受试者，和（3）将来自起始能量源的引发能量施用于受试者，其中所述等离子体激活剂增强或改变施加的引发能量，使得增强或修饰的引发能量通过原位同步双光子吸收事件激活可激活的药剂，从而导致发生预定的细胞变化，其中所述预定的细胞变化处理细胞增殖相关病症，以及使用等离子体激元增强光谱疗法（PEPST）和离开 - 增效光疗法（EPEP）治疗血管我们的细胞增殖障碍，以及PEPST和EPEP试剂和探针

8. 发明申请

WO2012019081A2 COLOR ENHANCEMENT UTILIZING UP CONVERTERS AND DOWN CONVERTERS 审中-公开
标题翻译：使用升级转换器和下变频器的颜色增强
公开(公告)号：WO2012019081A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046709
申请日：2011-08-05
申请人： IMMUNOLIGHT, LLC , BOURKE, Frederic, A., Jr. , WALDER, Harold
发明人： BOURKE, Frederic, A., Jr. , WALDER, Harold
IPC分类号： C09K11/08 , F21V9/16 , H01J1/62 , G02B5/23 , C09K11/77 , C09K11/64 , C09K11/62 , C09K11/60 , C09K11/58 , C09K11/87 , C09K11/78 , C09K11/84 , C09K11/85 , C09K11/80 , C09K11/81 , C09K11/82 , C09K11/59 , C09K11/54 , C09K11/88 , C09K11/55 , A61K8/19 , A61K8/02 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/24 , A61K8/21 , A61K8/20 , A61K8/23 , A61Q1/10 , A61Q19/00 , A61Q5/00 , A61Q1/08 , A61Q17/04 , C09D1/00 , C09D11/00 , F21V9/06 , B82Y30/00
CPC分类号： A61Q17/04 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/29 , A61K2800/42 , A61K2800/434 , A61Q1/02 , A61Q1/04 , A61Q1/10 , B82Y30/00 , C09D5/22 , C09D5/29 , C09D7/66 , C09D11/50 , G02B5/008 , G02B5/23
摘要： A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.
摘要翻译：一种发光组合物，包括第一颜色发射体和第二颜色发射体。第一颜色发射器配置成在暴露于能量源时响应于穿过第一波长带的能量的吸收而发射目标颜色的可见光。第二颜色发射器被配置为响应于穿过第二波长带的能量的吸收而在曝光到能量源时发射目标颜色的可见光。在目标颜色下可观察到的光强度相对于没有来自第一和第二颜色发射器的反射的白光增强。发光组合物可以是油漆，油墨，织物，螺纹，道路标志，公路标记，汽车，船，飞机，反射器，建筑产品，混凝土产品，环氧树脂产品，珠宝产品，彩色隐形眼镜，蜡烛产品，橡胶制品，塑料制品或其他有色表面。

9. 发明申请

WO2009114567A1 PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE 审中-公开
标题翻译：等离子体辅助系统和内部能源激活源的方法
公开(公告)号：WO2009114567A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036716
申请日：2009-03-11
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY , BOURKE, Frederic, A., Jr. , VO-DINH, Tuan
发明人： BOURKE, Frederic, A., Jr. , VO-DINH, Tuan
IPC分类号： B01J19/08
CPC分类号： B01J19/123 , A23L2/50 , A23L3/26 , A23L3/263 , A23L3/28 , A23L5/32 , A23V2002/00 , A61K41/0057 , A61K41/0066 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/082 , A61L2/088 , A61L2/10 , A61L2/16 , A61L2202/21 , A61L2202/22 , A61M1/3683 , A61N5/062 , A61N5/0624 , A61N5/10 , A61N2005/0661 , A61N2005/0662 , A61N2005/1087 , A61N2005/1089 , A61N2005/1098 , B01J19/082 , B01J19/085 , B01J19/12 , B01J19/125 , B01J19/127 , B01J19/128 , B01J23/50 , B01J23/52 , B01J31/0275 , B01J31/2295 , B01J35/0006 , B01J35/0013 , B01J35/004 , B01J37/0072 , B01J37/0221 , B01J2219/0877 , B01J2219/0879 , B01J2219/0892 , B01J2219/1203 , B01J2231/005 , B01J2531/005 , B01J2531/008 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C02F1/30 , C02F1/302 , C02F1/305 , C02F1/307 , C02F1/32 , C02F1/725 , C02F2305/10 , C08J3/24 , C08J3/28 , C08J7/18 , C08J2300/00 , C09D201/00 , C09J5/00 , C09J201/00 , C09J2205/31 , C12H1/06 , G02B5/008 , G21K5/00 , Y02W10/37 , Y10S977/774 , Y10S977/777 , Y10S977/896 , Y10S977/915 , Y10T156/10
摘要： A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.
摘要翻译：一种用于产生设置在人造容器中的介质的变化的方法和系统。该方法在介质附近放置等离子体激元和能量调节剂中的至少一种。该方法将引发能量通过人造容器施加到介质。起始能量与等离子体激元试剂或能量调节剂相互作用直接或间接地产生介质中的变化。该系统包括引发能量源，其被配置为向介质施加起始能量以激活等离子体激元试剂或能量调节剂。

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