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1. 发明申请

WO2016061517A3 CONTIGUITY PRESERVING TRANSPOSITION 审中-公开
标题翻译：保持运输的连续性
公开(公告)号：WO2016061517A3
公开(公告)日：2016-06-23
申请号：PCT/US2015056040
申请日：2015-10-16
申请人： ILLUMINA CAMBRIDGE LTD , STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
发明人： STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2525/191 , C12Q2563/179 , C12Q2565/514
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.
摘要翻译：本文提供的实施方案涉及用于制备靶核酸的条形码DNA片段的固定化文库，鉴定基因组变体，确定目标核酸的邻接信息，定相信息和甲基化状态的方法和组合物。

2. 发明申请

WO2012055929A1 SEQUENCING METHODS 审中-公开
标题翻译：序列方法
公开(公告)号：WO2012055929A1
公开(公告)日：2012-05-03
申请号：PCT/EP2011/068790
申请日：2011-10-26
申请人： ILLUMINA, INC. , RIGATTI, Roberto , BOUTELL, Jonathan, Mark , BETLEY, Jason, Richard , GORMLEY, Niall, Anthony , RONAGHI, Mostafa , EVERS, Dirk
发明人： RIGATTI, Roberto , BOUTELL, Jonathan, Mark , BETLEY, Jason, Richard , GORMLEY, Niall, Anthony , RONAGHI, Mostafa , EVERS, Dirk
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2565/514 , C12Q2537/155 , C12Q2525/186 , C12Q2525/185 , C12Q2537/113 , C12Q2525/204
摘要： The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to nucleic acid sequencing.
摘要翻译：本技术涉及分子科学，如基因组学。更具体地，本技术涉及核酸测序。

3. 发明申请

WO2006131768A3 TRIAZINES AS PROTEIN BINDING LIGANDS 审中-公开
公开(公告)号：WO2006131768A3
公开(公告)日：2006-12-14
申请号：PCT/GB2006/050146
申请日：2006-06-08
申请人： PROMETIC BIOSCIENCES LIMITED , BETLEY, Jason, Richard , PEARSON, James, Christopher , TATTON, Helen, Rosemary , BEACOM, Ben, Martin
发明人： BETLEY, Jason, Richard , PEARSON, James, Christopher , TATTON, Helen, Rosemary , BEACOM, Ben, Martin
IPC分类号： C07D251/44 , C07D251/50 , C07D251/70 , B01D15/38 , B01J20/286 , G01N30/00
摘要： Compounds of the general formula (I): in which inter alia Q 1 represents -NR 1 R 3 , -OR 1 or -SR 1 and Q 2 represents -NR 2 R 4 , -OR 2 or -SR 2 , and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R 1 , R 2 , R 3 and R 4 includes an alkyl group -C n H 2n+1 in which n is greater than or equal to 7; (b) at least two of R 1 , R 2 , R 3 and R 4 independently include an alkyl group -C n H 2n+1 or a cycloalkyl group -C n H 2n-1 in which n is greater than or equal to 4; or (c) at least three of R 1 , R 2 , R 3 and R 4 independently include a C 1-12 alkyl group substituted by -NR 5 R 6 or aryl.

4. 发明申请

WO2012050920A1 COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS 审中-公开
标题翻译：用于测序核酸的组合物和方法
公开(公告)号：WO2012050920A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053763
申请日：2011-09-28
申请人： ILLUMINA, INC. , BOUTELL, Jonathan, Mark , RIGATTI, Roberto , BETLEY, Jason, Richard , GORMLEY, Niall, Anthony
发明人： BOUTELL, Jonathan, Mark , RIGATTI, Roberto , BETLEY, Jason, Richard , GORMLEY, Niall, Anthony
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q2525/101 , C12Q2525/186 , C12Q2525/191 , C12Q2565/543 , C12Q2565/537 , C12Q2535/122 , C12Q2523/301 , C12Q2521/319
摘要： Disclosed herein are compositions and methods for sequencing nucleic acids.
摘要翻译：本文公开了用于测序核酸的组合物和方法。

