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1. 发明申请

WO2010146203A3 PORTABLE DEVICE FOR SELF-VIEWING BLOOD CELLS IN THE RETINA 审中-公开
标题翻译：用于在RETINA中自我观察血液细胞的便携式设备
公开(公告)号：WO2010146203A3
公开(公告)日：2011-07-14
申请号：PCT/ES2010000277
申请日：2010-06-15
申请人： UNIV GRANADA , HERNANDEZ ANDRES JAVIER , LOPEZ ALVAREZ MIGUEL ANGEL , NIEVES GOMEZ JUAN LUIS
发明人： HERNANDEZ ANDRES JAVIER , LOPEZ ALVAREZ MIGUEL ANGEL , NIEVES GOMEZ JUAN LUIS
IPC分类号： A61B3/00
CPC分类号： A61B3/1241 , A61B3/1233
摘要： The invention relates to a compact, portable instrument that is easy to use, enabling the patient to evaluate him/herself in a few seconds whether the blood circulation in his/her retina is correct, and to therefore self-detect pathologies such as vascular retinopathies, arteriosclerosis or diabetic retinopathy inter alia.
摘要翻译：本发明涉及一种易于使用的紧凑便携式仪器，使得患者能够在几秒钟内对他/她的视网膜中的血液循环是否正确进行评估，并因此自我检测诸如血管视网膜病变，动脉硬化或糖尿病性视网膜病变等。

2. 发明申请

WO2007050726A2 NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：非基础麦芽宁浓缩激素受体-1拮抗剂
公开(公告)号：WO2007050726A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041725
申请日：2006-10-26
申请人： BRISTOL-MYERS SQUIBB COMPANY , WASHBURN, William N. , HERNANDEZ, Andres S. , MANFREDI, Mark C. , ROBL, Jeffrey, A.
发明人： WASHBURN, William N. , HERNANDEZ, Andres S. , MANFREDI, Mark C. , ROBL, Jeffrey, A.
IPC分类号： C07D495/04 , A61K31/522 , A61P5/00 , A61P25/00
CPC分类号： C07D495/04
摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
摘要翻译：本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。最后，本申请提供了通过施用治疗有效剂量的根据式I的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法。

