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1. 发明申请

WO2006050032A2 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL 审中-公开
标题翻译：系统和方法分析采样和水凝胶分析
公开(公告)号：WO2006050032A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038785
申请日：2005-10-27
申请人： SONTRA MEDICAL CORPORATION , CHUANG, Han , BARMAN, Shikha, P.
发明人： CHUANG, Han , BARMAN, Shikha, P.
IPC分类号： A61B17/20
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003 , G06F19/00
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，该系统包括适于与生物膜接界并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中该介质是适于与分析物连续反应，由电极组件检测电信号，并且电信号与分析物值相关。分析物值可以是分析物通过生物膜的通量或者受试者体液中分析物的浓度。例如，介质可以包含基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包含纯铂。该系统可以包括位于生物膜和电极组件之间的干扰滤波器，用于减少系统中的干扰。该系统可以包括处理器，该处理器被编程为实施校正传感器漂移的错误校正方法。

2. 发明申请

WO2003070905A2 ELECTROPORATION METHODS FOR INTRODUCING BIOACTIVE AGENTS INTO CELLS 审中-公开
标题翻译：将生物活性剂引入细胞的电化学方法
公开(公告)号：WO2003070905A2
公开(公告)日：2003-08-28
申请号：PCT/US2003/004937
申请日：2003-02-18
申请人： ZYCOS, INC. , BARMAN, Shikha, P. , HEDLEY, Mary, Lynne , WANG, Daqing
发明人： BARMAN, Shikha, P. , HEDLEY, Mary, Lynne , WANG, Daqing
IPC分类号： C12N
CPC分类号： C12N15/87 , A61K9/0009 , A61K41/0047
摘要： The invention provides compositions and methods for introducing bioactive agents into cells. Bioactive agents are provided together with a delivery vehicle and a cell is subjected to electroporation, thereby resulting in the introduction of the bioactive agent into the cell.
摘要翻译：本发明提供了将生物活性剂引入细胞的组合物和方法。将生物活性剂与递送载体一起提供，并对细胞进行电穿孔，从而导致将生物活性剂引入细胞中。

3. 发明申请

WO02057424A3 NUCLEIC ACID DELIVERY FORMULATIONS 审中-公开
标题翻译：核酸递送配方
公开(公告)号：WO02057424A3
公开(公告)日：2002-10-03
申请号：PCT/US0201379
申请日：2002-01-17
申请人： ZYCOS INC , BARMAN SHIKHA P , ROY KRISHNENDU , HEDLEY MARY LYNNE , WANG DAQING
发明人： BARMAN SHIKHA P , ROY KRISHNENDU , HEDLEY MARY LYNNE , WANG DAQING
IPC分类号： C12N15/09 , A61K9/00 , A61K9/19 , A61K35/76 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K48/00 , C12N5/10 , C12N15/63 , A61K9/127 , C12N15/88
CPC分类号： A61K9/0019 , A61K9/0024 , A61K47/10 , A61K47/24 , A61K47/34 , A61K48/0041
摘要： The invention is based on the discovery that injectable and nucleic acid-compatible polymeric compositions and formulations can be structurally designed to regulate nucleic acid activity or gene expression in vivo , for example, by controlling the bioavailability of the nucleic acid via modulation of the biodegradability and crosslink density of the network formed by the components of the formulation. The polymeric network encases the nucleic acid, not only controlling the release of the DNA, but also providing protection from degradation. The invention described herein improves upon prior modes of gene delivery, in that gene expression can be regulated by modulation of a polymeric network formed by combination of at least two water-soluble components capable of reacting with one another. The nucleic acid of interest is incorporated into the network to be released in a sustained manner to achieve level and duration of activity or expression needed.
摘要翻译：本发明是基于以下发现：可结构地设计可注射和可与核酸相容的聚合物组合物和制剂以在体内调节核酸活性或基因表达，例如通过调节生物降解性来控制核酸的生物利用度，以及由制剂组分形成的网络的交联密度。聚合物网络包含核酸，不仅控制DNA的释放，而且提供防止降解的保护。本文描述的本发明改进了先前的基因递送模式，因为基因表达可以通过调节由能够彼此反应的至少两种水溶性组分形成的聚合物网络来调节。感兴趣的核酸以持续的方式并入网络中以实现所需的活性或表达的水平和持续时间。

