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1. 发明申请

WO2006137824A3 METHODS AND SYSTEMS FOR DETECTING BIOMOLECULAR BINDING USING TERAHERTZ RADIATION 审中-公开
标题翻译：用TERAHERTZ辐射检测生物分子结合的方法和系统
公开(公告)号：WO2006137824A3
公开(公告)日：2007-04-19
申请号：PCT/US2005025858
申请日：2005-07-20
申请人： INTEL CORP , KOO TAE-WOONG , BERLIN ANDREW , SALSMAN KEN , OSTROVSKY BRIAN
发明人： KOO TAE-WOONG , BERLIN ANDREW , SALSMAN KEN , OSTROVSKY BRIAN
IPC分类号： G01N21/35 , C12Q1/68
CPC分类号： G01N21/65 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00722 , B01L3/5027 , C12Q1/6825 , G01N21/3581 , G01N21/7743 , G01N33/54373 , G01N2021/651 , C12Q2545/114 , C12Q2523/313
摘要： Provided herein are methods and systems for detecting biomolecular binding events using gigahertz or terahertz radiation. The methods and systems use low-energy spectroscopy to detect biomolecular binding events between molecules in an aqueous solution. The detected biomolecular binding events include, for example, nucleic acid hybridizations, antibody/antigen binding, and receptor/ligand binding.
摘要翻译：本文提供了使用千兆兹或太赫兹辐射检测生物分子结合事件的方法和系统。该方法和系统使用低能谱来检测水溶液中分子之间的生物分子结合事件。检测到的生物分子结合事件包括例如核酸杂交，抗体/抗原结合和受体/配体结合。

2. 发明申请

WO2005097476A3 METHODS AND APPARATUS FOR 3D PRINTING 审中-公开
标题翻译： 3D打印的方法和设备
公开(公告)号：WO2005097476A3
公开(公告)日：2006-03-09
申请号：PCT/US2005011377
申请日：2005-04-01
申请人： CORP Z , RUSSEL DAVID , HERNANDEZ ANDRES , KINSLEY JOSHUA , BERLIN ANDREW
发明人： RUSSEL DAVID , HERNANDEZ ANDRES , KINSLEY JOSHUA , BERLIN ANDREW
IPC分类号： B28B7/46 , B29C41/02 , B29C67/00
CPC分类号： B28B7/465 , B28B1/001 , B29C64/165 , B33Y10/00 , B33Y30/00
摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.
摘要翻译：本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

3. 发明申请

WO2005090948A3 COMPOSITE ORGANIC-INORGANIC NANOCLUSTERS 审中-公开
标题翻译：复合有机无机纳米粒子
公开(公告)号：WO2005090948A3
公开(公告)日：2006-02-16
申请号：PCT/US2004043878
申请日：2004-12-28
申请人： INTEL CORP , SU XING , ZHANG JINGWU , SUN LEI , BERLIN ANDREW
发明人： SU XING , ZHANG JINGWU , SUN LEI , BERLIN ANDREW
IPC分类号： G01N21/65 , G01N33/543
CPC分类号： G01N33/54346 , G01N21/658
摘要： Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.
摘要翻译：提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。纳米团簇包括金属颗粒和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。此外，还提供了含有纳米簇的聚合物微球及其制备方法。纳米团簇和微球可用于例如生物分子多重检测的测定。

4. 发明申请

WO2005097476A2 METHODS AND APPARATUS FOR 3D PRINTING 审中-公开
标题翻译： 3D打印的方法和设备
公开(公告)号：WO2005097476A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/011377
申请日：2005-04-01
申请人： Z CORPORATION , RUSSEL, David , HERNANDEZ, Andres , KINSLEY, Joshua , BERLIN, Andrew
发明人： RUSSEL, David , HERNANDEZ, Andres , KINSLEY, Joshua , BERLIN, Andrew
IPC分类号： B29C67/00
CPC分类号： B28B7/465 , B28B1/001 , B29C64/165 , B33Y10/00 , B33Y30/00
摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.
摘要翻译：本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