5. 发明申请

WO2006120429A1 AFFINITY ADSOBENTS FOR FIBRINOGEN 审中-公开
公开(公告)号：WO2006120429A1
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001695
申请日：2006-05-09
申请人： PROMETIC BIOSCIENCES LTD. , BETLEY, Jason, Richard , PEARSON, James, Christopher , BEACOM, Ben, Martin , PODGORSKI, TAdeusz, Antoni , PANNELL, Robert, William
发明人： BETLEY, Jason, Richard , PEARSON, James, Christopher , BEACOM, Ben, Martin , PODGORSKI, TAdeusz, Antoni , PANNELL, Robert, William
IPC分类号： B01J20/32 , G01N30/00 , G01N33/86 , C07K14/75 , C07D251/50
CPC分类号： C07D251/48 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07K14/75 , G01N33/86
摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C-Cl or C-CN; Y is O, S or NR 2 ; 0 Z is O, S or NR 3 ; R 2 and R 3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; n is 0 to 6; A is a support matrix, optionally linked to the triazine ring by a spacer; R 7 is a group bearing a positive charge at neutral pH; W is an optional linker; V is an aromatic group; and R 8 and R 9 are each H, OH, alkyl, alkoxy, amino, NH 2 , acyloxy, acylamino, CO 2 H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R 8 and R 9 are linked to form such a cyclic structure.
摘要翻译：为了纤维蛋白原或纤维蛋白原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一个X为N且另一个为N，C的式II化合物 -Cl或C-CN; Y是O，S或NR 2; 0 Z是O，S或NR 3; R 2和R 3各自为H，烷基，羟基烷基，苄基或β-苯基乙基; n为0〜6; A是支撑基质，任选地通过间隔基连接到三嗪环上; R 7是在中性pH下带正电荷的基团; W是可选的接头; V是芳族基团; R 8和R 9各自为H，OH，烷基，烷氧基，氨基，NH 2，酰氧基，酰氨基， 2 H，磺酸，氨基甲酰基，氨磺酰基，烷基磺酰基或卤素或环状结构如吗啉代基或R 8和R 9连接到形成这样的循环结构。

6. 发明申请

WO2006120427A1 AFFINITY ADSORBENTS FOR FACTOR VIII AND VON WILLEBRAND'S FACTOR 审中-公开
标题翻译：影响因素VIII和VON WILLEBRAND'S FACTOR的亲属吸引力
公开(公告)号：WO2006120427A1
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001693
申请日：2006-05-09
申请人： PROMETIC BIOSCIENCES LTD. , BETLEY, Jason, Richard , BAINES, Baldev, Singh
发明人： BETLEY, Jason, Richard , BAINES, Baldev, Singh
IPC分类号： B01J20/32 , G01N30/00 , G01N33/86 , C07D251/48 , C07D251/50 , C07D251/70
CPC分类号： B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3244 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07D251/48 , C07D251/50 , C07D251/70 , C07D403/12 , C07K14/755 , G01N33/86 , G01N2333/755 , Y10T436/25375 , Y10T436/255
摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-C1 or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR 2 ; Z is O, S or N-R 3 ; R 2 and R 3 are each H, C 1-6 alkyl, C 1-6 hydroxyalkyl, benzyl or β-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH 2 ) 3-4 -NH 2 ; and R 7 is a group bearing a positive charge at neutral pH.
摘要翻译：为了分离，去除，分离，纯化，表征，鉴定或定量因子VIII，血管性血友病因子或与之类似的蛋白质，使用亲和吸附剂，其为一个X为 N，另一个是N，C-C1或C-CN; A是支撑基质，任选地通过间隔基连接到三嗪环上; Y是O，S或NR 2; Z是O，S或N-R 3; R 2和R 3各自为H，C 1-6烷基，C 1-6烷基，C 1-6烷基，苄基或β-苯基乙基; B和W各自为含有1至10个碳原子的任选取代的烃链; D是H，OH或伯氨基，仲氨基，叔氨基，季铵，咪唑，胍基或脒基; 或B-D是-CHCOOH - （CH 2）2 - ， - NH 2 - 。 R 7是在中性pH下带正电荷的基团。