4. 发明申请

WO2012078649A1 METHODS FOR TREATING BALDNESS AND PROMOTING HAIR GROWTH 审中-公开
标题翻译：治疗粘液和促进头发生长的方法
公开(公告)号：WO2012078649A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063557
申请日：2011-12-06
申请人： FOLLICA, INC. , BARMAN, Shikha, P. , JU, William, D. , KELLOGG, Scott, C. , PROUTY, Stephen, M. , SCHWEIGER, Eric , LEDERMAN, Seth , OSBAKKEN, Mary , SCHINAZI, Alan, D.
发明人： BARMAN, Shikha, P. , JU, William, D. , KELLOGG, Scott, C. , PROUTY, Stephen, M. , SCHWEIGER, Eric , LEDERMAN, Seth , OSBAKKEN, Mary , SCHINAZI, Alan, D.
IPC分类号： A61K8/00
CPC分类号： A61M37/00 , A45D2200/1054 , A61B17/00491 , A61B17/54 , A61B18/203 , A61B2017/00398 , A61B2017/00495 , A61B2017/00734 , A61B2017/00747 , A61B2017/00761 , A61B2017/320004 , A61B2018/00476 , A61B2018/00577 , A61H7/005 , A61H23/0245 , A61H2201/10 , A61H2201/105 , A61H2201/1215 , A61H2201/1604 , A61H2201/1671 , A61H2205/021 , A61K8/4953 , A61K8/63 , A61K8/69 , A61K38/4893 , A61K2800/884 , A61N5/0617 , A61N2005/0644 , A61N2005/067 , A61Q7/00
摘要： The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.
摘要翻译：本发明涉及治疗秃发，治疗脱发，促进毛发生长和/或促进毛囊发育和/或激活或刺激受试者（例如人）皮肤区域的方法，皮肤到皮肤扰动。视觉摄影可以与其他促进头发生长的治疗结合使用。本发明提供用于促进毛发生长的皮肤扰动装置，并提供用于促进头发生长的皮肤扰动组合使用的药物组合物。

5. 发明申请

WO2012065065A1 METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION 审中-公开
标题翻译：用于调节毛发生长，伤口愈合和SCAR修正的方法和组合物
公开(公告)号：WO2012065065A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/060375
申请日：2011-11-11
申请人： FOLLICA, INC. , BARMAN, Shikha, P. , JU, William, D. , KELLOGG, Scott, C. , PROUTY, Stephen, M. , SCHWEIGER, Eric , LEDERMAN, Seth , OSBAKKEN, Mary
发明人： BARMAN, Shikha, P. , JU, William, D. , KELLOGG, Scott, C. , PROUTY, Stephen, M. , SCHWEIGER, Eric , LEDERMAN, Seth , OSBAKKEN, Mary
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K8/49 , A61K8/492 , A61K8/4953 , A61K9/0014 , A61K9/7007 , A61K9/7015 , A61K31/404 , A61K31/433 , A61K31/4439 , A61K31/56 , A61Q7/00 , A61K2300/00
摘要： The invention relates to methods for (i) modulating hair growth and (ii) improving wound healing, e.g ., scarless wound healing, and scar revision in human subjects involving the administration of one or more compounds provided herein. Compositions and uses of compositions containing the compounds provided herein are also described. The compound, composition thereof, or treatment(s) comprising the compound may be administered alone or in combination with ( e.g ., concurrently with, before, and/or after) other treatments for the enhancement or inhibition of hair growth or for the improvement of wound healing or scar revision. Such combination treatments may involve mechanical or physical treatments that cause integumental perturbation ( e.g ., laser, dermabrasion, etc .); immune stimulation; chemical treatments; and/or surgical treatments for the enhancement or inhibition of hair growth or for the improvement of wound healing or scar revision.
摘要翻译：本发明涉及用于（i）调节毛发生长和（ii）改善人受试者的伤口愈合（例如无创伤口愈合和瘢痕修复）的方法，所述人受试者涉及给予一种或多种本文提供的化合物。还描述了含有本文提供的化合物的组合物和用途。包含该化合物的化合物，组合物或治疗剂可以单独施用或与其他治疗（例如，同时，之前和/或之后）组合施用以增强或抑制的头发生长或用于改善伤口愈合或瘢痕修正。这样的组合治疗可能涉及导致整体性干扰的机械或物理治疗（例如激光，磨皮等）。免疫刺激; 化学处理; 和/或手术治疗以增强或抑制毛发生长或改善伤口愈合或瘢痕修正。