5. 发明申请

WO2005066368A2 METHODS AND COMPOSITIONS FOR DETECTING NUCLEIC ACIDS USING SCANNING PROBE MICROSCOPY AND NANOCODES 审中-公开
标题翻译：使用扫描探针显微镜和纳米级检测核酸的方法和组合物
公开(公告)号：WO2005066368A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043632
申请日：2004-12-28
申请人： INTEL CORPORATION , BERLIN, Andrew , YAMAKAWA, Mineo
发明人： BERLIN, Andrew , YAMAKAWA, Mineo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B82Y5/00 , B82Y10/00 , C12Q2565/601 , C12Q2563/155 , C12Q2525/179
摘要： A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of an isolated labeled oligonucleotides that binds to the nucleic acid is then detected using SPM. Nanocodes of the present invention in certain aspects include detectable features beyond the arrangement of tags that encode information about the barcoded object, which assist in detecting the tags that encode information about the barcoded object. The detectable features include structures of a nanocode or associated with a nanocode, referred to herein as detectable feature tags, for error checking/error-correction, encryption, and data reduction/compression.
摘要翻译：提供了用于确定核酸的核苷酸序列的方法，其包括使核酸与一系列用于结合核酸的标记的寡核苷酸接触，其中每个标记的寡核苷酸包括已知的核苷酸序列和分子纳代码。然后使用SPM检测与核酸结合的分离的标记寡核苷酸的纳代码。在某些方面，本发明的纳代码包括超过编码关于条形码对象的信息的标签布置的可检测特征，其有助于检测编码关于条形码对象的信息的标签。可检测特征包括用于错误校验/纠错，加密和数据缩减/压缩的纳代码或与纳代码相关联的结构，这里称为可检测特征标签。

6. 发明申请

WO2017139653A1 SYSTEMS AND METHODS FOR IMAGING 审中-公开
标题翻译：用于成像的系统和方法
公开(公告)号：WO2017139653A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/017482
申请日：2017-02-10
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , BERLIN, Andrew, A. , GUPTA, Neil , MANGOUBI, Rami, S. , MALEK, Adel
发明人： BERLIN, Andrew, A. , GUPTA, Neil , MANGOUBI, Rami, S.
IPC分类号： A61K49/18 , A61B5/00 , A61B5/05 , A61B5/055 , A61K49/00 , A61K49/06
CPC分类号： A61B6/481 , A61B5/0515 , A61B5/055 , A61B6/032 , A61B6/54 , A61M31/005
摘要： A method of imaging an organism includes introducing a composite nanoparticle into a circulating fluid of an organism to form a circulating fluid mixture in the organism is provided. The composite nanoparticle comprises a core comprising at least one of a contrast agent and a magnetic material, and at least one layer of biocompatible material surrounding the core. The method further includes receiving an image of at least a portion of the organism where the circulating fluid has circulated, removing at least a portion of the circulating fluid mixture from the organism at a first rate, applying a magnetic field to the removed portion of the circulating fluid mixture to selectively remove the composite nanoparticle from the circulating fluid mixture and to produce a filtered fluid mixture, and returning the filtered fluid mixture to the circulating fluid of the organism at a second rate.
摘要翻译：对生物进行成像的方法包括将复合纳米粒子引入生物体的循环流体中以在生物体中形成循环流体混合物。该复合纳米颗粒包括包含造影剂和磁性材料中的至少一种的核心以及围绕该核心的至少一层生物相容性材料。该方法进一步包括接收循环流体已经循环的生物体的至少一部分的图像，以第一速率从生物体移除循环流体混合物的至少一部分，将磁场施加到生物体的移除部分循环流体混合物以从循环流体混合物中选择性地移除复合纳米粒子并产生过滤后的流体混合物，并且以第二速率将过滤的流体混合物返回到生物体的循环流体中。