3. 发明申请

WO2010104830A1 PYRIDONE ANALOGS USEFUL AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：吡咯烷酮类似物有效用于浓缩HORMONE受体-1拮抗剂的MELANIN
公开(公告)号：WO2010104830A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026626
申请日：2010-03-09
申请人： BRISTOL-MYERS SQUIBB COMPANY , AHMAD, Saleem , WASHBURN, William, N. , HERNANDEZ, Andres, S. , ROBL, Jeffrey, A. , NGU, Khehyong , WANG, Zhenghua
发明人： AHMAD, Saleem , WASHBURN, William, N. , HERNANDEZ, Andres, S. , ROBL, Jeffrey, A. , NGU, Khehyong , WANG, Zhenghua
IPC分类号： A61K31/4412 , A61P3/04 , C07D213/38 , C07D213/74 , C07D213/30 , C07D213/32 , C07D213/26 , C07D213/68 , C07D401/04 , A61K31/4409 , A61K31/4427
CPC分类号： C07D213/38 , A61K31/4412 , A61K31/4427 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/68 , C07D401/04
摘要： MCHR1 antagonists are provided having the following Formula I: wherein A 1 and A 2 are independently C or N; E is C or N; D 1 is a bond, -CR 8 R 9 X-, -XCR 8 R 9 -, -CHR 8 CHR 9 -, -CR 10 =CR 10' -, -C≡C-, or 1,2-cyclopropyl; X is O, S or -NR 11 ; R 1 , R 2 , and R 3 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, lower cycloalkoxy, -CF 3 , -OCF 3 , -OR 12 and -SR 12 ; G is O or S; D 2 is lower alkyl, lower cycloalkyl, lower alkylcycloalkyl, lower cycloalkylalkyl, lower cycloalkoxyalkyl or lower alkycycloalkoxy; Z 1 and Z 2 are independently hydrogen, halogen, lower alkyl, lower cycloalkyl, lower alkoxy, lower cycloalkoxy, halo, -CF 3 , -OCONR 14 R 14' , -CN, -CONR 14 R 14' , -SOR 12 , -SO 2 R 12 , -NR 14 COR 14' , -NR 14 CO 2 R 14' , -CO 2 R 12 , NR 14 SO 2 R 12 or -COR 12 provided that if Z 1 is -CH 3 and one of R 1 , R 2 , or R 3 is F, then Z 2 cannot be H;; R 5 , R 6 , and R 7 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, -CF 3 , -SR 12 , lower alkoxy, lower cycloalkoxy, -OCH 2 OMe, -CN, -CONR 14 R 14' , SOR 12 , SO 2 R 12 , NR 14 COR 14' , NR 14 CO 2 R 12 , CO 2 R 12 , NR 14 SO 2 R 12 and -COR 12 ; R 8 , R 9 , R 10 , R 10' , R 11 are independently hydrogen or lower alkyl; R 12 is lower alkyl or lower cycloalkyl; and R 14 and R 14' are independently H, lower alkyl, lower cycloalkyl or R 14 and R 14' together with the N to which they are attached form a ring having 4 to 7 atoms. Such compounds are useful for the treatment of MCHR1 mediated diseases, such as obesity, diabetes, IBD, depression, and anxiety.
摘要翻译：提供具有下式I的MCHR1拮抗剂：其中A1和A2独立地为C或N; E为C或N; D1是键，-CR8R9X-，-XCR8R9-，-CHR8CHR9-，-CR10 = CR10'-，-C = C-或1,2-环丙基; X是O，S或-NR 11; R 1，R 2和R 3独立地选自氢，卤素，低级烷基，低级环烷基，低级环烷氧基，-CF 3，-OCF 3，-OR 12和-SR 12; G为O或S; D2是低级烷基，低级环烷基，低级烷基环烷基，低级环烷基烷基，低级环烷氧基烷基或低级烷基环烷氧基; Z1和Z2独立地是氢，卤素，低级烷基，低级环烷基，低级烷氧基，低级环烷氧基，卤素，-CF3，-OCONR14R14'，-CN，-CONR14R14'，-SOR12，-SO2R12，-NR14COR14'，-NR14CO2R14' ，-CO 2 R 12，NR 14 SO 2 R 12或-COR 12，条件是如果Z 1是-CH 3并且R 1，R 2或R 3中的一个是F，则Z 2不能是H。 R5，R6和R7独立地选自氢，卤素，低级烷基，低级环烷基，-CF3，-SR12，低级烷氧基，低级环烷氧基，-OCH2OMe，-CN，-CONR14R14'，SOR12，SO2R12， NR14COR14'，NR14CO2R12，CO2R12，NR14SO2R12和-COR12; R8，R9，R10，R10'，R11独立地为氢或低级烷基; R12是低级烷基或低级环烷基; 并且R 14和R 14'独立地为H，低级烷基，低级环烷基或R 14和R 14'与它们所连接的N一起形成具有4至7个原子的环。这些化合物可用于治疗MCHR1介导的疾病，例如肥胖症，糖尿病，IBD，抑郁症和焦虑症。

4. 发明申请

WO2008134480A1 NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：非基础麦芽宁浓缩激素受体-1拮抗剂
公开(公告)号：WO2008134480A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061519
申请日：2008-04-25
申请人： BRISTOL-MYERS SQUIBB COMPANY , WASHBURN, William N. , AHMAD, Saleem , HERNANDEZ, Andres S.
发明人： WASHBURN, William N. , AHMAD, Saleem , HERNANDEZ, Andres S.
IPC分类号： C07D495/04 , A61K31/5025 , A61K31/53 , A61K31/381 , A61P25/24
CPC分类号： C07D495/04
摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula (I) and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-I modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula (I) where R 1 , R 1a , R 1b , A, R 3 , R 4 , R 5 , R5 b and R 6 are as defined herein.
摘要翻译：本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式（I）的化合物和任选的至少一种另外的治疗剂。最后，本申请提供了通过施用治疗有效剂量的根据式（I）的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法，其中R 1，R 1a，R 1b，A，R 3，R 4， R 5，R 5，R 6和R 6如本文所定义。

5. 发明申请

WO2006047533A2 A DOCUMENT AND INFORMATION DEFICIENCY PROCESSING SYSTEM 审中-公开
标题翻译：文件和信息缺陷处理系统
公开(公告)号：WO2006047533A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038423
申请日：2005-10-25
申请人： SIEMENS MEDICAL SOLUTIONS HEALTH SERVICES CORPORATION , LUSEN, William D. , RACIS, Frank W. , HERNANDEZ, Andres
发明人： LUSEN, William D. , RACIS, Frank W. , HERNANDEZ, Andres
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/10

6. 发明申请

WO2006034012A2 APPARATUS AND METHODS FOR SERVICING 3D PRINTERS 审中-公开
标题翻译：维修3D打印机的设备和方法
公开(公告)号：WO2006034012A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033112
申请日：2005-09-15
申请人： Z CORPORATION , FIENUP, William, James , BERLIN, Andrew, A. , HERNANDEZ, Andres, Tomas , KINSLEY, Joshua, P. , ZENGERLE, III, Walter, H.
发明人： FIENUP, William, James , BERLIN, Andrew, A. , HERNANDEZ, Andres, Tomas , KINSLEY, Joshua, P. , ZENGERLE, III, Walter, H.
CPC分类号： B41J29/393 , B29C64/112 , B33Y40/00 , B41J2/16532 , B41J2/16538 , B41J2/16552 , B41J2/1752 , B41J3/4073 , H04N1/6033
摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve 3D printing and servicing of the equipment used in the associated 3D printer.
摘要翻译：本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。该设备和方法涉及3D相关3D打印机中使用的设备的3D打印和维修。