7. 发明申请

WO2004022101A1 MODIFIED THERAPEUTIC AGENTS 审中-公开
标题翻译：改性治疗剂
公开(公告)号：WO2004022101A1
公开(公告)日：2004-03-18
申请号：PCT/GB2003/003867
申请日：2003-09-05
申请人： ADPROTECH LIMITED , ESSER, Dirk , BETLEY, Jason, Richard , RIDLEY, Simon, Hugh
发明人： ESSER, Dirk , BETLEY, Jason, Richard , RIDLEY, Simon, Hugh
IPC分类号： A61K47/48
CPC分类号： C07K7/06 , C07K7/08
摘要： The invention provides a modified therapeutic agent, said modified agent comprising three or more membrane binding elements with low membrane affinity covalently associated with the agent which elements are capable of interacting independently and with thermodynamic additivity, with components of cellular or artificial membranes exposed to extracellular fluids wherein at least two membrane binding elements are lipophilic elements, which may be aliphatic acyl groups, which may be selected from the list consisting of Myristoyl, Decanoyl or Hexanoyl.
摘要翻译：本发明提供了一种修饰的治疗剂，所述改性剂包含三种或更多种具有低膜亲和力的膜结合元件，所述膜结合元件与所述试剂共价结合，该元件能够独立地相互作用并具有热力学加和性，细胞或人造膜的组分暴露于细胞外液其中至少两个膜结合元件是亲脂性元件，其可以是脂族酰基，其可以选自由肉豆蔻酰，癸酰基或己酰基组成的列表。

8. 发明申请

WO2016061517A2 CONTIGUITY PRESERVING TRANSPOSITION 审中-公开
标题翻译：对等保存转换
公开(公告)号：WO2016061517A2
公开(公告)日：2016-04-21
申请号：PCT/US2015/056040
申请日：2015-10-16
申请人： ILLUMINA CAMBRIDGE LIMITED , STEEMERS, Frank J. , GUNDERSON, Kevin L. , ZHANG, Fan , BETLEY, Jason Richard , GORMLEY, Niall Anthony , MEULEMAN, Wouter , WEIR, Jacqueline , IOANNOU, Avgousta , JENKINS, Gareth , JACKSON, Rosamond , MORRELL, Natalie , POKHOLOK, Dmitry K. , NORBERG, Steven J. , HE, Molly , KIA, Amirali , GORYSHIN, Igor , PANTOJA, Rigo
发明人： STEEMERS, Frank J. , GUNDERSON, Kevin L. , ZHANG, Fan , BETLEY, Jason Richard , GORMLEY, Niall Anthony , MEULEMAN, Wouter , WEIR, Jacqueline , IOANNOU, Avgousta , JENKINS, Gareth , JACKSON, Rosamond , MORRELL, Natalie , POKHOLOK, Dmitry K. , NORBERG, Steven J. , HE, Molly , KIA, Amirali , GORYSHIN, Igor , PANTOJA, Rigo
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2525/191 , C12Q2563/179 , C12Q2565/514
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.
摘要翻译：本文提供的实施方案涉及用于制备靶核酸的条形码化DNA片段的固定文库，鉴定基因组变体，确定靶核酸的邻接信息，定相信息和甲基化状态的方法和组合物酸