7. 发明申请

WO2005066367A3 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A3
公开(公告)日：2007-03-01
申请号：PCT/US2004043364
申请日：2004-12-24
申请人： INTEL CORP , SU XING , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO , BERLIN ANDREW , SUN LEI , ZHANG YUEGANG
发明人： SU XING , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO , BERLIN ANDREW , SUN LEI , ZHANG YUEGANG
IPC分类号： C01B31/02 , C12Q1/68 , D01F9/127 , H01L51/00 , H01L51/30
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成，将聚合物（120,210）分子附着到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

8. 发明申请

WO2006034012A2 APPARATUS AND METHODS FOR SERVICING 3D PRINTERS 审中-公开
标题翻译：维修3D打印机的设备和方法
公开(公告)号：WO2006034012A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033112
申请日：2005-09-15
申请人： Z CORPORATION , FIENUP, William, James , BERLIN, Andrew, A. , HERNANDEZ, Andres, Tomas , KINSLEY, Joshua, P. , ZENGERLE, III, Walter, H.
发明人： FIENUP, William, James , BERLIN, Andrew, A. , HERNANDEZ, Andres, Tomas , KINSLEY, Joshua, P. , ZENGERLE, III, Walter, H.
CPC分类号： B41J29/393 , B29C64/112 , B33Y40/00 , B41J2/16532 , B41J2/16538 , B41J2/16552 , B41J2/1752 , B41J3/4073 , H04N1/6033
摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve 3D printing and servicing of the equipment used in the associated 3D printer.
摘要翻译：本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。该设备和方法涉及3D相关3D打印机中使用的设备的3D打印和维修。

9. 发明申请

WO2005066366A3 NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION 审中-公开
标题翻译：在分子复制期间通过拉曼监测核酸摄取的核酸序列
公开(公告)号：WO2005066366A3
公开(公告)日：2006-03-02
申请号：PCT/US2004043091
申请日：2004-12-24
申请人： INTEL CORP , RAO VALLURI , NEUBAUER GABI , KIRCH STEVEN , YAMAKAWA MINEO , BERLIN ANDREW
发明人： RAO VALLURI , NEUBAUER GABI , KIRCH STEVEN , YAMAKAWA MINEO , BERLIN ANDREW
IPC分类号： C12Q1/68 , B01L3/00 , G01N21/05 , G01N21/65
CPC分类号： G01N21/05 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2300/0896 , B01L2400/0454 , B01L2400/0463 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C12Q1/6869 , G01N21/658 , G01N2021/0346 , G01N2021/651 , G01N2021/653 , G01N2021/655 , G01N2021/656 , C12Q2565/628
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction.
摘要翻译：本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。该方法涉及使用表面增强拉曼光谱（SERS）检测核苷酸，核苷或碱基。检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。

10. 发明申请

WO2005095963A2 SENSOR ARRAY INTEGRATED CIRCUITS 审中-公开
标题翻译：传感器阵列集成电路
公开(公告)号：WO2005095963A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/010401
申请日：2005-03-25
申请人： INTEL CORPORATION , DUBIN, Valery , DAVID, Ken , BERLIN, Andrew
发明人： DUBIN, Valery , DAVID, Ken , BERLIN, Andrew
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , G01J3/02
摘要： An apparatus includes a condensed array addressed device; and a spectroscope optically coupled to the condensed array addressed device. A method includes determining bonding and/or lack-of-bonding of a target molecule to a condensed array addressed device by characterizing a subsequent rate of electrolysis on the condensed array addressed device. A method includes fabricating a condensed array addressed device using damascene patterning.
摘要翻译：一种装置包括一个聚光阵列寻址装置; 以及光学耦合到聚光阵列寻址装置的分光镜。一种方法包括通过表征冷凝阵列寻址装置上随后的电解速率来确定目标分子与冷凝阵列寻址装置的结合和/或缺少键合。一种方法包括使用镶嵌图案来制造聚光阵列寻址装置。

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