6. 发明申请

WO2011031990A1 INTERMITTENT AND PULSE LITHIUM TREATMENTS FOR MODULATING HAIR GROWTH 审中-公开
标题翻译：用于调节头发生长的间接和脉冲锂处理
公开(公告)号：WO2011031990A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048457
申请日：2010-09-10
申请人： FOLLICA, INC. , JU, William, D. , PROUTY, Stephen, M. , BARMAN, Shikha, P. , KELLOGG, Scott, C. , SCHWEIGER, Eric , LEDERMAN, Seth
发明人： JU, William, D. , PROUTY, Stephen, M. , BARMAN, Shikha, P. , KELLOGG, Scott, C. , SCHWEIGER, Eric , LEDERMAN, Seth
IPC分类号： A61K8/65
CPC分类号： A61K8/19 , A61K8/63 , A61K2800/78 , A61Q7/00 , A61Q7/02
摘要： The invention relates to intermittent lithium treatments, or a single pulse lithium treatment for modulating hair growth in human subjects. Uses of compositions containing compounds that liberate lithium ions are described, including adjuvants and devices for administration. The intermittent treatment protocol involves multiple courses of lithium treatment interrupted by lithium treatment "holidays." For the single pulse protocol, a dose of lithium is administered over a short period of time. The lithium treatment(s) can be used in combination with other treatments for the enhancement or inhibition of hair growth. Such combination treatments may involve mechanical or physical treatments that cause integumental perturbation ( e.g . such as electrology (electrolysis), laser, intense pulsed light, dermabrasion, etc .); immune stimulation ( e.g ., such as adjuvants, antigens, cytokines, growth factors, etc . ); and/or chemical treatments ( e.g ., that cause integumental perturbation or that enhance or inhibit hair growth); and/or surgical treatments ( e.g ., hair transplant) for the enhancement or inhibition of hair growth. The combination treatment(s) may be administered concurrently with, or during the "holidays'" between, cycles of intermittent lithium treatments; or concurrently with, or before and/or after the pulse lithium treatment.
摘要翻译：本发明涉及间歇性锂处理或用于调节人类受试者毛发生长的单脉冲锂处理。描述了含有释放锂离子的化合物的组合物的用途，包括佐剂和用于给药的装置。间歇治疗方案涉及多个锂处理过程，由锂处理“假期”中断。对于单脉冲方案，在短时间内施用一剂量的锂。锂处理可以与用于增强或抑制毛发生长的其它处理组合使用。这种组合治疗可能涉及导致皮肤干扰的机械或物理治疗（例如电学（电解），激光，强脉冲光，皮肤磨擦等）; 免疫刺激（例如佐剂，抗原，细胞因子，生长因子等）; 和/或化学处理（例如，引起皮肤扰动或增强或抑制头发生长）; 和/或用于增强或抑制毛发生长的外科治疗（例如毛发移植）。联合治疗可以在间歇性锂处理周期之间同时或在“假期”期间施用; 或与脉冲锂处理同时或之前和/或之后。

7. 发明申请

WO2006050032A3 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL 审中-公开
标题翻译：用于分析仪采样和分析的系统和方法
公开(公告)号：WO2006050032A3
公开(公告)日：2006-09-08
申请号：PCT/US2005038785
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , CHUANG HAN , BARMAN SHIKHA P
发明人： CHUANG HAN , BARMAN SHIKHA P
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

8. 发明申请

WO2003070905A3 ELECTROPORATION METHODS FOR INTRODUCING BIOACTIVE AGENTS INTO CELLS 审中-公开
公开(公告)号：WO2003070905A3
公开(公告)日：2003-08-28
申请号：PCT/US2003/004937
申请日：2003-02-18
申请人： ZYCOS, INC. , BARMAN, Shikha, P. , HEDLEY, Mary, Lynne , WANG, Daqing
发明人： BARMAN, Shikha, P. , HEDLEY, Mary, Lynne , WANG, Daqing
IPC分类号： A61K41/00
摘要： The invention provides compositions and methods for introducing bioactive agents into cells. Bioactive agents are provided together with a delivery vehicle and a cell is subjected to electroporation, thereby resulting in the introduction of the bioactive agent into the cell.