9. 发明申请

WO2007099374A1 ADSORBENTS FOR PROTEIN PURIFICATION 审中-公开
标题翻译：蛋白质纯化的吸附剂
公开(公告)号：WO2007099374A1
公开(公告)日：2007-09-07
申请号：PCT/GB2007/050095
申请日：2007-03-02
申请人： PROMETIC BIOSCIENCES LTD , BETLEY, Jason Richard , TATTON, Helen , LE RICHE, Kelly , WEBB, Matthew
发明人： BETLEY, Jason Richard , TATTON, Helen , LE RICHE, Kelly , WEBB, Matthew
IPC分类号： C07D251/48 , B01J20/22
CPC分类号： C07D251/48 , B01D15/3804 , B01J20/286 , B01J20/3251 , B01J20/3255 , Y10T436/25375 , Y10T436/255
摘要： Use of an affinity adsorbent for the separation, removal, isolation, purification, characterisation, identification or quantification of a proteinaceous material, wherein the affinity adsorbent is a compound of formula (III). wherein R 1 is H, alkyl, aryl, hydroxyalkyl, cyciohexyl, amino or a heterocyclic group which is optionally substituted with one or more of alkyl, aryl, alkoxy, aryloxy, acyloxy, acylamino, amino, OH, CO 2 H, sulphonyl, carbamoyl, sulphamoyl, alkylsuiphonyl and halogen; one X is N and the other is N, C-CI or C-CN; Y is O, S or NR 2 ; Z is O, S or NR 3 ; R 2 and R 3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; Q is benzene, naphthalene, benzthiazole, benzoxazole, 1-phenylpyrazole, indazoie or benzimidazoie; R 4 , R 5 and R 6 are each H, OH, alkyl, aryl, heterocyclic, alkoxy, aryloxy, amino, acyloxy, acylamino, CO 2 H, sulphonic acid, carbamoyl, suiphamoyl, atkylsulphonyl or halogen, or two or more of R 4 , R 5 and R 6 are linked to form a cyclic structure; U and V are the same or different C 1-10 straight-chain alkylene groups optionally substituted by one or more of hydroxyl, alkyl, aryl, hydroxyl, alkyl, β-phenylethyl and halogen; and A is a support matrix optionally linked to the X-containing ring by a spacer.
摘要翻译：使用亲和吸附剂来分离，去除，分离，纯化，表征，鉴定或定量蛋白质物质，其中亲和吸附剂是式（III）的化合物。其中R 1是H，烷基，芳基，羟烷基，环己基，氨基或杂环基，其任选被一个或多个烷基，芳基，烷氧基，芳氧基，酰氧基，酰氨基，氨基，OH CO 2 H，磺酰基，氨基甲酰基，氨磺酰基，烷基磺酰基和卤素; 一个X为N，另一个为N，C-Cl或C-CN; Y是O，S或NR 2; Z是O，S或NR 3; R 2和R 3各自为H，烷基，羟基烷基，苄基或β-苯基乙基; Q是苯，萘，苯并噻唑，苯并恶唑，1-苯基吡唑，indazoie或苯并咪唑; R 4，R 5和R 6各自为H，OH，烷基，芳基，杂环，烷氧基，芳氧基，氨基，酰氧基，酰基氨基 CO 2 H，磺酸，氨基甲酰基，磺酰基，烷基磺酰基或卤素，或两个或更多个R 4，R 5和R 5， SUB> 6连接形成环状结构; U和V是相同或不同的任选被羟基，烷基，芳基，羟基，烷基，β-苯基乙基和卤素中的一个或多个取代的C 1-10烷基亚烷基; 并且A是通过间隔物任选地连接到含X环的支撑基体。

10. 发明申请

WO2006120423A1 AFFINITY ADSORBENTS FOR PLASMINOGEN 审中-公开
标题翻译：适用于PLASMINOGEN的AFFINITY吸附剂
公开(公告)号：WO2006120423A1
公开(公告)日：2006-11-16
申请号：PCT/GB2006/001686
申请日：2006-05-09
申请人： PROMETIC BIOSCIENCES LTD. , BETLEY, Jason, Richard , PEARSON, James, Christopher , KUHN, Claudia, Hildegard , BAINES, Baldev, Singh
发明人： BETLEY, Jason, Richard , PEARSON, James, Christopher , KUHN, Claudia, Hildegard , BAINES, Baldev, Singh
IPC分类号： B01J20/32 , G01N30/00 , C07D251/50 , C07D251/48
CPC分类号： B01J20/289 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3244 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07D251/48 , C07D251/50 , C12Q1/56 , G01N33/86
摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-Cl or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N-R and R is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, benzyl or β-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH 2 ) 3-4 -NH 2 ; and q is 2 to 6.
摘要翻译：对于纤溶酶原或纤溶酶原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一个X为N且另一个为N的式（II）化合物，C-Cl或C-CN; A是支持基质，任选地通过间隔基与三嗪环连接; Z是O，S或N-R，R是H，C 1-6烷基，C 1-6 - 羟基烷基，苄基或β-苯基乙基; B是含有1至10个碳原子的任选取代的烃键; D是H，OH或伯氨基，仲氨基，叔氨基，季铵，咪唑，胍基或脒基; 或B-D是-CHCOOH - （CH 2）2 - ， - NH 2 - 。 q为2〜6。

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