7. 发明申请

WO2010047956A1 AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：阿莫洛林粉红素浓缩激素受体-1拮抗剂
公开(公告)号：WO2010047956A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/059924
申请日：2009-10-08
申请人： BRISTOL-MYERS SQUIBB COMPANY , DEVASTHALE, Pratik , WASHBURN, William, N. , WANG, Wei , HERNANDEZ, Andres , AHMAD, Saleem , ZHAO, Guohua
发明人： DEVASTHALE, Pratik , WASHBURN, William, N. , WANG, Wei , HERNANDEZ, Andres , AHMAD, Saleem , ZHAO, Guohua
IPC分类号： C07D487/04 , A61K31/4015 , A61P3/00
CPC分类号： C07D487/04
摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula (I) including all pharmaceutically acceptable salts and stereoisomers thereof: wherein A is a monocyclic aryl or monocyclic heteroaryl; W is a direct bond, -0-, or -N(R 6 )-, provided that if W is a direct bond, D must be a cyclic amine that is attached to A via the nitrogen atom of said cyclic amine; D is a direct bond, substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, cycloalkylalkyl, or a 4 to 6 membered cyclic amine; B and E are independently N or CH provided that both are not CH;
摘要翻译：本申请提供了包括其所有药学上可接受的盐和立体异构体的根据式（I）的所有立体异构体，溶剂化物，前药和药学上可接受的形式的化合物：其中A是单环芳基或单环杂芳基; W是直接键，-O-或-N（R6） - ，条件是如果W是直接键，则D必须是通过所述环胺的氮原子连接到A的环胺; D是直接键，取代或未取代的C1至C4烷基，取代或未取代的C3至C7环烷基，环烷基烷基或4至6元环胺; B和E独立地为N或CH，条件是两者都不是CH;

8. 发明申请

WO2007050726A3 THIENOPYRIMIDINONE DERIVATIVES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：作为MELANIN浓缩激素受体-1拮抗剂的三烯酰基嘧啶衍生物
公开(公告)号：WO2007050726A3
公开(公告)日：2007-08-30
申请号：PCT/US2006041725
申请日：2006-10-26
申请人： SQUIBB BRISTOL MYERS CO , WASHBURN WILLIAM N , HERNANDEZ ANDRES S , MANFREDI MARK C , ROBL JEFFREY A
发明人： WASHBURN WILLIAM N , HERNANDEZ ANDRES S , MANFREDI MARK C , ROBL JEFFREY A
IPC分类号： C07D495/04 , A61K31/522 , A61P5/00 , A61P25/00
CPC分类号： C07D495/04
摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
摘要翻译：本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。最后，本申请提供了通过施用治疗有效剂量的根据式I的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法。

9. 发明申请

WO2005097476A3 METHODS AND APPARATUS FOR 3D PRINTING 审中-公开
标题翻译： 3D打印的方法和设备
公开(公告)号：WO2005097476A3
公开(公告)日：2006-03-09
申请号：PCT/US2005011377
申请日：2005-04-01
申请人： CORP Z , RUSSEL DAVID , HERNANDEZ ANDRES , KINSLEY JOSHUA , BERLIN ANDREW
发明人： RUSSEL DAVID , HERNANDEZ ANDRES , KINSLEY JOSHUA , BERLIN ANDREW
IPC分类号： B28B7/46 , B29C41/02 , B29C67/00
CPC分类号： B28B7/465 , B28B1/001 , B29C64/165 , B33Y10/00 , B33Y30/00
摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.
摘要翻译：本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

10. 发明申请

WO2005097476A2 METHODS AND APPARATUS FOR 3D PRINTING 审中-公开
标题翻译： 3D打印的方法和设备
公开(公告)号：WO2005097476A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/011377
申请日：2005-04-01
申请人： Z CORPORATION , RUSSEL, David , HERNANDEZ, Andres , KINSLEY, Joshua , BERLIN, Andrew
发明人： RUSSEL, David , HERNANDEZ, Andres , KINSLEY, Joshua , BERLIN, Andrew
IPC分类号： B29C67/00
CPC分类号： B28B7/465 , B28B1/001 , B29C64/165 , B33Y10/00 , B33Y30/00
摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.
摘要翻译：本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

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