9. 发明申请

WO2012067632A1 SEQUENTIAL BODY SURFACE TREATMENT 审中-公开
标题翻译：顺序体表面处理
公开(公告)号：WO2012067632A1
公开(公告)日：2012-05-24
申请号：PCT/US2010/060227
申请日：2011-02-18
申请人： FOLLICA, INC. , LEDERMAN, Seth, M. , KELLOGG, Scott, C. , BARMAN, Shikha, P.
发明人： LEDERMAN, Seth, M. , KELLOGG, Scott, C. , BARMAN, Shikha, P.
IPC分类号： A61B17/20
CPC分类号： A61M35/003 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0061
摘要： The present methods and systems provide treatment of a preselected body surface by injuring a portion of the body surface, optionally applying a composition such as a pharmaceutical agent to the injured portion of the body surface, and selection of a further portion on the body surface for the same or different injury and optional contacting with the same or different composition, wherein the further portion has a preselected geometry with respect to the first injured portion. The repetition of the selection, injury, and optional exposure to a composition with respect to successive portions of the body surface, optionally under partial or total computer control, provides efficient treatment of the body surface pursuant to the objective of regeneration, remodeling, resurfacing, restoration, follicular neogenesis, neocollagenesis, stem cell recruitment, activation, or differentiation, reepitheliazation, wound healing, or any other desired biological or physical modification.
摘要翻译：本发明的方法和系统通过损伤身体表面的一部分，任选地将诸如药剂的组合物施加到身体表面的受损部分，以及选择身体表面上的另外部分来提供预选身体表面的治疗相同或不同的损伤和任选的与相同或不同组合物的接触，其中另外的部分相对于第一受伤部分具有预选的几何形状。根据再生，重塑，表面重建的目的，选择，损伤和任选地暴露于组合物相对于身体表面的连续部分（任选地部分或全部计算机控制）的重复提供对身体表面的有效治疗，恢复，滤泡新生，新胶原形成，干细胞募集，活化或分化，上皮替代，伤口愈合或任何其它所需的生物或物理修饰。

10. 发明申请

WO2006091719A2 COMPOSITIONS AND METHODS ENHANCING TRANSDERMAL DELIVERY OF DRUGS AND BIOLOGICS 审中-公开
标题翻译：组合物和方法增强药物和生物学的转运
公开(公告)号：WO2006091719A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006385
申请日：2006-02-23
申请人： SONTRA MEDICAL CORP , BARMAN SHIKHA P , FARNHAM HANNAH , ROODE LAUREN K , WAN ANNA
发明人： BARMAN SHIKHA P , FARNHAM HANNAH , ROODE LAUREN K , WAN ANNA
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/0019
摘要： Improved methods for transdermal transport of drug formulations are described herein. Formulations designed to enhance transport of therapeutic levels of topically applied drugs into the systemic circulation, methods of making the formulations are also described herein. The formulations contain at least one active agent to be delivered and at least one skin permeation enhancer in a polymeric hydrogel, and optional additional excipients. Methods for enhancing transport of formulations into and through the skin include: (a) pretreatment of the skin with a hydrating solution, (b) physical permeation of the stratum corneum by low frequency ultrasound (administered by a sono-permeation device, such as SONOPREP ® , available from Sontra Medical Corporation, Franklin, MA), (c) topical application of a formulation containing the bioactive molecule, and optionally (d) application of an electric potential difference that forces ionized drugs through the skin. Optionally, the formulation contains permeation-enhancing agents. The method may be used with the formulations described herein or with other formulations for topical administration. In a preferred embodiment, the active agent to be delivered is a drug. Preferably the drug is a local anesthetic, such as lidocaine.
摘要翻译：本文描述了用于药物制剂的透皮转运的改进方法。设计用于增强局部应用药物治疗水平进入体循环的制剂，制备制剂的方法也在本文中描述。制剂含有至少一种待递送的活性剂和聚合物水凝胶中至少一种皮肤渗透促进剂，以及任选的另外的赋形剂。用于增强制剂进入皮肤和通过皮肤的运输的方法包括：（a）用水合溶液预处理皮肤，（b）通过低频超声（由超音波渗透装置如SONOPREP施用的角质层的物理渗透（Sontra Medical Corporation，Franklin，MA）），（c）局部施用含有生物活性分子的制剂，以及任选地（d）施加电离差，其强制电离药物通过皮肤。任选地，制剂含有渗透增强剂。该方法可以与本文所述的制剂一起使用或与其它用于局部给药的制剂一起使用。在优选的实施方案中，待递送的活性剂是药物。优选地，药物是局部麻醉剂，例如利多卡因。

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